{ "about": "Press and media coverage of research from the Meydan Lab (Cem Meydan, Ph.D., Weill Cornell Medicine). Studies are ordered with those where Dr. Meydan is co-first or co-corresponding author first, then by prominence; items within a study are ordered by outlet reach. Summaries are lab-written. ocr_text holds OCR of the saved page screenshots (headline and lede, or the full page when no article text was captured).", "generated": "2026-10-31", "studies": { "swisnf3d": { "name": "SWI/SNF, CTCF and 3D chromatin architecture", "short_name": "SWI/SNF & 3D genome", "meydan_role": "Co-first and co-corresponding author", "featured": true, "papers": [ { "doi": "10.1038/s41586-026-11197-w", "year": "2026", "journal": "Nature", "title": "SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin" } ], "impact": "Shows how SWI/SNF chromatin remodelers shape 3D genome architecture through CTCF and cohesin, giving a unifying explanation for how some of the most common cancer mutations fuel tumor growth.", "links": [] }, "spen": { "name": "SPEN and female-specific lymphoma lethality", "short_name": "SPEN & lymphoma", "meydan_role": "Second author", "featured": false, "papers": [ { "doi": "10.1158/2159-8290.CD-25-1458", "year": "2026", "journal": "Cancer Discovery", "title": "SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities" } ], "impact": "SPEN loss identifies a subset of a common blood cancer that is more lethal in women than in men.", "links": [] }, "baf": { "name": "BAF / ARID1A and follicular lymphoma", "short_name": "ARID1A & lymphoma", "meydan_role": "Co-first author", "featured": true, "papers": [ { "doi": "10.1016/j.ccell.2024.02.010", "year": "2024", "journal": "Cancer Cell", "title": "ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis" } ], "impact": "Shows how ARID1A loss reprograms B cell fate in follicular lymphoma and leaves these tumors vulnerable to BAF inhibitors already in clinical trials.", "links": [] }, "soma": { "name": "SOMA: Space Omics and Medical Atlas / Inspiration4", "short_name": "SOMA / Inspiration4", "meydan_role": "Co-corresponding author", "featured": true, "papers": [ { "doi": "10.1038/s41586-024-07639-y", "year": "2024", "journal": "Nature", "title": "The Space Omics and Medical Atlas (SOMA) and international astronaut biobank" } ], "impact": "The largest release of biomedical data from astronauts, built from the civilian Inspiration4 crew: three days in orbit left measurable, mostly reversible changes. Covered by The New York Times, Science, Space.com and National Geographic, and hosted as an open atlas and biobank.", "links": [ { "label": "SOMA Browser", "url": "https://soma.weill.cornell.edu/apps/SOMA_Browser/" }, { "label": "SOMA site", "url": "https://soma.weill.cornell.edu" }, { "label": "CAMbank", "url": "https://cambank.weill.cornell.edu/" }, { "label": "Nature collection", "url": "https://www.nature.com/collections/ebdbcahdgc" } ] }, "melnick": { "name": "Other lymphoma epigenetics (Melnick lab collaborations)", "short_name": "Lymphoma epigenetics", "meydan_role": "co-author", "featured": false, "papers": [ { "doi": "10.1038/s41590-020-00827-8", "year": "2021", "journal": "Nature Immunology", "title": "Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation" }, { "doi": "10.1016/j.ccell.2024.11.006", "year": "2025", "journal": "Cancer Cell", "title": "EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function" }, { "doi": "10.1158/2159-8290.CD-21-1514", "year": "2022", "journal": "Cancer Discovery", "title": "SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis" } ], "impact": "Lymphoma epigenetics studies with the Melnick lab on Smc3, EZH2 and SETD2.", "links": [] }, "metasub": { "name": "MetaSUB: global urban microbiome atlas", "short_name": "Global urban microbiome", "meydan_role": "co-author", "featured": false, "papers": [ { "doi": "10.1016/j.cell.2021.05.002", "year": "2021", "journal": "Cell", "title": "Global Genetic Cartography of Urban Metagenomes and Anti-Microbial Resistance" } ], "impact": "The International MetaSUB Consortium's global atlas of urban microbiomes and antimicrobial resistance across 60 cities.", "links": [ { "label": "MetaSUB", "url": "https://metasub.org/" }, { "label": "MetaSUB map", "url": "https://metasub.org/map" }, { "label": "StuckOnU", "url": "https://metasub.org/stuckonu2017/" } ] }, "covid": { "name": "COVID-19 research in New York, 2020-2022", "short_name": "COVID-19", "meydan_role": "Co-first author (Nat Commun 2021) · co-corresponding author (Cell Rep Med 2022)", "featured": true, "papers": [ { "doi": "10.1038/s41467-021-21361-7", "year": "2021", "journal": "Nature Communications", "title": "Shotgun Transcriptome, Isothermal, and Spatial Omics Profiling of SARS-CoV-2 Infection" }, { "doi": "10.1016/j.xcrm.2022.100522", "year": "2022", "journal": "Cell Reports Medicine", "title": "System-wide transcriptome damage and tissue identity loss in COVID-19 patients" } ], "impact": "Rapid isothermal tests, host-response and spatial profiling, and the COVID Genes resource built during the first waves of the New York City outbreak.", "links": [ { "label": "COVID Genes", "url": "http://covidgenes.weill.cornell.edu/" } ] }, "cell2020": { "name": "The Biology of Spaceflight (Cell Press collection, 2020)", "short_name": "Biology of Spaceflight", "meydan_role": "Co-first author (Cell)", "featured": true, "papers": [ { "doi": "10.1016/j.cell.2020.11.002", "year": "2020", "journal": "Cell", "title": "Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Hub for Spaceflight Biological Impact" } ], "impact": "A multi-omic analysis across astronauts and model organisms that put mitochondrial stress at the center of spaceflight biology, part of the Biology of Spaceflight collection.", "links": [ { "label": "The Biology of Spaceflight (Cell Press)", "url": "https://www.cell.com/consortium/the-biology-of-spaceflight" } ] }, "telo": { "name": "Telomeres in spaceflight and on Mt. Everest", "short_name": "Telomeres & Mt. Everest", "meydan_role": "Coauthor", "featured": false, "papers": [ { "doi": "10.1016/j.celrep.2020.108457", "year": "2020", "journal": "Cell Reports", "title": "Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration Spaceflight" } ], "impact": "Telomere length and DNA-damage responses in NASA Twins Study and other astronauts, compared with twin climbers on Mt. Everest, also part of the Biology of Spaceflight collection.", "links": [] }, "twins": { "name": "NASA Twins Study", "short_name": "NASA Twins Study", "meydan_role": "Co-first author", "featured": true, "papers": [ { "doi": "10.1126/science.aau8650", "year": "2019", "journal": "Science", "title": "The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight" } ], "impact": "A year-long multi-omic comparison of astronaut Scott Kelly on the ISS with his identical twin on Earth, the most complete look at the human body in long-duration spaceflight. Covered by The New York Times, CNN, STAT and MIT Technology Review.", "links": [ { "label": "NASA Twins Study overview", "url": "https://www.nasa.gov/twins-study-the-research/" }, { "label": "NASA Meet the Researchers", "url": "https://www.nasa.gov/twins-study/meet-the-researchers/" } ] }, "pathomap": { "name": "PathoMap: the NYC subway microbiome", "short_name": "NYC subway microbiome", "meydan_role": "Co-first author (second listed)", "featured": true, "papers": [ { "doi": "10.1016/j.cels.2015.01.001", "year": "2015", "journal": "Cell Systems", "title": "Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics" } ], "impact": "The first city-scale DNA map of a subway system, sampling all 466 open New York stations. It made the front page of The Wall Street Journal, was covered by The New York Times, WIRED, TIME and PBS NewsHour, and led to the global MetaSUB consortium.", "links": [ { "label": "PathoMap", "url": "https://pathomap.org/" }, { "label": "PathoMap map", "url": "https://pathomap.org/map" }, { "label": "WSJ interactive map", "url": "https://graphics.wsj.com/patho-map/" } ] } }, "resources": [ { "id": "soma-browser", "study": "soma", "title": "SOMA Browser (interactive data portal)", "url": "https://soma.weill.cornell.edu/apps/SOMA_Browser/", "summary": "Landing page of an interactive data portal for the Space Omics and Medical Atlas, standardizing sampling and sharing multi-omic data from Inspiration4, Polaris Dawn, Axiom and control participants." }, { "id": "soma-cambank", "study": "soma", "title": "CAMbank: Cornell Aerospace Medicine Biobank", "url": "https://cambank.weill.cornell.edu/", "summary": "Describes CAMbank, Weill Cornell's biobank preserving specimens from spaceflight experiments for molecular profiling, following ISBER guidelines, with a web portal for researcher access planned." }, { "id": "covid-genes", "study": "covid", "title": "COVID Genes (interactive data portal)", "url": "http://covidgenes.weill.cornell.edu/", "summary": "Data portal for exploring human gene expression changes in SARS-CoV-2 infection, including nasopharyngeal swab transcriptomes from 735 patients and autopsy RNA-seq and spatial data from 39 COVID-19 deaths." }, { "id": "metasub-map", "study": "metasub", "title": "MetaSUB interactive map", "url": "https://metasub.org/map", "summary": "Interactive MetaSUB map page; no text was captured, so this is inferred from the title and outlet as a view of consortium sampling sites." }, { "id": "metasub-stuckonu", "study": "metasub", "title": "StuckOnU 2017 (interactive)", "url": "https://metasub.org/stuckonu2017/", "summary": "MetaSUB project page on a 48-hour experiment at the 2017 JP Morgan Health Summit, swabbing and sequencing attendees' phones to see what a surface's DNA reveals about people and microbes." }, { "id": "pathomap-site", "study": "pathomap", "title": "PathoMap interactive map", "url": "https://pathomap.org/map", "summary": "Archived project page for PathoMap, an effort to identify and map the New York City microbiome, citing the 2015 Cell Systems city-scale metagenomics paper." } ], "items": [ { "id": "swisnf3d-wcm", "study": "swisnf3d", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "A Unifying Mechanism for Cancer-Driving Mutations", "title_original": "A Unifying Mechanism for Cancer-Driving Mutations", "language": "English", "date": "2026-10-28", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2026/10/a-unifying-mechanism-for-cancer-driving-mutations", "archive_url": "https://web.archive.org/web/20261028165333/https://news.weill.cornell.edu/news/2026/10/a-unifying-mechanism-for-cancer-driving-mutations", "names_meydan": true, "meydan_context": "Named as co-corresponding author and co-first author and quoted in the release.", "passage_naming_meydan": "The other co-corresponding authors were Dr. Cem Meydan, assistant professor of research in systems and computational biomedicine at Weill Cornell Medicine; and Dr. Ari Melnick, director of the Josep Carreras Leukaemia Research Institute in Barcelon…", "summary": "Release on a Nature study showing that BAF-complex mutations, found in about 20% of cancers, work by letting CTCF reshape 3D genome architecture; deleting CTCF in an animal model reverses the effect.", "topics": [ "baf complex", "ctcf", "3d genome", "cancer mutations", "nature" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/swisnf3d-wcm.jpg", "passage_image": "media-archive/mentions/swisnf3d-wcm.jpg", "full_screenshot": "media-archive/shots/swisnf3d-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/swisnf3d-wcm.txt", "ocr_text": { "archived": "WeillCornellMedicine\nCare\nDiscover\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpactMagazine\nAbout Us\nHome\nNews\nA Unifying Mechanism for Cancer-Driving Mutations\nOCTOBER28,2026\nBackto News\nin\nWeill Cornell Medicine\nOffice of External Affairs\nPhone:(646)962-9476\nArtist rendering of a BAF remodeling complex bound to chromatin.The authors found that when the canonical BAF complex is\nlost, arelated complextakes its place atkeysites in thegenome.Illustrationbytheteamof INMYWORK Studio.\nA family of mutations seen in about 20% of human cancers drives malignancy by changing the accessibility of genes to a\ntherapeutic strategies for a variety of cancer types.\nThe study ,published Oct.28 in Nature,focused on a protein complex called the BAF\ncomplex, which regulates gene activity in the nucleus. Mutations in genes that encode\nsubunits of this complex are found in tumors as different as lymphoma, breast cancer,\novarian cancer and liver cancer,but the common mechanism underlying this broad\nconnection to cancers has been elusive.In the study,the scientists showed that these BAF\nmutations effectively allow the three-dimensional architecture of DNA to be reshaped\nextensively by a protein called CTCF. This shifts gene activity in a direction that promotes\n\"These findings help us establish a unifying mechanism for one of the most common\nclasses of cancermutations, and identify CTCF and its partner proteins as candidate\nDr.DarkoBarisic\nBarisic, an assistant professor of cancer biology in medicine and a member of the Sandra\nand Edward Meyer Cancer Center at Weill Cornell Medicine.\nThe other co-corresponding authors were Dr. Cem Meydan\nassistant professor of research\nin systems and computational biomedicine at Weill Cornell Medicine; and Dr.Ari Melnick\ndirector of the Josep Carreras Leukaemia Research Institute in Barcelona. The study's first\nauthors were\nDr.Meydan\nand postdoctoral research associatesDr.Sonia Debekand Dr.\nChristopher R.Chin.\nInvestigators at Memorial Sloan Kettering Cancer Center and The Rockefeller University also\ncollaborated on the study.\nDisruption of DNA Organization Common Thread in Multiple\nCancer Types\nThe BAF complex has multiple subunits, which in humans are encoded by more than two\nDr.Cem Meydan\ndozen genes.For years, researchers have tried to understand the mechanisms of its various\ncancer-linked mutations by looking at their effects in specific cell types or tissues, such as\nbreast tissue in the case of BAF-mutant breast cancers.\n\"The challenge for us was to find a potential cancer-promoting effect occurring across many different cell types and\ntissuemodels,\"said Dr.Barisic,who is also the John P.Leonard, M.D./Gwirtzman Family Research Scholar in Lymphoma.\nUltimately, using multiple animal and cell models of BAF deficiency, they found one such effect: The loss of BAF function\nled to the opening of the wrapped, looped structure of DNA at myriad sites across the genome, allowing a master gene-\nregulator protein called CTCF to bind at those sites.\n\"We normally think of the BAF complex as making DNA more accessible, and so we expected its loss to have the opposite\neffect,'\nDr.Meydan said.\"lnstead, its loss madeDNAmoreaccessible to CTCF,with surprisinglyfar-reaching effects.\"\nCTCF normally acts like a boundary marker,dividing DNA into separate neighborhoods and controlling which genes can\ntalk to which regulatory proteins. When the BAF complex is lost, CTCF binding increases at thousands of sites across the\ngenome and leads to a widespread reshaping of the three-dimensional loops and folds of DNA.These changes disrupt\ncell division.\nFinding Suggests Potential Therapeutics\nincluding evidence that disruptions of CTCFareassociatedwith better patient outcomes.\nThe scientists showed that two other protein complexes, known as PBAF and ISWl, work as key partners of CTCF, such\nthat their deletion also blocks effects of BAF mutations.\nThe results thus point to CTCF, PBAF and ISWI as potential targets for future therapies in cancers with BAF mutations.\n\"We're currently investigating in more detail what this extensive gain of CTCF does to the genome, and we hope before\nlong to find a drug that blocks this process,\" Dr. Barisic said.\nMany Weill Cornell Medicine physicians and scientists maintainrelationships and collaborate with external organizations to\nfoster scientific innovation and provide expertguidance.The institution makesthese disclosures public to ensure transparency.\nFor this information, please see the profile for Dr. Cem Meydan\nThis work was supported in part by the National Cancer Institute, the National Institute of General Medical Sciences, and the", "live": "WeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpactMagazine\nAbout Us\nHome\nNews\nA Unifying Mechanism for Cancer-Driving Mutations\nOCTOBER28,2026\nBackto News\nin\nWeill Cornell Medicine\nOffice of External Affairs\nPhone:(646)962-9476\nArtist rendering of a BAF remodeling complex bound to chromatin.The authors found that when the canonical BAF complex is\nlost, arelated complextakes its place atkeysites in thegenome.Illustrationbytheteamof INMYWORK Studio.\nA family of mutations seen in about 20% of human cancers drives malignancy by changing the accessibility of genes to a\ntherapeutic strategies for a variety of cancer types.\nThe study ,published Oct.28 in Nature,focused on a protein complex called the BAF\ncomplex, which regulates gene activity in the nucleus. Mutations in genes that encode\nsubunits of this complex are found in tumors as different as lymphoma, breast cancer,\novarian cancer and liver cancer,but the common mechanism underlying this broad\nconnection to cancers has been elusive.In the study,the scientists showed that these BAF\nmutations effectively allow the three-dimensional architecture of DNA to be reshaped\nextensively by a protein called CTCF. This shifts gene activity in a direction that promotes\n\"These findings help us establish a unifying mechanism for one of the most common\nclasses of cancermutations, and identify CTCF and its partner proteins as candidate\nDr.DarkoBarisic\nBarisic, an assistant professor of cancer biology in medicine and a member of the Sandra\nand Edward Meyer Cancer Center at Weill Cornell Medicine.\nThe other co-corresponding authors were Dr. Cem Meydan\nassistant professor of research\nin systems and computational biomedicine at Weill Cornell Medicine; and Dr.Ari Melnick\ndirector of the Josep Carreras Leukaemia Research Institute in Barcelona. The study's first\nauthors were\nDr.Meydan\nand postdoctoral research associatesDr.Sonia Debekand Dr.\nChristopher R.Chin.\nInvestigators at Memorial Sloan Kettering Cancer Center and The Rockefeller University also\ncollaborated on the study.\nDisruption of DNA Organization Common Thread in Multiple\nCancer Types\nThe BAF complex has multiple subunits, which in humans are encoded by more than two\nDr.Cem Meydan\ndozen genes.For years, researchers have tried to understand the mechanisms of its various\ncancer-linked mutations by looking at their effects in specific cell types or tissues, such as\nbreast tissue in the case of BAF-mutant breast cancers.\n\"The challenge for us was to find a potential cancer-promoting effect occurring across many different cell types and\ntissuemodels,\"said Dr.Barisic,who is also the John P.Leonard, M.D./Gwirtzman Family Research Scholar in Lymphoma.\nUltimately, using multiple animal and cell models of BAF deficiency, they found one such effect: The loss of BAF function\nled to the opening of the wrapped, looped structure of DNA at myriad sites across the genome, allowing a master gene-\nregulator protein called CTCF to bind at those sites.\n\"We normally think of the BAF complex as making DNA more accessible, and so we expected its loss to have the opposite\neffect,'\nDr.Meydan said.\"lnstead, its loss madeDNAmoreaccessible to CTCF,with surprisinglyfar-reaching effects.\"\nCTCF normally acts like a boundary marker,dividing DNA into separate neighborhoods and controlling which genes can\ntalk to which regulatory proteins. When the BAF complex is lost, CTCF binding increases at thousands of sites across the\ngenome and leads to a widespread reshaping of the three-dimensional loops and folds of DNA.These changes disrupt\ncell division.\nFinding Suggests Potential Therapeutics\nincluding evidence that disruptions of CTCFareassociatedwith better patient outcomes.\nThe scientists showed that two other protein complexes, known as PBAF and ISWl, work as key partners of CTCF, such\nthat their deletion also blocks effects of BAF mutations.\nThe results thus point to CTCF, PBAF and ISWI as potential targets for future therapies in cancers with BAF mutations.\n\"We're currently investigating in more detail what this extensive gain of CTCF does to the genome, and we hope before\nlong to find a drug that blocks this process,\" Dr. Barisic said.\nMany Weill Cornell Medicine physicians and scientists maintainrelationships and collaborate with external organizations to\nfoster scientific innovation and provide expertguidance.The institution makesthese disclosures public to ensure transparency.\nFor this information, please see the profile for Dr. Cem Meydan\nThis work was supported in part by the National Cancer Institute, the National Institute of General Medical Sciences, and the" } }, { "id": "swisnf3d-miragenews", "study": "swisnf3d", "outlet": "Mirage News", "outlet_original": "Mirage News", "outlet_score": 5, "title": "Unifying Mechanism Behind Cancer-Driving Mutations", "title_original": "Unifying Mechanism Behind Cancer-Driving Mutations", "language": "English", "date": "2026-10", "kind": "news", "url": "https://www.miragenews.com/unifying-mechanism-behind-cancer-driving-1768088/", "archive_url": "https://web.archive.org/web/20261028165505/https://www.miragenews.com/unifying-mechanism-behind-cancer-driving-1768088/", "names_meydan": true, "meydan_context": "Named as co-corresponding and co-first author and quoted in the reprinted release.", "passage_naming_meydan": "The other co-corresponding authors were Dr. Cem Meydan , assistant professor of research in systems and computational biomedicine at Weill Cornell Medicine; and Dr. Ari Melnick , director of the Josep Carreras Leukaemia Research Institute in Barcel…", "summary": "Reprint of the release describing how BAF mutations, present in roughly one fifth of cancers, let CTCF extensively remodel DNA's 3D structure, a shift reversed by deleting CTCF in an animal model.", "topics": [ "baf complex", "ctcf", "3d genome", "cancer mutations", "nature" ], "audience": "trade", "thumbnail": "media-archive/thumbs/swisnf3d-miragenews.jpg", "passage_image": "media-archive/mentions/swisnf3d-miragenews.jpg", "full_screenshot": "media-archive/shots/swisnf3d-miragenews--live.jpg", "saved_html": "", "saved_article_text": "media-archive/text/swisnf3d-miragenews.txt", "ocr_text": { "archived": "INTERNET\nSearch\nAUDIO\nSOFTWARE\nTEXTS\nVIDEO\nSIGNUPILOGIN\nARCHIVE\nUPLOAD\nABOUT\nBLOG\nEVENTS\nPROJECTS\nHELP\nDONATE\nCONTACT\nJOBS\nVOLUNTEER\nINTERNET ARCHIVE\nwayBack machine\nDONATE\nhttps://www.miragenews.com/unifying-mechanism-behi\nLatest\nShow All\nThis URLhas beenexcluded fromtheWayback Machine.\nThe Wayback Machine is an initiative of the Internet Archive, a 5oi(c)(3) non-profit,\nbuilding a digital libraryof ntermet sites andother calturalartifacts in digital form\nOtherprojects inclade OpenLbrary&archie-it.org\nYour use of the Wayback Machine is subject to the Internet Archive's Terms of Use.", "live": "MIRAGE\nWorld\nNational\nTechnology\nLocal\nBusiness\nLife\nScience\nTimeline\nLATEST oung People\nProtectingTasmania's HomeCourtAdvantage\nLight Reveals Superconductors'HiddenWorkings\nHastings Ceni\nScience\n29 OCT-2026 3:06 AM AEDT\nShare\nPoll\nUnifying Mechanism Behind Cancer-Driving Mutations\nFederal election today: Who\nwould you vote for?\nWeill Cornell Medicine\nA family of mutations seen in about 20% of human cancers drives malignancy by changing the\nLabor\naccessibility of genesto a particularregulatoryprotein,accordingto a studybyWeill Cornell\nMedicine investigators.The findings suggest new therapeutic strategies for a variety of cancer types.\nCoalition(Liberal/Nationals)\nThestudy,publishedOct.28 inNature,focusedonaprotein complexcalled theBAFcomplex,which\nOne Nation\nregulatesgene activity inthenucleus.Mutations ingenesthat encode subunits ofthis complex are\nGreens\nfoundintumorsas differentaslymphoma,breastcancer,ovarian cancer and liver cancer,but the\ncommon mechanism underlyingthis broad connectionto cancers has been elusive.Inthe study,the\nIndependent\nscientists showed that these BAF mutations effectively allowthethree-dimensional architectureof\nOther\nDNAtobereshapedextensivelybyaproteincalled CTCF.Thisshiftsgeneactivity inadirectionthat\npromotes malignancy, but deleting CTCF in an animal model reverses the effect.\nUndecided\n\"These findings help us establish a unifying mechanism for one of the most common classes of\nVote\nResults \ncancermutations,and identifyCTcFand itspartnerproteinsascandidatetherapeutictargets in\nthese cancers,saidstudy co-correspondingauthorDr.Darko Barisic,an assistantprofessorof\ncancerbiology inmedicineand amemberofthe Sandra and Edward MeyerCancerCenterat Weill\nTimeline\nCornell Medicine.\nTheotherco-correspondingauthorswereDr.CemMeydan\nTasmania Roadmap Aims to\nassistantprofessorofresearchin\nImproveCareforYoung People\nsystems and computational biomedicine at Weill Cornell Medicine; and Dr.Ari Melnick,director of\n29OCT20268:52AMAEDT\nthe Josep Carreras Leukaemia Research Institute in Barcelona. The study's first authors were Dr.\nMeydan and postdoctoral research associates Dr.Sonia Debek and Dr.Christopher R.Chin.\nProtecting Tasmania's Home\nCourt Advantage\nInvestigators atMemorial SloanKetteringCancerCenterandTheRockefellerUniversityalso\n29 OCT.2026 8:52 AM AEDT\ncollaborated on the study.\nLight Reveals Superconductors'\nHidden Workings\nDisruptionofDNAOrganization Common Thread in MultipleCancerTypes\n29OCT20268:50AMAEDT\nTheBAFcomplexhasmultiplesubunits,whichinhumansareencodedbymorethantwodozen\nHastings Center Report:\ngenes.For years, researchers have tried to understand the mechanisms of its various cancer-linked\nSeptember-0ctober2026\n29 OCT20268:50AM AEDT\nof BAF-mutant breast cancers.\nRunning Red To Court\n29 OCT 2026 8:45 AM AEDT\n\"The challenge forus was to find a potential cancer-promoting effect occurring across many\nAsset Seizure Closes Joint Police-\ndifferent cell types and tissue models,\"said Dr.Barisic,who is also theJohn P.Leonard,\nImmigration Operation\nM.D./GwirtzmanFamily ResearchScholarinLymphoma.\n29OCT20268:44.AMAEDT\nUltimately,using multiple animal and cell models of BAF deficiency,they found one such effect: The\nCity's Grass Slashing Program\nlossofBAFfunctionledtotheopeningofthewrapped,loopedstructureofDNAatmyriadsites\nWell Underway\nacross the genome, allowing a master gene-regulator protein called CTCF to bind at those sites.\n29OCT20268:40AMAEDT\n\"Wenormallythink ofthe BAFcomplexas makingDNAmoreaccessible,and so weexpected its loss\nG20 And Quad Foreign Ministers'\ntohavethe oppositeeffect,Dr.Meydan said.\"Instead,itslossmade DNAmore accessibletoCTCF,\nMeeting\nwith surprisinglyfar-reaching effects.\"\n29 0CT 2026 8:36 AM AEDT\nTrump Ends Federal Diversity,\nCTCF normally acts like a boundarymarker,dividing DNA into separate neighborhoods and\nEquity and Inclusion Programs\ncontrolling which genes can talk to which regulatory proteins. When the BAF complex is lost, CTCF\n29 OCT20268:34AM AEDT\nbinding increases at thousands of sites across thegenome and leads to awidespreadreshaping of\nAustralians\"unfriend\"Trump's\nthethree-dimensional loops andfoldsof DNA.These changes disruptthenormal contactsbetween\nAmerica-New Poll\n29 OCT 2026 8:24 AM AEDT\ndivision.\nUniversitiesAllocate2027Places\nUnderNewGrowthSystem\nFinding Suggests Potential Therapeutics\n29OCT20268:24AMAEDT\nInmousemodels and humanpatientdata,theteamfound confirmatory evidence of CTcF's role in\nAirNewZealandAddsYear-\nBAF-mutant cancers,includingevidencethatdisruptionsof cTcFareassociatedwithbetterpatient\nRound Singapore Flights, Bali\noutcomes.\nService\n29 OCT20268:12AM AEDT\nThescientists showed thattwootherprotein complexes,knownas PBAFand Iswi,work askey\npartners of CTCF, such that their deletion also blocks effects of BAF mutations.\nContractors Get More Support\nAmid Fuel Price Volatility\n29OCT20268:06AMAEDT\nwith BAF mutations.\nDarwin WinsBidtoHost2027\nDarwinWinsBid toHost2027\n\"We're currently investigating in more detail what this extensive gain of cTCF does to the genome,\nMeetingPlacewdnnny\n29 OCT20268:06 AM AEDT\nand we hopebefore longto find a drug thatblocks this process,\"Dr.Barisic said.\nWHO Urges Coexistence of\nManyWeill Cornell Medicinephysicians andscientistsmaintainrelationshipsand collaboratewith\nDigitalandPaperShipHealth\nexternalorganizations tofoster scientific innovation and provide expertguidance.The institution\nRecords\nmakesthesedisclosurespublictoensuretransparency.Forthisinformation,pleaseseetheprofile\n29OCT20268:02AMAEDT\nor\nDr.Cem Meydan\nStatementon DPRK Sanctions\n29 OCT 2026 8:02 AM:AEDT\nThis work was supported in part by the National Cancer Institute,the National Institute of General\nUN Women Marks International\nMedical Sciences,andtheNational Institute of Neurological DisordersandStroke,all part of the\nDayof Care and Support 2026\nNational institutesof Health.Additional supportwasprovidedbytheLeukemiaResearch\n29OCT20268:01AMAEDT\nFoundation,theAndrewMcDonoughB+Foundation,LLs,theSTARRFoundation,theRitaAllen\nFoundation, theIrma T.Hirschl/Monique Weill-Caulier Trust,the Simons Foundation and the Tri-\nMoth Study Supports Butterfly\nMolecular Cookie Cutter Theory\nInstitutional Stem Cell Initiative.\n29OCT20268:00AMAEDT\n/Public Release.This material fromtheoriginating organization/author(s)mightbe of thepoint-in-\ntime nature,and edited for clarity,style and length.Mirage.News does not take institutional\nFungal NetworksMaySpread\nAntibiotic Resistancein\npositions orsides,andallviews,positions,andconclusionsexpressedhereinaresolelythoseofthe\nComposting Manure\nauthor(s).View in full here.\n29 OCT20268:00AM AEDT\nDonate with\nCouncil to Deepen Ties With\nPayPal\nSoutheast Europe Local\nWhy?\nAuthorities\nTags:health,universityDNA,Scientists,Barcelona,breastcancer,architecture,ovariancancer,\n29 OCT 2026 7:52 AM AEDT\ninnovation,Accessibility,RockefellerUniversity,cancermutations,National CancerInstitute,\nCapturing Complete Process Of\npatientoutcomes,mutations,livercancer\nEmbryonicDevelopment\nYou might also like\n29OCT20267:40AMAEDT\nSudanCiviliansTrappedBetween\nDronesand Detention in El\nObeid\n29 OCT2026.7:38 AMAEDT\nHow to Cut Electricity Costs Amid\nPolicy Uncertainty\nThe Science of Hiccups:Why\nFoods to Limit or Avoid for\nBenefits of Creative\n29 0CT 2026 7:38 AM AEDT\nDo We Hiccup?\nHealthier Lifestyle:Science\nHobbies: Exploring Arts and\nAGSReleasesFindingsFrom\nCrafts\nOlder Adults Vaccine Initiative\n29OCT20267:38AMAEDT\nUNRightsChiefUrgesBetter\nCivilian Protectionin Conflicts\n29OCT20267:28AMAEDT\nOfficers Injured During Albert\nPark Arrest\nGolden Ratio:Mysterious\nPowerof Scent:The\nHuman Hibernation:Science\n29 0CT 2026 7:22 AM AEDT\nNumberFound in Nature\nInfluenceofSmell on\nFiction or Future Reality?\nand Art\nHuman Behavior\nQantasGroundWorkerstoStrike\nAgain OverJoyce-Era Tactics\n29 OCT20267:20 AM AEDT\nHow Risky Is Leaving Bluetooth\nOn?\n29 OCT 2026 7:10 AM AEDT\nMore News\nPopular Topics\nAustralia\nGovernment\nuniversity\ncommunity\npolice\nAustralian\nNSW\nresearch\nVictoria\nProfessor\n health\nenvironment\nMinister\nQueensland\nbusiness\ncouncil\nUK\ncovid-19\nlocal council\nNew SouthWales\ninfrastructure\neducation\nInvestment\ntechnology\nindustry\ninvestigation\nAusPol\nUnited states\nproject\ncrime" } }, { "id": "swisnf3d-medicalxpress", "study": "swisnf3d", "outlet": "Medical Xpress", "outlet_original": "Medical Xpress", "outlet_score": 6, "title": "Unifying mechanism explains how common cancer mutations fuel tumor growth", "title_original": "Unifying mechanism explains how common cancer mutations fuel tumor growth", "language": "English", "date": "2026-10", "kind": "news", "url": "https://medicalxpress.com/news/2026-10-mechanism-common-cancer-mutations-fuel.html", "archive_url": "", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Carries the Weill Cornell report that mutations in BAF (SWI/SNF) chromatin remodelers, found in about a fifth of human cancers, act through a shared mechanism: reshaping 3D DNA architecture through CTCF and cohesin.", "topics": [ "cancer mutations", "baf complex", "tumor growth", "mechanism" ], "audience": "science-press", "thumbnail": "", "passage_image": "", "full_screenshot": "", "saved_html": "", "saved_article_text": "", "ocr_text": { "live": "Justaquickcheck\nWe'recheckingyourconnectiontopreventautomatedabuse\nVerify you are human\nCLOUDFLARE\nPrivacr * Hele\nWhyam I seeing this?\nHaving probiems? Contact support" } }, { "id": "spen-carreras", "study": "spen", "outlet": "Josep Carreras Leukaemia Research Institute", "outlet_original": "Josep Carreras Leukaemia Research Institute", "outlet_score": 6, "title": "For the first time, scientists discover that a subset of a common blood cancer is more deadly in women than in men — and find a new targeted treatment approach", "title_original": "For the first time, scientists discover that a subset of a common blood cancer is more deadly in women than in men — and find a new targeted treatment approach", "language": "English", "date": "2026-05", "kind": "press-release", "url": "https://www.carrerasresearch.org/en/news/for-the-first-time-scientists-discover-that-a-subset-of-a-common-blood-cancer-is-more-deadly-in-women-than-in-men-%E2%80%94-and-find-a-new-targeted-treatment-approach", "archive_url": "https://web.archive.org/web/20260506160820/https://www.carrerasresearch.org/en/news/for-the-first-time-scientists-discover-that-a-subset-of-a-common-blood-cancer-is-more-deadly-in-women-than-in-men-%E2%80%94-and-find-a-new-targeted-treatment-approach", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Institute release on a study finding a DLBCL subtype far deadlier in women than men, explaining the biology behind the disparity and pointing to an existing drug class that may protect female patients.", "topics": [ "dlbcl", "sex differences", "spen", "notch2", "lymphoma" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/spen-carreras.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/spen-carreras--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/spen-carreras.txt", "ocr_text": { "archived": "English\nSearch...\nJosepCarreras\nNews\nLEUKAEMIA\nOutreach\nManagement\nResearch\nEvents\nDirectory\ninstitute\nPath2Cure\nCorefacilities\nCareers\nResearch Institute\nNews\nHomeNewsForthefirsttime, scientistsdiscoverthat asubsetofacommonblood canceris more deadly inwomenthan inmenand find anewtargeted treatment.approach\nFor the first time,scientists discover\nSearch...\nthat a subset of a common blood\nMedia Mentions\ncancer is more deadly in women than\nin men and find a new targeted\ntreatment approach\nMay 06, 2026\nA new study reveals that a subtype of large B cell lymphomakills women at a\nmuch higher rate than men, driven by instability of the X chromosome. The\nfindings open the door to a precision therapy specifically for female patients.\nIn a finding that challenges decades of assumptions\nabout blood cancer, an international research team\nhas shown for the first time that a specific subtype\nof diffuselargeB cell lymphoma(DLBCL),which is\nthemostcommonbloodcancerinadults,is\ndramatically more lethal in women than in men.\nThe study.led bythelaboratoryof Prof.AriMelnick\nDirector of the Josep Carreras Leukaemia\nResearch Institute, along with the laboratories of\nDrs.Wendy Beguelin from the New York\nUniversity Grossman School of Medicine and\nLeandro Venturutti from the University of British Columbia, not only identifies the biological\nreason for this disparity but points to an existing class of drugs that could specifically protect female\npatients.\nDLBCL affects hundreds of thousands of people worldwide each year. Although outcomes vary\nwidely between patients, sex had never previously been identified as a driver of survival differences\nin this disease.By analyzing data from nearly 5,000 patients across 14 independent studies, the team\nfound that women whose tumors carry simultaneous faults in two genes called SPEN and NOTCH2,\nhad a more than fourfold higher mortality risk than men with the same mutations, Dr.Benedikt\nPelzer, first author of this study commented:\n\"When we noted that women were doing far worse than men with these specific\nmutations, we knew we had to understand why.What we found was unexpected, that the\nXchromosome itself wasthekey.\"\nDr.Benedikt Pelzer,first author,Weill Cornell Medicine\nThe answer lies in one of the most fundamental differences between male and female biology.\nWomen carrytwo copies of the X chromosome, and one is normallykept permanently switched off,a\nprocess partly controlled by the SPEN gene. When SPEN is damaged alongside NOTCH2, that\nprocess partly controlled by the SPEN gene.When SPEN is damaged alongside NOTCH2,that\nsilencing becomes unstable. Genes on the supposedly dormant X chromosome begin to wake up,\nincluding TLR7, a gene that when overactive, acts like a jammed accelerator for cancer cell growth\nand survival. In men, who carry only one X chromosome, this mechanism simply cannot occur.\nImportantly, the researchers showed this is not driven by female hormones. The effect persisted in\nanimals even after removal of the ovaries, confirming that the vulnerability is built into the\nchromosomes themselvesa genuinely new concept in understanding how sex shapes cancer\nbiology.\n\"Sex differences in cancer have too often been attributed to lifestyle or hormones.This\nstudy shows the biology itself can be fundamentally different between men and women at\nthe molecular level, and that this can be invisible unless you specifically look for it.\"\nDr.Leandro Venturutti, co-corresponding author, BC Cancer Research Institute/\nUniversityof British Columbia,Vancouver\nThe discovery carries immediate therapeutic implications.The overactive TLR7pathway that drives\ntumor growth in female patients can beblocked bydrugs called IRAK inhibitors, whichare already in\nclinical development for other conditions. In laboratory experiments and animal models, these drugs\nwere significantly more effective at killing female tumor cells than male ones. A tumor model derived\ndirectly froma female DLBCL patient responded well, with growth slowing substantially over the\ncourse of treatment. Combining the IRAK inhibitor with standard chemotherapy enhanced the effect\nfurther, potentially allowing lower chemotherapy doses, which is especially important for the older\npatients who most commonly develop this disease.\n\"IRAK inhibitors are already in clinical trials.The path from this discovery to a treatment\noption for patients is shorter than it usually is in cancer research, and that urgency is\nsomethingwefeel strongly.\"\nSchoolof Medicine,New York\nThe study also upends anotherlong-held assumption about how this cancer develops. It had been\nthought that this subtype of DLBCL originates deep within the immune system's active response\ncenters. The new data show it likely begins from a cell type that accumulates with aging and\nexposure to infections, and is closely associated with autoimmune diseases, consistent with a\ndifferent developmental path,and potentially explaining why the disease is more common in older\npatients who may have had an undetected precursor condition for years.\n\"This work reframes theX chromosome froma bystanderto an active driver of cancer\nbiology in women. Combined with the discovery of a druggable target, it is a genuine\nparadigm shift,and a compelling argument for making biological sex a standard variable\nin how we design cancer trials going forward.\"\nProf.Ari M.Melnick, co-corresponding author, Director of the Josep Carreras Leukaemia\nResearch Institute(Spain),and GebroeFamily Professor of Hematology/Oncology,Weill\nCornellMedicine\nAbout the study\n\"SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and TLR\npathway therapeutic vulnerabilities\"was led by first author Dr.Benedikt Pelzer and conducted by an\ninternational team spanning the Josep Carreras Leukaemia Research Institute (UC), Weill Cornell\nMedicine, BC Cancer Research Institute, Memorial Sloan Kettering Cancer Center, the University of\nPennsylvania and other institutions. The study was supported by the Us National Institutes of Health\n(NIH/NCl),Blood Cancer United,theLymphomaResearchFoundation,the German Research\nFoundation (DFG),the German Cancer Aid, and the Canadian Institutes of Health Research (ClHR),\namong other funders.\nBenedikt Pelzer, et al.; SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-\nspecific lethality and therapeutic vulnerabilities.Cancer Discovery2026;\nhttps:/doi.org/10.1158/2159-8290.CD-25-1458\nWhat is DLBCL?\nDiffuse large B cell lymphoma is a cancer of white blood cells. It is the most common form of blood\nrespond to standard treatment, around one in three does not achieve lasting remission and the\ndisease remains life-threatening.\nBack", "live": "English\nSearch...\nJosepCarreras\nNews\nLEUKAEMIA\nOutreach\nManagement\nResearch\nEvents\nDirectory\ninstitute\nPath2Cure\nCorefacilities\nCareers\nResearch Institute\nNews\nHomeNewsForthefirsttime, scientistsdiscoverthat asubsetofacommonblood canceris more deadly inwomenthan inmenand find anewtargeted treatment.approach\nFor the first time,scientists discover\nSearch...\nthat a subset of a common blood\nMedia Mentions\ncancer is more deadly in women than\nin men and find a new targeted\ntreatment approach\nMay 06, 2026\nA new study reveals that a subtype of large B cell lymphomakills women at a\nmuch higher rate than men, driven by instability of the X chromosome. The\nfindings open the door to a precision therapy specifically for female patients.\nIn a finding that challenges decades of assumptions\nabout blood cancer, an international research team\nhas shown for the first time that a specific subtype\nof diffuselargeB cell lymphoma(DLBCL),which is\nthemostcommonbloodcancerinadults,is\ndramatically more lethal in women than in men.\nThe study.led bythelaboratoryof Prof.AriMelnick\nDirector of the Josep Carreras Leukaemia\nResearch Institute, along with the laboratories of\nDrs.Wendy Beguelin from the New York\nUniversity Grossman School of Medicine and\nLeandro Venturutti from the University of British Columbia, not only identifies the biological\nreason for this disparity but points to an existing class of drugs that could specifically protect female\npatients.\nDLBCL affects hundreds of thousands of people worldwide each year. Although outcomes vary\nwidely between patients, sex had never previously been identified as a driver of survival differences\nin this disease.By analyzing data from nearly 5,000 patients across 14 independent studies, the team\nfound that women whose tumors carry simultaneous faults in two genes called SPEN and NOTCH2,\nhad a more than fourfold higher mortality risk than men with the same mutations, Dr.Benedikt\nPelzer, first author of this study commented:\n\"When we noted that women were doing far worse than men with these specific\nmutations, we knew we had to understand why.What we found was unexpected, that the\nXchromosome itself wasthekey.\"\nDr.Benedikt Pelzer,first author,Weill Cornell Medicine\nThe answer lies in one of the most fundamental differences between male and female biology.\nWomen carrytwo copies of the X chromosome, and one is normallykept permanently switched off,a\nprocess partly controlled by the SPEN gene. When SPEN is damaged alongside NOTCH2, that\nprocess partly controlled by the SPEN gene.When SPEN is damaged alongside NOTCH2,that\nsilencing becomes unstable. Genes on the supposedly dormant X chromosome begin to wake up,\nincluding TLR7, a gene that when overactive, acts like a jammed accelerator for cancer cell growth\nand survival. In men, who carry only one X chromosome, this mechanism simply cannot occur.\nImportantly, the researchers showed this is not driven by female hormones. The effect persisted in\nanimals even after removal of the ovaries, confirming that the vulnerability is built into the\nchromosomes themselvesa genuinely new concept in understanding how sex shapes cancer\nbiology.\n\"Sex differences in cancer have too often been attributed to lifestyle or hormones.This\nstudy shows the biology itself can be fundamentally different between men and women at\nthe molecular level, and that this can be invisible unless you specifically look for it.\"\nDr.Leandro Venturutti, co-corresponding author, BC Cancer Research Institute/\nUniversityof British Columbia,Vancouver\nThe discovery carries immediate therapeutic implications.The overactive TLR7pathway that drives\ntumor growth in female patients can beblocked bydrugs called IRAK inhibitors, whichare already in\nclinical development for other conditions. In laboratory experiments and animal models, these drugs\nwere significantly more effective at killing female tumor cells than male ones. A tumor model derived\ndirectly froma female DLBCL patient responded well, with growth slowing substantially over the\ncourse of treatment. Combining the IRAK inhibitor with standard chemotherapy enhanced the effect\nfurther, potentially allowing lower chemotherapy doses, which is especially important for the older\npatients who most commonly develop this disease.\n\"IRAK inhibitors are already in clinical trials.The path from this discovery to a treatment\noption for patients is shorter than it usually is in cancer research, and that urgency is\nsomethingwefeel strongly.\"\nSchoolof Medicine,New York\nThe study also upends anotherlong-held assumption about how this cancer develops. It had been\nthought that this subtype of DLBCL originates deep within the immune system's active response\ncenters. The new data show it likely begins from a cell type that accumulates with aging and\nexposure to infections, and is closely associated with autoimmune diseases, consistent with a\ndifferent developmental path,and potentially explaining why the disease is more common in older\npatients who may have had an undetected precursor condition for years.\n\"This work reframes theX chromosome froma bystanderto an active driver of cancer\nbiology in women. Combined with the discovery of a druggable target, it is a genuine\nparadigm shift,and a compelling argument for making biological sex a standard variable\nin how we design cancer trials going forward.\"\nProf.Ari M.Melnick, co-corresponding author, Director of the Josep Carreras Leukaemia\nResearch Institute(Spain),and GebroeFamily Professor of Hematology/Oncology,Weill\nCornellMedicine\nAbout the study\n\"SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and TLR\npathway therapeutic vulnerabilities\"was led by first author Dr.Benedikt Pelzer and conducted by an\ninternational team spanning the Josep Carreras Leukaemia Research Institute (UC), Weill Cornell\nMedicine, BC Cancer Research Institute, Memorial Sloan Kettering Cancer Center, the University of\nPennsylvania and other institutions. The study was supported by the Us National Institutes of Health\n(NIH/NCl),Blood Cancer United,theLymphomaResearchFoundation,the German Research\nFoundation (DFG),the German Cancer Aid, and the Canadian Institutes of Health Research (ClHR),\namong other funders.\nBenedikt Pelzer, et al.; SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-\nspecific lethality and therapeutic vulnerabilities.Cancer Discovery2026;\nhttps:/doi.org/10.1158/2159-8290.CD-25-1458\nWhat is DLBCL?\nDiffuse large B cell lymphoma is a cancer of white blood cells. It is the most common form of blood\nrespond to standard treatment, around one in three does not achieve lasting remission and the\ndisease remains life-threatening.\nBack" } }, { "id": "spen-eurekalert", "study": "spen", "outlet": "EurekAlert! (AAAS)", "outlet_original": "EurekAlert! (AAAS)", "outlet_score": 6, "title": "For the first time, scientists discover that a subset of a common blood cancer is more deadly in women than in men", "title_original": "For the first time, scientists discover that a subset of a common blood cancer is more deadly in women than in men", "language": "English", "date": "2026-05", "kind": "press-release", "url": "https://www.eurekalert.org/news-releases/1127051", "archive_url": "", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Release on the Cancer Discovery study finding that a SPEN-defined subset of diffuse large B cell lymphoma is more lethal in women than in men, and pointing to a targeted treatment approach.", "topics": [ "dlbcl", "sex differences", "lymphoma", "targeted therapy" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/spen-eurekalert.jpg", "passage_image": "", "full_screenshot": "", "saved_html": "media-archive/html/spen-eurekalert--live.html", "saved_article_text": "", "ocr_text": { "live": "EurekAlert!\nNAAAS\nWebsite Unavailable\nThe EurekAlertl website is currently unavailablefor scheduled maintenance or due to unexpected technical\nissues.Please try again later or contact webmaster@eurekalert.org for an estimated outageduration.\nEurekAlert!AAAS\nNAAAS\n1200NewYorkAvenueNWIWashington,DC20005/USA\nPhone:1-202-326-6716|Fax:1-202-898-0391\nCopyright@2023AmericanAssociationfortheAdvancementof Science" } }, { "id": "spen-medicalxpress", "study": "spen", "outlet": "Medical Xpress", "outlet_original": "Medical Xpress", "outlet_score": 6, "title": "New treatment approach targets a subset of common blood cancer that is more deadly in women", "title_original": "New treatment approach targets a subset of common blood cancer that is more deadly in women", "language": "English", "date": "2026-05", "kind": "news", "url": "https://medicalxpress.com/news/2026-05-treatment-approach-subset-common-blood.html", "archive_url": "https://web.archive.org/web/20260506213225/https://medicalxpress.com/news/2026-05-treatment-approach-subset-common-blood.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Republished institute release reporting that a DLBCL subtype is dramatically more lethal in women, challenging long-held assumptions and indicating a targeted treatment approach.", "topics": [ "dlbcl", "sex differences", "lymphoma", "targeted therapy" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/spen-medicalxpress.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/spen-medicalxpress--archived.jpg", "saved_html": "media-archive/html/spen-medicalxpress--archived.html", "saved_article_text": "media-archive/text/spen-medicalxpress.txt", "ocr_text": { "archived": "Medicalpress\nWeek's top\nUnread news\nSubscribe\nLatestnews\nSpecialities\nWell-being\nConditions\nMAY6,2026\nTrending \nFeatured\nLastComments\nNewtreatmentapproachtargetsa\nOmega-3supplementsmaybe linked to\nShare\nfastercognitivedeclineinseniors,study\nsubsetof commonbloodcancer\nfinds\nTweet\nMAY4,2026\nthat is more deadly in women than\nShare\nin men\nOnedoseof psilocybin changes the human\nbrain,leading tohigher entropy\nEmail\n①MAY5,2026\nbyJosepCarrerasLeukaemiaResearchInstitute\nedited byStephanieBaum,reviewedbyRobertEgan\nEditors notes\nFamilydata reveal two genetic pathsto\nO TheGIST\nG Add as preferred source\nchildhood depression and anxiety\n①MAY3,2026\nCreatine is claimed to benefit body and mind:\nThe potential benefitsand limitations of the\npopularsupplement\nMAY3,2026\nThe GLP-1 paradox:Weight loss drugsmay\nleadtostigma\n①MAY4.2026\nHow changes to proteins can\nalter drug interactions for\nnewprecisiontherapies\n12MINUTESAGO\nCredit:Cco Public Domain\nElevated blood sugar levels\nduring pregnancy may result\nInafindingthatchallengesdecadesof assumptionsaboutblood\nin poorerbirthoutcomes\ncancer,an international researchteamhasshownforthefirst\n①32MINUTESAGO\ntimethat aspecificsubtypeof diffuselargeBcell lymphoma\nCommon inflammatorygenes\n(DLBCL),whichisthemostcommonbloodcancerinadults,is\nlinkpancreaticcancerwith\ndramatically more lethal in women than in men.\nobesity and diabetes\n1HOURAGO\nThe study,led by the laboratory of Prof.Ari Melnick,Director of\nOne overlooked detail in\nthe JosepCarreras Leukaemia ResearchInstitute,along withthe\ncancer genomes is rewriting\nlaboratoriesofDrs.WendyBeguelinfromtheNewYork\nwhichmutations really matter\nUniversity Grossman School of Medicineand Leandro Venturutti\n①1HOURAGO\nfromthe University of British Columbia, not only identifiesthe\nLithium uncovers fresh\nbiological reason for this disparity,but points to an existing class\nAlzheimer'stargetsbeyond\nofdrugs that could specifically protect female patients.The\nTau\nfindings arepublished in thejournal Cancer Discovery.\n①1HOURAGO\nBloodproteinstudyof 78,000\nDLBCL affects hundreds of thousands of peopleworldwide each\npeople uncovers disease\nmechanisms and drug\nyear.Although outcomes varywidelybetween patients, sexhad\nrepurposing leads\nneverpreviouslybeen identifiedas adriverof survival\n①2HOURS AGO\ndifferences in this disease.By analyzingdata from nearly5,000\npatients across 14 independent studies, the team found that\nTo combat theyouth vaping\nepidemic,Alcanhelp\nwomen whosetumors carry simultaneousfaults intwogenes\ndetermine which cessation\nstrategies work best\ncalledSPENandNOTCH2,hadamorethanfourfoldhigher\n2HOURSAGO\nmortality risk than men with the same mutations.\nHow HIV hijacksa cellular\n'gateway'to infect resting\nimmunecells\n①2HOURSAGO\nRNA blood markers may\nreveal illnesstrajectoryand\ntreatment success within\ndays\n①3HOURSAGO\nFish revealfour distinct sleep\nstates,including three with\neye movements\n04:09\n3HOURSAGO\nProf.Ari Melnick explains their study published in Cancer Discovery.\nFootage of Prof.Melnick's lab.Credit:Josep Carreras Leukaemia\nResearchInstitute\nDr.Benedikt Pelzer,first author of this study,commented,\"When\nwenotedthatwomenweredoingfar worsethanmen withthese\nspecific mutations, weknew we had to understand why.What we\nfoundwasunexpected:thattheXchromosomeitself wasthe\nkey.\"\nThe answer lies in one of the mostfundamental differences\nbetween male and female biology. Women carry two copies of\nthe X chromosome, and one is normally kept permanently\nWhen SPEN is damaged alongside NOTCH2, that silencing\nbecomes unstable.Genes on the supposedly dormant X\nchromosome begin to wake up, including TLR7,a gene that-\nwhen overactive-acts like a jammed accelerator for cancer cell\ngrowthand survival.In men,who carry only one X chromosome,\nthis mechanism simply cannot occur.\nImportantly, the researchers showed this is not driven by female\nhormones.The effect persisted in animals even after removal of\nthe ovaries, confirming that the vulnerability is built into the\nchromosomes themselves-a genuinely new concept in\nunderstanding how sex shapes cancer biology.\n\"Sex differences in cancer have too often been attributed to\nlifestyleorhormones.Thisstudy shows that biology itself can be\nfundamentallydifferent betweenmen andwomenatthe\nmolecular level,andthatthiscanbe invisibleunlessyou\nspecifically look for it, said Dr. Venturutti.\nThe discovery carries immediate therapeutic implications.The\noveractive TLR7pathwaythat drives tumorgrowth in female\npatients can be blocked by drugs called IRAK inhibitors, which\nare already in clinical development for other conditions.In\nlaboratory experiments andanimal models,thesedrugs were\nsignificantly more effective at killing female tumor cells than\nmale ones.Atumormodel derived directlyfromafemaleDLBCL\npatient responded well, with growth slowing substantially over\nthe course of treatment.\nCombining the IRAK inhibitor with standard chemotherapy\nenhanced the effect further,potentiallyallowing lower\nchemotherapydoses,whichisespecially importantfortheolder\npatients who most commonly develop this disease.\n\"IRAK inhibitors are already in clinical trials.Thepath fromthis\ndiscoveryto a treatment option for patients is shorter than it\nusually is in cancer research, and that urgency is something we\nfeel strongly' noted Dr.Beguelin.\nThe study also upends another long-held assumption about how\nthis cancerdevelops.It had beenthoughtthat this subtypeof\nDLBCLoriginatesdeepwithintheimmunesystem'sactive\nresponse centers. The new data show it likely begins from a cell\ntype that accumulates with aging and exposureto infections,\nandiscloselyassociatedwithautoimmunediseases,consistent\nwith a different developmental path, and potentially explaining\nwhy the disease is more common in older patients who may\nhavehad an undetected precursor condition for years.\n\"This work reframes theX chromosomefroma bystanderto an\nactive driver of cancer biology in women.Combined with the", "live": "Justaquickcheck\nWe'recheckingyourconnectiontopreventautomatedabuse\nVerify you are human\nCLOUDFLARE\nPrivacr * Hele\nWhyam I seeing this?\nHaving probiems? Contact support" } }, { "id": "spen-ascopost", "study": "spen", "outlet": "The ASCO Post", "outlet_original": "The ASCO Post", "outlet_score": 5, "title": "Study Finds DLBCL Subtype May Have Higher Mortality Risk in Female Patients", "title_original": "Study Finds DLBCL Subtype May Have Higher Mortality Risk in Female Patients", "language": "English", "date": "2026-05", "kind": "news", "url": "https://ascopost.com/news/may-2026/study-finds-dlbcl-subtype-may-have-higher-mortality-risk-in-female-patients/", "archive_url": "https://web.archive.org/web/20260515164836/https://ascopost.com/news/may-2026/study-finds-dlbcl-subtype-may-have-higher-mortality-risk-in-female-patients/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Oncology news item on a Cancer Discovery study associating a DLBCL subtype with higher mortality in women, with the biological cause identified and an existing drug class suggested as helpful.", "topics": [ "dlbcl", "sex differences", "cancer discovery", "mortality", "lymphoma" ], "audience": "trade", "thumbnail": "media-archive/thumbs/spen-ascopost.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/spen-ascopost--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/spen-ascopost.txt", "ocr_text": { "archived": "TheASCOPost\nSearch...\nMEETINGSTOPICS-\nVIDEOSPODCASTS\nSUBSCRIBE\nABOUT\nNEWS-\nStudyFindsDLBCLSubtypeMayHaveHigher\nMortalityRiskinFemalePatients\nByThe Asco Post Staff\nTODAY IN ONCOLOGY\nPosted:5/15/20269:55:00AM\nLastUpdated:5/15/202610:11:58AM\nSigmoidoscopyReducesCRCIncidenceRatesin\nGet Permission\nMen inNorwegianScreeningStudy\nAn international research team has shown thata specific subtype of diffuse large B-cell lymphoma (DLBCL)is\nEarly Ovarian CancerMinimally InvasiveSurgery\nassociated with higher mortality risk in women than in men.The study was led by the laboratory of Ari\nIntraoperativeCapsuleRupture,andSurvival\nMelnick,MD,Director ofthe Josep Carreras Leukaemia Research Instituteand the Gebroe Family Professor of\nHematology/Oncology at Weill Cornell Medicine,along with thelaboratories ofWendyBeguelin,PhD,of\nLocalSalvageTherapyforPost-RadiotherapyLocal\nthe New York University Grossman School of Medicine,and Leandro Venturutti,PhD, of the University of\nRecurrenceofProstateCancer\nBritish Columbia.Researchers identified thebiological reason for this disparity and discussed an existing class\nStudyFindsDLBCLSubtypeMayHaveHigher\nofdrugsthat maybenefitfemale patients.Findings were published by Pelzer etal in CancerDiscovery.\nMortalityRisk inFemalePatients\nSPENandNOTCH2 Variants\nRelacorilantPlusNab-Paclitaxel Improves Overall\nSurvival in Platinum-Resistant Ovarian Cancer\nDLBcL affects hundreds of thousands of people worldwide each year. Although outcomes vary widely between\npatients, sex had never previously been identified as a driver of survival differences in this disease.By analyzing\nVIEWMORE\ndata from nearly 5,000 patients across 14 independent studies, the team found that women who carry\nsimultaneous faults in two genes called SPEN and NOTCH2 had a morethan fourfold higher mortality risk than\nmen with the same mutations.Benedikt Pelzer, MD,ofWeill Cornell Medicine, the first author ofthe study,\ncommented, \"When we noted that women were doing far worse than men withthese specificmutations, we\nknew we had to understand why.What we found was unexpected, that the X chromosome itself was the key.\nThe researchers explained that the reason for this is due to fundamental differences in male and female biology.\nWomen carry two copies of the X chromosome,and oneis normallykept permanently switched off,a process\npartly controlled bythe SPENgene.When SPEN is damagedalongside NOTCH2,that silencingbecomes unstable.\nGenes on the supposedlydormant X chromosome begin to wake up, including TLR7,agene that when\noveractive acts like a jammed accelerator for cancercellgrowth and survival.In men,who carry only oneX\nchromosome, this mechanism cannot occur.\nImportantly,the researchers showed this is not driven byfemale hormones.The effect persisted in animals\neven after removal of the ovaries, confirming that thevulnerability is built into the chromosomes themselves.\n\"sex differences in cancer have too often been attributed to lifestyle or hormones. This study shows the biology\nitselfcanbefundamentallydifferentbetweenmenandwomenatthemolecularlevel,andthatthiscanbe\ninvisibleunless you specificallylook forit,said Dr.Venturutti.\nPotential TherapeuticOptions\nAccording to investigators,the overactive TLR7pathway that drives tumor growth infemale patients can be\nblocked by IRAK inhibitors, which are in clinical developmentfor other conditions.In laboratory experiments\nand animal models, these drugs were significantly more effective at killing female tumor cells than male ones.\nA tumor model derived directly from a female patient with DLBCL responded well, with growth slowing\nsubstantially over the course of treatment.Combining the IRAK inhibitor with standard chemotherapy\nenhanced the effect further.\n\"IRAK inhibitors arealready in clinical trials.The pathfrom this discovery toa treatment option forpatients is\nshorter than it usually is in cancer research,and that urgency is something wefeel strongly,'said Dr. Beguelin.\nThe study also upends another long-held assumption about how this cancer develops,noted the investigators.\nIt had been thought that this subtype of DLBCL originates deep within the immune system's active response\ncenters.Thenew data show it likely beginsfrom a cell typethat accumulates with aging and exposure to\ninfections,andis closelyassociated withautoimmunediseases,consistent witha differentdevelopmental path,\nand potentially explaining why the disease is more common in older patients who may have had an undetected\nprecursor condition for years.\n\"This work reframes theX chromosome from a bystanderto an activedriver of cancer biology in women.\nCombined with the discovery ofa druggabletarget,it is a genuine paradigm shift,and a compellingargument\nfor making biological sex a standard variable in how we design cancer trials going forward, said Dr. Melnick.\nDIsCLOSURE:For full disclosures of the study authors,visit aacrjournals.org/cancerdiscovery.\nThe content in thispost hasnot been reviewedbytheAmerican Societyof Clinical Oncology,Inc.(AscO)anddoesnot\nnecessarilyreflecttheideasandopinionsofAScO?\n2026HSPNewsService,L.L.C.\nconexiant", "live": "Search....\nMEETINGSTOPICS-\nVIDEOSPODCASTS\nABOUT\nNEWS-\nSUBSCRIBE\nTheASCOPost\nStudyFindsDLBCLSubtypeMayHaveHigher\nMortalityRiskinFemalePatients\nByTheAsco PostStaff\nTODAY IN ONCOLOGY\nPosted:5/15/20269:55:00AM\nLastUpdated:5/15/202610:11:58AM\nTILTherapyPlus PembrolizumabforAdvanced\nGetPermission\nMelanoma\nAn international research teamhas shownthata specific subtype of diffuse large B-celllymphoma (DLBCL)is\nMachineLearningModelsOutperformTraditional\nassociated with higher mortality risk in women than in men.The study was led by the laboratory of Ari\nApproachestoMulticancerRiskPrediction\nMelnick,MD,Director ofthe Josep Carreras Leukaemia Research Instituteand the Gebroe Family Professor of\nHematology/Oncology at Weill Cornell Medicine,along with thelaboratories of WendyBeguelin,PhD,of\nSacituzumabTirumotecanExtendsPFSosin\nthe New York University Grossman School of Medicine, and Leandro Venturutti,PhD, of the University of\nAdvancedRecurrentEndometrial Cancer\nBritish Columbia. Researchers identified the biological reason for this disparity and discussed an existing class\nExpertHistopathologyandMolecularTesting\nof drugs that may benefit female patients. Findings were published by Pelzer et al in Cancer Discovery.\nImproveDiagnosisofAmbiguousCutaneous\nMelanocytic Tumors\nSPEN and NOTCH2 Variants\nRadiation Addedto SystemicTherapyImproves PFS\nDLBCLaffects hundreds of thousands of peopleworldwide each year.Althoughoutcomes vary widelybetween\nButNotOSforoligometastaticNSCLC\npatients, sex had never previously been identified as a driver of survival differences in this disease. By analyzing\ndata from nearly 5,ooo patients across 14 independent studies, the team found that women who carry\nVIEWMORE\\\nsimultaneous faults intwogenes called SPENand NOTCH2 hadamorethanfourfold highermortalitvrisk than\nNoticeatcollection\nCookie settings\nYour Privacy Choices\nClose\nyourpersonal information.You can opt outatany time.\nWomen carrytwo copies oftheX chromosome,and oneis normallykept permanently switched off,a process\npartly controlledbythe SPENgene.When SPEN is damagedalongside NOTCH2,that silencingbecomes unstable.\nGenes on the supposedly dormant X chromosome begin to wake up,including TLR7,a gene that when\noveractive acts likea jammedaccelerator for cancer cell growth and survival. In men,who carry only oneX\nchromosome,this mechanism cannot occur.\nImportantly,the researchers showed this is notdriven byfemale hormones.The effect persisted in animals\neven after removal ofthe ovaries, confirming that thevulnerability is built into the chromosomes themselves.\n\"Sex differences in cancer have too often been attributed to lifestyle or hormones.This study shows the biology\nitself can befundamentally differentbetween men and women at themolecular level,and that this canbe\ninvisibleunless you specifically look forit,”said Dr.Venturutti.\nPotential Therapeutic Options\nAccording to investigators,the overactive TLR7pathway thatdrives tumorgrowth infemalepatients can be\nblocked by IRAK inhibitors,which are in clinical developmentfor other conditions.Inlaboratory experiments\nand animal models, these drugs were significantly more effective at killing female tumor cells than male ones.\nA tumor model derived directly from a female patient with DLBCL responded well, with growth slowing\nsubstantially over the course of treatment. Combining the IRAK inhibitor with standard chemotherapy\nenhanced the effectfurther.\n\"IRAK inhibitors are already in clinical trials.The path from this discovery toa treatment option for patients is\nshorter than it usually is in cancer research, and that urgency is something we feel strongly,' said Dr. Beguelin.\nThe study also upends another long-held assumption about how this cancer develops,noted the investigators.\nIt had been thought thatthis subtype of DLBCL originates deep within theimmune system'sactive response\ncenters. The new data show it likely begins from a cell type that accumulates with aging and exposure to\ninfections,and is closely associated withautoimmunediseases,consistent with a different developmental path,\nand potentially explaining whythe disease is more common in older patients who may have had an undetected\nprecursor condition for years.\n\"This work reframes theX chromosome from a bystander toanactivedriverofcancer biology in women.\nCombinedwiththediscovery ofa druggabletarget,it isa genuine paradigm shift,and a compelling argument\nfor making biological sex a standard variable in how we design cancer trials goingforward,said Dr.Melnick.\nDISCLOSURE: For full disclosures of the study authors, visit aacrjournals.org/cancerdiscovery.\nThecontent in this post has not been reviewedbythe American Societyof Clinical Oncology,Inc.(Asco)anddoes not\nnecessarilyreflecttheideasandopinionsofAsco\n2026HSPNewsService,L.L.C." } }, { "id": "spen-healthtree", "study": "spen", "outlet": "HealthTree Foundation", "outlet_original": "HealthTree Foundation", "outlet_score": 4, "title": "Study Finds Higher Risks for Some Women with DLBCL", "title_original": "Study Finds Higher Risks for Some Women with DLBCL", "language": "English", "date": "2026-06-01", "kind": "news", "url": "https://healthtree.org/b-cell-lymphoma/news/06-01-2026-risk-and-treatment-women-with-bn2-dlbcl", "archive_url": "", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Patient-oriented summary of a Cancer Discovery study of nearly 5,000 patients: women with both SPEN and NOTCH2 changes in BN2-DLBCL had over four times the mortality risk of men, suggesting a treatment target.", "topics": [ "dlbcl", "spen", "notch2", "sex differences", "patient information" ], "audience": "other", "thumbnail": "media-archive/thumbs/spen-healthtree.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/spen-healthtree--live.jpg", "saved_html": "", "saved_article_text": "media-archive/text/spen-healthtree.txt", "ocr_text": { "live": "HealthTree\nDonate\nFoundation\nLog in\n← Back\nPersonal HealthRecord\nwMyFeed\nCreateyourPersonal HealthRecord and unlock support\nDon'tshowthisagain\nRecentlyviewed\nbuilt around you\nAligned with your diagnosis,treatment and where you are in your care.It lets HealthTree show you:\nLearn\nTreatments andtrials youqualifyfor\nEducation for your stage of care\nTopics\n@Financial supportforyourmedications\nSolutions to your side effects\nEvents\nTrial match foryou\nMatched on subtype and prior lines\nExplore\nFindtreatments&trials\nFinancial help\nSupportprogramforyourcurrentmedication\nParticipate in research\nCoach support\nFind a coach\nCoachsuggestionwith.yoursametreatmentpath\nFinda specialist\nGet started\nLearn more about HealthTree→\nTalkto a patientnavigator\nGet involved\nFor researchers\nFor healthcare providers\nAbout us\nNotifications\nYou're all caught up\nMessages\nMessages\nNoconversationsyet" } }, { "id": "baf-wcm", "study": "baf", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Discovery Suggests New Strategy Against Follicular Lymphoma", "title_original": "Discovery Suggests New Strategy Against Follicular Lymphoma", "language": "English", "date": "2024-03", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2024/03/discovery-suggests-new-strategy-against-follicular-lymphoma", "archive_url": "https://web.archive.org/web/20240331163751/https://news.weill.cornell.edu/news/2024/03/discovery-suggests-new-strategy-against-follicular-lymphoma", "names_meydan": true, "meydan_context": "Named as a co-first author and quoted on possible transformation-risk markers.", "passage_naming_meydan": "The study’s co-first authors were postdoctoral researchers Dr. Darko Barisic and Dr. Christopher Chin, and senior research associate Dr. Cem Meydan, all members of the Melnick laboratory. A team led by Dr. Michael Green, an associate professor at the University of Texas MD Anderson Cancer Center, also collaborated in the study, and publish…", "summary": "Release on a Cancer Cell study identifying BAF-complex mutations as drivers of follicular lymphoma transformation to aggressive disease, while also making it sensitive to experimental BAF inhibitors; trials are being planned.", "topics": [ "follicular lymphoma", "baf complex", "transformation", "cancer cell", "inhibitors" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/baf-wcm.jpg", "passage_image": "media-archive/mentions/baf-wcm.jpg", "full_screenshot": "media-archive/shots/baf-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/baf-wcm.txt", "ocr_text": { "archived": "Weill CornellMedicine\nCare\nDiscover\nTeach\nMenu\nSearch\nNewsroom\nNews\nPressRoom\nVideo&Photography\nSocial Media\nImpact Magazine\nAbout Us\nHome\nNews\nDiscoverySuggests New Strategy AgainstFollicular\nLymphoma\nMARCH28,2024\nBacktoNews\nWeill Cornell Medicine\nOfficeofExternalAffairs\nPhone:(646)962-9476\nMutations that disrupt the BAF machinery affect its ability to remodel DNA packaging in nucleosomes,resulting in changes of\n(green) to form nucleosomes.\nA team led by researchers at Weill Cornell Medicine has identified important drivers of the transformation of a type of\nblood cancer called follicular lymphoma from a slow-growing form to the aggressive form it takes in some patients.\nThe study , published March 7 in Cancer Cell, showed that while mutations affecting a gene-regulating complex called\nBAF can put the cancer on a dangerous trajectory,they also make follicular lymphoma highly susceptible to experimental\nBAF-inhibitor drugs.\n\"These encouraging findings could address critical and urgent challenges with this\ndisease and have promptedus to begin planning clinical trials of BAFinhibitors in\nfollicular lymphoma patients,\"said study senior author Dr.Ari Melnick,theGebroe\nFamily Professor of Hematology/Oncology and a member of the Sandra and Edward\nMeyer Cancer Center at Weill Cornell Medicine.\nThe study's co-first authors were postdoctoral researchers Dr. Darko Barisic and Dr.\nChristopher Chin, and senior research associate Dr. Cem Meydan\nallmembersofthe\nMelnick laboratory.A team led by Dr.Michael Green,an associate professor at the\nUniversity of Texas MD Anderson Cancer Center,also collaborated in the study,and\npublished a paper with parallel findings.\nAriMenick,Mn\nFollicular lymphoma is the second most common type\nof lymphoma in the United States, with about 15,000\nDr. Ari Melnick\nnew cases per year, according to the Lymphoma\nResearchFoundation.Likemostlymphomas,itarises\nfrom immune cells called Bcells.Usually,follicularlymphoma progressesslowly,and\nremains manageable with various treatments.But a subset of these patients rapidly\nprogress to a transformed, rapidly dividing,and treatment-resistant form offollicular\nlymphoma within 24 months. The reason for this is unknown, and hence it is very hard\nto predict if a patient is at risk for this unfavorable outcome. Thus, there is a critical\nunmet need to identify and develop early intervention therapies for these cases.\nDr.Darko Barisic\nIn the study,researchers started out byexamining the role of mutations inagene called\nARiD1A, which encodes a subunit of a versatile,multi-protein molecular machine called\ncell identity by physically changing the shape of the genome. ARID1A mutations and other mutations that disrupt BAF are\nfound in a significant number of patients with follicular lymphoma.\nThe researchers found that ARID1A deficiency in B cells, and the resulting BAF\ndysfunction, steers the cells towards an unusual, immature\"memory B cell\" identity. In\nthis abnormal state, the cells keep re-entering a temporary phase of the B-cell mediated\nimmune response which orchestrates rapid cell division and the diversification of\nantibodies needed during infections. During this phase, the cells undergo a high rate of\nmutation, presumably driving them towards ever-greater malignancy.\nThe investigators wondered whether the tendency of B cells with ARID1A mutations to\nenter periods of rapid cell division and mutationmight explain rapidlyprogressive\nfollicularlymphoma.Collaboratingwithcolleaguesfrom theBritishColumbia Cancer\nAgency,they observed that ARiD1A mutations were enriched in the memory B cell-like\ntype of follicular lymphoma, which are at much higher and earlier risk of transformation.\nThechallengethen,would beto target these\nDr.Cem Meydan\ndangerous cells to prevent these outcomes. Dr.Melnick\nand colleagues reasoned that ARID1A-mutant\nlymphomas might be especially vulnerable to drugs attacking their last remaining BAF\nfunctions, which are already compromised by these mutations. Working with BAF\ninhibitors that are already in clinical trials, they showed in preclinical experiments that\nARID1A mutations indeed makes lymphomas profoundly sensitiveto these drugs.Mice\nbearing ARID1A-mutant lymphomas went into complete remission with this drug alone.\n\"These data raise the possibility of developing early intervention precision therapies for\nthose follicular lymphoma patients at risk for rapid progression, who currently do not\nhave such options,\" said Dr. Melnick, who is now working with the clinical team at Weill\nDr.Christopher Chin\nCornell Medicineto implement such studies.\nDi,cistopercn\nCornellMedicinetoimplementsuchstudies.\n\"These findings suggest that ARID1A is effectively a tumor suppressor, whose deficiency\nin follicular lymphoma promotes the transformation to a more aggressive lymphoma,\" Dr. Barisic said. Other BAF-\nadded.\n\"lit might even turn out that anymutation affecting the BAF complex,or anything else leading to the formation of these\nabnormal memory B-likecells, is a marker of transformation risk,Dr.Meydansaid.\nBAF inhibitors might also turn out to have a much broader role in oncology,given that BAF-affecting mutations have\nbeen reported in about 20 percent of human cancers.\n\"What is the common mechanism that explains why BAF mutations appear in so many different cancers? There are so\nmany factors at play, untangling the complexity of them would address a significant unmet need in the field of precision\noncology,\" Dr. Chin said.\nThis work was supported in partby the National Cancer Institute,part of the National Institutes of Health, throughgrant\nnumbers:K99CA246080,F31CA254302,R01CA266279,R01MH117406,P01CA214274,R01CA249054andR35CA220499.\nMany Weill Cornell Medicine physicians and scientists maintainrelationships and collaborate with external organizations to\nfoster scientific innovation and provide expert guidance.The institution makes these disclosures publicto ensure transparency.\nFor this information, see profile for Dr.Melnick.\nDr.Ari Melnick,Graduate School of Medical Sciences,Hematology/Medical Oncology,Patient Care,Research,News from WCM\nRELATED NEWS\nAwards&Honors:March2024\nStand Up To CancerDream Team Collective Seeksto Transform Care of Gastroesophageal Cancer\nResearchers IdentifyProtein Sensorthat Plays a Role in LungFibrosis\nNewsroom\nContact Us\nNews\nWeill Cornell Medicine\nPress Room\nImpact Magazine\nVideo&Photography\nSocial Media\nAbout Us\nOfficeofExternalAffairs\nPhotography\nFor Journalists\nSocial Media\nStaff Directory\nEmail: pr@med.cornelledu\nFor Faculty, Staff and\nVideos\nGuidelines\nPhone: (646) 962-9476\nStudents\nCare.Discover.Teach.Witha legacyof puttingpatientsfirst,Weill Cornell Medicineiscommittedtoprovidingexemplaryand individualized\nclinical care,makinggroundbreaking biomedicaldiscoveries,and educating generations ofexceptional doctorsand scientists.\nWeill CornellMedicine\n@Weill Cornell Medicine.Privacy & Legal Careers GivingDirectory WebAccessibility Assistance", "live": "WeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpactMagazine\nAbout Us\nHome\nNews\nDiscovery Suggests New Strategy Against Follicular\nLymphoma\nMARCH28,2024\nBack to News\nin\nWeill Cornell Medicine\nOfficeof External Affairs\nPhone: (646)962-9476\nMutations that disrupt the BAF machinery affect its ability to remodel DNA packaging in nucleosomes, resulting in changes of\ngene expression that lead to aggressive lymphoma. The illustration shows how DNA (cyan) is wrapped around histone proteins\n(green) to form nucleosomes.\nA team led by researchers at Weill Cornell Medicine has identified important drivers of the transformation of a type of\nblood cancer called follicular lymphoma from a slow-growing form to the aggressive form it takes in some patients.\nThe study , published March 7 in Cancer Cell, showed that while mutations affecting a gene-regulating complex called\nBAF can put the cancer on a dangerous trajectory,they also make follicular lymphoma highly susceptible to experimental\nBAF-inhibitor drugs.\n\"These encouraging findings could address critical and urgent challenges with this\ndisease and have prompted us to begin planning clinical trials of BAF inhibitors in\nFamily Professor of Hematology/Oncology and a member of the Sandra and Edward\nMeyer Cancer Center at Weill Cornell Medicine.\nThe study's co-first authors were postdoctoral researchers Dr. Darko Barisic and Dr.\nChristopher Chin, and senior research associate Dr. Cem Meydan\nallmembersofthe\nMelnick laboratory.Ateamled by Dr.Michael Green ,an associateprofessor at the\nUniversity of Texas MD Anderson Cancer Center,also collaborated in the study,and\npublished a paper with parallel findings.\nAriMenick.Mn\nFollicular lymphoma is the second most common type\nof lymphoma in the United States, with about 15,000\nDr.Ari Melnick\nnew casesper year,according to the Lymphoma\nResearchFoundation.Likemostlymphomas,itarises\nfrom immune cells called B cells.Usually,follicular lymphoma progresses slowly,and\nremains manageable with various treatments. But a subset of these patients rapidly\nprogress to a transformed, rapidly dividing,and treatment-resistantform offollicular\nlymphoma within 24 months. The reason for this is unknown, and hence it is very hard\nto predict if a patient is at risk for this unfavorable outcome. Thus, there is a critical\nunmet need to identify and develop early intervention therapies for these cases.\nDr. Darko Barisic\nIn the study,researchers started out by examining the role of mutations in a gene called\nARID1A, which encodes a subunit of a versatile, multi-protein molecular machine called\ncell identity by physically changing the shape of the genome. ARID1A mutations and other mutations that disrupt BAF are\nfound in a significant number of patients with follicular lymphoma.\nThe researchers found that ARID1A deficiency in B cells, and the resulting BAF\ndysfunction, steers the cells towards an unusual, immature \"memory B cell\" identity. In\nthis abnormal state, the cells keep re-entering a temporary phase of the B-cell mediated\nimmune response which orchestrates rapid cell division and the diversification of\nantibodies needed during infections. During this phase, the cells undergo a high rate of\nmutation, presumably driving them towards ever-greater malignancy.\nThe investigators wondered whether the tendency of B cells with ARID1A mutations to\nenter periods of rapid cell division and mutation might explain rapidly progressive\nfollicular lymphoma.Collaborating withcolleaguesfrom theBritish Columbia Cancer\nAgency, they observed that ARID1A mutations were enriched in the memory B cell-like\ntype of follicular lymphoma, which are at much higher and earlier risk of transformation.\nThe challenge then, would be to target these\nDr.Cem Meydan\ndangerous cells to prevent these outcomes. Dr. Melnick\nand colleagues reasoned that ARID1A-mutant\nlymphomas might be especially vulnerable to drugs attacking their last remaining BAF\nfunctions, which are already compromised by these mutations. Working with BAF\ninhibitors that are already in clinical trials, they showed in preclinical experiments that\nARID1Amutations indeedmakes lymphomasprofoundlysensitiveto thesedrugs.Mice\nbearing ARID1A-mutant lymphomas went into complete remission with this drug alone.\n\"These data raise the possibility of developing early intervention precision therapies for\nthose follicular lymphoma patients at risk for rapid progression, who currently do not\nhave such options,said Dr. Melnick, who is now working with the clinical team at Weill\nDr. Christopher Chin\nCornell Medicinetoimplement such studies.\nDr.cistopnerch\nCornell Medicinetoimplement suchstudies.\n\"These findings suggest that ARID1A is effectively a tumor suppressor, whose deficiency\nadded.\n\"lt might even turn out that any mutation affecting the BAF complex, or anything else leading to the formation of these\nabnormal memory B-likecells, is a marker of transformation risk,Dr.Meydansaid.\nBAFinhibitorsmight also turn out to have a much broader role in oncology,given that BAF-affecting mutations have\nbeen reported in about 20 percent of human cancers.\n\"What is the common mechanism that explains why BAF mutations appear in so many different cancers? There are so\nmany factors at play, untangling the complexity of them would address a significant unmet need in the field of precision\noncology,\" Dr. Chin said.\nThis work was supported in part by the National Cancer Institute, part of the National Institutes of Health, through grant\nMany Weill Cornell Medicine physicians and scientists maintain relationships and collaboratewith external organizations to\nfoster scientific innovation and provide expert guidance.The institution makes these disclosures publicto ensure transparency.\nFor this information, see profile for Dr.Melnick.\nDr.Ari Melnick, Graduate School of Medical Sciences,Hematology/Medical Oncology, Patient Care, Research,News from WCM\nRELATED NEWS\nAUnifying Mechanism forCancer-Driving Mutations\nNoninvasive Focused Ultrasound Treatment Can Ease Motor Symptoms of Parkinson's Disease\n2026RituBangaAwardsSupportInnovativeResearch\nNewsroom\nContact Us\nNews\nWeill Cornell Medicine\nPress Room\nImpact Magazine\nVideo&Photography\nSocial Media\nAbout Us\nOfficeofExternalAffairs\nPhotography\nFor Journalists\nSocial Media\nStaff Directory\nEmail: pr@med.cornelledu\nFor Faculty,Staff and\nVideos\nGuidelines\nPhone: (646) 962-9476\nStudents\nCare.Discover.Teach.Witha legacyof puttingpatientsfirst,Weill Cornell Medicineiscommittedtoprovidingexemplaryand individualized\nclinical care, makinggroundbreaking biomedicaldiscoveries,and educatinggenerations ofexceptional doctorsand scientists.\nWeill CornellMedicine\n@ Weill Cornell Medicine:Privacy&Legal Equal Education & Employment CareersGiving Directory Web Accessibility Assistance" } }, { "id": "baf-carreras-seminar", "study": "baf", "outlet": "Josep Carreras Leukaemia Research Institute", "outlet_original": "Josep Carreras Leukaemia Research Institute", "outlet_score": 6, "title": "Seminar: Integrative epigenomics of SWI/SNF driven 3D genome rewiring (Dr. Cem Meydan)", "title_original": "Seminar: Integrative epigenomics of SWI/SNF driven 3D genome rewiring (Dr. Cem Meydan)", "language": "English", "date": "2025", "kind": "talk", "url": "https://www.carrerasresearch.org/en/events/integrative-epigenomics-of-swisnf-driven-3d-genome-rewiring", "archive_url": "", "names_meydan": true, "meydan_context": "He is the invited speaker, and the page carries his biography.", "passage_naming_meydan": "Dr. Cem Meydan is an Assistant Professor of Computational Biology at Weill Cornell Medicine. He uses single cell, spatial, and 3D epigenomic profiling to map the gene-regulatory circuits that drive hematologi…", "summary": "Event listing for a seminar on SWI/SNF-driven 3D genome rewiring, with a speaker biography covering his single-cell, spatial and 3D epigenomic work on blood cancers.", "topics": [ "seminar", "swi/snf", "3d genome", "epigenomics", "hematologic cancer" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/baf-carreras-seminar.jpg", "passage_image": "media-archive/mentions/baf-carreras-seminar.jpg", "full_screenshot": "media-archive/shots/baf-carreras-seminar--live.jpg", "saved_html": "media-archive/html/baf-carreras-seminar--live.html", "saved_article_text": "media-archive/text/baf-carreras-seminar.txt", "ocr_text": { "live": "English\nSearch...\nJosep Carreras\nLEUKAEMIA\nEvents\nNews\nManagement\nInstitute\nResearch\nCore facilities\nOutreach\nDirectory\nPath2Cure\nCareers\nResearch Institute\nEvents\nJUNE15,2026(12:00)\n\"Integrativeepigenomicsof SWI/SNF\ndriven3D genome rewiring\nInvited Lectures\nDr Cem Meydan\nWeill Cornell Medicine, Department of Medicine,Division of Hematology and Medical Oncology\nThehost of this seminaris Eduard Porta.\nDr.Cem Meydan\nisan AssistantProfessorof Computational BiologyatWeill Cornell Medicine.Heuses\nsingle cell, spatial, and 3D epigenomic profiling to mapthe gene-regulatory circuits that drive hematologic\ncancers and B-cellfate.His research applies integrative multi-omics analyses to connect epigenetic\nmodifiers and chromatin remodelers with enhancerrewiring,immune-microenvironment shifts,and\ntherapeutic response.His work spanning city-scalemetagenomic profiling,multi-omic cancer research.and\ndeep molecular characterization of spaceflight biology have appeared on the covers of Nature,Scienceand\nCell and havebeen reported byTheWall Street Journal, TheNew York Times, CNN and othermedia\noutlets.\nDr Meydan\nearnedaBSinComputerSciencefromIzmirInstituteof Technology.aPhDfrom\nSabanci Universityfocused on machine learning and bioinformatics, and completed postdoctoral training at\nWeill Cornell.\nJCAuditorium+Online\nRegistration here\nOCTOBER29,2026(12:00)\nNOVEMBER05,2026-NOVEMBER06,2026\n\"Rewriting Tissue Repair:\nIJCSymposium2026:Immunityin\nMicroenvironmental Control of Early\nHaematologicalMalignancies:from\nTumour Persistence\"\nMolecularMechanismsto\nTransformative Therapies\nDr Maria P.Alcolea\nUCAuditorium+Online\nUCAuditorium\nRegistration here\n[GRegistration here\nInvited Lectures\nSymposium\nNOVEMBER13,2026(12:00)\nNOVEMBER19,2026-NOVEMBER20,2026\nBeyond tumor B-cell depletion:can we\nACHILLESOpeningSymposium\nachieve an immune reset in follicular\nlymphoma?\nACHILLESMSCADoctoralNetwork\nJCAuditorium.+Online\nDr Karin Tarte\nRegistration here\nUC Auditorium + Online\nSymposium\nRegistration here\nInvited Lectures\nRegistration here\nInvitedLectures\nNOVEMBER27,2026(12:00)\n\"Modelling Clonal Hematopoiesis and\nEpigeneticAging froman Evolutionary\nPerspectiveuncoversnovelearly\ndetection strategies for Leukaemia\"\nDr Eric Latorre Crespo\nJCAuditorium +Online\nRegistration here\nInvited Lectures\nJosep Carrerasg\nSocial media\nWeare\nRecognised by\nLEUKAEMIA\nResearchInstitute\nCERCA\nEXCELENCA\nfundacioncientifica\nSEVERO\nCentres du Recerea\nasociacionespanola\nOCHOA\nde Catalunya\nContact us\ncontraelcancer\n04/2024-03/2030\nLegaldisclaimer\nCookies policy\n2026@JosepCarrerasLeukaemiaResearchInstitute\nWhistleblowingChannel" } }, { "id": "baf-medicalxpress", "study": "baf", "outlet": "Medical Xpress", "outlet_original": "Medical Xpress", "outlet_score": 6, "title": "Discovery suggests new strategy against follicular lymphoma", "title_original": "Discovery suggests new strategy against follicular lymphoma", "language": "English", "date": "2024-03", "kind": "news", "url": "https://medicalxpress.com/news/2024-03-discovery-strategy-follicular-lymphoma.html", "archive_url": "https://web.archive.org/web/20240328171355/https://medicalxpress.com/news/2024-03-discovery-strategy-follicular-lymphoma.html", "names_meydan": true, "meydan_context": "Named as a co-first author and quoted on possible transformation-risk markers.", "passage_naming_meydan": "The study's co-first authors were postdoctoral researchers Dr. Darko Barisic and Dr. Christopher Chin, and senior research associate Dr. Cem Meydan, all members of the Melnick laboratory. A team led by Dr. Michael Green, an associate professor at the University of Texas MD Anderson Cancer Center, also collaborated in the study, and publish…", "summary": "Reprint of the release on drivers of follicular lymphoma turning aggressive; BAF mutations raise risk but make the cancer highly susceptible to BAF inhibitors, and a parallel study reached similar findings.", "topics": [ "follicular lymphoma", "baf complex", "transformation", "cancer cell", "inhibitors" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/baf-medicalxpress.jpg", "passage_image": "media-archive/mentions/baf-medicalxpress.jpg", "full_screenshot": "media-archive/shots/baf-medicalxpress--archived.jpg", "saved_html": "media-archive/html/baf-medicalxpress--archived.html", "saved_article_text": "media-archive/text/baf-medicalxpress.txt", "ocr_text": { "archived": "Medical press\nWeek's top\nSubscribe\nLatestnews\nUnread news\nTopics\nConditions\nHome/ Oncology&Cancer\nFeatured\nLast Comments\nPopular\nHome/ Genetics\nMARCH28,2024\nEditors'notes\nResearch review suggests fourkey\nmechanisms are involved in changing one's\nDiscovery suggestsnew strategy\npersonality\n23MINUTES AGO\nagainstfollicularlymphoma\nAmountof protein consumed by pregnant\nby Weill Cornell Medical College\nwomen modulates thefacial appearance of\noffspring,studyfinds\nARID1Amutant\n①1HOURAGO\nWT\nPU.1Moe\nNF-KBMol\nStudy suggests maintaining optimism\ncontributestobettermobilityinwomenas\nthey grow older\n①1HOURAGO\nWhy sometypesof music makepeople want\nto dance more than others\nSLOWEXT\nightZone\nMAR27.2024\nGerminal Center\nGerminal\nCenter\nGoogle's HeAR Al system uses sounds to\nRe-entry\ndetect lung diseases,such as CoVID-19\nMAR26,2024\nMemory B-call\nPlasma Cell\nLymphoma\nPlasma Ceil\nMemory B-Cells\nPreoursors\nPharmacological disruption of SwSNF complexes\nPredicting infection risk in\nGraphical abstract. Credit: Cancer Cell (2024).D0l:10.1016/j.ccell.202..\nchildhood cancer\n①9MINUTESAGO\nAteamledbyresearchersatWeill Cornell Medicinehas\nidentified important drivers of the transformation of a type of\nblood cancer calledfollicularlymphoma from a slow-growing\nResearch review suggests\nfour key mechanisms are\nformto theaggressiveform ittakes in some patients.\ninvolved in changing one's\npersonality\nThestudy,published in Cancer Cell,showed that whilemutations\n①23MINUTESAGO\naffecting a gene-regulating complex called BAF can put the\nMiscarriages linked to health\ncancerona dangeroustrajectory,theyalso makefollicular\nrisks inlaterpregnancies\nlymphoma highly susceptibletoexperimental BAF-inhibitor\n①33MINUTESAGO\ndrugs.\nCell phone video technology\n\"These encouraging findings could address criticaland urgent\nunveils newmethod for\nanalyzing walking and gait\nchallenges with this disease and have prompted us to begin\n①36MINUTESAGO\nplanning clinical trials of BAFinhibitors in follicular lymphoma\npatients,said study seniorauthorDr.Ari Melnick,theGebroe\nBabies attend to clues of\nmeaning as they take in\nFamilyProfessorof Hematology/Oncologyandamemberof the\ncomplex visual world\nSandra and Edward Meyer Cancer Center at Weill Cornell\n41MINUTESAGO\nMedicine.\nDoctors received\napproximately S12.1billion\nThe study's co-first authors were postdoctoral researchers Dr.\nfrom drug and devicemakers\nDarkoBarisicandDr.ChristopherChin,andseniorresearch\nbetween2013-2022,study\nreveals\nassociateDr.Cem Meydan all members of theMelnick\n①1HOURAGO\nlaboratory.Ateamled byDr.Michael Green,an associate\nprofessoratthe Universityof Texas MDAndersonCancer Center,\nUnlocking howtouse mRNA\nto target Alzheimer's disease\nalso collaborated inthestudy,andpublishedapaperinthesame\n①1HOURAGO\njournal with parallel findings.\nFollicularlymphoma is the secondmost commontype of\nAmountof protein consumed\nbypregnant women\nlymphoma intheUnited States,withabout15,000newcasesper\nmodulates the facial\nyear, according to the Lymphoma Research Foundation. Like\nappearance of offspring,\nstudy finds\nmost lymphomas, it arises from immune cells called B cells.\n①1HOURAGO\nUsually,follicularlymphomaprogressesslowly,andremains\nNewtool detects signs of\nmotorneurondiseasebefore\nmanageable with various treatments.But a subset of these\nsymptoms begin\npatients rapidly progress to a transformed, rapidly dividing, and\n①1HOURAGO\ntreatment-resistant form of follicular lymphoma within 24\nmonths. The reason for this is unknown, and hence it is very hard\nStudy suggests maintaining\noptimism contributesto\nto predictif a patient is at risk for this unfavorable outcome.\nbetter mobility in womenas\nto predict if a patient is at risk for this unfavorable outcome.\nbetter mobility in women as\nThus, there is a critical unmet need to identify and develop early\ntheygrowolder\n1HOURAGO\nintervention therapies for these cases.\nIn the study, researchers started out by examining the role of\nmutations in a gene called ARID1A, which encodes a subunit of a\nversatile, multi-protein molecular machine called BAF. The BAF\nmachinerynormallyworks in cells asamajorregulatorof gene\nactivity and cell identity by physically changing the shape of the\ngenome.ARID1Amutations and other mutations that disrupt\nBAF are found in a significant number of patients withfollicular\nlymphoma.\nThe researchers found thatARID1A deficiency in B cells,and the\nresultingBAFdysfunction,steersthecellstowardsanunusual,\nimmature\"memory B cell\"identity.\nIn this abnormal state,the cells keep re-entering a temporary\nphase of the B-cell mediated immune responsewhich\norchestratesrapid cell divisionandthediversificationof\nantibodies needed during infections. During this phase, the cells\nundergo a high rate of mutation, presumably driving them\ntowards ever-greater malignancy.\nThe investigators wondered whetherthetendency of B cells with\nARID1Amutations to enter periods of rapid cell divisionand\nmutation mightexplain rapidlyprogressivefollicularlymphoma.\nCollaborating with colleagues from the British Columbia Cancer\nAgency,they observed that ARID1A mutations were enriched in\nthememory B cell-liketype offollicularlymphoma, whichare at\nmuch higher and earlier risk of transformation.\nThe challenge then, would be to target these dangerous cells to\nprevent these outcomes.Dr.Melnick and colleagues reasoned\nthatARID1A-mutant lymphomas might be especially vulnerable\nto drugsattackingtheirlastremaining BAFfunctions,whichare\nalready compromised by these mutations.\nWorking with BAF inhibitors that are already in clinical trials, they\nshowed inpreclinical experimentsthatARiD1Amutations indeed\nmakeslymphomas profoundly sensitiveto these drugs.Mice\nbearing ARID1A-mutant lymphomas went into complete\nremission with this drugalone.\n\"These data raise the possibility of developing early intervention\nprecisiontherapiesforthosefollicularlymphomapatientsatrisk\nfor rapidprogression,who currentlydo not havesuch options,\nsaid Dr. Melnick, who is now working with the clinical team at\nWeill Cornell Medicine to implement such studies.\n\"These findings suggest thatARID1A is effectivelya tumor\nsuppressor,whosedeficiencyinfollicularlymphoma promotes\nthe transformation to a more aggressive lymphoma,' Dr.Barisic\nsaid.OtherBAF-subunitmutationsfrequentlyfoundinlymphoma\npatients might haverelated roles in driving the disease\nprogression, he added.\n\"lt might even turn out that any mutation affecting the BAF\ncomplex,oranything elseleadingtotheformationofthese\nabnormalmemoryB-likecells,isamarkeroftransformationrisk,\nDr.Meydansaid.\nBAF inhibitors might also turn out to have a much broader role in\noncology,given that BAF-affecting mutations havebeen reported\nin about 20 percent of human cancers.\nin about 20 percentof human cancers.\n\"What is the common mechanismthat explains why BAF\nmutations appear in so many different cancers?There are so\nmanyfactorsatplay,untanglingthecomplexityofthemwould\naddressa significantunmetneedinthefieldofprecision\noncology' Dr. Chin said.\nMore information: Darko Barisic et al,ARID1A orchestrates SWI/SNF-\nmediated sequentialbindingof transcriptionfactorswithARID1Aloss\ndriving pre-memoryBcell fate and lymphomagenesis, Cancer Cell (2024)\nD0l:10.1016/j.ccell.2024.02.010\nQingDeng etal,SMARCA4isahaploinsufficient Bcell lymphoma tumor\nsuppressor that fine-tunes centrocyte cell fate decisions, Cancer Cell\n(2024).DOl:10.1016/j.ccell.2024.02.011\nJournal information:Cancer Cell \nProvided byWeill Cornell Medical College\n+ Explorefurther\nTumor heterogeneity and immune-evasive environment in malignant lymphoma\nat single-cell resolution\nFacebook\nTwitter\nshares\n≥Email\nFeedbacktoeditors\nRelatedStories\nTumorheterogeneity and immune-evasive\nT-cell receptor diversity may bekey to treatment of\nenvironment in malignant lymphoma at single-cell\nfollicularlymphoma,studyfinds\nresolution\nFEB20.2019\nDEC5.2023\nGenomic data shed light on how lymphoma can turn\nStudy shows protein inhibitoras potentialtreatment\nlethal\napproachfor commonmutations found in non-\n①DEC18.2023\nHodgkinlymphomas\nJAN8.2020\nCombination immunotherapy produces high\nSomelymphomas becomeresistanttotreatment.\nresponse rate in early results of trial targeting high-\nGene discovery may offer path to overcome it.\nriskfollicularlymphoma\nOMAR16.2024\nDEC11,2023\nLoadcomments (0)\nPhys.org\nTechXplore\nScienceX\nDaily science news on research\nThelatest engineering,electronics and\nThemostcomprehensivesci-tech news\ndevelopments and the latest scientific\ntechnology advances\ncoverage on the web\ninnovations\nNewsletters\nNewsletters\nEmail\nSubscribe\nScience X Daily and the Weekly Email Newsletter are freefeatures that allow you to receive your\nfavorite sci-tech news updates in your email inbox\nFollow us\nin\nTop\nHelp\nScienceXAccount\nAndroidapp\nFAQ\nHome\nPremiumAccount\niosapp\nAbout\nNewsletter\nSearch\nRSSfeeds\nMobile version\nContact\nArchive\nPush notification\nMedicalXpress2011-2024poweredbyScienceXNetwork\nPrivacypolicyTermsofuse\nMedicalDisclaimer", "live": "Justaquickcheck\nWe'recheckingyourconnectiontopreventautomatedabuse\nVerify you are human\nCLOUDFLARE\nPrivacr * Hele\nWhyam I seeing this?\nHaving probiems? Contact support", "image": "WT\nARID1A mutant\nPU.1 Motif\nNF-kBMotif\nNaive B-cell\nCBAF\nNF-KB\nDark Zone\nCBAF\nPU.1\nTransitioning\nCBAF\nPU.1\nNF-KB\nSLOW EXIT\nLight Zone\nFASTEXIT\nGerminalCenter\nGerminal\nCenter\nRe-entry\nMemory B-cell\nPlasma Cell\nLymphoma\nCD8oneg PD-L2neg\nPlasma Cell\nMemory B-Cells\nPrecursors\nPharmacological disruption of SwWvSNF complexes\nSWI/SNF\nSWI/SNF\ninhibition\ninhibition\n. WT\n·ARID1AMutant\nLymphoma Cells\nLymphomaCells\nApoptosis\nSWISNF\nSWIISNF\nnhibitor\ninhibltor\nXenograft\nXenograft\nSWI/SNF\nSWI/SNF\ninhibition\ninhibition\nTumor Growth Inhibition" } }, { "id": "baf-pharmacytimes", "study": "baf", "outlet": "Pharmacy Times", "outlet_original": "Pharmacy Times", "outlet_score": 5, "title": "Study: Mutation Found to Make Follicular Lymphoma More Susceptible to Experimental Drug", "title_original": "Study: Mutation Found to Make Follicular Lymphoma More Susceptible to Experimental Drug", "language": "English", "date": "2024-03", "kind": "news", "url": "https://www.pharmacytimes.com/view/study-mutation-found-to-make-follicular-lymphoma-more-susceptible-to-experimental-drug", "archive_url": "https://web.archive.org/web/20240403075529/https://www.pharmacytimes.com/view/study-mutation-found-to-make-follicular-lymphoma-more-susceptible-to-experimental-drug", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Trade summary of a Cancer Cell study finding that BAF mutations can drive follicular lymphoma progression yet increase sensitivity to experimental BAF inhibitors, with clinical trials in planning.", "topics": [ "follicular lymphoma", "baf complex", "drug sensitivity", "clinical trials" ], "audience": "trade", "thumbnail": "media-archive/thumbs/baf-pharmacytimes.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/baf-pharmacytimes--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/baf-pharmacytimes.txt", "ocr_text": { "archived": "Application error:a client-side exception hasoccurred (seethebrowser consoleformore information).", "live": "pharmacy\nSearch..\nConferencesv\nSubscribe\nNewsvWatch\nPublications\nMore v\n My Account \nClinical\nSpotlight - Community/Retail|Health Systems | Oncology | Pharmacy Technician | Student\nin]\nNewsArticlesApril2,2024\nStudy: Mutation Found to Make Follicular Lymphoma More Susceptible to\nExperimental Drug\nTrending on Pharmacy Times\nAuthor(s)Ashley Gallagher, Editor\nWalgreens Adds Pharmacist Outreach,\nCoverage Help for GLP-1s\nThe mutation impacts BAF proteins and can lead to progressionoffollicularlymphoma, according to the investigators.\nCystatin C and the Future of Kidney\nFunctionAssessment\nAlthough mutations affect BAF and can lead to dangerous outcomes, the mutation can also make follicular\nlymphoma more susceptible to experimental BAF-inhibitor drugs, according to results of a study published\nGLP-1 RAs Tied to Lower Kidney Failure\nRisk inPatientsWithObesity.CKD\nin Cancer Cell.12\nThe Growing Role the Specialty Pharmacy\n\"These encouraging findings could address critical\nTeamPlays in Helping Breast Cancer\nand urgent challenges with this disease and have\nPatients Navigate Treatment\nprompted us to begin planning clinical trials of BAF\nPCSK9 Inhibition Lowers LDL-C in Patients\ninhibitors in follicular lymphoma patients,\" Ari\nWithKidneyDisease\nMelnick, MD, the Gebroe Family Professor of\nHematology/Oncology at Weill Cornell Medicine,\nsaid in a press release.?\nAccording to the Lymphoma Research Foundation,\nImageCredit:David A Litman-stock.adobe.com\nfollicular lymphoma is a slow-growing form of\nnon-Hodgkin lymphoma developing from B-lymphocytes. The subtype accounts for approximately 20% to\n30% of all non-Hodgkin lymphoma cases, according to the foundation.3\nInvestigators examined the role of mutations in ARID1A, which encodes the BAF protein. The BAF protein,\naccording to the press release, works to regulate gene activity and cell identity by changing the shape of the\ngenome. The ARID1A mutations disrupting BAF are found in a significant number of individuals with\nfollicular lymphoma, according to the press release.2\nRecommendations tailored to you\nSign in or sign up\nSign in or create an account to see articles, videos, and podcasts matched to your specialties.\nThe results showed that the ARID1A deficiency in B cells resulted in unusual immature memory B cell\nidentity, resulting in BAF dysfunction. Investigators said that the cell kept re-entering a temporary phase of\nB-cell mediated immune response, facilitating cell division and diversification of antibodies that are needed\nduring infection, but as a result, the cell would undergo high rates of mutation, during even-grater\nmalignancy, according to the press release.?\n\"These data raise the possibility of developing early intervention precision therapies for those follicular\nlymphoma patients at risk for rapid progression, who currently do not have such options,\" Melnick said in\nthe press release.?\nInvestigators observed that the mutations were enriched in the memory B cell-like follicular lymphoma which\nwere, higher and at earlier risk for transformation. They wondered if the B cells with the mutation entering\nrapid cell division could explain the rapid progression of follicular lymphoma. They hypothesized that the\nmutant lymphomas could be especially vulnerable to drugs that attack the BAF functions. In a preclinical\nexperiment, the investigators proved that the ARID1A mutation made lymphoma more susceptible to these\ndrugs, according to the press release. Investigators found that mice bearing the ARiD1A mutations went into\ncomplete remission with the drug alone.?\npharmacy\npharmeeyo\nYour pharmacy\nThe Pharmacy Times\nNetworkapp ishere!\nDOWNLOAD NOW\nNETWORK\npractice,connected.\n\"Thesefindings suggest that ARID1A is effectively a tumor\nKey Takeaways\nsuppressor, whose deficiency in follicular lymphoma promotes\nthe transformation to a more aggressive lymphoma,\" Darko\n1. Mutations in the BAF complex,\nBarisic a postdoctoral researcher at Weill Cornell Medicine, said\nparticularly ARID1A, are common\nin the press release.?\nin follicular lymphoma and may\ncontribute to aggressive disease\nAccording to Barisic in the press release, other BAF-subunits\nprogression.\nmutations could have related roles in driving disease\n1. These mutations lead to abnormal\nprogression.2 Investigators said that these findings could\nB cell development and increased\npotentially pave the way for precision therapy to be used in\ncell division, potentially\npatients who are high risk, according to the study authors.\naccelerating lymphoma\ndevelopment.\nReferences\n1. The study suggests that\n1. Barisic D, Chin CR\nMeydan\net al.ARID1Aorchestrates SWI/SNF-\nlymphomas with BAF mutations\nmediated sequential binding of transcription factors with ARID1A loss\ndriving pre-memory B cell fate and lymphomagenesis. Cancer Cell.\nare more susceptible to drugs\nPublishedonlineMarch7.2024.doi:10.1016/j.ccell.2024.02.010\ntargeting the BAF complex\nfunction.\nrelease. EurekAlert. March 28, 2024. Accessed April 1. 2024.\nhttps://www.eurekalert.org/news-releases/1039473\n3.Lymphoma Research Foundation.Follicular Lymphoma. Accessed April 1,2024.https:/lymphoma.org/understanding-\nlymphoma/aboutlymphoma/nh/follicular-lymphoma/\nNewsletter\nStay informed on drug updates,treatment guidelines,and pharmacy practicetrends-subscribe to Pharmacy Times for\nweekly clinical insights.\nyou@example.com\nSubscribe\nFree.Unsubscribe anytime·By subscribing youagree to our privacy.policy.\nLymphoma|HematologyISpecialtyPharmacy|Oncology\nRecommendations tailored to you\nSign in or create an account to see articles, videos, and podcasts matched to your specialties.\nSign in or sign up\nRelated to this article\nView more\nOctober21st,2026\nOctober21st,2026\nOctober28th,20\nDoes MultipleMyeloma Maintenance\nOncology Pharmacists Reduce\nKidney Week\nAdverseDruaReactionsin\nherapvNeedto\nntinue\nGrowingRole\nOncologyPharmacistsReduce\nDoesMultipleMyelomaMaintenance\nKidneyWeek\nTherapy Need to Continue\nAdverseDrug Reactions in\nGrowing Role\nHematologic Cancer Care\nIndefinitely?\nFrom AKIdosing\nA randomized clinical trial found that dedicated\nENDURANCEtrial finds fixed 2-year\nexperts at ASN K\noncologypharmacist care reduced adverse\nlenalidomidemaintenancematches continuous\npharmacists ask\ndrug reactions among patients with...\ntherapy for standard-risk multiple.myeloma...\nRead More→\nRead More→\nReadMore→\nAbout Us\nClinical Forums\nAdvertise\nContact Us\nEditorial Staff\nPrivacy Policy\nTerms&Conditions\nDo Not Sell My Information\nYour Privacy Choices\nContact Info\n259 Prospect Plains Rd, BldgH\nCranbury.NJ08512\npharmacy\nMH\nlife sciences'BRAND\nC2026MJH Life Sciences\nAll rights reserved.\nAbout Us\nNews\nHome\nContact Us\nSATELLITE SYMPOSIA\n2.0\nheld in conjunction with\nCE CREDITS\nASCP2026\nAVAILABLE\nPTce\n2SATELLITESYMPOSIA\nOCTOBER30,2026\nIn Person\nand Virtual\nNATIONALHARBOR.MD" } }, { "id": "soma-independent-original", "study": "soma", "outlet": "The Independent", "outlet_original": "The Independent", "outlet_score": 9, "title": "Can the bodies of astronauts survive Mars missions?", "title_original": "Can the bodies of astronauts survive Mars missions?", "language": "English", "date": "2024-06-11", "kind": "news", "url": "https://www.independent.co.uk/news/science/mars-dna-soma-ucl-usa-b2560682.html", "archive_url": "https://web.archive.org/web/20240612014458/https://www.independent.co.uk/news/science/mars-dna-soma-ucl-usa-b2560682.html", "names_meydan": true, "meydan_context": "Named among the authors of the flagship paper providing a detailed guide to the data.", "passage_naming_meydan": "In a flagship paper Eliah Overbey, Cem Meydan, Susan Bailey, Afshin Beheshti, Christopher Mason and colleagues offer a detailed guide to the data.", "summary": "Original article on the Inspiration4-based SOMA atlas, reporting kidney structural changes from space radiation, mostly quick-to-recover changes, no major risk from short flights, and hints that women tolerate flight better.", "topics": [ "soma", "inspiration4", "kidney", "mars", "spaceflight" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/soma-independent-original.jpg", "passage_image": "media-archive/mentions/soma-independent-original.jpg", "full_screenshot": "media-archive/shots/soma-independent-original--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-independent-original.txt", "ocr_text": { "archived": "USEDITION\nSUBSCRIBENOW\nLOG IN/REGISTER\nINDEPENDENT\nUS election\nENHANCED BY Google\nVOICES\nNEWS\nSPORTS\nCULTURE\nLIFESTYLE\nTRAVEL\nPREMIUM\nMORE\nINDEPENDENT\nNews>Science\nCan the bodies of astronauts survive\nMars missions?\nThe new researchanalysed samples collected fromthefirst all-civilian crewfromthe SpaceX Inspiration4\nmission.\nNina Massey9hours ago\nCan the bodies of astronauts survive Marsmissions? (Inspiration4/John Kraus)\nSign up for a full digest of all the best opinions of the\nMost Popular\nweek in our Voices Dispatches email\nFossil-hunting diver says he\nSIGN UP\nhas found large section of\nEmail\nmastodontusk\nKate Middleton gives\ncomebackupdate as King\nTravelling into space changes the structure of kidneys, with galactic\nCharles ramps up return\nradiation causingdamagethat could potentiallyput human missions to\nTV doctor Michael Mosley's\nMars at risk, new research suggests.\nfinal moments revealed-live\nSpaceflight is known to cause a number of changes in astronauts' bodies,\nSenatorJohnFettermanand\nandasmorepeopleventureintospace,understandingthehealthrisks\nwife hospitalized after\nassociated with space exploration is key for the preparation of long-\nMaryland car crash\nduration, lunar, and potentially Martian missions, experts say.\nMom and son shot dead\noutsidebank before gunman\nDespite the findings in relation to kidneys, researchers suggest that short-\ntakes his own life\nduration spaceflights pose no significant health risks to private\nPopular videos\nastronauts.\nIt's really mostly good news in the sense that there are many, many\nchanges across all those layers of biology and modalities of biochemistry,\nuttheastmaioritwof\nelineauicky\nchanges acrossall those layersof biologyandmodalities of biochemistry,\nbut the vast majority of them return to baseline quickly\nMichael Mosleytold wifehewasn't\nfeeling wellbeforegoingmissing\nChristopher Mason, Weill Cornell Medicine\nKevin Spacey describes past\nOther findings indicated that women may be better able to physiologically\nbehaviour as handsy during\nnewinterview\ntolerate space flight than men, but further research is needed.\nThe newresearch analysed samples collected from the first all-civilian\nHEROLE\nViggo Mortensen on the role\nHATGOT\ncrewfromtheSpaceXInspiration4missionwhichlaunchedon\nthat got away\nSeptember 152021 and returned three days later.\nAs well as theharmcaused to kidneys,the research suggests thatthe\nindy100\neffects of short term spaceflight mirror those of longer missions.\nThis includes elevated levels of a protein (cytokines) that could lead to\nSidemen has XIX Vodka advert\nbanned by watchdog as it\nexcess inflammation, and lengthening of sections of DNA found atthe\nbreaches advertising code\nends ofeach of ourchromosomes (telomeres)-which could result in\nDid Eminem take his lyrics\nmutations.\nabout Gen Z trying to cancel\nhim froma TikTok?\nThe research found that although more than 95% of changes returned to\nnormal in the months after the mission, some proteins, genes, and\n‘Hardest Geezer'running to\nGermany to'support the boys'\ncytokines appeared to be still activated in the recovery period after\nin Euro2024campaign\nspaceflight and persisted after flight for at least three months.\nRing launches free dog\ntakeaways including pizza,\nChristopher Mason, of Weill Cornell Medicine, New York, uSA, one of\nsushi and'wine'\nthe authors of the papers published in the Space Omics and Medical Atlas\n(SOMA) package, said: \"It's really mostly good news in the sense that\nFinal Fantasy14 developers\nwarn players to clean out\nthere are many, many changes across all those layers of biology and\ninventories before Dawntrail\nmodalities of biochemistry,but the vastmajority of them return to\nbaseline quickly.\nSponsored Features\n\"So I think it bodes well for people who think: Maybe I'll go to space in\nFossil-hunting diver says he\nhas found large section of\nsix months' because anyone can really quickly get ready to go, and not\nmastodon tusk\nonly go and safely go and return, but also get trained and get just skills\nTV doctor Michael Mosley's\nand tools to do experiments in space very quickly.\"\nfinal moments revealed-live\nResearchers at UCL looked at the effect of space flight on the kidneys.\nSenator John Fetterman and\nwife hospitalized after\nThey found that both human and animal kidneys are remodelled by the\nMaryland car crash\nconditions in space, with specific parts of the organs showing signs of\nMom and son shot dead\nshrinkage after less than a month in space.\noutside bank before gunman\ntakes his own life\nResearchers suggest the likely cause of this is microgravity rather than\nNetflix users point out same\ngalactic cosmic radiation (GCR), though further research is required to\nissue'with Glen Powell in Hit\ndetermine if the interaction of microgravity and GCR can accelerate or\nMan\nworsen these structural changes.\nThe main reason that kidney stones develop during space missions had\npreviously been assumed to be solely due to microgravity-induced bone\nloss that leads to a build-up of calcium in the urine.\nHowever, the new findings, published in Nature Communications,\nindicated that the way the kidneys process salts is fundamentally altered\nby space flight and likely a primary contributor to kidney stone formation.\nThe scientists suggest the most alarming finding is that the kidneys of\nmiceexposed toradiation simulating GCR for2.5years experienced\npermanent damage and loss of function.\nThey say it will be necessary to develop measures to protect the kidneys\nfrom harm if missions to Mars are to be successful.\nDr Keith Siew, first author of the study from the London Tubular Centre,\nbased at theuCLDepartment of Renal Medicine, said:\"Weknow what\nhas happened to astronauts on therelatively short spacemissions\nconducted so far, in terms of an increase in health issues such as kidney\nstones.\n\"What we don't know is why these issues occur, nor what is going to\nhappentoastronauts on longerflights suchastheproposedmissionto\nMars.\n\"if we don't develop new ways to protect the kidneys, I'd say that while an" }, "note": "The Independent later rewrote this story: by June 15, 2024 the original URL redirected to a UK-focused article that no longer names Dr. Meydan. The archived copy keeps the original version." }, { "id": "soma-nyt", "study": "soma", "outlet": "The New York Times", "outlet_original": "The New York Times", "outlet_score": 10, "title": "Four Astronauts Spent 3 Days in Space. Here's What It Did to Their Bodies.", "title_original": "Four Astronauts Spent 3 Days in Space. Here's What It Did to Their Bodies.", "language": "English", "date": "2024-06-12", "kind": "news", "url": "https://www.nytimes.com/2024/06/12/science/astronauts-space-health-inspiration4-medical-records.html", "archive_url": "https://web.archive.org/web/20240613011541/https://www.nytimes.com/2024/06/12/science/astronauts-space-health-inspiration4-medical-records.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports a package of papers on four Inspiration4 crew members showing short-lived cognitive dips, immune stress and genetic changes after three days in space, all largely reversing without ruling out future flights.", "topics": [ "inspiration4", "soma", "cognition", "immune system", "spaceflight" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/soma-nyt.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-nyt--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-nyt.txt", "ocr_text": { "archived": "SCIENCE\nCheNew orkCimes\nADVERTISEMENT\n3 Days in Space Were Enough to\nChange 4 Astronauts' Bodies and\nMinds\nAn extensive examination of medical data gathered from the\nprivate Inspiration4 mission in 2021 revealed temporary\ncognitive declines and genetic changes in the crew.\nListen to this article·7:47 min Lean more\nSharefllarticle\n24\nJared Isaacman,left,and Hayley Arceneaux,two of thefourInspiration4 crew\nmembers,duringthemissionin2021:Spacex\nBy Kenneth Chang\nJune12,2024Updated6:38p.m.ET\nSpace changes you, even during short trips off the planet.\nFour people who spent three days off Earth in September 2021\nexperienced physical and mental changes that included modest\ndeclines in cognitive tests, stressed immune systems and genetic\nchanges within their cells, scientists report in a package of papers\npublished on Tuesday in the journal Nature and several other\nrelated journals.\nAlmost all of what changed in the astronauts returned to normal\nafter they splashed down on Earth. None of the alterations\nafter theysplashed down on Earth.Noneof thealterations\nappeared to pose a showstopping caution for future space\ntravelers. But the results also highlighted how little medical\nresearchers know.\nChristopher Mason,aprofessorofgenomics,physiologyand\nbiophysics at Weill Cornell Medicine in NewYork City and one of\nthe leaders of the research, called the collection of papers and data\n\"themost in-depth examination we've ever had of a crew\"as he\nspoke during a news conference on Monday.\nThefour astronauts traveled on a mission, known as the\nInspiration4, which was the first trip to orbit where not one of the\ncrew members was a professional astronaut. Jared Isaacman,a\nbillionaire entrepreneur, led the mission. Instead of bringing\nfriends along, he recruited three travelers who represented a wider\nswath of society:Hayley Arceneaux, a physician assistant who\nsurvived cancer during her childhood; Sian Proctor, a community\ncollege professor who teaches geoscience; and Christopher\nSembroski, an engineer.\nThe Inspiration4 crew members consented to participating in\nmedical experiments-collecting samples of blood, urine,feces\nand saliva during their flight - and to allowing the data to be\ncatalogedinanonlinearchiveknownastheSpaceOmicsand\nMedical Atlas, or soMA, which is publicly available.\nAlthough the data is anonymous, that does not provide much\nprivacy because there were only four crew members on\nDr.Proctor said inaninterview.\nBut she added, \"I just feel that there's more good than harm that\ncomes from me being able to sharemy information and for science\ntoprogress and learn.\"\nsoMA also includes data from other people who have flown on\nprivate space missions, as well as Japanese astronauts who have\nflown to the International Space Station, and a study that\ncompared the healthof Scott Kelly,a NAsAastronaut who lived on\nthe International SpaceStation for 340days in 2015and 2016,with\nhistwin brother,Mark,aretired astronautwhois nowasenator\nrepresenting Arizona.\nWith more private citizens buying trips to space, the hope is that\nSOMA will quickly fill up with more information about a wider\nrange of people than the older white men who were selected to be\nastronauts in theearlydecadesof thespaceage.That could lead to\ntreatments tailored to individual astronauts to combat the effects\nof spaceflight.\nThe wealth of information has also allowed scientists to compare\nshort-term effects with what happens during longer missions.\nDuring Mr. Kelly's year in space, age markers in his DNA known as\ntelomeresgrew longer -suggesting, surprisingly, that he had\nbecomebiologicallyyounger.Butthetelomeresmostlyreturnedto\ntheir earlier size after he returned to Earth, although some ended\nup even shorter than before he had left. Scientists interpreted that\nas a sign of accelerated aging.\nThetelomeres of all fourof the Inspiration4 astronauts also\nlengthened and thenshortened,indicatingthat thechanges occur\nin all astronauts and that they occur quickly.\n“A remarkable finding in a number of ways,\" said Susan Bailey, a\nprofessorof radiationcancerbiology and oncology at Colorado", "live": "Che New Jork Cimes\nSCIENCE\nLOGIN\nADVERTISEMENT\nTo continue to The New York Times, please\nconfirm that you are human.\nSlide right to secure your access\nEnjoy unlimited access to all of The Times.\nSeesubscriptionoptions\nJared Isaacman, left, and Hayley Arceneaux,two of thefour Inspiration4 crew\nmembers,during themission in202l:Spacex\nBy Kenneth Chang\nJune12,2024\nLeerenespaniol\nSpace changes you, even during short trips off the planet.\nFourpeoplewhospentthreedaysoffEarthinSeptember2o2l\nexperienced physical and mental changes that included modest\ndeclines in cognitive tests, stressed immune systems and genetic\nchangeswithintheir cells,scientistsreport inapackageofpapers\npublished on Tuesday in the journal Nature and several other\nrelated journals.\nAlmost all of what changed in the astronauts returned to normal\nafterthey splashed down on Earth.None of thealterations\ntravelers. But the results also highlighted how little medical\nresearchers know.\nresearchersknow.\nChristopher Mason, a professor of genomics, physiology and\nbiophysics at Weill Cornell Medicine in New York City and one of\nthe leaders of theresearch, called the collection of papers and data\n\"the most in-depth examination we've ever had of a crew\"as he\nspoke during a news conference on Monday.\nThefour astronautstraveled on amission, knownas the\nInspiration4, which was the first trip to orbit where not one of the\ncrew members was a professional astronaut.Jared Isaacman,a\nbillionaire entrepreneur, led the mission. Instead of bringing\nfriends along, he recruited three travelers who represented a wider\nsurvived cancer duringher childhood; Sian Proctor, a community\ncollege professor who teaches geoscience; and Christopher\nSembroski, anengineer.\nTheInspiration4 crewmembersconsented toparticipatingin\nmedical experiments - collecting samples of blood, urine, feces\nand saliva during their flight - and to allowing the data to be\ncatalogedinanonlinearchiveknownastheSpaceOmicsand\nMedical Atlas, or soMA, which is publicly available.\nAlthough the data is anonymous, that does not provide much\nprivacy because there were only four crew members on\nInspiration4.“You could probably figure out who is who, actually”\nDr Proctor said in an interview.\nSubscribe to The Times to read as manyarticles as you like.\nKennethChang,a sciencereporteratTheTimes,coversNASAandthesolarsystem,and\nresearch closer to Earth.\nheadline:BodyandMind,Affectedby Space.Order ReprintsIToday'sPaperISubscribe\nSeemore on:HayieyArceneaux,Jared Isaacman,Nature (Joumal)\nREAD69COMMENTS\n Sharefullarticle", "image": "@/Published2024" } }, { "id": "soma-science", "study": "soma", "outlet": "Science", "outlet_original": "Science", "outlet_score": 10, "title": "Astronauts face health risks—even on short trips in space", "title_original": "Astronauts face health risks—even on short trips in space", "language": "English", "date": "2024-06-11", "kind": "news", "url": "https://www.science.org/content/article/astronauts-face-health-risks-even-short-trips-space", "archive_url": "https://web.archive.org/web/20240612013641/https://www.science.org/content/article/astronauts-face-health-risks-even-short-trips-space", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Describes the Space Omics and Medical Atlas, over 40 studies mostly from Inspiration4, covering genomes, microbiomes, transcriptomes and proteomes, called the largest release of astronaut biomedical data.", "topics": [ "soma", "inspiration4", "omics", "astronaut data", "spaceflight" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/soma-science.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-science--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-science.txt", "ocr_text": { "archived": "Science\nNEWS\nCAREERS\nCOMMENTARY\nJOURNALSV\nLOG IN\nAll News\nDONATE\nNews Home\nSciencelnsider\nNewsFeatures\nGET OURE-ALERTS\nHOME\nASTRONAUTSFACEHEALTHRISKS-EVENONSHORTTRIPSIN SPACE\nNEWS\nAstronauts face health risks-even on short trips in\nspace\nIn-depth studies includefirsthealthdatacollectedfrom spacetourists\n11JUN202411:00AMETBYRAMINSKIBBA\nMAN\nONA\nENEAUX\nJared Isaacman (left)and HayleyArceneaux (right)gathered healthdata ontheprivateInspiration4mission.INspiRATioN4cREw\nSHARE:\nGotatipforScience'snewsdepartment?\nIn 2021, four passengers,including billionaire businessman Jared Isaacman, rode into\nCONNECT)\nspace on a SpaceX rocket, orbiting Earth for 3days in the company's Dragon capsule\nbefore splashing down in the Atlantic Ocean. The trip, financed by Isaacman and called\nInspiration4, was the first privately funded orbital mission on a private rocket carrying\nSignupforScienceAdviser\nprivate citizens-setting the stage for more routine tourist space travel today.\nSubscribetoScienceAdvisertogetthelatestnews,\ncommentary,andresearch,freetoyour inboxdaily.\nThe astronauts also underwent intensive medical monitoring before, during, and after\nSUBSCRIBE\ntheir flight. Now, researchers have analyzed how the space radiation and weightlessness\nthey experienced affected their bodies,releasing a package ofmore than 40 studies,most\nof them based on Inspiration4 data.Published todayin Naturejournals,the Space Omics\nand Medical Atlas (SOMA) includes studies of the participants'genomes, microbiomes,\nSCIENCEINSIDER\ntranscriptomes (the messenger RNAmade from theirgenes), and proteomes (their\n11JUN.2024\nBYKAIKUPFERSCHMIDT\npanoply of proteins).\nHouse Republicans fault NIHfor\nevasiveanswersonrisky\nmonkeypoxvirusstudy\n\"This is the biggest release of biomedical data from astronauts,\" says Christopher Mason,\na geneticist at Weill Cornell Medicine who led many of the new papers.\n11JUN2024BYCHARLESPILLER\na geneticist at Weill Cornell Medicine who led many of the new papers.\n11 JUN2024BY CHARLES PILLER\nStar botanist likely made updata\nNAsA and other space agencies have studied the health of hundreds of astronauts over\nabout nutritional supplements,new\nprobefinds\nthe past 6 decades, finding a wide range of impacts, including elevated long-term cancer\nrisks from exposure to spaceradiation, muscle atrophy and bone loss from life in\nmicrogravity, and changes in vision. But private spaceflights are giving researchers the\n11JUN2024\nBYJENNIFER COUZIN-FRANKEL\nchance to study therisks in more detail, with the latest biomedical technologies.\"A good\nFDApanelbacksnewAlzheimer's\n30%to40%of [the s0MAassays] are new,”Mason says.\ndrug,despite risks and uncertainties\n10JUN.2024\nOne message from the SOMA studies, Mason says, is that the same health effects that\nBY TANIA RABESANDRATANA\nprofessional astronauts experience over their long expeditions turn up among space\nEurope's far-right tilt has scientists\ntourists who only spend a few days in orbit.\nonthealert, butelection'couldhave\nbeen much worse'\nThe findings could also have implications for long-duration space exploration beyond the\nVIEWMORE\nprotective cocoon of Earth's magnetic field, which deflects some space radiation.\"We\ndon't yet fully understand all of the risks,\" says Amy McGuire, a biomedical ethicist at\nBaylor College of Medicine.\"This is also why it is so important that early space tourists\nSIFTER\nparticipate in research.\"\n10JUN2024BYVIVIAN LA\nVERTISEMENT\nElephants seemto usenames to call\none another like humans do\nMason and his colleagues focused their studies on roughly 20 astronauts for whom\nextensive data were collected: the four Inspiration4 passengers, recent astronauts from\n7JUN2024BYSEANCUMMINGS\nMagnetic minerals offera finer\nJapan's space agency, and NASA astronauts Scott and Mark Kelly, twins who tookpart in an\ngrained look at when Neanderthals\nearlier study of space effects.\nbuilt fires\nThe group represents a broader range of people than in past studies-not just healthy, fit,\n6JUN20241BYSEANCUMMINGS\nHowweremodern horses\nand relatively young NASA astronauts, says J.D.Polk, NASA's chief health and medical\ndomesticated? Ancient DNA may\noffcer.“Private companies are flying a wider breadth of the population, so it's helpful for\nsettle debate\nthem to do research,\" he says.\n31MAY2024BYCHRISTIEWILCOX\nFirst transgenic urchins glow like\nMoreover, the Inspiration4 crew orbited Earth at 585 kilometers above the ground, a\njellyfish\nsignificantly higher altitude than the International Space Station (IsS) and China's\nTiangong station, subjecting the passengers to a different, and likely more intense, space\nradiation environment.\nVIEW MORE\nOne study confirms NASA's research on the Kelly twins, showing how space stressed the\nInspiration4 crew's immune cells, affecting the chromatin,or chromosome material, in a\nRECOMMENDED\nNEWS&COMMENT\naggravated.\" The researchers also sequenced RNA in astronauts' blood, finding that the\nFEBRUARY1986\nstress of spaceflight affected the transcription of immune system genes, possibly reducing\nThe Shuttle Record:Risks,Achievements\nthe body's ability to defend against viruses.\nRANDOMSAMPLES\nOCTOBER1997\nIndianRocket FallsShort\nIn another hint of trouble, the team documented a peculiar lengthening of passengers\ntelomeres, caps that protect chromosomes and prevent them from fraying.Aging shrinks\nNEWS&COMMENT\nOCTOBER1994\ntelomeres, but longer than normal telomeres aren't healthy either, as they're associated\nTestingthePsychologyofWould-BeAstronauts\nwith higher cancer risks.\nSCIENCESCOPE\nJULY2007\nTheteam did explore a possible way to prevent some of the radiation damage:by\nSpace Probes Add side Trips\nsuppressing the function of microRNAs-short RNA molecules that can silence genes and\nare considered to be markers of space radiation damage. The researchers developed\ninhibitors of microRNA, called antagomirs, and applied them to cell cultures derived from\nRECOMMENDED\nblood samples from the Inspiration4 crew and Japanese astronauts. The treated cells\nNEWS&COMMENT\nFEBRUARY1986\nsuffered less radiation damage than control samples.The scientists are still far from\nTheShuttleRecord:Risks,Achievements\ndeveloping a therapeutic, however.\nRANDOMSAMPLES\nOCTOBER1997\nThe studies suggest men and women face different risks in space and recover at different\nIndianRocket Falls Short\nrates after returning to Earth, says Tejaswini Mishra, a geneticist at Stanford University\nwho previously worked on NASA's twins study.\nNEWS&COMMENT\nOCTOBER1994\nTesting thePsychology of Would-BeAstronauts\nWomen's vision appears to be less affected by microgravity, and their monocytes returned\nto normal more quickly than men's. But women space travelers appear to be more\nSCIENCESCOPE\nJULY2007\nvulnerable to some cardiovascular and cancer risks. There's still not much data available\nSpace Probes Add Side Trips\nfor women astronauts, though, Mishra says, and those sex differences need further study.\nAs commercial spaceflight becomes more common,researchers will need to develop an\nethical framework that balances the research's potential benefits with the passengers", "live": "This websiteutilizestechnologies suchas cookiesto enableessential sitefunctionality,as wellasforanalytics,personalization,andtargeted advertising.Tolearn\nmore,view thefollowing link:PrivacyPolicy.\nMANAGEPREFERENCES\nScience\nbrought to you by\nNEWS\nLOG IN\nCAREERS\nCOMMENTARY\nJOURNALS\nCornell Univeraity\nBECOMEAMEMBER\nNews Home\nAllNews\nNews Features\nSciencelnsider\nDONATE\nGETOURE-ALERTS\nHOME>\nNEWS>\nALLNEWS>\nASTRONAUTSFACEHEALTHRISKS-EVENONSHORTTRIPSINSPACE\nNEWS\nHEALTH\nAstronauts face health risks-even on short trips in\nspace\nIn-depth studies include first health data collected from space tourists\nMAN\nSPACEX\nNONA\nENEAUX\nSHARE:\nGot a tip forScience's newsdepartment?\nScience\nCONNECT)\nAversionofthis storyappeared inScience, Vol384, Issue6701.\nTEADER\nSignupforScienceAdviser\nGet Science's award-winningnewsletterwith the\nlatestnews,commentary,andresearch,freetoyour\ninbox daily.\nIn 2021, four passengers, including billionaire businessman Jared Isaacman, rode into\nSUBSCRIBE\nbefore splashing down in the Atlantic Ocean.Thetrip, financed by Isaacman and called\nInspiration4, was the first privately funded orbital mission on a private rocket carrying\nADVERTISEMENT\nInspiration4, was the first privately funded orbital mission on a private rocket carrying\nADVERTISEMENT\nprivate citizens-setting the stage for more routine tourist space travel today.\nThe astronauts also underwent intensive medical monitoring before, during, and after\ntheir flight.Now,researchers have analyzed how the space radiation and weightlessness\nthey experienced affected their bodies, releasing a package of more than 40 studies, most\nof them based on Inspiration4 data. Published today in Nature journals, the Space Omics\nand Medical Atlas (SOMA) includes studies of the participants' genomes, microbiomes,\npanoply of proteins).\n“This is the biggest release of biomedical data from astronauts, says Christopher Mason,\na geneticist at Weill Cornell Medicine who led many of the new papers.\nSIGNUPFORTHEAWARD-WINNINGSCIENCEADVISERNEWSLETTER\nThe latest news,commentary,andresearch,freeto your inboxdaily\nSIGNUP>\nNASA and other space agencies have studied the health of hundreds of astronauts over\nthe past 6 decades, finding a wide range of impacts, including elevated long-term cancer\nrisks from exposure to space radiation, muscle atrophy and bone loss from life in\nmicrogravity, and changes in vision. But private spaceflights are giving researchers the\nchance to study the risks in more detail, with the latest biomedical technologies.“A good\n30% to 40% of [the SOMA assays] are new,\" Mason says.\nOne message from the SOMA studies, Mason says, is that the same health effects that\nprofessional astronauts experience over their long expeditions turn up among space\nSCIENCEINSIDER O\ntourists who only spend a few days in orbit.\n230CT2026BYJOCELYNKAISER\nKennedy to select MAHA-aligned\nThe findings could also have implications for long-duration space exploration beyond the\nresearcherto head mental health\nprotective cocoon of Earth's magnetic field, which deflects some space radiation.“\"We\ninstitute,overrulingNIH director\ndon't yet fullyunderstand all of the risks,\" says Amy McGuire,a biomedical ethicist at\nBaylor College of Medicine.“This is also why it is so important that early space tourists\n21OCT2026BY SARAREARDON\nWith blood test looming,\nparticipate in research.\"\ngovernment puts $41million into\nclinical trials toward off Alzheimer...\nADVERTISEMENT\n21OCT2026BY JEFFREY MERVIS\nTwotopNSFofficialsareleaving.In\nan agency under Trump's thumb, it\nmay notmatter\n200CT2026BYKAIKUPFERSCHMIDT\nMason and his colleagues focused their studies on roughly20 astronauts for whom\nAsEbola epidemicrages,Congo\nextensive data were collected: the four Inspiration4 passengers, recent astronauts from\nbets on high-stakes hope'vaccine\nJapan's space agency, and NASA astronauts Scott and Mark Kelly, twins who took part in an\ntrial\nearlier study of space effects.\nVIEW MORE\nThe group represents a broader range of people than in past studies-not just healthy, fit,\nand relatively young NASA astronauts, says J. D. Polk, NASA's chief health and medical\nADVERTISEMENT\nofficer.“Private companies are flying a wider breadth of the population, so it's helpful for\nthem to do research,\" he says.\nMoreover, the Inspiration4 crew orbited Earth at 585 kilometers above the ground, a\nBRIEFS\nsignificantly higher altitudethan the International Space Station (IsS)and China's\n20OCT2026\nTiangong station, subjecting the passengers to a different, and likely more intense, space\nBYKAIKUPFERSCHMIDT\nEurope hit bya record West Nile\nradiation environment.\nvirusseason\nOne study confirms NASA's research on the Kelly twins, showing how space stressed the\n160CT2026\nBYADRIANCHO\nInspiration4 crew's immune cells, affectingthe chromatin, or chromosomematerial,ina\nSay goodbye to the leap second\ntype of white blood cell called monocytes. Mason says the immune system is “on high alert,\naggravated.\" The researchers also sequenced RNA in astronauts' blood, finding that the\nstress of spaceflight affected the transcription of immune system genes, possibly reducing\n9OCT.2026\nBY JULIAVAZ\nthe body's ability to defend against viruses.\nTrumpadministration proposes\n10o,o0ofeeforworkauthorization\nfor international students\nIn another hint of trouble, the team documented a peculiar lengthening of passengers\"\ntelomeres, caps that protect chromosomes and prevent them from fraying. Aging shrinks\n6 0CT.2026BY TAYLORMITCHELL BROWN\ntelomeres, but longer than normal telomeres aren't healthy either, as they're associated\nExclusive:Archaeology megafirm\nwith higher cancer risks.\nabruptly shuts down", "image": "11\nOK\nMAN\nENEAUX" } }, { "id": "soma-nature-immersive", "study": "soma", "outlet": "Nature", "outlet_original": "Nature", "outlet_score": 10, "title": "Space Omics and Medical Atlas (SOMA) across orbits (immersive)", "title_original": "Space Omics and Medical Atlas (SOMA) across orbits (immersive)", "language": "English", "date": "2024-06-11", "kind": "interactive", "url": "https://www.nature.com/immersive/d42859-024-00009-8/index.html", "archive_url": "https://web.archive.org/web/20240611203857/https://www.nature.com/immersive/d42859-024-00009-8/index.html", "names_meydan": true, "meydan_context": "Listed by name and affiliation among contributors credited in the feature.", "passage_naming_meydan": "Cem Meydan, Weill Cornell Medicine, Meydan Lab", "summary": "Nature's interactive feature presenting the Space Omics and Medical Atlas, a compendium of data, protocols and code from over 100 institutions, including samples from the first all-civilian orbital crew.", "topics": [ "soma", "space omics", "inspiration4", "aerospace medicine", "atlas" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/soma-nature-immersive.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-nature-immersive--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-nature-immersive.txt", "ocr_text": { "archived": "Your Privacy\nWe use cookies to make sure that our website works properly, as well as some optional cookies to personalise content and advertising. provide social media features and analyse\nhow people use our site.By accepting some or all optional cookies you give consent to the processing of your personal data, including transfer to third parties,some in\ncountries outside of the European Economic Area that do not offer the same data protection standards as the country where you live. You can decide which optional cookies to\naccept by clicking on Manage preferences,where you can also find more information about how your personal data is processed.Further information can be found in our\nprivacy policy.\nAccept all cookies\nManage preferences\nnature portfolio\nSpace Omics and\nMedical Atlas\n(SOMA)across\norbits\nNew studies on astronauts and space biology\nbring humanity one step closer to the final frontier\nPLAYVIDEO\nTime-lapse video taken bythe Expedition28 crewon boardtheInternational SpaceStation duringa night pass over North and SouthAmerica.Credit:Earth Science\nand RemoteSensing Unit,NASA JohnsonSpace Center.\nhe Space Omics and Medical Atlas (SOMA) package of\nmanuscripts,data,protocols, and coderepresents the\nlargest-ever compendium of data for aerospace medicine\nand spacebiology.Over100 institutionsfrom>25countries\nworked togetherfora coordinated 2024 release of molecular\ncellular, physiological, phenotypic, and spaceflight data.\nNotably,thisincludesanalysisofsamplescollectedfromthefirst\nall-civilian crew of the Inspiration4 mission, which consisted of\ncommercialastronautswhoembarkedonashort-termmissiontoa\nhigh-altitudeorbit(575km),fartherthantheInternational Space\nStation (ISS). This data is distinct from the longer-duration\nmissionsofIsS-basedastronauts,whotypicallystay120,180,or\n365 days.Whilein orbit, theInspiration4 crewperformed an\nextensivebatteryofscientificexperiments,whichhavenowbeen\nextensivebattery ofscientific experiments,whichhave now been\nprocessed, sequenced, and analyzed, contributing to most of the 44\npapers in the SOMA package, some of which are highlighted\nbelow.Embracing the spirit of Open Science at NASAand data\naccessibility, all raw and processed data acquired from the crew\nduring andaftertheirmissionshave beenmade available in\nNASA's Open Science Data Repository an expansion of NASA\nGeneLab. Additionally, four new data portals have been created for\nbrowsing results from the mission, which also include linked data\nfrom the NASA Twins Study, enhancing our understanding of\nhuman health in space.\n575km\nSpacexInspiration4\n540km\nHubbleSpace\nTelescope\n420km\nInternational\nSpaceStation\nSamplesfromdifferentorbits (i.e.IsSand Inspiration4)havenowbeen\nanalyzed and integrated. Photo credit: Inspiration4 crew\nThe SOMA package represents a milestone in several other\nrespects. It features a >10-fold increase in the number of next-\ngeneration sequencing (NGS) data from spaceflight, a 4-fold\nincrease in the number of single-cells processed from spaceflight,\nthe launch of the first aerospace medicine biobank (Weill Cornell\nMedicine'sCAMbank),thefirst-ever directRNA sequencing data\nfrom astronauts,the largest number of processed biological\nsamples from a mission (2,911), and the first ever spatially-\nresolved transcriptomedatafrom astronauts.\nWorkingacross borders and teams, between companies and\ngovernments, and spanning myriad international laboratories\nenabled thegreatest amount of science and erudition to begained\nin this package. These data can serve as a springboard for new\nexperiments, hypotheses, and follow-up studies, as well as guide\nfuture mission planning and countermeasure development. Finally\nthis package shows how the modern tools of molecular biology and\nprecision medicine can help guide humanity into more challenging\nmissions, which will be critical for a permanent presence on the\nmoon, Mars, and beyond.", "live": "natureportfolio\nSpace Omics and\nMedicalAtlas\n(SOMA)across\norbits\nYour privacy,yourchoice\nWe use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as\ntoallowvideo informationtobesharedforbothmarketing,analyticsand editorial purposes.\nBy accepting optional cookies,you consent to the processing of your personal data-including transfers to third parties. Some third parties are outside of the European\nEconomic Area, with varying standards of data protection.\nSeeourprivacypolicyformoreinformationontheuseofyourpersonal data.\nManage preferences for further information and to change your choices.\nAcceptallcookies\nRejectoptionalcookies\nhe Space Omics and Medical Atlas (SOMA)package\nofmanuscripts,data,protocols,and code\nrepresents the largest-ever compendium of data\nforaerospacemedicineandspacebiology.Over100\ninstitutionsfrom>25countriesworkedtogetherfora\ncoordinated2024releaseofmolecular,cellular,\nphysiological,phenotypic,andspaceflightdata.\nNotably,thisincludesanalysisofsamplescollectedfrom\nthefirst all-civilian crewofthe Inspiration4 mission,which\nconsistedofcommercialastronautswhoembarkedona\nshort-term mission to a high-altitude orbit (575 km), farther\nthantheInternationalSpaceStation(isS).Thisdatais\ndistinctfrom the longer-duration missions of iss-based\nastronauts, whotypically stay120,180,or 365 days.While\nin orbit, the Inspiration4 crew performed an extensive\nbatteryofscientificexperiments,whichhavenowbeen\nprocessed,sequenced,andanalyzed,contributingtomost\nof the44papers in the SOMA package,some ofwhichare\nhighlighted below. Embracing the spirit of Open Science at\nNASAanddataaccessibility,allrawandprocesseddata\nacquiredfromthecrewduringandaftertheirmissions\nhavebeenmadeavailable inNASA's Open ScienceData\nRepository an expansion of NASA GeneLab.Additionally,\nfour newdata portalshave beencreatedfor browsing\nresultsfromthemission,whichalsoincludelinkeddata\nresultsfromthemission,whichalsoincludelinkeddata\nfrom theNASATwins Study,enhancingour understanding\nofhumanhealthinspace.\n575km\nSpacexInspiration4\n540km\nHubbleSpace\nTelescope\n420km\nInternational\nSpaceStation\nSamplesfromdifferentorbits (i.e.IsSand Inspiration4)havenow\nbeenanalyzedand integrated.Photocredit Inspiration4crew\nTheSOMApackagerepresentsamilestonein severalother\nrespects. It features a >10-fold increase in the number of\nnext-generation sequencing (NGS)datafrom spaceflight,a\n4-foldincreaseinthenumberofsingle-cellsprocessed\nfromspaceflight,thelaunchofthefirstaerospacemedicine\nbiobank (Weill Cornell Medicine's CAMbank), thefirst-ever\ndirectRNAsequencingdatafromastronauts,thelargest\nnumberofprocessedbiologicalsamplesfromamission\n(2,911),and the first ever spatially-resolved transcriptome\ndatafromastronauts.\nWorkingacrossbordersandteams,betweencompanies\nand governments,and spanning myriad international\nlaboratories enabled thegreatest amount of scienceand\nerudition to be gained in this package. These data can serve\nas a springboardfornewexperiments,hypotheses,and\nfollow-up studies,as well asguidefuture missionplanning\nand countermeasure development. Finally, this package\nshows how the modern tools of molecular biology and\nprecisionmedicinecan helpguide humanity intomore\nchallengingmissions,whichwillbecriticalforapermanent\npresenceon themoon, Mars, and beyond." } }, { "id": "soma-natgeo", "study": "soma", "outlet": "National Geographic", "outlet_original": "National Geographic", "outlet_score": 10, "title": "What toll does spaceflight take on the human body?", "title_original": "What toll does spaceflight take on the human body?", "language": "English", "date": "2024-06", "kind": "news", "url": "https://www.nationalgeographic.com/science/article/space-human-body-astronaut-health", "archive_url": "https://web.archive.org/web/20240709155515/https://www.nationalgeographic.com/science/article/space-human-body-astronaut-health", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Describes the June 2024 package of 44 papers in Nature journals, drawing on four civilian Inspiration4 crew, that builds a baseline for understanding how spaceflight affects human biology beyond professional astronauts.", "topics": [ "spaceflight", "inspiration4", "astronaut health", "soma", "nature papers" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/soma-natgeo.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-natgeo--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-natgeo.txt", "ocr_text": { "archived": "NATIONAL\nNewsletters\nSUBSCRIBE\nMENU\nGEOGRAPHIC\nSCIENCE\nWhat toll does spaceflight take on\nastronauts?Here's what weknow.\nAnewdatabaseaims topavethewayfora better understanding of spacehealthand medicine\nasmorecivilianmissionslaunch.\nIOn September15,2021,a SpaceX Dragon capsule carriedtheInspiration4crew into space via aFalcon 9rocket.During their\nthree-day mission,spacecraft reached an altitude of575kilometers (km)above Earth's surface,fartherin space than the orbit\noftheInternational SpaceStation,whichrangesfrom370kmto460km.\nPHOTOGRAPHCOURTESYINSPIRATION4/JOHNKRAUS\nBy Liz Kruesi\nJuly9,2024\nOverthepastfivedecades,underoohumanshaveflowninspace.Nearlyeveryoneof\nthose humans were professionally trained astronauts and in similar peak physical\ncondition. And most of those astronauts were men. But in 2021, the first space mission\nwith four civilian astronauts - meaning, not government agency astronauts - flew. It\nopened a new path for the scientists who study the effects of spaceflight on human\nbiology.\nOn June 11, 2024, more than 200 of those researchers published a suite of 44 papers\nacross multiple Nature journals. These papers are helping to build a foundation, a\nbaseline of sorts, to understand not just how being in space affects the human body but\nhow scientists can mitigate those effects.\nHumanity is a long way from being an interplanetary species, but this is \"the very first\nstep on what will be many steps to prepare for the Moon and Mars,\" says Weill Cornell\nMedicine's Christopher Mason, the biophysicist and physician who led the data\naccumulation and analysis behind the papers.\nThese data are also showing scientists how the human body reacts under extreme\nstress, both physically and cognitive. \"We really need to know how the human\nstress, both physically and cognitive.\"we really need to know how the human\ncondition reacts\"to theradiation and the extreme accelerationforces, in addition to\nchanges in the body's circadian rhythm, or sleep cycle, says Stanford geneticist Michael\nSnyder who was not involved in these recent papers.\nThese varied studies show that just a few days in space affects biology in ways that\ndon't seem to reverse. And they're starting to hint at differences between females and\nmales.\nStudying the body in space\nWhen human space missions took flight in the1960s, space health investigations\nbegan. Apollo astronauts wore biosensor harnesses to monitor the heart and lungs and\nunderwent thorough physical exams and tests preflight and postflight. The astronauts\nexperienced back pain from microgravity,flashes of lightfrom radiation, and other\nhealth changes.But this was just the start.\nFuel theircuriositywithyourgift\nGIVENAT GEO\nOver the past two decades, the International Space Station (Iss) has served as an\norbiting biological laboratory to investigate everything from bacterial changes to bone\nloss to brain deformation. Then in 2015, biologists had the unique opportunity to better\nunderstand how the environment of space environment affects biology at the smallest\nscales.In an experiment NAsA called theTwins Study,one astronaut, Scott Kelly,\nboarded the Iss for a year and his identical twin, Mark Kelly, who was also an astronaut,\nstayed on the ground.\nBy directly comparing identical twins, biologists could study the genetic effects of\nspace. When Scott returned to Earth, his telomeres, the ends of chromosomes that act\nto protect genetic material, had lengthened. (Read more about NASA's Twins Study.)\nSCOTTKELLY", "live": "NATIONAL\nMore\nHealth\nShows\n Animals\nHistory&Culture\nScience&Nature\nLog In\nTravel\nGEOGRAPHIC\nSubscribe\nSCIENCE\nWhat toll does spaceflight take on\nastronauts? Here's what we know.\nAnewdatabaseaims to pave the wayfor a betterunderstanding of space health and medicine\nas more civilian missions launch.\nEnteryouremail to read this article\nPlus,getunlimitedaccesstofreeNational Geographiccontent\nEmailAddress\nEnteryouremail\nSUBMIT\nDisney Family of Companies.By creating an account,you agree to our Terms ofUseandacknowledgethat you\nhave read ourPrivacy Policy and Us StatePrivacy RightsNotice.\nAlready have an account? sIGN IN\n(From Space, Astronaut Snaps Photo of Planets Aligned)\nHumanity is a long way from being an interplanetary species, but this is\"the very first\nstep on what will be many steps to prepare for the Moon and Mars,\" says Weill Cornell\nandnhvsicianwholedthedat:\nMedicine's Christopher Mason, the biophysicist and physician who led the data\naccumulation and analysis behind the papers.\n(SpaceX Wants to Go to Mars. Here's Why Humans Aren't There Yet.)\nThese data are also showing scientists how the human body reacts under extreme\nstress, both physically and cognitive.“We really need to know how the human\ncondition reacts\" to the radiation and the extreme acceleration forces, in addition to\nchanges in the body's circadian rhythm, or sleep cycle, says Stanford geneticist Michael\nSnyder who was not involved in these recent papers.\nAs more humans make the journey to space, prepare for trips to the moon and beyond,\nor even get 'stuck' like career astronauts Sunita Williams and Barry Wilmore, it's\nimportant to have a complete picture of the body's response.\nThese varied studies show that just a few days in space affects biology in ways that\ndon't seem to reverse. And they're starting to hint at differences between females and\nmales.\nStudying the body in space\nWhen human space missions took flight in the 1960s, space health investigations\nbegan. Apollo astronauts wore biosensor harnesses to monitor the heart and lungs and\nunderwent thorough physical exams and tests preflight and postflight. The astronauts\nexperienced back pain from microgravity,flashes of light from radiation, and other\nhealth changes. But this was just the start.\nOver the past two decades, the International Space Station (Iss) has served as an\norbiting biological laboratoryto investigate everything from bacterial changes to bone\nloss to brain deformation. Then in 2015, biologists had the unique opportunity to better\nunderstand how the environment of space environment affects biology at the smallest\nscales. In an experiment NASA called the Twins Study, one astronaut, Scott Kelly,\nboarded the Iss for a year and his identical twin, Mark Kelly, who was also an astronaut,\nstayed on theground.\nBy directly comparing identical twins, biologists could study the genetic effects of\nspace. When Scott returned to Earth, his telomeres, the ends of chromosomes that act\nto protect genetic material, had lengthened. (Read more about NASA's Twins Study.)" } }, { "id": "soma-nyt-2021", "study": "soma", "outlet": "The New York Times", "outlet_original": "The New York Times", "outlet_score": 10, "title": "Who Gets Sick in Space? Inspiration4 May Offer More Clues.", "title_original": "Who Gets Sick in Space? Inspiration4 May Offer More Clues.", "language": "English", "date": "2021-09-16", "kind": "news", "url": "https://www.nytimes.com/2021/09/16/science/inspiration4-medical-research.html", "archive_url": "https://web.archive.org/web/20210917012025/https://www.nytimes.com/2021/09/16/science/inspiration4-medical-research.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Pre-launch era reporting on how commercial spaceflight, with a more diverse set of travelers, will give medical researchers new data on how the human body adapts to space, framed around Inspiration4.", "topics": [ "commercial spaceflight", "inspiration4", "space medicine", "astronaut diversity" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/soma-nyt-2021.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-nyt-2021--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-nyt-2021.txt", "ocr_text": { "archived": "SCIENCE\nCheNework Cimes\nADVERTISEMENT\nWho Gets Sick in Space? Orbital Tourists\nMay Offer Better Clues.\nCommercial spaceflight brings a more diverse cross section of\nhumanity beyond Earth, helping medical researchers collect data.\nINPIRATON\nSt.JudeChildren's\nResearchHe\nHayley Arceneaux, Inspiration4's medical officer, during a training flight. She is\nyoungerthan most astronauts,a cancer survivor and thefirst person with a prosthetic\ndevicetovisitspace,JohnKraus/Inspiration4\nByKennethChang\nSept.16,2021,9:15p.m.ET\nDoctors have poked and prodded NASA astronauts for years, and\nthe astronauts, as government employees, have largely acceded to\ntheir roles as test animals in studying how an alien environment \nouter space affects the human body.\nBut professional astronauts have historically been a small slice of\nhumanity. Initially, they were chosen from the ranks of military test\npilots who were white, physically fit men. Later, as NAsA\nbroadened its criteria, it still chose only astronauts who passed\ntheir physical thresholds.\nBut that could be changing as private spaceflight opens space to a\nmore diverse cross section of humanity.\nmore diverse cross section of humanity.\nFor scientists,the change will createabonanza of new data on how\nthe human body adapts to space.\nThe Inspiration4 mission, which launched on wWednesday, shows\nhowmedicalresearcherscanbenefitfromthenew commercial\nspace travel. The crew of four, none of whom is a professional\nastronaut, will spend a fair amount of time in orbit helping to\nadvance medical research.\nOne of the passengers, Hayley Arceneaux, exemplifies those\npossibilities. At 29, she is younger than most space travelers, a\ncancersurvivor andwillbethefirstpersoninspacewitha\nprosthesis - metal rods that were implanted after a tumor was\nremoved from her left leg.\n\"We're going to learn some things that are very fundamental,' said\nDorit Donoviel, executive director of the Translational Research\nInstitute for Space Health, or TRISH, at the Baylor College of\nMedicine in Houston, which is coordinating research during the\nInspiration4 flight.\nResearch to date has revealed that fluids shift upward in the body\nin the absence of gravity - swollen heads, shrunken legs. The lack\nof gravity also weakens bones. Not only does radiation in space\nslam into DNA creating mutations, but the unusual conditions of\nweightlessness cause some genes to turn on and others to turn off.\nThe biological repercussions of these alterations are not yet\nunderstood.\nThe crew aboard Inspiration4 will takelo tests originallydesigned\nto gauge the mental performance of NASA astronauts each day.\nThe tests take about 20 minutes to complete.\n\"It needed to be brief, because astronauts kind of hate doing these\nUniversity of Pennsylvania who is the lead investigator for that\nexperiment.\nBut in a dangerous environment like space, small errors can lead to\ncatastrophe.\n\"So we need our astronauts to perform at their best all the time,\"\nbad at self-assessing their performance capability, especially in\nchronic exposure situations. If you sit in the same environment all\nthe time, you think you'll be fine, but you're actually not.\"\nWednesday's launch from Cape Canaveral in Florida.The crew will perform several\ntests,from those designed to gauge mental performance and visual acuity,to trying\nout ultrasound devices that track how water shifts in their bodies in low\ngravity.Chandan Khanna/Agence France-Presse-Getty Images\nOne test is simply a square that appears on a screen, and one has\nto tap on it. The square changes position and progressively\nbecomes smaller. That measures the reaction speed and eye-hand\ncoordination.\nAnother measures what is known as psychomotor vigilance. First,\nthe subject stares at a box on the screen. A stopwatch suddenly\npops up within the box, counting the milliseconds until the subject\npresses a button. “Which is extremely sensitive to sleep\ndeprivation,\" Dr. Basner said.\nYet another test gauges a person's ability to identify emotions in\nother people.", "live": "Che New ork Cimes\nLOGIN\nSpaceX\nSpacex-Tesla Merger?\nEarnings Report\nStarship Test Flights\nLouisiana Spaceport\nADVERTISEMENT\nTo continue to The New York Times, please\nconfirm that you are human.\nSlide right to secure your access\nEnjoyunlimited accesstoall of TheTimes.\nSeesubscriptionoptions\nSt.JudeChildren's\nResearchHe\nHayley Arceneaux, Inspiration4's medical officer, during a trainingflight.She is\nyounger than most astronauts,a cancer survivor and thefirst person with a prosthetic\ndevicetovisitspace.JohnKraus/Inspiration4\nBy Kenneth Chang\nPublished Sept.16,2021UpdatedSept.18,2021\nDoctors have poked and prodded NASA astronauts for years, and\ntheastronauts,as government employees,havelargely accededto\ntheir roles as test animals in studying how an alien environment-\nouter space - affects the human body.\nBut professional astronauts havehistorically been a small slice of\nhumanity. Initially, they were chosen from the ranks of military test\npilots who were white, physically fit men. Later, as NASA\nbroadened its criteria, it still chose only astronauts who passed\ntheir physical thresholds.\nBut that could be changing as private spaceflight opens space to a\nmore diverse cross section of humanity.\nForscientists,thechangewill createabonanzaof newdata onhow\nthe human body adapts to space.\nthehuman body adapts to space.\nTheInspiration4mission,whichlaunchedonWednesday,shows\nhowmedicalresearcherscanbenefitfromthenewcommercial\nspace travel. The crew of four, none of whom is a professional\nastronaut, will spend a fair amount of time in orbit helping to\nadvancemedicalresearch.\nOne of the passengers, Hayley Arceneaux, exemplifies those\npossibilities. At 29, she is younger than most space travelers, a\ncancer survivor and willbethefirstperson in spacewitha\nprosthesis -metal rods that were implanted after a tumor was\nremoved from her left leg.\n\"We're going to learn some things that are very fundamental,' said\nDorit Donoviel, executive director of the Translational Research\nInstitute for Space Health, or TRISH, at the Baylor College of\nMedicine in Houston, which is coordinating research during the\nInspiration4 flight.\nSubscribe to The Times to read as many articles as you like.\nKenneth Chang has been at The Times since 2000, writing about physics,geology,\nchemistry, and the planets. Before becoming a science writer, he was a graduate student\nwhoseresearchinvolvedthecontrol ofchaos.\nAversionofthisarticleappears inprintonSept.21,2021,SectionD,Page3oftheNewYorkedition withthe\nheadline:WhoGets SickinSpace?.OrderReprints/Today'sPaperISubscribe\nSeemoreon:National Aeronautics and SpaceAdministration,Spacex,Baylor University\nSharefllarticle", "image": "@/Published2021\nzer\nSt.JudeChildren's\nResearch" } }, { "id": "soma-independent-revised", "study": "soma", "outlet": "The Independent", "outlet_original": "The Independent", "outlet_score": 9, "title": "Human missions to Mars in doubt after astronaut kidney shrinkage revealed", "title_original": "Human missions to Mars in doubt after astronaut kidney shrinkage revealed", "language": "English", "date": "2024-06-12", "kind": "news", "url": "https://www.independent.co.uk/space/mars-mission-space-radiation-kidneys-b2561132.html", "archive_url": "https://web.archive.org/web/20240613021000/https://www.independent.co.uk/space/mars-mission-space-radiation-kidneys-b2561132.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Rewritten UK-focused article on kidney findings from over 40 human and mouse missions, with UCL researchers warning of kidney shrinkage after under a month in space and possible Mars risks.", "topics": [ "kidney", "mars", "spaceflight", "ucl", "radiation" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/soma-independent-revised.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-independent-revised--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-independent-revised.txt", "ocr_text": { "archived": "US EDITION\nSUBSCRIBENOW\nLOGIN/REGISTER\nNDEPENDENT\nUS election\nENHANCED BY Google\nNEWS\nSPORTS\nVOICES\nCULTURE\nLIFESTYLE\nTRAVEL\nPREMIUM\nMORE\nINDEPENDENT\nSpace\nHuman missions to Mars in doubt after\nastronaut kidney shrinkage revealed\n“An astronaut could make it to Mars but they might need dialysis on the way back, scientist warns\nAnthonyCuthbertson17hoursago\nComments\nSamples from 40 space missionsrevealed astronauts kidneys shrunk the longerthey were exposed to the extreme conditions (Nasa)\nSignupto ourfreeweeklyIndyTech newsletter\nMost Popular\ndelivered straight to your inbox\nKategivescomebackupdateas\nINDY/TECH\nSIGN UP\nWilliam reveals Harry Potter\nEmail\nscar\nIwould like tobeemalledaboutoffers\n.events and updates from The Iindependent.Read our privacyLpolicy\nBilly Ray Cyrus files for divorce\nfrom Firerose\nHumanmissionstoMars couldbeatrisk afternewresearchrevealed that\nlong-duration space travel can impact the structure of astronauts'kidneys.\nFossil-hunting diver says he\nhas found large section of\nSamples from more than 40 spacemissions involving humans and mice\nmastodontusk\nrevealed thatkidneys are remodelled bythe conditions in space, with\nUkraine strikes Russian missile\ncertainpartsshowingsigns ofshrinkageafterlessthanamonthin space.\nsystems in Crimea-live\nThe findings could jeopardise plans by SpaceX and Nasa to send crewed\nmissions to Mars in the coming decades, with SpaceXboss Elon Musk\nBlack superintendent speaks\non white dad who shoved him\nrecently claiming that it could be possible within the next \"10 to 20 years\"\non grad stage\nPopular videos\nTHEROLE\nTHATGOT\nViggo Mortensen on the role that\nViggo Mortensen on the role that\ngot away\nAudience gasp as post-Brexit\nmigration numbers revealed to\nRishi Sunak\nMichael Mosley told wife he\nwasn't feeling well before going\nmissing\nindy100\nSpaceX created a five minute animation demonstrating what a crewed tripto Mars aboard a\nStarshiprocketmight looklike(Spacex)\nWaitress fired for sharing video\nof man dining with a blow-up\ndoll\nScientists at University College London (uCL), who carried out the study.\nsaid thatmicrogravityand galactic radiation from space flight caused\nAmericanTaylor Swiftfans\nserious health risks to emerge the longer a person is exposed to it.\ncan't understand why Scotland\nis so cold in June\nFuture missions to Mars were not ruled out, though the scientists said\nMetallica headlining new\nthatmeasures toprotect thekidneys would need to be developed to avoid\nFortnite Festival season-\nserious harm to astronauts. Methods of recovery could also be introduced\neverything you need to know\nonboard spacecraft, such as dialysis machines.\nRarefungal STIdetected inthe\nUS for the first time\n\"We know what has happened to astronauts on the relatively short space\nmissions conducted so far, in terms of an increase in health issues suchas\nNew date confirmed for Jake\nkidney stones,said DrKeith Siew,first author ofthe study from the\nPaul v Mike Tyson fight\nLondon Tubular Centre, based at the UCL Department of Renal\nMedicine.\nSponsored Features\n\"What we don't know is why these issues occur, nor what is going to\nFossil-hunting diver says he\nhappen to astronauts on longer flights such as the proposed mission to\nhas found large section of\nmastodon tusk\nMars. If we don't develop new ways to protect the kidneys, I'd say that\nwhilean astronaut could make it to Mars they might need dialysis on the\nUkrainestrikesRussianmissile\nway back.\nsystems in Crimea-live\n\"Weknow that the kidneys are late to show signs of radiation damage; by\nBlack superintendent speaks\nthe time this becomes apparent it's probably too late to prevent failure,\non white dad who shoved him\non grad stage\nwhich would be catastrophic for the mission's chances of success.\"\nTrump is selling policies for his\nsecond term to the highest\nbidders\nViggo Mortensen shares brutal\nway hewasfired from1980s\nclassic\nAn artist's impression ofa Mars colony (iStock/Getty Images)\nProfessor Stephen Walsh, senior author ofthe study from the London\nTubular Centre, UCL Department of Renal Medicine, said:\"Our study\nhighlights thefact that if you'replanninga spacemission,kidneys really\nmatter.\n\"You can't protect them from galactic radiation using shielding,but as we\nlearn more about renal biology it may be possible to develop\ntechnological orpharmaceuticalmeasures tofacilitate extended space\ntravel\"\nThe research was detailed in a paper published in the journal Nature\nCommunications.\nMore about:Mars", "live": "USEditionY\nNDEPENDENT\nLog in\nNews\nCulture\nLifestyle\nMoney\nHealth&Science\nSports\nTravel\nMore\nSpace\nHuman missions to Mars in doubt after\nastronaut kidney shrinkage revealed\n'An astronaut could make it to Mars but they might need dialysis on the way back, scientist warns\nAnthonyCuthbertson\nQ5Comments\nTuesday18 June202416:37BST\nSamplesfrom40 spacemissionsrevealed astronauts'kidneys shrunkthe longerthey wereexposedtotheextremeconditions (Nasa)\nAskThe Independent\nDeeperDiveAl\nMost popular\nWhat are the top sports stories today?\nRichard Hammond\nannouncesmoveto small\nWelsh village aftersplit\nWhat are the top news stories today?\nStrictly Come Dancing judge\nWhatarethemost readstoriestoday?\nmakesdecision on future\nwith show\n@DeeperDive|AskThe Independent Al anything\nWidow searches for ring\nafter husband dies days after\nVegas wedding\nHuman missions to Mars could be at risk after new research revealed that\nMartinLewisdelivers his\nBudget verdict with three key\nlong-duration space travel can impact the structure of astronauts' kidneys.\ntakeaways\nSamples from more than 40 space missions involving humans and mice\nUkrainewar:Zelenskytouts\nrevealed thatkidneys are remodelled by the conditions in space,with\nrecaptured territory after\ncertain parts showing signs of shrinkage after less than a month in space.\nsecretmissions\nThe findings could jeopardise plans by SpaceX and Nasa to send crewed\nPopularvideos\nmissions toMars inthe comingdecades, withSpaceXboss ElonMusk\nrecently claiming that it could be possible within the next \"10 to 20 years\"\nMoment great white shark\nthrashes at women leaning\ndown to pet it\nSpain high-speed train crash\ndevastationshowninaerial\nfootage\nObama'smictossafter\ncampaigning for El-Sayed\ngoes viral\nbulletin\nStrictly ComeDancing judge\nmakes decision on future with\nshow\nSpaceX createda fiveminuteanimation demonstrating whata crewed trip toMars aboarda Starship\nrocketmight:looklike(Spacex)\nTom Jones shares health\nupdate after postponingUs\nScientists at University College London (UCL), who carried out the study,\ntour\nsaid that serious health risks are more likely to emerge the longer that an\nastronaut is exposed to the extreme conditions of space.\nNational Lottery results and\nwinning numbers for28\nOctober\nFuture missions to Mars were not ruled out, though the scientists said\nthat measures to protect the kidneys would need to be developed to avoid\nTrump sparks wave of\nserious harm to astronauts. Methods of recovery could also be introduced\nmockerywith strange attack\nonboard spacecraft, such as dialysis machines.\nonDemocrat\n\"We know what has happened to astronauts on the relatively short space\nRobson Green's new detective\ndrama-five things to know\nmissions conducted so far, in terms of an increase in health issues such as\nkidney stones, said Dr Keith Siew, first author of the study from the\nLondon Tubular Centre, based at the UCL Department of Renal\nMedicine.\nRead next\n\"What we don't know is why these issues occur, nor what is going to\nRichard Hammond\nannouncesmovetosmall\nhappen to astronauts on longerflights such as the proposed mission to\nWelsh village after split\nMars. If we don't develop new ways to protect the kidneys, I'd say that\nwhile an astronaut could make it to Mars they might need dialysis on the\nStrictlyComeDancing judge\nmakes decision on future\nway back.\nwith show\n\"We know that the kidneys are late to show signs of radiation damage; by\nWidowsearches forring\nthe time this becomes apparent it's probably too late to prevent failure,\nafter husband dies days after\nVegas wedding\nwhich would be catastrophic for the mission's chances of success.\"\nMartin Lewis delivers his\nBudgetverdictwiththreekey\ntakeaways\nUkraine war:Zelensky touts\nrecaptured territory after\nsecretmissions\nAn artist's impressionofa Mars colony (iStock/Getty Images)\nProfessor Stephen Walsh, senior author of the study from the London\nTubular Centre, uCL Department of Renal Medicine, said:\"Our study\nhighlights the fact that if you're planning a space mission, kidneys really\nmatter.\n\"You can't protect them from galactic radiation using shielding, but as we\nlearn more about renal biology it may be possible to develop" }, "note": "The rewritten version of The Independent's June 11, 2024 story; it does not name Dr. Meydan. The archived original does." }, { "id": "soma-wcm", "study": "soma", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Commercial Astronauts Shed Light on Flights' Health Impacts and Create Spaceflight Atlas", "title_original": "Commercial Astronauts Shed Light on Flights' Health Impacts and Create Spaceflight Atlas", "language": "English", "date": "2024-06-11", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2024/06/commercial-astronauts-shed-light-on-flights%E2%80%99-health-impacts-and-create-spaceflight", "archive_url": "https://web.archive.org/web/20240611212643/https://news.weill.cornell.edu/news/2024/06/commercial-astronauts-shed-light-on-flights%E2%80%99-health-impacts-and-create-spaceflight", "names_meydan": true, "meydan_context": "Named as co-corresponding author of the SOMA work in the release.", "passage_naming_meydan": "The SOMA team, including co-corresponding author, Dr. Cem Meydan, an assistant professor of computational biology research in medicine at Weill Cornell Medicine, also has compiled more than 75 billion genetic sequences in an interactive atlas accessible to o…", "summary": "Release saying short-term spaceflight causes many molecular and physiologic changes of long missions, mostly reversing within months, and announcing a large multi-institution atlas with over 75 billion sequences and a biobank of nearly 3,000 samples.", "topics": [ "soma", "spaceflight", "multi-omics", "biobank", "inspiration4" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/soma-wcm.jpg", "passage_image": "media-archive/mentions/soma-wcm.jpg", "full_screenshot": "media-archive/shots/soma-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-wcm.txt", "ocr_text": { "archived": "WeillCornellMedicine\nCare\nDiscover\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nImpactMagazine\nVideo&Photography\nSocial Media\nAbout Us\nHome\nNews\nCommercial Astronauts Shed Light onFlights'Health\nImpactsandCreateSpaceflightAtlas\nJUNE11,2024\nBack toNews\nfX in\nWeill Cornell Medicine\nOfficeof External Affairs\nPhone: (646)962-9476\nJumpToTop\nCredit: Inspiration4 crew\nShort-term space travel causes many of the same molecular.and physiologic changes as long-term space missions, but\nmost reverse within months of returning to Earth. Yet, those changes that are longer-lasting and distinct between crew\nmembers reveal new targets for aerospace medicine and can guide new missions, according to the results of a massive\ninternational research endeavor by investigators at Weill Cornell Medicine, SpaceX, and other organizations.\nDr. Christopher Mason,the WorldQuant Professor of Genomics and Computational Biomedicine at Weill Cornell\nMedicine, led the Space Omics and Medical Atlas (SOMA)project with Dr.Afshin Beheshti of the Broad Institute and\nNASA. In total, more than 1oo investigators from institutions in more than two dozen countries contributed to the\nproject. Together, the collaborators increased the amount of human spaceflight data by 10-fold, including analyses of\nchanges in geneexpression,gene regulation,protein production,metabolism, and the microbes in the human body.The\nresults were published on June 11 as a 40-article collection in Nature journals and summarized in an overview paper.\nThe SOMA team, including co-corresponding author,Dr.Cem Meydan\nanassistant\nprofessor of computational biology research in medicine at Weill Cornell Medicine,\nalso has compiled more than 75 billion genetic sequences in an interactive atlas\naccessible to other researchers, and Weill Cornell Medicine will host a repository for\nnearly 3,000biological samples from the studies.Dr.Mason's team has already\nbegun collecting samples from other missions and forged several new international\ncollaborations to harmonize efforts for spaceflight research.\n\"This is the largest treasure trove of data from astronauts and space biology ever\nreleased,\" Dr.said Mason, who is also a professor of physiology and biophysics, a\nprofessor ofneuroscience in the Feil Family Brain and Mind Research Institute,\nmember of the Sandra and Edward Meyer Cancer Center,and director of the\nWorldQuant Initiative for Quantitative Prediction at Weill Cornell Medicine.\"We hope\nDr.ChristopherMason.Credit:\nthat sharing the data will help accelerate discoveries on the health impacts of space\nAshleyJones.\nflight and yield fundamental discoveries on human health overall.\"\nCommercial Astronauts\nWhen the Inspiration4 mission launched on September 16, 2021, with the first all-civilian, four-person crew for a three-\nhealth impacts of space travel had been collected bygovernment-sponsored space agencies from carefully selected and\nhighly trained astronauts, but it was unclear if such data collected from the astronauts would apply more widely to the\npublic; the Inspiration4 mission provided an opportunity to find out.\nDr. Mason served as the principal investigator for the Inspiration4\nmission's work on clinical profiles of the crew,multi-omics\nresearchandbiobanking.Crewmemberscollectedbiological\nsamples before, during, and after the flight and gave researchers\nfull access to study and share their data. They also conducted a\nbattery of experiments midflight, including the first-ever direct\nRNA sequencing and biopsied skin from astronauts. Drs.David\nLyden, Richard Granstein,and Ari Melnick at Weill Cornell\nMedicine,and Dr.Iwijn De Vlaminck ,at Cornell's Ithaca campus,\nalso contributed to the project.\nCrew members of the Inspiration4 mission, from left: Chris\nThe new data was compared withthat collectedfrom previous\nSembroski,Sian Proctor,Jared Isaacman, and Haley\nflights, in particular,the NASA Twins Study,for which Dr.Mason\nArseneaux.Credit:theInspiration4crew.\nwas also a principal investigator.That endeavor analyzed data\nfrom astronaut Scott Kelly during and after his one-year mission\nshowed these differences also appeared in the skin.\nThe Inspiration4 data showed that many of the same changes also occurred in short-term space travelers. For example,\nDr.Mason publisheda study with Dr.Susan Baileyshowingthatthetelomeres,whichcap the ends of chromosomes,\nbegan lengthening even during the 3-day Inspiration4 mission. They also saw similar immune system changes, with a\nspike in anti-inflammatory proteins called cytokines in the astronauts after their return to gravity.\nImmuneSystemAiterations\nFhecvtokine", "live": "Weill Cornell Medicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPressRoom\nImpactMagazine\nVideo&Photography\nSocial Media\nAbout Us\nHome\nNews\nCommercial Astronauts Shed Light onFlights'Health\nImpactsandCreateSpaceflightAtlas\nJUNE11,2024\nBack toNews\nfX in\nWeill Cornell Medicine\nOffice of External Affairs\nPhone:(646)962-9476\nCredit: Inspiration4 crew\nShort-term space travel causes many of the same molecular.and physiologic changes as long-term space missions, but\nmost reverse within months of returning to Earth. Yet, those changes that are longer-lasting and distinct between crew\nmembers reveal new targets for aerospace medicine and can guide new missions, according to the results of a massive\ninternational research endeavor by investigators at Weill Cornell Medicine, SpaceX, and other organizations.\nDr. Christopher Mason,the WorldQuant Professor of Genomics and Computational Biomedicine at Weill Cornell\nMedicine, led the Space Omics and Medical Atlas (SOMA)project with Dr.Afshin Beheshti of the Broad Institute and\nNASA. In total, more than 1oo investigators from institutions in more than two dozen countries contributed to the\nproject. Together, the collaborators increased the amount of human spaceflight data by 10-fold, including analyses of\nchanges in geneexpression,gene regulation,protein production,metabolism, and the microbes in the human body.The\nresults were published on June 11 as a 40-article collection in Nature journals and summarized in an overview paper.\nThe SOMA team, including co-corresponding author,Dr.Cem Meydan\nanassistant\nprofessor of computational biology research in medicine at Weill Cornell Medicine,\nalso has compiled more than 75 billion genetic sequences in an interactive atlas\naccessible to other researchers, and Weill Cornell Medicine will host a repository for\nnearly 3,000biological samples from the studies.Dr.Mason's team has already\nbegun collecting samples from other missions and forged several new international\ncollaborations to harmonize efforts for spaceflight research.\n\"This is the largest treasure trove of data from astronauts and space biology ever\nprofessor ofneuroscience in the Feil Family Brain and Mind Research Institute,\nmember of the Sandra and Edward Meyer Cancer Center,and director of the\nWorldQuant Initiative for Quantitative Prediction at Weill Cornell Medicine.\"We hope\nDr.Christopher Mason.Credit:\nthat sharing the data will help accelerate discoveries on the health impacts of space\nAshleyJones.\nflight and yield fundamental discoveries on human health overall.\"\nCommercial Astronauts\nWhen the Inspiration4 mission launched on September 16, 2021, with the first all-civilian,four-person crew for a three-\nhealth impacts of spacetravel had been collected bygovernment-sponsored space agencies from carefully selected and\nhighly trained astronauts, but it was unclear if such data collected fromthe astronauts would apply more widely to the\npublic; the Inspiration4 mission provided an opportunity to find out.\nDr.Mason served as the principal investigator for the Inspiration4\nmission's work on clinical profiles of thecrew,multi-omics\nresearchandbiobanking.Crewmemberscollectedbiological\nsamples before, during,and after theflight and gave researchers\nfull access to study and share their data. They also conducted a\nbattery of experiments midflight, including the first-ever direct\nRNA sequencing and biopsied skin from astronauts. Drs.David\nLyden, Richard Granstein,and Ari Melnick at Weill Cornell\nMedicine,and Dr.Iwijn De Vlaminck ,at Cornell's Ithaca campus,\nalso contributedto the project.\nCrew members of the Inspiration4 mission, from left: Chris\nThe new data was compared with that collected from previous\nSembroski, Sian Proctor,Jared Isaacman, and Haley\nflights, in particular,the NASA Twins Study,for which Dr.Mason\nArseneaux.Credit:theInspiration4crew.\nwas also a principal investigator.That endeavor analyzed data\nfrom astronaut Scott Kelly during and after his one-year mission\nshowed these differences also appeared in the skin.\nThe Inspiration4 data showed that many of the same changes also occurred in short-term space travelers. For example,\nDr.Mason publisheda study with Dr.Susan Baileyshowingthatthetelomeres,whichcap the ends of chromosomes,\nbegan lengthening even during the 3-day Inspiration4 mission. They also saw similar immune system changes, with a\nspike in anti-inflammatory proteins called cytokines in the astronauts after their return to gravity.\nImmuneSystemAiterations\nFhecvtokin" } }, { "id": "soma-independent-2021", "study": "soma", "outlet": "The Independent", "outlet_original": "The Independent", "outlet_score": 9, "title": "SpaceX's Inspiration4 crew will do 'first-of-its-kind health research' during trip into orbit", "title_original": "SpaceX's Inspiration4 crew will do 'first-of-its-kind health research' during trip into orbit", "language": "English", "date": "2021-09", "kind": "news", "url": "https://www.independent.co.uk/space/spacex-s-insipration4-health-research-trip-orbit-b1912994.html", "archive_url": "https://web.archive.org/web/20240714201548/https://www.independent.co.uk/space/spacex-s-insipration4-health-research-trip-orbit-b1912994.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Previews the Inspiration4 crew's planned health research, with blood, sleep and genetic data gathered on the three-day orbital trip to inform future missions and medicine on Earth.", "topics": [ "inspiration4", "health research", "spacex", "orbital flight" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/soma-independent-2021.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-independent-2021--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-independent-2021.txt", "ocr_text": { "archived": "US EDITION\nSUBSCRIBENOW\nLOGIN/REGISTER\nNDEPENDENT\nUS election\nENHANCED BY Google\nVOICES\nMORE\nNEWS\nSPORTS\nCULTURE\nLIFESTYLE\nTRAVEL\nPREMIUM\nINDEPENDENT\nSpace\nSpaceX's all-civilian Inspiration4 crew\nwill do 'first-of-its-kind health research'\nduring trip into orbit\nThe information gathered from the crew's blood,sleep,genetics,and other metrics could help future missions\naswellasmedicalpractisesonEarth\nAdamSmithThursday02September202113:04BSTComments\nSpacexCrewLaunch(NASA/JoelKowsky)Forcopyrightandrestrictionsreferto-http://www.nasa.gov/multimedia/guidelines/index.html)\nSignuptoourfreeweekly IndyTechnewsletter\nMost Popular\ndelivered straight to your inbox\nWhat we knowabout the\nINDY/TECH\nSIGNUP\nEmail\ngunman who shot at Trump at\nPennsylvania rally\nI would ltike to\ndent, Read our privacy_colicy\nEngland v Spain LIVE: Euro\n2024final scoreand latest\nThecrewofSpaceX'sInspiration4,thefirstall-civilian spaceflightto\nupdates\norbit, will be used to collect a huge amount of healthdata that will be used\nTrump rally shooting-live:\nto help future humans travel off-planet.\nFBI names assassination\nattemptsuspect\nThe four humans riding the Dragon capsule are us billionaire\nEngland vs Spain referee: Who\nJared Isaacman, who commissioned the flight, St. Jude physician's\nis Euro2024official Francois\nassistant Hayley Arcenaux, data engineer Chris Sembroski and\nLetexier?\ngeoscientist and artist Sian Proctor.\nFamily of Thomas Matthew\nCrooks trying to make sense of\nThe mission, scheduled for 15 September, will orbit the planet at 575\nTrump shooting\nkilometresforthreedaysbeforereturningto Earth,descending intothe\nPopular videos\nAtlanticOcean.This is thefurthestdistancefromEarthforanyhuman\nspaceflight since the Hubble Space Telescope repair missions, Spacex\nsays.\nThe crew will collect a range of medical data including ECG\n(electrocardiograph)activity,movement, sleep,heart rate andrhythm,\nKylie Minogue carried to BST stage\nblood oxygen saturation, cabin noise and light intensity-which will be\nbyAndrew Scott and Jonathan\nused tohelp assess changes in behaviouraland cognitiveperformance\nBailey\nover time.\nStevieNicks performs\nDrops of blood will also be collected to monitor the function of the\n“Landslide'with Harry Styles at\nBST HydePark\nimmune system, and balance and perception tests will be taken before\nand immediately after the flight to explore the humans'response to\nFrantic video from Trump rally\nchange in gravity.\ncrowd shows chaos during\nshooting\nIn collaboration with researchers at Weill Cornell Medicine,SpaceX will\nmonitor the crew's genetics, microbiomes, and other variables -with the\nindy100\nsamples and data cryogenically frozen in a planned Biobank.\nFinally, the crew's organ systems will be scanned via an artificially-\nThe best memes as England\nintelligent ultrasound device, currentlybeing tested by astronauts on the\nlosethe Euro2024final to\nSpain\nInternational Space Station, that provides guidance for non-medical\nexperts. The aim is to determine how much ground support is necessary\nWhyis Marc Cucurella being\nfor the crew to acquire clinical-level images, as well as providing a\nbooed in theEuro2024final?\ntimeline of biological changes pre-and post-flight.\nThe BBC's montages for the\nSpaceX says all this research will have potential applications for human\nEuro 2024 final reduce\nEnglandfans to tears\nhealth on Earth and during future spaceflights.\nNigel Farage's response to\nTrump shooting contains three\nBefore the mission, the crew will have spent months in classrooms and\nsmall problems\nsimulators to learn the systems aboard the spacecraft, training for\nShould we be worried about\nemergencies,andexperiencingg-force.\nthe shocking newtampon\nstudy?\n\"There's north of 60 procedures that range from normal contingency to\nemergency,\"Isaacman told Time.\"In a multi-day mission there is a lot of\nSponsored Features\ntime for a lot of things to go wrong.\"\nWhat we know about the\ngunman who shot at Trump at\nIn an ideal situation,however,the spacecraftwill work autonomously,\nPennsylvania rally\n\"and if the automation doesn't take care of a problem, then the ground is\nyour next layer of defense, said Doug Hurley, the commander of the first\nTrump rally shooting-live:\nFBI names assassination\ncrewed SpaceX mission. The crew would only be required to take action if\nattempt suspect\nthe craft failed to function and ground control could not solvetheissue.\nJay Slater's mother slams'vile\nconspiracy theories in new\n\"In space you've got to trust and verify\"Hurley says.\"But there's no plans\nstatement\nto do any more manual flying, unless there's a need for it from a systems\nfailure kind of scenario.\"\nFamily of Thomas Matthew\nCrooks trying to make sense of\nTrump shooting\nMore about: Spacex\nKate Middleton pictured at\nJoinourcommentingforum\nWimbledon in rare public\nJoin thought-provoking conversations,follow otherIndependent readers and see their replies\nappearance\nComments", "live": "USEditionY\nINDEPENDENT\neLog in\nLifestyle\nNews\nMoney\nSports\nCulture\nTravel\nHealth&Science\nMore\nSpace\nSpaceX's all-civilian Inspiration4 crew\nwill do 'first-of-its-kind health research'\nduring trip into orbit\nTheinformation gathered from the crew's blood,sleep,genetics,and other metrics could help futuremissions as well as\nmedical practisesonEarth\nAdam Smith\nComments\nThursday02September202113:04BST\nSpaceXCrewLaunch(NASA/JoelKowsky)Forcopyrightandrestrictionsreferto-http://www.nasa.gov/multimedia/guidelines/index.html)\nAskTheIndependent\nDeeperDiveAl\nMost popular\nWhat are the top sports stories today?\nCelebrity Race Across the\nWorld: Meet this year's cast\nWhat are themost read stories today?\nRichard Hammond\nWhat are the top news stories today?\nannounces move to small\nWelshvillageaftersplit\nDeeperDive|AskTheIndependentAlanything\nWidow searches for ring\nafter husband dies days after\nVegas wedding\nThe crew of SpaceX's Inspiration4, the first all-civilian spaceflight to\nMartin Lewis delivers his\nBudget verdict with three key\norbit, will be used to collect a huge amount of health data that will be used\ntakeaways\nto help future humans travel off-planet.\nHayden Panettiere:Police\nThe four humans riding the Dragon capsule are uS billionaire\nreveal findings from death\nJared Isaacman,who commissioned theflight, St.Judephysician's\ninvestigation\nassistant Hayley Arcenaux, data engineer Chris Sembroski and\ngeoscientist and artist Sian Proctor.\nonarideo\ngeoscientist and artist Sian Proctor.\nPopularvideos\nThe mission, scheduled for 15 September, will orbit the planet at 575\nkilometres for three days before returning to Earth, descending into the\nAtlantic Ocean. This is the furthest distance from Earth for any human\nspaceflight since the Hubble Space Telescope repair missions, Spacex\nsays.\nObama'smictossafter\nThe crew will collect a range of medical data including ECG\ncampaigningforEl-Sayedgoes\n(electrocardiograph)activity,movement, sleep,heart rateand rhythm,\nviral\nblood oxygen saturation, cabin noise and light intensity - which will be\nMoment great white shark\nused to help assess changes in behavioural and cognitive performance\nthrashes at women leaning\nover time.\ndown to pet it\nDrops of blood will also be collected tomonitorthe function of the\nMom arrested for leaving\nimmune system,and balance and perception tests will be taken before\nfour kids at homewhileshe\nwent to Vegas\nand immediately after the flight to explore the humans'response to\nchange in gravity.\nbulletin.\nIn collaboration with researchers at Weill Cornell Medicine, SpaceX will\nmonitor the crew's genetics, microbiomes, and other variables -with the\nStrictly Come Dancing judge\nmakes decision on future with\nsamples and data cryogenically frozen in a planned Biobank.\nshow\nFinally, the crew's organ systems will be scanned via an artificially-\nNational Lottery results and\nintelligent ultrasound device, currently being tested by astronauts on the\nwinning numbers for28\nInternational Space Station, that provides guidance for non-medical\nOctober\nexperts. The aim is to determine how much ground support is necessary\nTom Jones shares health\nfor the crew to acquire clinical-level images, as well as providing a\nupdate after postponing Us\ntimeline of biological changes pre- and post-flight.\ntour\nSpaceX says all this research will have potential applications for human\nNorway PM says“worries'\nhealth on Earth and during future spaceflights.\noverUS ledtocontroversial\ncall withPutin\nBefore the mission, the crew will have spent months in classrooms and\nTrump stunsTexas rally with\nwild claimaboutVenezuela's\nsimulators to learn the systems aboard the spacecraft, training for\nfuture\nemergencies, and experiencing g-force.\n\"There's north of 60 procedures that range from normal contingency to\nRead next\nemergency\" Isaacman told Time. \"In a multi-day mission there is a lot of\ntime for a lot of things to go wrong.\"\nCelebrity Race Across the\nWorld: Meet this year's cast\nIn an ideal situation, however, the spacecraft will work autonomously,\n\"and if the automation doesn't take care of a problem, then the ground is\nRichard Hammond\nyour next layer of defense, said Doug Hurley, the commander of the first\nannouncesmoveto small\ncrewed Spacex mission. The crew would only be required to take action if\nWelsh village after split\nthe craft failed to function and ground control could not solve the issue.\nWidow searches for ring\nafter husband dies days after\n\"In space you've got to trust and verify, Hurley says.\"But there's no plans\nVegas wedding\nto do any more manual flying, unless there's a need for it from a systems\nfailure kind of scenario.\"\nMartin Lewis delivers his\nBudget verdict with three key\nMore about: SpaceX\ntakeaways\nJoin our commenting forum\nHayden Panettiere: Police\nJointhought-provoking conversations,follow otherIndependentreadersand seetheirreplies\nreveal findings from death\ninvestigation\nComments" } }, { "id": "soma-cornell-chronicle", "study": "soma", "outlet": "Cornell Chronicle", "outlet_original": "Cornell Chronicle", "outlet_score": 6, "title": "Commercial astronauts shed light on flights' health impacts", "title_original": "Commercial astronauts shed light on flights' health impacts", "language": "English", "date": "2024-06-11", "kind": "press-release", "url": "https://news.cornell.edu/stories/2024/06/commercial-astronauts-shed-light-flights-health-impacts", "archive_url": "https://web.archive.org/web/20240613170254/https://news.cornell.edu/stories/2024/06/commercial-astronauts-shed-light-flights-health-impacts", "names_meydan": true, "meydan_context": "Named as co-corresponding author of the SOMA work in the story.", "passage_naming_meydan": "The SOMA team, including co-corresponding author, Cem Meydan, an assistant professor of computational biology research in medicine at Weill Cornell Medicine, also has compiled more than 75 billion genetic sequences in an interactive atlas accessible to o…", "summary": "University news story reporting that brief commercial spaceflight reproduces many long-mission molecular changes that mostly reverse after return, and that the team built a shared atlas and sample repository.", "topics": [ "soma", "spaceflight", "multi-omics", "biobank", "inspiration4" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/soma-cornell-chronicle.jpg", "passage_image": "media-archive/mentions/soma-cornell-chronicle.jpg", "full_screenshot": "media-archive/shots/soma-cornell-chronicle--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-cornell-chronicle.txt", "ocr_text": { "archived": "MEDIARELATIONS\nCORNELL.EDU\nCORNELLCHRONICLE\nEDA.V\nCampus & Community\nTopics\nAll Stories\nExpert Quotes\nIn the News\nCornellians\nProvided\nCrew membersof the Inspiration4mission,from left:Chris Sembroski,Sian Proctor, Jared Isaacman and HaleyArseneaux\nCommercial astronauts shed light on flights' health impacts\nBy Bridget Kuehn, Weill Cornell Medicine\nJune13,2024\nShort-term space travel causes many of the same molecular and physiologic\nchanges as long-term space missions, but most reverse within months of\nreturning to Earth. Yet, those changes that are longer-lasting and distinct\nbetween crew members reveal new targets for aerospace medicine and can\nguide new missions, according to the results of a massive international\nresearch endeavor by investigators at Weill Cornell Medicine, SpaceX and\nother organizations.\nChristopher Mason, the WorldQuant Professor of Genomics and\nComputational Biomedicine at Weill Cornell Medicine, led the Space Omics\nand Medical Atlas (SOMA) project with Afshin Beheshti of the Broad\nInstitute and NASA. In total, more than 1o0 investigators from institutions in\ncollaborators increased the amount of human spaceflight data by tenfold,\nproduction, metabolism and the microbes in the human body. The results\nwere published on June 11 as a 40-article collection in Nature journals and\nsummarized in an overview article.\nThe sOMA team, including co-corresponding author, Cem Meydan\nassistant professor of computational biology research in medicine at Weill\nCornell Medicine, also has compiled more than 75 billion genetic sequences\nCornell Medicine, also has compiled more than 75 billion genetic sequences\nin an interactive atlas accessible to other researchers, and Weill Cornell\nMedicine will host a repository for nearly 3,o00 biological samples from the\nstudies. Mason's team has already begun collecting samples from other\nmissions and forged several new international collaborations to harmonize\nefforts for spaceflight research.\nThis is the largest treasure trove of data from astronauts and space biology\never released, said Mason, who is also a professor of physiology and\nbiophysics, a professor of neuroscience in the Feil Family Brain and Mind\nResearch Institute, member of the Sandra and Edward Meyer Cancer Center,\nand director of the WorldQuant Initiative for Quantitative Prediction.\"We\nhope that sharing the data will help accelerate discoveries on the health\nimpacts of space flight and yield fundamental discoveries on human health\noverall.\"\nCommercial astronauts\nWhen the Inspiration4 mission launched on Sept. 16, 2021, with the first all-\nan unprecedented opportunity for science. Before the mission, most data on\nthe health impacts of space travel had been collected by government-\nsponsored space agencies from carefully selected and highly trained\nastronauts, but it was unclear if such data collected from the astronauts\nwould apply more widely to the public, the Inspiration4 mission provided an\nOpportunity to find out.\nMason served as the principal investigator for the Inspiration4 mission's work\non clinical profiles of the crew, multi-omics research and biobanking.\nCrewmembers collected biological samples before, during and after the flight\nand gave researchers full access to study and share their data. They also\nconducted a battery of experiments midflight, including the first-ever direct\nRNA sequencing and biopsied skin from astronauts. Drs. David Lyden,\nRichard Granstein, and Ari Melnick at Weill Cornell Medicine, and Iwijn De\nVlaminck, associate professor in the Meinig School of Biomedical Engineering\nin Cornell Engineering, also contributed to the project.\nThe new data was compared with that collected from previous flights, in\nparticular, the NASA Twins Study, for which Mason was also a principal\ninvestigator. That endeavor analyzed data from astronaut Scott Kelly during\nand after his one-year mission on the International Space Station in 2015-16\nsystems. New data from Jiwoon Park showed these differences also appeared\nin the skin.\nThe Inspiration4 data showed that many of the same changes also occurred in\nshort-term space travelers. For example, Mason published a study with Susan\nBailey showing that the telomeres, which cap the ends of chromosomes,\nbegan lengthening even during the 3-day Inspiration4 mission. They also saw\nsimilar immune system changes, with a spike in anti-inflammatory proteins\ncalled cytokines in the astronauts after their return to gravity.\nImmune system alterations\nThe cytokine spike after reentry was one of several immune system changes\ndocumented by Weill Cornell Medicine investigators. Single-cell genetic", "live": "MEDIARELATIONS\nCORNELL.EDU\nCORNELLCHRONICLE\nTopics\nCampus & Community\nAll Stories\nPodcast\nMedia Relations\nCornellians\nProvided\nCrew membersof the Inspiration4mission,from left:Chris Sembroski,Sian Proctor, Jared Isaacman and HaleyArseneaux\nCommercial astronauts shed light on flights' health impacts\nBy Bridget Kuehn, Weill Cornell Medicine\nJune13,2024\nShort-term space travel causes many of the same molecular and physiologic\nchanges as long-term space missions, but most reverse within months of\nreturning to Earth. Yet, those changes that are longer-lasting and distinct\nbetween crew members reveal new targets for aerospace medicine and can\nguide new missions, according to the results of a massive international\nresearch endeavor by investigators at Weill Cornell Medicine, SpaceX and\nother organizations.\nChristopher Mason, the WorldQuant Professor of Genomics and\nComputational Biomedicine at Weill Cornell Medicine, led the Space Omics\nand Medical Atlas (SOMA) project with Afshin Beheshti of the Broad\nInstitute and NASA. In total, more than 1o0 investigators from institutions in\ncollaborators increased the amount of human spaceflight data by tenfold,\nproduction, metabolism and the microbes in the human body. The results\nwere published on June 11 as a 40-article collection in Nature journals and\nsummarized in an overview article.\nThe sOMA team, including co-corresponding author, Cem Meydan\nassistant professor of computational biology research in medicine at Weill\nCornell Medicine, also has compiled more than 75 billion genetic sequences\nCornell Medicine, also has compiled more than 75 billion genetic sequences\nin an interactive atlas accessible to other researchers, and Weill Cornell\nMedicine will host a repository for nearly 3,o00 biological samples from the\nstudies. Mason's team has already begun collecting samples from other\nmissions and forged several new international collaborations to harmonize\nefforts for spaceflight research.\nThis is the largest treasure trove of data from astronauts and space biology\never released, said Mason, who is also a professor of physiology and\nbiophysics, a professor of neuroscience in the Feil Family Brain and Mind\nResearch Institute, member of the Sandra and Edward Meyer Cancer Center,\nand director of the WorldQuant Initiative for Quantitative Prediction.\"We\nhope that sharing the data will help accelerate discoveries on the health\nimpacts of space flight and yield fundamental discoveries on human health\noverall.\"\nCommercial astronauts\nWhen the Inspiration4 mission launched on Sept. 16, 2021, with the first all-\nan unprecedented opportunity for science. Before the mission, most data on\nthe health impacts of space travel had been collected by government-\nsponsored space agencies from carefully selected and highly trained\nastronauts, but it was unclear if such data collected from the astronauts\nwould apply more widely to the public, the Inspiration4 mission provided an\nOpportunity to find out.\nMason served as the principal investigator for the Inspiration4 mission's work\non clinical profiles of the crew, multi-omics research and biobanking.\nCrewmembers collected biological samples before, during and after the flight\nand gave researchers full access to study and share their data. They also\nconducted a battery of experiments midflight, including the first-ever direct\nRNA sequencing and biopsied skin from astronauts. Drs. David Lyden,\nRichard Granstein, and Ari Melnick at Weill Cornell Medicine, and Iwijn De\nVlaminck, associate professor in the Meinig School of Biomedical Engineering\nin Cornell Engineering, also contributed to the project.\nThe new data was compared with that collected from previous flights, in\nparticular, the NASA Twins Study, for which Mason was also a principal\ninvestigator. That endeavor analyzed data from astronaut Scott Kelly during\nand after his one-year mission on the International Space Station in 2015-16\nsystems. New data from Jiwoon Park showed these differences also appeared\nin the skin.\nThe Inspiration4 data showed that many of the same changes also occurred in\nshort-term space travelers. For example, Mason published a study with Susan\nBailey showing that the telomeres, which cap the ends of chromosomes,\nbegan lengthening even during the 3-day Inspiration4 mission. They also saw\nsimilar immune system changes, with a spike in anti-inflammatory proteins\ncalled cytokines in the astronauts after their return to gravity.\nImmune system alterations\nThe cytokine spike after reentry was one of several immune system changes\ndocumented by Weill Cornell Medicine investigators. Single-cell genetic" } }, { "id": "soma-spacecom", "study": "soma", "outlet": "Space.com", "outlet_original": "Space.com", "outlet_score": 7, "title": "SpaceX's Inspiration4 astronauts got genetically younger in space: study", "title_original": "SpaceX's Inspiration4 astronauts got genetically younger in space: study", "language": "English", "date": "2024-06-11", "kind": "news", "url": "https://www.space.com/spacex-inspiration4-crew-younger-in-space", "archive_url": "https://web.archive.org/web/20240611210910/https://www.space.com/spacex-inspiration4-crew-younger-in-space", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports that the four Inspiration4 crew appeared genetically younger in some measures during the three-day flight, but briefly, as three papers detailed fast, profound effects of space on the body.", "topics": [ "inspiration4", "soma", "aging", "dna", "spaceflight" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/soma-spacecom.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-spacecom--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-spacecom.txt", "ocr_text": { "archived": "SPACE\nSubscribe\nSearchQ\nSpace Exploration\nStargazing\nThe Universe\nLaunches&Spacecraft\nVideos\nThe Moon\nMore\nTRENDING\nSpacex Starship Flight 4 launch video!\nNext Full Moon\nBestTelescopes\nBest Binoculars\nWhen you purchase through links on our site,wemay earn an afliate commission.Here'show it works.\nHuman Spaceflight\nMOREFROMSPACE...\nSpaceX's Inspiration4astronautsgot\ngeneticallyyounger in space: study\nNews\nBy Tereza Pultarova published 5 hours ago\nSolar storm douses Mars in\n\"We are getting closer to the point where we can almost measure\nradiation as auroras flicker in\nthe dose of space on the body.\"\nthe Red Planet sky (video)\nComments (2)\n2 India's Aditya-L1 solar probe\nsnaps shots of ourhyperactive\nsun during May outburst\n(photos)\nAn interstellar cloud mayhave\ncaused an ice age on Earth.\nHere's how\nAmissing link in the timelineof\nEarth's chemistry mayhave\nbeenfound\n5 SpaceX's Inspiration4\nastronauts got genetically\nyounger in space: study\nThe crew of the Spacex Inspiration4 all-civilian spaceflight conducts biological research during their flight.\n(lmage credit: SpaceX/lnspiration4)\nThe four crew members of Inspiration4, the first ever all-civilian space mission,\ngot genetically younger during their stay in space, a study has found. But the\neffectsdidn't last long.Scientists arenowtryingtounravelhowthespace\nenvironmentaffectshumanDNA.\nInspiration4crewmembershadapacked scheduleduringtheirthree-daytripto\nspace inSeptember2021.Instead of justfloating around in weightlessness and\nenjoyingthebreathtakingviewsfromtheirmodified CrewDragonResilience\nspacecapsule,they lenttheirbodiestoscience.\nHayleyArceneaux,themission'sthechiefmedicalofficerandtrainedphysician\nassistant, was busyduringtheirtimeorbittakingfingerpick blood samples and\nskinswabsof herselfandhercrewmates.Abatteryoftestsfollowedtheirreturn\nto Earthand continued for several months afterthat.\nClick here for moreSpace.com videos.\nResultsoftheseexperimentshavebeenpublished inthreescientificpapers in\nthe journals Natureand Nature Communications on Tuesday,June 11.Thetests\nshowed that the space environment has fast-acting and profound effects on the\nhumanbody,which can bedetected in markers in blood after onlyafew hours\nin orbit.\nNASA,JAXAand theEuropean Space Agency have previously conducted similar\nexperiments with astronauts during long-duration stays on the International\nexperiments with astronauts during long-duration stays on the International\nSpace Station,but theInspiration4mission provided scientists withan\nopportunity to study the earliest stages of these space-induced processes in the\nhuman body.\nRelated: Inspiration4:The first all-civilian spaceflight on Spacex Dragon\nChromosomecapsgettinglonger\n\"We are getting closer to the point where we can almost measure the dose of\nbiophysicsatWeill Cornell Medicineand ScientificAdvisoryBoardmemberat\nbiotechnology company Seer whose Proteograph was usedto analyzethe data,\ntold Space.com in an interview.\"They were in space onlyfor a fewdays, but we\ncould already see early signatures of spaceflight exposure on the body including\nprotein changes and gene expression changes.\"\nGettheSpace.comNewsletter\nBreaking space news, the latest updates on rocket launches, skywatching\nevents and more!\nYourEmail Address\nSIGN MEUP\n Contact me with news and offers from other Future brands\nReceive email from us on behalf of our trusted partners or sponsors\nBy submittingyourinformation you agree to theTerms &Conditions and Privacy Policy\nand are aged 16 or.over.\nFor example,the researchers observed that markers indicating theaging of DNA\ndecreased in space, making the crewmembers'DNAappear younger and\nhealthier.Those markers, known as telomeres, are caps that protect\nchromosomes that areknownto shorten with age and due to environmental\nfactorsand stress.\nFor the Inspiration4 participants, however, the telomeres got longer during the\nspacemission.Scientistspreviouslyobservedtelomerelengthening inNASA\nastronaut Scott Kelly when they studied the effects of his one-year stay in orbit\nin2015 on his body.Thefindings were already surprising back then as the\nresearchers expected theoppositetohappenduetothehighlevelsof stressthe\norganismissubjecttoinspace.\nScott Kelly, shown here in the cupola of the International Space Station, completed a year-long mission in\nMarch2016. (lmagecredit:NASA)\nTo see those effects in the Inspiration4 crew members after onlya fewdays in\nspace was even more unexpected, scientists say.\n\"We did see telomere elongation in all four of the crew members,\" Susan Bailey,\nUniversitywholed theresearch,said ina pressconferencepresentingthe\npapers on Monday,June 10.\"it's really a remarkable finding in a number of ways\nand helps us solidify our findings.\"\nThe researchers think the telomere elongation is triggered as a protective\nresponseby exposureto thehigher radiationenvironment of space.Similar\neffects havebeenmeasured inmountain climbers afterthey scaledtheworld's", "live": "SPACE\nSignin\nFeed\nSearch\nAstronomy\nStargazing\nEntertainment\nVideos\nSpaceExploration\nTech&Science\nMore\nSpaceExploration >HumanSpaceflight\nSpaceX'sInspiration4astronautsgot\ngeneticallyyoungerinspace:study\nNews\nByTerezaPultaroval|Published June1l,2024\n\"Wearegettingcloserto the point wherewe canalmostmeasure the\ndoseof spaceon thebody.\"\nWhenyou purchasethroughlinksonoursite,wemayearnanaffliate commission.Here'showit\nworks.\n(lmagecredit:SpaceX/lnspiration4)\n share\nFollowus\nNewsletter\nThefourcrewmembers of Inspiration4,thefirst everall-civilianspace\nmission.gotgeneticallyyoungerduringtheirstayinspace,astudyhas\nfound.But theeffects didn'tlastlong.Scientists arenowtryingto\nunravelhowthespaceenvironmentaffects humanDNA.\nInspiration4crewmembershadapackedscheduleduringtheirthree-\ndaytriptospaceinSeptember2021.Insteadofjustfloatingaroundin\nweightlessnessandenjoyingthebreathtakingviewsfromtheir\nmodifiedCrewDragonResiliencespacecapsule,theylenttheirbodies\nto science.\nHayleyArceneaux,themission'sthechiefmedicalofficerandtrained\nphysicianassistant,wasbusyduringtheirtimeorbittakingfingerpick\nbloodsamplesand skinswabsof herselfandhercrewmates.Abattery\noftestsfollowedtheirreturntoEarthandcontinuedforseveralmonths\nafter that.\nResultsoftheseexperimentshavebeenpublishedinthreescientific\npapers in thejournals Nature and Nature Communications on Tuesday.\nJune11.Thetests showedthat thespaceenvironment hasfast-acting\nJune 11. The tests showed that the space environment has fast-acting\nandprofoundeffectsonthehumanbody.whichcanbedetectedin\nmarkers inbloodafteronlyafewhoursinorbit.\nNASAJAXAand theEuropean SpaceAgencyhavepreviously\nconductedsimilarexperimentswithastronautsduringlong-duration\nstays onthe International Space Station,buttheInspiration4mission\nprovided scientists withanopportunityto study the earliest stages of\nthese space-induced processes inthe humanbody.\nYOUMAYLIKE\nCould gravityitself beafuturemedication?\n'ltreallydoeschangeyou':SpacexCrew-12commanderwishes\nwecouldallseeourfragileEarthfromspace\n'I'msolookingforwardto seeingnatureagain':SpaceX's Crew-12\nastronautsgearingupfortriphometo Earth\nRelated:Inspiration4:Thefirst all-civilian spaceflighton Spacex\nDragon\nChromosomecapsgettinglonger\n\"Wearegetting closerto the point where we can almost measure the\ndoseofspaceonthebody,\"ChrisMason,aprofessorofgenomics,\nphysiology andbiophysics at Weill Cornell Medicine and Scientifc\nAdvisoryBoardmemberatbiotechnologycompany Seerwhose\nProteograph wasusedto analyzethedata,told Space.com inan\nseeearly signatures of spaceflightexposure on the body including\nprotein changes andgene expression changes.\"\nSPACE\nSignup to our newsletter\nFollowusonGoogle\nForexample,theresearchersobservedthatmarkersindicatingthe\nagingof DNAdecreasedinspace,makingthecrewmembers'DNA\nappearyoungerandhealthier.Thosemarkers,knownastelomeres,are\ncapsthatprotectchromosomesthat areknownto shorten withage\nand duetoenvironmental factors andstress.\nFortheInspiration4participants,howeverthetelomeresgotlonger\nduringthespacemission.Scientistspreviouslyobservedtelomere\nlengtheninginNAsAastronautScottKellywhentheystudiedthe\neffects of his one-year stay in orbit in2015on hisbody.Thefindings\nsubjecttoinspace." } }, { "id": "soma-physorg", "study": "soma", "outlet": "Phys.org (AFP)", "outlet_original": "Phys.org (AFP)", "outlet_score": 6, "title": "Human bodies mostly recover from space, tourist mission shows", "title_original": "Human bodies mostly recover from space, tourist mission shows", "language": "English", "date": "2024-06-11", "kind": "news", "url": "https://phys.org/news/2024-06-human-bodies-recover-space-tourist.html", "archive_url": "https://web.archive.org/web/20240611224703/https://phys.org/news/2024-06-human-bodies-recover-space-tourist.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "AFP report on dozens of papers using data from four SpaceX tourists, finding that spaceflight changes bodies in many ways but most changes revert within months after returning to Earth.", "topics": [ "space tourism", "inspiration4", "health effects", "recovery", "soma" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/soma-physorg.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-physorg--archived.jpg", "saved_html": "media-archive/html/soma-physorg--archived.html", "saved_article_text": "media-archive/text/soma-physorg.txt", "ocr_text": { "archived": "PHYS\nORG\nWeek's top\nSubscribe\nLatest news\nUnreadnews\nTopics\nNanotechnology\nChemistry\nBiology\nMedicine\nPhysics\nEarth\nOther Sciences\nAstronomy&Space\nTechnology\nHome/Astronomy&Space/SpaceExploration\nFeatured\nLast Comments\nPopufar\nJUNE11.2024\nEditors'notes\nAremendissatisfiedwiththeirpenissize\nHuman bodies mostly recover\nmore likely to own a gun? Researchers find\nino\nTwit\nfromspace,touristmissionshows\n①8HOURS AGO\nShare\nby Daniel Lawier\nChemists discover spontaneous nanoparticle\nformation in charged microdroplets\nEmail\n9HOURSAGO\nThermoelectric effect between two liquid\nmaterials observed forthefirst time\n9HOURSAGO\nChinese astronomers discovera high-velocity\nstarejected fromglobularclusterMessier15\nO9HOURS AGO\nPseudomagicquantumstates:Apath to\nquantumsupremacy\n9HOURSAGO\nStudy finds human-caused\nHowbadforyourhealthisspacetravel?Answeringthisquestion\nnitrousoxideemissionsgrew\n40%from1980-2020,greatly\nwill be crucial not just for astronauts aiming to go to Mars, but for\naccelerating climate change\na boomingspacetourism industryplanningtoblastanyonewho\n①47MINUTESAGO\ncan afford it into orbit.\nWind from black holesmay\ninfluence development of\nsurrounding galaxies\nInwhathasbeenbilledasthemost comprehensivelookyetat\n①1HOURAGO\nthe health effects of space, dozens of papers were published on\nTuesday using new data from four SpaceX tourists onboard the\nMachine leaming speeds up\nclimate model simulations at finer\nfirst all-civilian orbital flight in 2021.\nresolutions,making them usable\nonlocallevels\n①2HOURSAGO\nResearchersfrommorethan1o0 institutionsacrossthe world\nsifted through the data to demonstratethat human bodies\nCoastalresearch shows flood risk\nfor several Alaska communities\nchange in a variety of ways once they reach spacebut most go\n①2HOURSAGO\nback to normal withinmonths of returningto Earth.\nCombined X-ray surveys and\nOur bodies are put under a huge amount of stress while in\nsupercomputer simulations track\nspace, from being blasted with radiation to the disorientating\n12 billion years ofcosmicblack-\nholegrowth\neffect ofweightlessness.\n①2HOURSAGO\nScientists spot more Milky Way-\nBy studying astronauts, researchers have known for decades\nlike galaxies in early universe,\nadvancing our understanding of\nthat space flight can cause health issues such as loss of bone\nhowgalaxies were formed\nmass, as well as heart, eyesight and kidney problems.\n①2HOURSAGO\nUnlocking the future of\nFewer than 700 people have ever traveled into space, meaning\nsustainablemining through\ncarbon sequestration\nthat the sample size is small-and governments can be reticent\n①2HOURSAGO\nwhen it comes to sharing all their findings.\nScientists engineer yellow-seeded\ncamelina with high oil output\nHowever, the four American tourists who spent three days in\n①3HOURSAGO\nspace during the Inspiration4 mission were happy to see their\ndata made public.\nAre plants intelligent? It depends\non the definition\nThe early results,whichwerecompared to 64 otherastronauts,\n①4HOURSAGO\nwere published in Nature journals on Tuesday.\n4,000-year-old Greek hilltop site\nWhen people are in space, they undergo changes to their blood,\nmystifies archaeologists. It could\nspell troublefor new airport.\nheart,skin,proteins,kidneys,genes,mitochondria, telomeres,\n①6HOURSAGO\ncytokines and other health indicators, the researchers found.\nBut around 95 percent of their health markers returned to their\nRelevantPhysicsForumsposts\nslevelwithinth\nBut around 95percentof theirhealthmarkersreturnedtotheir\nRelevantPhysicsForumsposts\nprevious level within three months.\nShould luminosity distance be O at z=0?\n4HOURSAGO\n'I lovemy spacescar'\nSolar Activity and Space Weather Update\nthread\n①13HOURSAGO\nThe\"big take-home\"message is that people mostly make a\nWill weevercommunicatewith\nrapid recovery after space flight, said one of the main study\nextraterrestial life in a reasonable time\nauthors,ChristopherMason from Weill Cornell Medicine.\nframe?\nJUN10.2024\nMasontold journalistshehoped the\"most in-depthexamination\nUnknown Radio Signal from Space\nRepeats Every Hour -- Usually\nwe've ever had of a crew\"would help scientists understandwhat\nJUN10.2024\ndrugs or measures will be needed in the future to help protect\nDark Energy:Are We All Missing The\npeople blasting off into space.\nObvious?\n①JUN9,2024\nThe Inspiration4 mission, financed by its billionaire captain Jared\nOur Beautiful Universe-Photosand\nIsaacman, had the stated goal of demonstrating that space is\nVideos\nOJUN8.2024\naccessibletopeoplewhohavenotspent yearstrainingforthe\nMorefromAstronomyand Astrophysics\nfeat.\nThe Inspiration4 crew had significant changes to their bodies --but they mostly..\nTo do so, the four civilian astronauts received a huge number of\nmedical tests.\n\"l love my space scar,\" nurse Hayley Arceneaux said of the\nlingeringmark fromaskinbiopsy.Shewas just29whenshe\nwent into space.\nOne studyfound that the telomeres-caps similar to those on\nshoelaces which protect the ends of chromosomes from fraying\n-ofall foursubjectsdramaticallylengthenedwhentheyarrived\nin space.\nBut their telomeres all shrunk back to near their original length\nwithin months of them returning to Earth.\nBecause telomeres also lengthen as people age, finding a way\nto address this problem could help\"us mere Earthlings\"in the\nnever-ending fight against aging,said Colorado State\nUniversity's Susan Bailey.\nIt even could lead to anti-aging products such as \"telomerase-\ninfused face cream\", the study author speculated.\nSafe mission to Mars?\nLooking at the data so far, \"there's no reason we shouldn't be\nable to safely get to Mars and back,\" Mason said.\n\"You probably wouldn't take multiple trips because it's a lot of\nradiation,\" he added.\nOne of the studies found that mice exposed to radiation\nntki", "live": "Justaquickcheck\nWe'recheckingyourconnectiontopreventautomatedabuse\nVerify you are human\nCLOUDFLARE\nPrivacr * Hele\nWhyam I seeing this?\nHaving probiems? Contact support" } }, { "id": "soma-techtimes", "study": "soma", "outlet": "Tech Times", "outlet_original": "Tech Times", "outlet_score": 5, "title": "Space Tourists Experience Similar Body Changes to Astronauts, Studies Reveal", "title_original": "Space Tourists Experience Similar Body Changes to Astronauts, Studies Reveal", "language": "English", "date": "2024-06-11", "kind": "news", "url": "https://www.techtimes.com/articles/305581/20240611/space-tourists-experience-similar-body-changes-astronauts-studies-reveal.htm", "archive_url": "https://web.archive.org/web/20240612003219/https://www.techtimes.com/articles/305581/20240611/space-tourists-experience-similar-body-changes-astronauts-studies-reveal.htm", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports that short-duration space tourists showed some of the same physical changes seen in long-stay astronauts, which largely resolved after return; cites an outside expert on implications for future missions.", "topics": [ "space tourists", "astronaut health", "molecular changes", "inspiration4" ], "audience": "trade", "thumbnail": "media-archive/thumbs/soma-techtimes.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/soma-techtimes--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/soma-techtimes.txt", "ocr_text": { "archived": "TECH\nfX\nTiMES\nTECH\nSCIENCE\nBUSINESS\nHEALTH\nCULTURE\nDEALSREVIEWS\nJOBS\nHOME>SCIENCE\nSCIENCE\nENERGY\nANIMALS\nSPACE\nEARTH/ENVIRONMENT\nROBOTICS\nSpace Tourists ExperienceSimilarBody ChangestoAstronauts,Studies\nReveal\nThe study aims to improve preparations for\nse travel.\nMOSTPOPULAR\nBill Gates'\nTerraPower\nBreaksGround\non Revolutionary\nNuclearPower\nPlant in\nWyoming\nBy QuincyJon\nfXin\nApple Ads on\nPublishedJun11,20248:25PMEDT\nSocial Networks\nHint at Back to\nSchool Sale in US,\nNew researchreleased Tuesday suggests space tourists have some of the same physical\nCanada\nchanges as astronauts who spend months in orbit. Researchers reported that once space\nItalyFines Meta\npassengers returned to Earth, these modifications largely returned to normal.\nMoreThan $5\nMeta\nMillionfor Unfair\nCommercial\nAmolecular-level study on the health impacts of space travel examined four space passengers.\nPractices\nAccording to a report published by ABC News, researchers claimed the findings clarify how non-\nastronauts adapt to weightlessness and space radiation.\nAdobe to Unveil\nAAdobe\nNewTerms of\nService After Al\nModel Training\nConcerns\nChina's Kuaishou\nAl-Powered\nVideo Generator\nCan Create\nStunning 1080p\nClips Up to 2\nMinutes Long,\nRivaling\nOpenAl's Sora\nSubscribeto Tech Times!\nSignupforourfreenewsletterforthe Latest\ncoverage!\nEmail Address\nsign Up\nVirgin Galacticfounder Sir Richard Branson(L),with Sirisha Bandla on his shoulders, cheers with crew\nmembersafter flying into space aboard a Virgin Galactic vessel at SpaceportAmerica,near Truth and\nConsequences,NewMexicoonJuly11,2021.\n(Photo:PATRICKT.FALLON/AFPviaGetty Images)\nUniversity of Michigan mechanical engineering professor Allen Liu, who was not involved in the\nresearch, remarked that the study will help prepare experts better for \"sending humans into\nspace\"forany purpose.\nNAsA and other agencies have examined the effects of space flight on astronauts, including Iss\ninhabitants. Space visitors, however, have received less attention. The first tourist visit to the\nspace station occurred in 2001, and private space flight has grown.\nphvatespacemghithas\nSusan Bailey, a radiation expert at Colorado State University, said a three-day chartered flight in\n2021 allowed researchers to study how rapidly the body adjusts to spaceflight.\nResearchers identified extensive cell and immune system alterations in the samples.Most of\nthese changes stabilized in the months after the four returned home, and the researchers\nidentified no health risks from short-term spaceflight.\nWeill Cornell Medicine researcher and co-author Chris Mason said it was the first time to conduct\na\"cell-by-cell examination of a crew,\" which would help scientists identify what treatments or\nHow Does Short Space Voyage Impact the Body?\nBillionairecaptainJared IsaacmanfinancedInspiration4,whichshowed thatspaceisaccessible\nwithout training.Four civilian astronautsreceived many medical exams.During the voyage,29-\nIn one study, all four patients' telomeres grew considerably in space but recovered to near their\noriginal lengths withinmonths afterreturning to Earth.According to Susan Baileyof Colorado\nState University, tackling this problem might help prevent aging.\nRead Also: Japanese Researchers Discover Treating Skin Diseases Possible Through\nHealthy Skin Transplants\nMason said humans can\"safely getto Mars and back,\"but spaceradiation concerns limit the\nnumber of trips, according to NonStop Local. Research indicated that mice exposed to 2.5 years\nof spaceradiationhadlastingkidneydamage.Withoutnewprotectivemeasures,astronauts\nreturning from Mars may need dialysis, according to Keith Siew of the London Tubular Centre.\nMason also suggested that childbirth-related physiological modifications may make female\nastronauts more tolerant of spaceflight hardship. Nevertheless, he called the latest discovery\n\"really good news\" for future space explorers.\nVirginGalacticSpaceplaneTakesFlight\nVirgin Galactic reported that it sent four people to the edge of space and returned on its\nspaceplane,marking Richard Branson's firm's second flight of the year,as recentlyreported by\nReuters.\nOn Saturday, the Galactic 07 voyage sent passengers from Turkey, the US, and Italy to 55 miles\n(88.51 km) altitude in slightly over an hour. The Virgin Galactic mission was launched in\nSpaceport America in Mexico and returned to the same location.\nThis was Virgin Galactic's last commercial flight of theVSSUnity.VirginGalacticsaid it is\nconcentrating on its fourth-generation spacecraft, which will commence commercial operation in\n2026.\nRelated Article:SpaceXIs Working on Upgrading Starfactory,Aiming toProduce One\nStarshipRocketDaily\nWrittenbyQuincyJon\nTECH\nThis article is publishedon\nTiMES\nITechTimesNews\n@TechTimesNews\n@2024TECHTIMES.comAll rightsreserved.Donotreproducewithoutpermission.", "live": "TECHTiMES\nTECH\nSCIENCE\nBUSINESSTECH\nHEALTH\nCULTURE\nDEALS&REVIEWS\nHOME>SCIENCE\nSpace Tourists Experience Similar Body Changes to Astronauts,\nStudiesReveal\nThe study aims to improve preparations for space travel.\nfXin\nByQuincy Jon\nMOSTPOPULAR\nPublished:Jun112024,8:25PMEDT\nNew research released Tuesday suggests spacetourists have someof the same physical\nApple Offers iPhone\nDuo Screen\nchanges as astronauts who spend months in orbit. Researchers reported that once space\nReplacementsAfter\npassengers returned to Earth, these modifications largely returned to normal.\nReports of Display\nProblems\nA molecular-level study on the health impacts of space travel examined four space passengers.\nMFN Drug Policy\nAccording to a report published by ABC News, researchers claimed the findings clarify how non-\nCuts Us Costs; It\nastronautsadapttoweightlessnessand spaceradiation.\nMay Block Europe's\nFirst sjogren's\nTherapy\n3.\nios 27.2 Puts\nBiometric Gate\nBelow App Layer:\nAny Government\nCan Now Mandate\nFace Scans on\niPhones\nOpenAI Claims\nYang-Mills Proof;\nNobel Laureate\nWhose Discovery\nEnables It Now\nReviewsIt\nTrump\nAdministration\nDefies FIsA\nDeclassification\nLaw as Senators\nPress DNI Clayton\nto Act\nVirgin GalacticfounderSir Richard Branson(L),with Sirisha Bandla onhis shoulders,cheers with crewmembers afterflying\nintospaceaboardaVirginGalacticvesselatSpaceportAmerica,nearTruthandConsequences,NewMexicoonJuly11,\n2021.\n(PHOTO:PATRICKT.FALLON/AFPVIAGETTY IMAGES)\nUniversity of Michigan mechanical engineering professor Allen Liu, who was not involved in the\nspace\" for any purpose.\nNASA and other agencies have examined the effects of space flight on astronauts, including ISS\ninhabitants. Space visitors, however, have received less attention. The first tourist visit to the\nspace station occurred in 2001, and private space flight has grown.\nSusan Bailey, a radiation expert at Colorado State University, said a three-day chartered flight in\n2021 allowed researchers to study how rapidly the body adjusts to spaceflight.\nThe four Spacex Inspiration4 passengers took blood, saliva, skin, and other samples in orbit.\nResearchers identified extensive cell and immune system alterations in the samples.Most of\nthese changes stabilized in the months after the four returned home, and the researchers\nidentified no health risks from short-term spaceflight.\nWeill Cornell Medicine researcher and co-author Chris Mason said it was the first time toconduct\nprecautions to take to safeguard future space passengers.\nHow Does Short Space Voyage Impact the Body?\nBillionaire captain Jared Isaacman financed Inspiration 4,which showed that space is accessible\nwithout training. Four civilian astronauts received many medical exams. During the voyage, 29-\nyear-old nurse Hayley Arceneaux called a skin biopsy scar her\"space scar.\"\noriginal lengths within months after returning to Earth. According to Susan Bailey of Colorado\nState University, tackling this problem might help prevent aging.\nRead Also:Japanese Researchers Discover Treating Skin Diseases Possible\nThrough Healthy Skin Transplants\nMason said humans can\"safely get to Mars and back,\"but spaceradiation concerns limit the\nnumber of trips, according to NonStop Local. Research indicated that mice exposed to 2.5 years\nof spaceradiationhadlastingkidneydamage.Withoutnewprotectivemeasures,astronauts\nreturning fromMarsmayneed dialysis,accordingtoKeithSiew of theLondonTubularCentre.\nMason also suggested that childbirth-related physiological modifications may make female\nastronauts more tolerant of spaceflight hardship. Nevertheless, he called the latest discovery\n\"really good news\"for future space explorers.\nVirgin Galactic Spaceplane Takes Flight\nVirgin Galactic reported that it sent four people to the edge of space and returned on its\nspaceplane, marking Richard Branson's firm's second flight of the year, as recently reported by\nReuters.\nOn Saturday, the Galactic 07 voyage sent passengers from Turkey, the US, and Italy to 55 miles\n(88.51 km) altitude in slightly over an hour. The Virgin Galactic mission was launched in\nSpaceport America in Mexico and returned to the same location.\nThis was Virgin Galactic's last commercial flight of theVSSUnity.VirginGalacticsaid it is\nconcentratingon itsfourth-generation spacecraft,whichwill commencecommercial operation in\n2026.\nRelated Article:SpaceX Is Working on Upgrading Starfactory, Aiming to Produce\nOne Starship Rocket Daily\nWrittenbyQuincyJon\nTECH\nThisarticle is published on\nTiMES\nITechTimesNews\n@TechTimes.News\nbyline quincy\n(PHOTO:BYLINEQUINCY)\n@2026TECHTIMES.comAll rightsreserved.Donotreproducewithoutpermission.\nTags:NASA Space ScienceHealthVirgin Galactic SpaceTourism\nTECHTiMES\nTOPICS\nSECTIONS\nDATA SETS\nApple\nTesla\nTech\n-Intemet\nAl Benchmarks\nGoogle\nNintendo\n-Gadgets\n-Car\nAl Timeline\n-Security\niPhone\n-Computers\nLLMAPI Status\n-Phones/Tablets/Mobile\nMicrosoft\nSpacex\n-Smart Home\nCVE Tracker\nSamsung\nFacebook\n-Wearable\n-Defense\nCrypto Prices\nElon Musk\nAmazon\n-Apps/Software\n-Artificial Intelligence\nPAGES" } }, { "id": "ezh2-wcm", "study": "melnick", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Anticancer Drugs Could Make Immunotherapies More Effective", "title_original": "Anticancer Drugs Could Make Immunotherapies More Effective", "language": "English", "date": "2024-12-05", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2024/12/anticancer-drugs-could-make-immunotherapies-more-effective", "archive_url": "https://web.archive.org/web/20241206025328/https://news.weill.cornell.edu/news/2024/12/anticancer-drugs-could-make-immunotherapies-more-effective", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Release on a preclinical Cancer Cell study in which EZH2 inhibitors combined with T-cell immunotherapy shrank B-cell lymphomas better than immunotherapy alone; pilot patient studies have begun.", "topics": [ "ezh2 inhibitors", "immunotherapy", "lymphoma", "car-t", "preclinical" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/ezh2-wcm.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/ezh2-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/ezh2-wcm.txt", "ocr_text": { "archived": "WeillCornellMedicine\nCare\nDiscover\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpact Magazine\nAbout Us\nHome\nNews\nAnticancer Drugs Could Make Immunotherapies More\nEffective\nDECEMBER5,2024\nBack to News\nin\nLymphoma B-cell\nCAR-TCell\nLymph node\nWeill Cornell Medicine\nOfficeofExternalAffairs\nPhone: (646) 962-9476\n150μm\n100μm\nCell Culture\n20μM\n20μM\nPretreatment with EZH2 inhibitor (top right) leads to higher recruitment of CAR-T cells (red) into the lymph node tumor\ncompared withcontrol (top left). Pretreatmentwith EZH2 inhibitor (bottom right) also leads to closer contacts between\nlymphoma B cells and T cells in culture. Credit: Courtesy of the Beguelin lab.\nimmunotherapies, according to a preclinical study led by Weill Cornell Medicine lymphoma researchers:\nThe inhibitors target the EZH2 enzyme, whose activity in tumor cells is now recognized as a significant factor in many\ncancers.The study,published Dec.5 in Cancer Cell,found that EZH2 inhibition combined withT-cell based\nimmunotherapy worked better at shrinking non-Hodgkin B-cellymphomas than immunotherapy alone.\n\"These encouraging preclinical results have prompted us to initiate pilot studies of an EZH2 inhibitor with\nimmunotherapies in lymphoma patients,\"said senior authorDr.Wendy Beguelin,theJohn P.Leonard,MD/Gwirtzman\nFamily Research Scholar in Lymphoma and an assistant professor of pharmacology in medicine at Weill Cornell Medicine.\nThe first author of the study is Dr. Yusuke Isshiki, a postdoctoral fellow in the\nlaboratories of Dr.Beguelin and Dr.Ari Melnick, the Laurel Gebroe Family Professor of\nHematology/OncologyatWeill Cornell Medicine.\nT-cell-based immunotherapies, including engineered anticancer T cells called CAR-T\ncells, have been effective at reducing or eliminating signs of cancer in some patients\nwith lymphomas and other blood malignancies.In most cases,however, signs of cancer\neventually return.\nThis study proposed that inhibiting EZH2 might help enhance the potency and durability\nof these immunotherapies. EZH2 is an enzyme that normally helps program cell\nbehavior by controlling the expression of specific genes.Mutations in the EZH2 gene,\nwhich makes the enzyme more active, are now recognized as common features of\nDr.WendyBeguelin\nlymphomas, and inhibiting this enzyme has been found to benefit lymphoma patients\neven when they have non-mutant EZH2.\nIn 2020,the United States Food and Drug Administration approved an EZH2 inhibitor called tazemetostat for use in\nvalemetostat, was approved in Japan in 2022 for the treatment of patients with relapsed or refractory adult T-cell\nleukemia/lymphoma.\nResearch by Dr.Beguelin and others has shown that EZH2 activity makes lymphoma\ncells less visible to the immune system, and generally helps create an\nimmunosuppressive environment around lymphomas. EZH2 inhibition would reverse\nwell as T-cell immunotherapies.\nSuitable preclinical animal models to test this hypothesis have not been available, so Dr.\nBeguelin and her colleagues started by developing a new mouse model for follicular\nlymphoma.The researchers then detailed changes in these lymphomas during\nDr. Yusuke Isshiki\ncell therapy and the other a\"bispecific antibody\"therapy that binds lymphoma cells to\nthe patients'own T cells.\nThe results showed that EZH2 inhibition on its own enhanced the killing of lymphoma cells by T cells, and that\npretreatment with an EZH2 inhibitor could greatly improve the effectiveness of T cell immunotherapies against these\nlymphomas.In one experiment, treatment withtazemetostat plus CAR-T cells enabled 100% ofmiceto survive for the\n40-day study period and beyond, whereas most died within 11 days after the same dose of CAR-T treatment alone.\nalso greatly boosted survival over bispecific antibody treatment alone.\nThe researchers found that EZH2 inhibition boosted these immunotherapies'effects not just by making lymphoma cells\ncells, and reprogramming of anticancer T cells in a way that makes their activity more durable.\nIn addition to their clinical trial-based work, the researchers are continuing to study how EZH2 inhibition boosts\nanticancer T cells, and this research could someday yield more precise therapeutic targets, said Dr. Beguelin, who is also\na member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.\nMany Weill Cornell Medicine physicians andscientists maintainrelationships and collaborate with external organizations to\nfoster scientific innovation and provide expert guidance.The institution makes these disclosures public to ensure transparency.\nFor this information, see profile for Dr.Wendy Beguelin.", "live": "WeillCornellMedicine\nCare\nDiscover\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpact Magazine\nAbout Us\nHome\nNews\nAnticancer Drugs Could Make Immunotherapies More\nEffective\nDECEMBER5,2024\nBack to News\nin\nLymphoma B-cell\nCAR-Tcell\nLymph node\nWeill Cornell Medicine\nOfficeofExternalAffairs\nPhone: (646) 962-9476\n150μm\n100μm\nCell Culture\n20μM\n20μM\nPretreatment with EZH2 inhibitor (top right) leads to higher recruitment of CAR-T cells (red) into the lymph node tumor\ncompared withcontrol (top left). Pretreatmentwith EZH2 inhibitor (bottom right) also leads to closer contacts between\nlymphoma B cells and T cells in culture. Credit: Courtesy of the Beguelin lab.\nimmunotherapies, according to a preclinical study led by Weill Cornell Medicine lymphoma researchers:\nThe inhibitors target the EZH2 enzyme, whose activity in tumor cells is now recognized as a significant factor in many\ncancers.The study,published Dec.5 in Cancer Cell,found that EZH2 inhibition combined withT-cell based\nimmunotherapy worked better at shrinking non-Hodgkin B-cellymphomas than immunotherapy alone.\n\"These encouraging preclinical results have prompted us to initiate pilot studies of an EZH2 inhibitor with\nimmunotherapies in lymphoma patients,\"said senior authorDr.Wendy Beguelin,theJohn P.Leonard,MD/Gwirtzman\nFamily Research Scholar in Lymphoma and an assistant professor of pharmacology in medicine at Weill Cornell Medicine.\nThe first author of the study is Dr. Yusuke Isshiki, a postdoctoral fellow in the\nlaboratories of Dr.Beguelin and Dr.Ari Melnick, the Laurel Gebroe Family Professor of\nHematology/OncologyatWeill Cornell Medicine.\nT-cell-based immunotherapies, including engineered anticancer T cells called CAR-T\ncells, have been effective at reducing or eliminating signs of cancer in some patients\nwith lymphomas and other blood malignancies.In most cases,however, signs of cancer\neventually return.\nThis study proposed that inhibiting EZH2 might help enhance the potency and durability\nof these immunotherapies. EZH2 is an enzyme that normally helps program cell\nbehavior by controlling the expression of specific genes.Mutations in the EZH2 gene,\nwhich makes the enzyme more active, are now recognized as common features of\nDr.WendyBeguelin\nlymphomas, and inhibiting this enzyme has been found to benefit lymphoma patients\neven when they have non-mutant EZH2.\nIn 2020,the United States Food and Drug Administration approved an EZH2 inhibitor called tazemetostat for use in\nvalemetostat, was approved in Japan in 2022 for the treatment of patients with relapsed or refractory adult T-cell\nleukemia/lymphoma.\nResearch by Dr.Beguelin and others has shown that EZH2 activity makes lymphoma\ncells less visible to the immune system, and generally helps create an\nimmunosuppressive environment around lymphomas. EZH2 inhibition would reverse\nwell as T-cell immunotherapies.\nSuitable preclinical animal models to test this hypothesis have not been available, so Dr.\nBeguelin and her colleagues started by developing a new mouse model for follicular\nlymphoma.The researchers then detailed changes in these lymphomas during\nDr. Yusuke Isshiki\ncell therapy and the other a\"bispecific antibody\"therapy that binds lymphoma cells to\nthe patients'own T cells.\nThe results showed that EZH2 inhibition on its own enhanced the killing of lymphoma cells by T cells, and that\npretreatment with an EZH2 inhibitor could greatly improve the effectiveness of T cell immunotherapies against these\nlymphomas.In one experiment, treatment withtazemetostat plus CAR-T cells enabled 100% ofmiceto survive for the\n40-day study period and beyond, whereas most died within 11 days after the same dose of CAR-T treatment alone.\nalso greatly boosted survival over bispecific antibody treatment alone.\nThe researchers found that EZH2 inhibition boosted these immunotherapies'effects not just by making lymphoma cells\ncells, and reprogramming of anticancer T cells in a way that makes their activity more durable.\nIn addition to their clinical trial-based work, the researchers are continuing to study how EZH2 inhibition boosts\nanticancer T cells, and this research could someday yield more precise therapeutic targets, said Dr. Beguelin, who is also\na member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.\nMany Weill Cornell Medicine physicians andscientists maintainrelationships and collaborate with external organizations to\nfoster scientific innovation and provide expert guidance.The institution makes these disclosures public to ensure transparency.\nFor this information, see profile for Dr.Wendy Beguelin." } }, { "id": "ezh2-sciencedaily", "study": "melnick", "outlet": "ScienceDaily", "outlet_original": "ScienceDaily", "outlet_score": 6, "title": "Anticancer drugs could make immunotherapies more effective", "title_original": "Anticancer drugs could make immunotherapies more effective", "language": "English", "date": "2024-12-05", "kind": "news", "url": "https://www.sciencedaily.com/releases/2024/12/241205142530.htm", "archive_url": "https://web.archive.org/web/20241210183901/https://www.sciencedaily.com/releases/2024/12/241205142530.htm", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reposted release reporting a preclinical Cancer Cell study that EZH2 inhibition boosts the effectiveness of T-cell immunotherapy against B-cell lymphomas, prompting pilot trials.", "topics": [ "ezh2 inhibitors", "immunotherapy", "lymphoma", "preclinical" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/ezh2-sciencedaily.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/ezh2-sciencedaily--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/ezh2-sciencedaily.txt", "ocr_text": { "archived": "ScienceDaily\nFollow.\nSubscribe:\nYour source forthe latest research news\nNew! Sign upfor ourfree email newsletter.\nSD\nQuirky \nSociety\nHealth \nTech \nEnviro\nSearch\nScience News\nfromresearchorganizations\ne Print\nEmail\nShare\nAnticancerdrugs could make immunotherapies more\nBreaking\nthis hour\neffective\n>AlCracksComplexEngineeringProblemsFast\nDate:December6,2024\n>UniverseExpansion StudyChallengesCosmic\nSource:Weill Cornell Medicine\nSummary:An emerging class of anticancer drugs called EZH2 inhibitors may greatly\n>EarliestDeep-CaveRitual Compound\nenhance the potency of some cancerimmunotherapies.\n>Dogs Hit Button-CombosOn Soundboards\n>ExistingEVBatteriesMayLastUpto40%\nShare:\nLonger\n>Black Hole DebateSettled?\nFULL STORY\n>NewOceanPredatorfromtheAtacamaTrench\nRELATEDTOPICS\nSmallestMain-BeltAsteroidsEverDetected\nHealth&Medicine\nAn emerging class of anticancerdrugs called\n>DesertAntsUseGeomagneticFieldfor\nNavigation\nLymphoma\nEZH2 inhibitors may greatly enhance the\n>DarkChocolate:LowerRiskofType2\npotency of some cancer immunotherapies,\nStemCells\nDiabetes\naccording to a preclinical study led by Weill\n>Lung Cancer\nTrending Topics\nCornell Medicine lymphoma researchers.\nthis week\n>Diseases and\nThe inhibitors target the EZH2 enzyme, whose activity in\nConditions\nHEALTH&MEDICINE\ntumor cells is now recognized as a significant factor in\nBreast Cancer\nBrain Tumor\nmanycancers.Thestudy,publishedDec.5inCancer\nLeukemia\nCancer\nCell, found that EZH2 inhibition combined with T-cell\nbased immunotherapy worked better at shrinking non-\nLung Cancer\n>ImmuneSystem\nHodgkin B-cellymphomas than immunotherapy alone.\nMIND&BRAIN\n>Leukemia\n\"These encouraging preclinical results have prompted us\nIntelligence\nto initiate pilot studies of an EZH2 inhibitor with\nRELATEDTERMS\nBrain Injury\nimmunotherapiesin lymphoma patients,\"said senior\nauthor Dr.Wendy Beguelin, John P.Leonard,\nInsomnia\n>Antiviral drug\nMD/GwirtzmanFamilyResearchScholarinLymphoma\nLIVING&WELL\nChemotherapy\nand an assistantprofessor of pharmacology in medicine at\nHealthy Aging\nWeill Cornell Medicine\nColorectal cancer\nGenderDifference\nThefirst author of the studyis Dr.Yusuke Isshiki,a\n>Anti-obesitydrug\npostdoctoralfellow in the laboratories of Dr.Beguelin and\nTeen Health\nPenicillin-like\nDr.Ari Melnick,theLaurel GebroeFamilyProfessorof\nHematologyiOncologyatWeillCornell Medicine.\nantibiotics\nStrange &Offbeat\nT-cell-based immunotherapies, including engineered\n>Analgesic\nanticancerTcells called CAR-Tcells,havebeen effective\nHEALTH&MEDICINE\nCervical cancer\natreducing or eliminating signs ofcancer in some patients\nGetting to the Bottom of Things: Latrine\nwithlymphomasandotherbloodmalignancies.Inmost\nFindings HelpResearcherTracethe\nBreastcancer\nMovement of PeopleandDisease\ncases,however,signs ofcancereventuallyreturn.\nTheHeart Has ItsOwn'Brain\nThisstudyproposedthatinhibitingEZH2mighthelp\nenhance the potency and durability of these\nUncoveredaMysteryof'Electron Carrier\nExisting inAllLivingOrganisms:Discoveryofa\nimmunotherapies.EZH2is an enzyme that normally helps\n'Nano-SwitchMechanism'Controlledbya\nprogramcellbehaviorbycontrollingtheexpressionof\nSingle HydrogenAtom\nspecificgenes.MutationsintheEZH2gene,whichmakes\nMIND&BRAIN\ntheenzymemore active,arenow recognized as common\nResearchers'See'Vulnerability to Gaming\nfeatures of lymphomas, and inhibiting this enzyme has\nAddiction in theAdolescent Brain\nbeen found to benefit lymphoma patients even when they\nScientists Create Al That'Watches'Videos by\nhave non-mutant EZH2.\nMimicking theBrain\nIn2020,the United StatesFood and DrugAdministration\nScientists Identify Brain Cell Type as Master\napproved an EZH2 inhibitor calledtazemetostatforuse in\nControllerof Urination\npatients withfollicular lymphoma that has relapsed or not\nLIVING&WELL\nresponded to standard treatments.Asecond EZH2\ninhibitor,valemetostat, was approved in Japan in 2022for\nDogs Use Two-Word Button Combos to\nCommunicate\nthe treatment of patients with relapsed or refractory adult\nGaming for the Good!\nT-celleukemia/lymphoma.\nAl Headphones Create a'Sound Bubble,\nResearchbyDr.Beguelinand othershasshownthat\nQuietingAll SoundsMoreThanaFewFeet\nEZH2activitymakes lymphoma cells less visibleto the\nAway\nimmune system,andgenerallyhelpscreatean\nimmunosuppressiveenvironmentaroundlymphomas.\nEZH2 inhibitionwould reversethis immunosuppression,\nenhancing theactivities of patients'own anticancerT cells\nhurosuppression,\nenhancing the activities of patients'own anticancer T cells\nas well as T-cell immunotherapies.\nSuitablepreclinical animalmodelstotestthishypothesis\nhave not been available,so Dr.Beguelin and her\ncolleagues startedbydeveloping a new mousemodel for\nfollicularlymphoma and a tumor lineforthemore common\nand aggressive diffuse large B-cell lymphoma.The\nresearchersthendetailedchangesintheselymphomas\nduringtreatmentwithEZH2inhibitorsand/ortwoT-cell\nbased immunotherapies -- one a CAR-T cell therapy and\nthe other a\"bispecific antibody\"therapy that binds\nlymphomacellstothepatients'ownTcells.\nTheresultsshowedthat EZH2inhibitionon itsown\nenhanced thekillingof lymphoma cellsbyT cells,andthat\npretreatment with an EZH2 inhibitor could greatly improve\nthe effectiveness of T cell immunotherapies against these\nlymphomas. In one experiment, treatment with\ntazemetostat plus CAR-Tcells enabled 100%of miceto\nsurviveforthe 40-day study periodandbeyond,whereas\nmostdiedwithin11daysafterthesamedoseofCAR-T\ntreatment alone.Resultsforvalemetostat plus CAR-T\ntreatmentweresimilar.EZH2inhibition combinedwith\nbispecificantibody treatment also greatly boosted survival\noverbispecificantibodytreatmentalone.\nThe researchers found that EZH2 inhibition boosted these\nimmunotherapies'effectsnotjustbymakinglymphoma\ncells more visible to them, but also bymultiple other\nmechanisms,includingreductionofimmunosuppressive\nregulatoryT-cells,and reprogrammingofanticancerT\ncells in a way that makes their activity more durable.\nIn addition to theirclinical trial-based work,the\nresearchersarecontinuing tostudy howEZH2 inhibition\nboosts anticancer T cells, and this research could\nBeguelin, who isalsoamemberof theSandra and\nEdwardMeyerCancerCenteratWeill Cornell Medicine.\nStory Source:\nMaterials provided byWeill Cornell Medicine.Note:Content maybeedited for style and\nlength.\nJournal Reference:\n1.Isshiki,Yusukeetal.EzH2 inhibition enhances Tcell immunotherapies by\ninducing lymphoma immunogenicity and improving T cellfunction.Cancer Cell,\nCite This Page.\nMLA\nAPA\nChicago\nWeill Cornell Medicine.\"Anticancer drugs could make immunotherapies more effective.\"\nScienceDaily.ScienceDaily,6December2024.www.sciencedaily.com/releases/2024/12\n/241205142530.htm>\nExploreMore\nfromScienceDaily\nRELATEDSTORIES\nMetabolicReprogramming of TCells May EnhanceCheckpoint InhibitorTherapy\nSep.26,2024Stimulating a keymetabolic pathway in T cells can make them work\nmore effectively against tumors when combined with immune checkpoint inhibitortherapy,\naccording to a preclinical study.The...\nPopular Breast Cancer Drugs Don't Work the Way We Thought TheyDid\nFeb.3,2021Newresearchsuggeststhata classofdrugs calledPARPinhibitors,\ndesigned to treat hereditaryforms of ovarian and breast cancer, don't work the way we\nthought they did. It also paints a fuller..\nA BoostforCancer Immunotherapy\nJune 1,2020-MiT engineers have found a waytoboost the effectiveness of cancer\nimmunotherapydrugscalled checkpoint inhibitors.They showed that if they treated mice\nwiththesedrugs alongwith new...\nMissingBAP1 GeneAssociatedWithImmunosuppressiveMolecules inUveal\nMelanoma", "live": "ScienceDaily\nFollow.\nSubscribe:\nYour source for the latest research news\nNew! Sign upfor ourfree email newsletter.\nSD\nQuirky →\nSociety\nHealth \nTech \nEnviro\nSearch\nScience News\nfromresearchorganizations\ne Print\nEmail\nShare\nAnticancerdrugs could make immunotherapies more\nBreaking\nthis hour\neffective\n>FireSalamanders Havea Secret Glow\nDate:December9,2024\n>ScientistsDiscovera LostVolcanicSystem\nSource:Weill Cornell Medicine\n>TheHiddenTriggerBehind Earth's IceAges\nSummaryAn emerging class of anticancer drugs called EZH2 inhibitors may greatly\n>SurprisingRadiationLevels NeartheMoon\nenhance the potency of some cancerimmunotherapies.\nHowAutistic Brains ProcessFaces Differently\nShare:\n>HowAnts ConqueredtheWorld\nin\n>ImmuneCellsHaveaHiddenSenseofTouch\nCommonDrugsCan HelpViruses Spread\nRELATEDTOPICS\nFULL STORY\n>ALavaPlanetWitha GiantSunscreen\nScientistsRecreatetheEarlyUniverse\nHealth&Medicine\nAn emerging class of anticancerdrugs called\nEZH2 inhibitors may greatly enhance the\nTrending Topics\nLeukemia\nthis week\npotency of some cancerimmunotherapies,\n>Lymphoma\nHEALTH&MEDICINE\naccording to a preclinical study led by Weill\n）Pharmacology\nCornell Medicine lymphoma researchers.\nImmune System\n>Pharmaceuticals\nPersonalized Medicine\nThe inhibitors target the EZH2 enzyme, whose activity in\nPharmacology\n>ImmuneSystem\ntumor cells is now recognized as a significant factor in\nMIND&BRAIN\n>WorkplaceHealth\nmanycancers.Thestudy,publishedDec.5inCancer\nCell, found that EZH2 inhibition combined with T-cell\nIntelligence\nDiseases and\nbased immunotherapy worked better at shrinking non-\nConditions\nSocial Psychology\nHodgkin B-cellymphomas than immunotherapy alone.\nDepression\n>Foodborne Illness\n\"These encouraging preclinical results have prompted us\nLIVING&WELL\nto initiate pilot studies of an EZH2 inhibitor with\nRELATEDTERMS\nimmunotherapiesin lymphoma patients,\"said senior\nFitness\nauthor Dr.Wendy Beguelin, John P.Leonard,\nNutrition\nCancer\nMD/GwirtzmanFamilyResearchScholarinLymphoma\nand anassistant professorof pharmacology in medicineat\nSkinCare\n>Anti-obesity drug\nWeill Cornell Medicine.\nChemotherapy\nThe first author of the study is Dr.Yusuke Isshiki,a\nStrange &Offbeat\n>Colorectalcancer\npostdoctoralfellow in thelaboratoriesofDr.Beguelin and\nDr.Ari Melnick,theLaurel GebroeFamilyProfessorof\nHEALTH&MEDICINE\n>Analgesic\nHematologyiOncologyatWeillCornell Medicine.\nASimpleDailyFiberSupplementReduced\n>Pharmaceutical\nArthritisPainand Improved Strength\nT-cell-based immunotherapies,including engineered\ncompany\nanticancerTcells called CAR-Tcells,havebeeneffective\nASimpleLiquid Can Stop Cavities Without\nDrilling.Major Study Confirms\n>Antiviral drug\natreducing or eliminating signsofcancer in some patients\nwithlymphomasandotherbloodmalignancies.Inmost\nCould Lowering HighBlood PressureBeas\n>Stomachcancer\nSimple as Stimulating Your Ear?\ncases,however,signs ofcancer eventuallyreturn.\nMIND&BRAIN\nThisstudyproposedthatinhibitingEZH2mighthelp\nenhance the potency and durability of these\nThisMysteriousMushroomMakesPeopleSee\nHundreds of Tiny Humans\nimmunotherapies.EZH2is an enzyme that normally helps\nScientists Win 2026 Nobel Prize for Controlling\nprogramcellbehaviorbycontrollingtheexpressionof\nBrainCells With Light\nspecificgenes.Mutations intheEZH2gene,whichmakes\ntheenzymemoreactive,arenowrecognizedascommon\nModernNeuroscienceIsRediscoveringa\nSurprising Idea Freud Had 130Years Ago\nfeatures of lymphomas, and inhibiting this enzyme has\nbeen found to benefit lymphoma patients even when they\nLIVING&WELL\nhave non-mutant EZH2.\nScientistsTested39Sweetenersand\nUncoveredSurprising Gut Effects\nIn2020,the United StatesFood and DrugAdministration\napproved an EZH2 inhibitor calledtazemetostatforuse in\nThe Secret to Easier Exercise as an Adult May\nStart in Childhood\npatients withfollicular lymphoma that has relapsed or not\nresponded to standard treatments.Asecond EZH2\nPopular Weight LossDrugs Linked toa\nSurprisingFingernail Problem\ninhibitor,valemetostat,wasapproved inJapanin2022for\nthe treatment of patients with relapsed or refractory adult\nT-celleukemia/lymphoma.\nResearchbyDr.Beguelinand othershasshownthat\nEZH2activitymakes lymphoma cells lessvisibleto the\nimmune system,andgenerallyhelpscreatean\nimmunosuppressiveenvironmentaroundlymphomas.\nEZH2 inhibition would reversethis immunosuppression,\nenhancing theactivities of patients'own anticancerT cells\nnurosuppression,\nenhancing the activities of patients'own anticancer T cells\nas well as T-cell immunotherapies.\nSuitablepreclinical animalmodelstotestthishypothesis\nhave not been available,soDr.Beguelin and her\ncolleagues startedbydeveloping a new mousemodel for\nfollicular lymphoma and a tumor line for themore common\nand aggressive diffuse large B-cell lymphoma.The\nresearchers then detailed changes in these lymphomas\nduringtreatmentwithEZH2inhibitorsand/ortwoT-cell\nbased immunotherapies -- one a CAR-T cell therapy and\nthe other a\"bispecific antibody\"therapy that binds\nlymphomacellstothe patients'ownTcells.\nTheresults showed that EZH2 inhibition on itsown\nenhanced thekillingof lymphoma cellsby T cells,andthat\npretreatment with an EZH2 inhibitor could greatly improve\nthe effectiveness of T cell immunotherapies against these\nlymphomas. In one experiment, treatment with\ntazemetostat plus CAR-T cells enabled 100%of miceto\nsurviveforthe 40-day study periodandbeyond,whereas\nmostdiedwithin11daysafterthesamedoseofCAR-T\ntreatmentalone.ResultsforvalemetostatplusCAR-T\ntreatmentweresimilar.EZH2inhibitioncombinedwith\nbispecific antibody treatment also greatly boosted survival\noverbispecificantibodytreatmentalone.\nThe researchers found that EZH2 inhibition boosted these\nimmunotherapies'effects not justbymakinglymphoma\ncells more visible to them, but also bymultiple other\nmechanisms,includingreductionofimmunosuppressive\nregulatoryT-cells,and reprogramming ofanticancerT\ncells in a way that makes their activity more durable.\nIn additionto theirclinical trial-based work,the\nresearchersarecontinuing tostudy how EZH2 inhibition\nboosts anticancer T cells, and this research could\nBeguelin, who isalsoamemberof theSandra and\nEdwardMeyerCancerCenteratWeill Cornell Medicine.\nStory Source:\nMaterials provided byWeill Cornell Medicine.Note:Content maybeedited forstyle and\nlength.\nJournal Reference:\n1.Isshiki,Yusukeetal.EzH2 inhibition enhances Tcell immunotherapies by\ninducing lymphoma immunogenicity and improving T cellfunction.Cancer Cell,\nCite This Page.\nMLA\nAPA\nChicago\nWeill Cornell Medicine.\"Anticancer drugs could make immunotherapies more effective.\"\nScienceDaily.ScienceDaily,9December2024.www.sciencedaily.com/releases/2024/12\n/241205142530.htm>\nExplore More\nfrom ScienceDaily\nRELATEDSTORIES\nThis“chaos Enzyme\"MayHoldtheKeyto StoppingCancer Spread\nOct.4,2025AWeill Cornell Medicine team has found that triple-negativebreast cancer\ndependsontheenzymeEZH2tospread.Bysilencingkeygenes,EZH2driveschaotic\ncell divisions andfuelsmetastasis...\nMetabolic Reprogramming of T Cells May Enhance Checkpoint Inhibitor Therapy\nSep.26,2024Stimulatingakey metabolic pathway in Tcells can make themwork\nmore effectively against tumors when combinedwith immune checkpoint inhibitortherapy,\naccording to a preclinical study. The...\nWhole Exome Sequencing Predicts WhetherPatients Respond to Cancer\nImmunotherapy\nJuly8,2022Immunotherapies,suchas immunecheckpointinhibitors,have\ntransformed the treatment of advanced stage cancers. Unlike chemotherapies that kill\ncancer cells, these drugs help the body's immune ..\nSome Blood Pressure Medicine May Decrease the Aneurysm Rupture Risk for\nPeopleWithHighBloodPressure" } }, { "id": "ezh2-newsmedical", "study": "melnick", "outlet": "News-Medical", "outlet_original": "News-Medical", "outlet_score": 5, "title": "EZH2 inhibitors enhance effectiveness of cancer immunotherapies", "title_original": "EZH2 inhibitors enhance effectiveness of cancer immunotherapies", "language": "English", "date": "2024-12-05", "kind": "news", "url": "https://www.news-medical.net/news/20241205/EZH2-inhibitors-enhance-effectiveness-of-cancer-immunotherapies.aspx", "archive_url": "https://web.archive.org/web/20241206180714/https://www.news-medical.net/news/20241205/EZH2-inhibitors-enhance-effectiveness-of-cancer-immunotherapies.aspx", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports a preclinical study showing EZH2 inhibitors can substantially strengthen T-cell based immunotherapy against non-Hodgkin B-cell lymphomas, with pilot clinical studies starting.", "topics": [ "ezh2 inhibitors", "immunotherapy", "lymphoma", "cancer cell" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/ezh2-newsmedical.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/ezh2-newsmedical--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/ezh2-newsmedical.txt", "ocr_text": { "archived": "Becomea Member\nMEDICALHOME\nLIFESCIENCES HOME\nAnAZoNetworkSite\nQ Search...\nMEDICAL\nWhite Papers\nCOVID-19\nAbout\nLIFE SCIENCES\nNews\nHealthA-Z\nDrugs\nMedical Devices\nInterviews\nMore...\nTrending\nLatest\nTop Health\nStories\nInterviews\nArticles\nScientists uncover coffee's\nsurprising effect on gut\nmicrobiota\nCovid-19may raise risk of\ndeveloping multiple sclerosis\nReinstatingmasking curbs\nhospital viral outbreaks,\nstudy confirms\nResearchersdiscovernew\ncauseofcytokinestorm in\nCOVID-19\nEZH2inhibitorsenhanceeffectivenessof\ncancerimmunotherapies\nVisceral fatfoundto\ncontributeto Alzheimer's\nDownload PDF Copy\n国Reviewed\ndisease development\nWeill Cornell Medicine\nDec52024\n0100/100\nLatest News\nAn emerging class of anticancer drugs called EzH2 inhibitors maygreatly enhancethe\npotencyof somecancerimmunotherapies,accordingtoapreclinical studyledbyWeill\nResearchersmapneural\nCornell Medicinelymphomaresearchers.\npathwaysinvolved in\nresponse inhibition\nThe inhibitors target the EZH2 enzyme,whose activity in tumor cells is now recognized as\na significantfactor in manycancers.The studypublished Dec.5 in Cancer Cell,found that\nEZH2 inhibition combined withT-cell based immunotherapy worked better at shrinking\nAreduction in BMI among\nnon-HodgkinB-cell lymphomasthan immunotherapyalone.\nadults isassociated with\nlower health care spending.\nstudy suggests\nof an EZH2 inhibitor with immunotherapies in lymphoma patients.\"\nAl-enhancedmammography\nimprovescancerdetectionin\nDr.WendyBeguelin,seniorauthor,JohnP.Leonard,MD/GwirtzmanFamily\nself-payprogram\nmedicineatWeill Cornell Medicine\nResearchersdiscovernew\npathway toforming long-\nThefirst author of thestudy isDr.Yusuke Isshiki,a postdoctoralfellow inthelaboratories\ntermmemories inthebrain\nof Dr.BeguelinandDr.Ari Melnick,theLaurelGebroeFamilyProfessorof\nHematology/OncologyatWeill Cornell Medicine.\nMore plant protein,less\nT-cell-based immunotherapies,including engineered anticancerT cells called CAR-T cells,\nanimal protein tied to lower\nhave been effective at reducing or eliminating signs of cancer in some patients with\nheart diseaserisk,notstroke\nlymphomasandotherbloodmalignancies.Inmostcases,however,signsofcancer\neventually return.\nNewsletters you may be\nThisstudyproposed that inhibitingEZH2mighthelpenhancethepotencyanddurability\ninterested in\nof these immunotherapies.EzH2 is an enzyme that normally helps program cell behavior\nbycontrollingtheexpressionofspecificgenes.Mutations inthe EzH2gene,whichmakes\nPharmacy/Pharmacology\nthe enzymemore active,are now recognizedas commonfeatures of lymphomas,and\n(Subscribe or Preview)\ninhibiting this enzymehas beenfoundto benefit lymphoma patients evenwhen theyhave\nnon-mutant EZH2.\nHematology\nIn2020,theUnited StatesFoodandDrugAdministrationapprovedanEZH2inhibitor\n(Subscribe or Preview)\ncalledtazemetostatforuse inpatientswithfollicularlymphoma that hasrelapsedornot\ncalledtazemetostatforuse inpatients withfollicularlymphoma that has relapsed ornot\nresponded to standard treatments.Asecond EZH2 inhibitor,valemetostat,was approved\nOncology\nin Japan in 2022 for thetreatmentof patients with relapsed or refractoryadult T-cell\n(Subscribe orPreview)\nleukemia/lymphoma.\nResearchbyDr.Beguelinand others has shown thatEZH2activitymakes lymphoma cells\nSeeallNewsletters\"\nenvironmentaround lymphomas.EzH2inhibition would reversethis immunosuppression,\nenhancing theactivities of patients'own anticancerT cells as wellas T-cell\nimmunotherapies.\nSuitable preclinical animal models to test this hypothesis have not been available, so Dr.\nBeguelinandhercolleagues startedbydevelopinga newmousemodelforfollicular\nlymphoma and a tumor lineforthemore common and aggressive diffuselarge B-cell\nlymphoma.The researchers then detailed changes intheselymphomas during treatment\nwith EZH2 inhibitors and/or two T-cell based immunotherapies-one a CAR-Tcell therapy\nand the othera\"bispecific antibody\"therapythat binds lymphoma cells to the patients\nown T cells.\nTheresults showed that EZH2 inhibition on its own enhancedthekillingoflymphoma cells\nbyT cells, and that pretreatmentwith an EzH2 inhibitor could greatly improve the\neffectiveness of T cell immunotherapies against these lymphomas. In one experiment,\ntreatment withtazemetostat plus CAR-T cells enabled 100%ofmice to survivefor the40-\nday study period and beyond, whereas most died within 11 days after the same dose of\nCAR-Ttreatmentalone.Resultsfor valemetostat plus CAR-T treatment were similar.EZH2\ninhibition combinedwithbispecificantibodytreatmentalsogreatlyboostedsurvival over\nbispecific antibody treatment alone.\nThe researchers found that EZH2 inhibition boostedthese immunotherapies'effects not\njustbymakinglymphomacellsmorevisibletothem,butalsobymultipleother\nmechanisms,includingreductionofimmunosuppressiveregulatoryT-cells,and\nreprogramming of anticancer T cells in a way that makes their activity more durable.\nIn addition to their clinical trial-based work,the researchers are continuing to study how\nEZH2 inhibitionboosts anticancerTcells,andthisresearch could somedayyieldmore\nprecise therapeutic targets, said Dr.Beguelin,who is also a member ofthe Sandra and\nEdwardMeyerCancerCenteratWeill CornellMedicine.\nSource:\nWeill CornellMedicine\nJournal reference:\nIsshiki, Y., et al. (2024) EZH2 inhibition enhances T cell immunotherapies by inducing\nlymphoma immunogenicityand improvingT cell function.Cancer Cell.\ndoi.0rg/10.1016/j.ccell.2024.11.006.\nBe the first to rate this article\n★★★★\nPosted in:Medical ResearchNewsIMedical Condition News\nTags:ntibodyBipcificantbodyBloodCancCellClinicalrial,ugs,nzymeFollicul\nLymphoma,Food,Gene,Genes,Hematology,ImmuneSystem,Immunosuppression,Immunotherapy\nLeukemiaLymphNode,Lymphoma,Medicine,MouseModel,Oncology.Pharmacology.Preclinical\nResearch,T-Cell,Tumor\nComments(0)\nDownload PDF Copy\nSuggested Reading\nNanozyme\nSquid-inspired\nExpanding access to\nExpanded access to\nbreakthroughoffers new technology couldreplace GLp-1weight-loss drugsweight-loss drugs could\nhopeforviral\nneedles formedicationscould savethousands of savethousands of lives\npneumonia treatment\nand vaccines\nlives", "live": "MEDICALHOME\nLIFESCIENCES HOME\nAnAZoNetworkSite\nBecomea Member\nQ Search...\nMEDICAL\nWhite Papers\nDrugs\nAbout\nFunctional Food\nLIFE SCIENCES\nNews\nHealthA-Z\nMedical Devices\nInterviews\nMore...\nTrending\nLatest\nTop Health\nStories\nInterviews\nArticles\nBeer,wine or spirits: Alarge\nstudy finds different\nmortalitypatternsforeach\nPsilocybinreshapesbrain\nconnections through distinct\ncellular pathways\nHigh intake ofsaturatedfat\ncan promote favorable\nchanges in cardiovascular\nriskmarkers\nStudy links recreational\ncannabis legalization to rising\nheartattackadmissions\nEZH2inhibitorsenhanceeffectivenessof\ncancer immunotherapies\nFruitsandvegetablesmaybe\nAdd News Medical on Google\nabetteroptionto improve\nDownload PDF Copy\nas a preferred source\nkidneydiseaseoutcomes\nWeill Cornell Medicine\nDec52024\nReviewed\nAn emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the\nLatest News\npotencyofsomecancer immunotherapies,accordingtoapreclinical studyledbyWeill\nUCSF scientists develop\nCornellMedicinelymphomaresearchers.\nsmart CAR-T cells to fight\nchildhood braintumors\nThe inhibitorstargetthe EZH2enzyme,whoseactivity intumor cellsis nowrecognized as\na significantfactorinmany cancers.The study,publishedDec.5inCancerCell,found that\nEZH2 inhibition combined with T-cell based immunotherapy worked better at shrinking\nStudy shows income gaps\ndrive disparities in universal\nhealthcareaccess\nSign in to keep reading\nInflammatorymacrophages\nWe're committed to providing free access to quality science.By registering and\nidentified as drivers of\nproviding insight into your preferences you're joininga community of over 1m\nchronic joint osteoarthritis\nscience interested individuals and helpus to provideyou withinsightful content\nwhilst keeping our service free.\nResearchersidentifyprotein\nSign in with Google\nthat drives chronic\ninflammation in psoriasis\nSign in with Apple\nHuman challenge study\nSign in with Linkedin\nreveals how preexisting\nimmunityaffectsdengue\nSign in with Facebook\nor\nNewsletters you may be\ninterested in\nSign in with email\nPharmacy&Pharmacology\n(Subscribe or Preview)\nPosted in:Medical ResearchNewsIMedical Condition News\nComments (0)\nHematology\n(SubscribeorPreview)\nDownload PDF Copy\nDownload PDF Copy\nSuggested Reading\nOncology\n(Subscribe or Preview)\nSeeallNewsletters\nMillions get GLP-1 drugs\nResearchers linkGLP-1\nWhyaddiction\nGLP-1 drugs may\nthrough channels\ndrugs to lower\nresearchers arepaying\ninfluence chronic pain\ninsurancerecordsmay\ntuberculosisrisk intype\ncloserattentionto GLP-1 through gut-brainand\ndrugs\nmiss\n2 diabetes\nimmunepathways\nGLP-1 drugs looked\nGLP-1 drugs may\nIs there a best day to\nGLP-1 drugs have\npromising for\ntake GLP-1 drugs?\nreshape obesity care,\nbenefitsbeyondweight\nbut clinicians still have\ndepression.The\nResearchers lookedfor\nloss.Couldmicrodoses\nevidence tells a more\nquestions\nananswer\npreserve them?\ncomplicated story\nComments\nThe opinions expressed here are theviews ofthewriterand do not necessarily reflect the views and\nopinions ofNews Medical.\nPostanewcomment\nLogin\nQuirkyCommentTitle(optional)\nPost\nONewsGuard1oo/100\nHigh Credibility:Thiswebsiteadheresto allninestandards of credibility and transparency.\nTrusted\nTRUSTe\nInformation\nCYBER\nCreator\nESSENTIALS\nPLUS\nPatient InformationForum\nMedical Links\nLife Sciences Links\nOtherUseful Links\nOtherAZoNetwork Sites\nLife Sciences Home\nAbout\nMedical Home\nAZoM\nFunctional Food\nNews\nMeet the Team\nAZoNano\nNews\nLabInstruments &Equipment\nSearch\nAZoCleantech\nHealth A-Z\nNewsletters\nLife Sciences A-Z\nAZoOptics\nWhite Papers\nWhite Papers\nSitemap\nAZoRobotics\nThought Leaders\nThought Leaders\nAdvertise\nAZoSensors\nInsights\nInsights\nContact\nAZoMining\nMediknowledge Series\nWebinars\nTerms&Conditions\nAZoQuantum\nPrivacy&CookiePolicy\nHealth&Personal Care\neBooks\nAZoBuild\nMedicalDevices\nContent Policy\nPosters\nAZoLifeSciences\nDrugs\nPodcasts\nOwnership&FundingInformation\nAZoAi\neBooks\nVideos\nPosters\nPodcasts\nVideos\nEWS\nNews-Medical.Netprovidesthismedical informationservice inaccordancewiththeseterms and conditions,Please\nMEDICAL\npatientand physician/doctorand themedicaladvicetheymayprovide.\nLIFE SCIENCES\nUpdateYour PrivacyPreferences\nLastUpdated:Wednesday28Oct2026\nAZO\nNETWORK" } }, { "id": "ezh2-gen", "study": "melnick", "outlet": "GEN (Genetic Engineering & Biotechnology News)", "outlet_original": "GEN (Genetic Engineering & Biotechnology News)", "outlet_score": 6, "title": "Lymphoma Immunotherapy Enhanced by Enzyme Inhibitor in Preclinical Model, Prompting Pilot Clinical Studies", "title_original": "Lymphoma Immunotherapy Enhanced by Enzyme Inhibitor in Preclinical Model, Prompting Pilot Clinical Studies", "language": "English", "date": "2024-12", "kind": "news", "url": "https://www.genengnews.com/topics/cancer/lymphoma-immunotherapy-enhanced-by-enzyme-inhibitor-in-preclinical-model-prompting-pilot-clinical-studies/", "archive_url": "https://web.archive.org/web/20241212101819/https://www.genengnews.com/topics/cancer/lymphoma-immunotherapy-enhanced-by-enzyme-inhibitor-in-preclinical-model-prompting-pilot-clinical-studies/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Biotech news coverage of mouse-model work indicating EZH2 inhibition makes T-cell immunotherapy more effective against B-cell non-Hodgkin lymphoma, leading to pilot clinical studies.", "topics": [ "ezh2 inhibitors", "immunotherapy", "lymphoma", "mouse models" ], "audience": "trade", "thumbnail": "media-archive/thumbs/ezh2-gen.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/ezh2-gen--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/ezh2-gen.txt", "ocr_text": { "archived": "GEN\nGenetic Engineering\n&Biotechnology News\nGEN Edge\nNews\nMultimediay\nTopics\nMagaziney\nResourcesy\nSubscribe\nHomeTopics>Cancer>Lymphoma Immunotherapy Enhancedby Enzyme Inhibitor In Preclinical Model,Prompting Pilot Cilinical.\nLymphoma Immunotherapy Enhanced\nby Enzyme Inhibitor In Preclinical Model,\nPrompting Pilot Clinical Studies\nDecember 8, 2024\nSource:SCIENCEARTWORK/SCIENCEPHOTOLIBRARY/GettyImages\nThe results of a preclinical study by lymphoma researchers at Weill Cornell Medicine\nsuggest that an emerging class of anticancer drugs called EZH2 inhibitors may greatly\nenhance the potency of some cancer immunotherapies.\nRelated Content\nEZH2 enzyme activity in tumor cells is recognized as a significant factor in many cancers.\nThe newly reported study, including work in mouse models, found that combining T-cell.-\nStandardizing CGT Supply Chain\nManagement\nbased immunotherapy with EZH2 inhibition was more effective at shrinking B-cell non-\nHodgkin lymphomas (B-NHL) than immunotherapy alone.\nPatientGlioblastomaResponse\n\"These encouraging preclinical results have prompted us to initiate pilot studies of an\nto CAR-T Cell Therapy Mirrored\ninTumor-DerivedOrganoidsin\nEZH2 inhibitor with immunotherapies in lymphoma patients,\" said Wendy Beguelin, PhD,\nReal Time\nthe John P. Leonard, MD/Gwirtzman Family Research Scholar in Lymphoma and an\nKillerT Cells Programmed for\nassistant professor of pharmacology in medicine at Weill Cornell Medicine.\nTissue-andTumor-Specific\nTargeting\nSenior author Beguelin, together with colleagues including first author Yusuke Isshiki,\nPhD, a postdoctoral fellow in the laboratories of Beguelin and Ari Melnick, MD, the Laurel\nGoing Public:Doudna's Dream\nTeamLaunchesGroundbreaking\nGebroe Family Professor of Hematology/Oncology at Weill Cornell Medicine, reported\nSickle Cell Trial\ntheir findings in Cancer Cell, in a paper titled, \"EZH2 inhibition enhances I cell\nimmunotherapies by inducing lymphoma immunogenicity and improving T cell function.\"\nIn their paper, the team confirmed that their therapeutic approach is being evaluated in two\nIn their paper, the team confirmed that their therapeutic approach is being evaluated in two\nclinical trials investigating immunotherapy outcomes in B-cell lymphoma patients.\nT-cell-based immunotherapies, including CAR-T cells, have been effective at reducing or\neliminating signs of cancer in some patients with lymphomas and other blood\nRead theDigital Edition\nmalignancies. In most cases, however, signs of cancer eventually return. \"Chimeric antigen\nreceptor (CAR) T cell therapy targeting CD19 has transformed the treatment of refractory\nB-cell non-Hodgkin's lymphomas (B-NHL), including diffuse large B cell lymphoma \nSuper-Res Microscopy\n(DLBCL) and multiply relapsed follicular lymphoma (FL),\" the team wrote. \"However, only\nMoreThanPrettyPictures\n30-40% of DLBCL and FL patients maintain durable complete remission after five years.\"\n10\ncompanit\nexpression of specific genes. Mutations in the EZH2 gene, which makes the enzyme more\nactive, are now recognized as common features of lymphomas, and inhibiting this enzyme\nhas been found to benefit lymphoma patients even when they have non-mutant EZH2.\nAn EZH2 inhibitor called tazemetostat was approved by the FDA in 2020 for use in patients\nwith follicular lymphoma that has relapsed or not responded to standard treatments. A\nsecond EZH2 inhibitor, valemetostat, was approved in Japan in 2022 for the treatment of\npatients with relapsed or refractory adult T-cell leukemia/lymphoma.\nResearch by Beguelin and others has shown that EZH2 activity makes lymphoma cells less\nvisible to the immune system, and generally helps to create an immunosuppressive\nenvironment around lymphomas.\"In established lymphomas, EZH2 promotes immune\nevasion by silencing major histocompatibility complex (MHC) expression, hindering\ntumor-T cell interactions,\" the investigators wrote.\nThe newly reported study proposed that inhibiting EZH2 might help enhance the potency\nand durability of immunotherapies.\"We hypothesized that EZH2 inhibitors can restore\ninteractions of lymphoma B cells with T cells beyond MHC-dependent interactions, and\nthat combining EZH2 inhibitors with T cell immunotherapies may enhance tumor\nrecognition and elimination.\"\nSuitable preclinical animal models to test this hypothesis have not been available, so\nBeguelin and her colleagues started by developing a new mouse model for follicular\nlymphoma and a tumor line for the more common and aggressive diffuse large B-cell\nlymphoma. The researchers then detailed changes in these lymphomas during treatment\nwith EZH2 inhibitors and/or two I-cell-based immunotherapies -one a CAR-T cell therapy\nand the other a bispecific antibody therapy (CD20xCD3) that binds lymphoma cells to the\npatients' own T cells.\n\"Despite the different pathways for target recognition and engagement, both CD20xCD3\nbispecific antibodies and CD19 CAR-T therapies ultimately rely on the activation of T cells\nto exert their anti-tumor effects,\" the investigators noted. \"... we evaluated the combination\nof EZH2 inhibitor tazemetostat with CD20xCD3 T cell engaging bispecific antibody or\nCD19 CAR-T cells (CAR-T19).\"\nThe results showed that EZH2 inhibition on its own enhanced the killing of lymphoma cells\nby T cells, and that pretreatment with an EZH2 inhibitor could greatly improve the\neffectiveness of T-cell immunotherapies against these lymphomas. \"We investigated EZH2\ninhibition in combination with both therapies, showing its potential to reduce the\nimmunosuppressive properties of the TME and improve T cell-mediated killing,\" the\nresearchers commented.\"\nIn one experiment, treatment with tazemetostat\nplus CAR-T cells enabled 100% of mice to survive\nLymph node\nfor the 40-day study period and beyond, whereas\nmost died within 11 days after the same dose of\nCAR-T cell treatment alone. Results for\nvalemetostat plus CAR-T treatment were similar.", "live": "GEN\nGenetic Engineering\n&BiotechnologyNews\nMultimediay\nTopics v\nResourcesV\nSubscribev\nGEN EdgeV\nContent V\nMagazinev\nLymphoma Immunotherapy Enhanced by\nEnzyme Inhibitor In Preclinical Model,\nPrompting Pilot Clinical Studies\nDecember 8, 2024\nSource: SCIENCEARTWORK/SCIENCE PHOTO LIBRARY/Getty Images\nThe results of a preclinical study by lymphoma researchers at Weill Cornell Medicine\nBCG Vaccine-Induced Trained Immunity May\nHelpProtect AgainstDementia\ngreatly enhance the potency of some cancer immunotherapies.\nEQTtoAcquireQiagenforS12.1B,Plansto\nEZH2 enzyme activity in tumor cells is recognized as a significant factor in many\nTakeTools,DiagnosticsProviderPrivate\ncancers. The newly reported study, including work in mouse models, found that\nHowAlzheimer's RiskGeneAPOE4Disrupts\ncombining T-cell-based immunotherapy with EZH2 inhibition was more effective at\nMyelination\nshrinking B-cell non-Hodgkin lymphomas (B-NHL) than immunotherapy alone.\nDiasome'sHDV-Insulin forT1D Finalizing\nPhase Ill PlansAfterPromisingData\n\"These encouraging preclinical results have prompted us to initiate pilot studies of\nAnthropicIPoDisclosesPlansforLife\nSciencesGrowth\nBeguelin, PhD, the John P. Leonard, MD/Gwirtzman Family Research Scholar in\nLymphoma and an assistant professor of pharmacology in medicine at Weill Cornell\nResources\nMedicine.\nRecommendedForYou\nSenior author Beguelin, together with colleagues including first author Yusuke\nIsshiki, PhD, a postdoctoral fellow in the laboratories of Beguelin and Ari Melnick,\nMD, the Laurel Gebroe Family Professor of Hematology/Oncology at Weill Cornell\nMedicine, reported their findings in Cancer Cell, in a paper titled, \"EZH2 inhibition \nMedicine, reported their findings in Cancer Cell, in a paper titled, \"EZH2 inhibition\nenhances T cell immunotherapies by inducing lymphoma immunogenicity and\napproach is being evaluated in two clinical trials investigating immunotherapy\noutcomes in B-cell lymphoma patients.\nVitaminDerivativePantethineAlleviatesPsoriasis\nSymptoms in Small HumanTrial\nT-cell-based immunotherapies, including CAR-T cells, have been effective at\nreducing or eliminating signs of cancer in some patients with lymphomas and other\nArtivaAxes94%ofWorkforce,WeighsStrategic\nAlternatives After Two Patients in Phase lla Trial\nblood malignancies. In most cases, however, signs of cancer eventually return.\nDie\n\"Chimeric antigen receptor (CAR) T cell therapy targeting CD19 has transformed the\ntreatment of refractory B-cell non-Hodgkin's lymphomas (B-NHL), including diffuse\nBonjour Genomics:AVideofromASHG\nlarge B cell lymphoma (DLBCL) and multiply relapsed follicular lymphoma (FL),\"\nthe team wrote. \"However, only 30-40% of DLBCL and FL patients maintain durable\nASHG:Nabsys Links Cytogenetics and Genomics\ncomplete remission after five years.\"\ntoMapHematologicCancers\nEZH2 is an enzyme that normally helps program cell behavior by controlling the\nexpression of specific genes. Mutations in the EZH2 gene, which makes the enzyme\nmore active, are now recognized as common features of lymphomas, and inhibiting\nthis enzyme has been found to benefit lymphoma patients even when they have non-\nmutant EZH2.\nAn EZH2 inhibitor called tazemetostat was approved by the FDA in 2020 for use in\npatients with follicular lymphoma that has relapsed or not responded to standard\ntreatments. A second EZH2 inhibitor, valemetostat, was approved in Japan in 2022\nfor the treatment of patients with relapsed or refractory adult T-cell\nleukemia/lymphoma.\nResearch by Beguelin and others has shown that EZH2 activity makes lymphoma\ncells less visible to the immune system, and generally helps to create an\nimmunosuppressive environment around lymphomas.\"In established lymphomas,\nEZH2 promotes immune evasion by silencing major histocompatibility complex\n(MHC) expression, hindering tumor-T cell interactions,\" the investigators wrote.\nThe newly reported study proposed that inhibiting EZH2 might help enhance the\npotency and durability of immunotherapies. “We hypothesized that EZH2 inhibitors\ncan restore interactions of lymphoma B cells with T cells beyond MHC-dependent\ninteractions, and that combining EZH2 inhibitors with T cell immunotherapies may\nenhance tumor recognition and elimination.\"\nSuitable preclinical animal models to test this hypothesis have not been available, so\nBeguelin and her colleagues started by developing a new mouse model for follicular\nlymphoma and a tumor line for the more common and aggressive diffuse large B-cell\nlymphoma. The researchers then detailed changes in these lymphomas during\ntreatment with EZH2 inhibitors and/or two T-cell-based immunotherapies-one a\nCAR-T cell therapy and the other a bispecific antibody therapy (CD20xCD3) that \nbinds lymphoma cells to the patients' own T cells.\nactivation of T cells to exert their anti-tumor effects,\" the investigators noted. \".. we\nevaluated the combination of EZH2 inhibitor tazemetostat with CD20xCD3T cell\nengaging bispecific antibody or CD19 CAR-T cells (CAR-T19).\"\nThe results showed that EZH2 inhibition on its own enhanced the killing of\nlymphoma cells by T cells, and that pretreatment with an EZH2 inhibitor could\ngreatly improve the effectiveness of T-cell immunotherapies against these\nlymphomas.\"We investigated EZH2 inhibition in combination with both therapies,\nshowing its potential to reduce the immunosuppressive properties of the TME and\nimprove T cell-mediated killing,\" the researchers commented.\"" } }, { "id": "setd2-sciencedaily", "study": "melnick", "outlet": "ScienceDaily", "outlet_original": "ScienceDaily", "outlet_score": 6, "title": "Study reveals cause, potential precision therapies for aggressive type of lymphoma", "title_original": "Study reveals cause, potential precision therapies for aggressive type of lymphoma", "language": "English", "date": "2022-05-25", "kind": "news", "url": "https://www.sciencedaily.com/releases/2022/05/220525131158.htm", "archive_url": "https://web.archive.org/web/20220526005959/https://www.sciencedaily.com/releases/2022/05/220525131158.htm", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "ScienceDaily carries the release on how a partial SETD2 mutation leads to aggressive B-cell lymphoma and why drugs hitting SETD2 might work, with relevance for patients of African ancestry.", "topics": [ "setd2", "lymphoma", "dlbcl", "precision therapy", "cancer discovery" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/setd2-sciencedaily.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/setd2-sciencedaily--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/setd2-sciencedaily.txt", "ocr_text": { "archived": "ScienceDaily\nFollow\nSubscribe\nYour source for the latest research news\nNew:HIV Drug toCombat Middle-Aged MemoryL.\nADVERTISEMENT\nFollowall of ScienceDaily's\nlatest research news and\ntop science headlines!\nSociety\nQuirky\nHealth\nTech \nEnviro\nSearch\nScience News\nfromresearchorganizations\n Print\nEmail\nShare\nADVERTISEMENT\nStudyreveals cause,potential precisiontherapiesfor\naggressivetype of lymphoma\nMost Popular\nthis week\nDate:\nMay 25,2022\nSource:\nWeill Conell Medicine\nHEALTH&MEDICINE\nDNAmutations are essential to the rapid development of an array of antibody-producing\nSummary\nHowCranberriesCould ImproveMemoryand\nWardOffDementia\ntargets.But this process cango awry in people with a mutation in a gene called SETD2,\nNewResearchMayExplainUnexpectedEffects\nleading to atypeofaggressiveblood cancer,accordingtoanew study.\nofCommonPainkillers\nEveryoneEatsThree Extra Cheeseburgersa\nShare:\nDayThanTheyAdmit,StudyShows\nMIND&BRAIN\nRELATEDTOPICS\nFULLSTORY\nChimpanzees CombineCallstoFomNumerous\nVocal Sequences\nHealth&Medicine\nDNAmutationsareessential totherapid\nNovel Preclinical Drug Could HavePotential to\ndevelopment of an array of antibody-producing\nLymphoma\nCombat Depression,Brain Injuryand Cognitive\nDisorders\nimmunecells called B cells that collectively can\nCancer\nDiet PlaysKeyRole inADHDSymptoms in\nrecognizea vast number of specific targets.But this\nLeukemia\nChildren\nprocess can goawry inpeoplewithamutationina\nBrain Tumor\nLIVING&WELL\ngenecalled SETD2,leading to a type of aggressive\nNew Weight-Loss Intervention Targets Instinctive\nBreast Cancer\nDesireto Eat\nLung Cancer\nMedicine investigators.\nHowSleepHelpstoProcessEmotions\n>Diseases and Conditions\nThe study.published April 2o in Cancer Discovery,found that\nClimate Change Likely to Reduce the Amount of\nSleepThatPeopleGetPerYear\nPersonalizedMedicine\nhaving a mutation in one of the two copies of SETD2 in B cells can\nADVERTISEMENT\nDNA,causing an aggressivetype ofcancer called diffuselargeB\nRELATEDTERMS\ncellymphoma(DLBCL).\nStrange &Offbeat\nChemotherapy\n\"However, when both copies of this gene are mutated in the\ncancer cell, it is fatal to the cell, suggesting that drugs that target\n>Monoclonal antibody\nSETD2might offeran effective treatment option for this type of\nHEALTH&MEDICINE\ntherapy\nlymphoma,\"said senior author Dr.Ari Melnick,the Gebroe Family\nWake Upand Smell the Bumning Rubbish?\nWhitebloodcell\nSecrets of Disordered Smell Found\nand Clinical Oncology and a member of the Sandra and Edward\nCancer\nThe Limits of Vision: Seeing Shadows in the Dark\nMeyer CancerCenterat Weill Cornell Medicine.\n>DNArepair\nScent Dogs Detect Coronavirus Reliably from\nResearchershavepreviouslyfoundthattheSETD2mutation\nSkinSwabs\nAllele\ndisproportionatelyoccurs inDLBCLinpeopleofAfricanancestry\nMIND&BRAIN\nBRCA1\n\"Thefinding points toa possible therapeutic interventionforthese\npatients, who don't otherwise have good options,\"said Dr.Melnick.\nComponentforBrain-InspiredComputing\nLeukemia\nThe strategy is nowbeing tested in a phase 1 clinical trial.\nScientists See Signs of Traumatic Brain Injury in\nHeadbuttingMuskox\nDiffuse largeBcell lymphomadevelopsinBcells inthelymph\nChimpanzees Combine Calls to Form Numerous\nthe underlying causes, lead authorDr.Wilfred Leung examined B\nVocal Sequences\ncellsofmicegeneticallyengineeredtolackonecopyofSETD2.\nLIVING&WELL\nHebegan the study as a doctoral candidate in the laboratory of Dr.\nKristyRichards,whowas anassociateprofessorwithajoint\nArePeopleSwappingTheirCatsandGoldfishfor\nPraying Mantises?\nappointment at the College of Veterinary Medicine at Cornell\nUniversity and Weill Comell Medicine.Her laboratoryhad studied\nExposingLiarsbyDistraction\ncancer in humans and canines to accelerate the development of\nThis Algorithm Has Opinions About YourFace\npotential new treatments.Dr.Leung joined Dr.Melnick'slaboratory\ntocompletetheworkafterDr.Richards diedofbreastcancerin\n2019\nNormally,during B cell productionmanymutations occur to churn\nLeung said.\n\"The Bcells have to beableto shuffleand mutate antibodygenes\nto comeupwith newantibodies that protectagainstanewtypeof\npathogen,\"Dr.Melnickadded.\nSETD2providestheabilityofthegenometosensedamagedDNA\nby adding chemical tags to DNA-support proteins called histones,\nthus monitoring the integrity of the DNA, said co-senior author Dr.\nChristopherMason,co-directoroftheWorldQuant Initiativefor\nQuantitativePredictionand professorof physiology and biophysics\nlosetheabilitytosenseDNAdamageandrepair itAsaresult,\nmutations accumulate unchecked, and the cells begin to grow\nuncontrollably.\nuncontrollably.\n\"WefoundanewwaycancerformsinsideBcells,\"saidDr.\nMason,whoisalsotheWorldQuantResearchScholar,professor\nofcomputationalgenomicsincomputationalbiomedicineinthe\nHRHPrinceAlwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for\nComputationalBiomedicineandprofessorofneuroscienceinthe\nFeil Family Brainand Mind Research Instituteat Weill Cornell\nMedicine.\nThe experiments also revealed that having two mutated copies of\nSETD2isfatalto the cancercells,suggesting thatdrugstargeting\nSETD2might bean effectivetreatment optionforpeople with this\ntypeofcancer.Asluck wouldhaveit,a pharmaceuticalcompany\nhas already created a SETD2 inhibitorthat is in clinical trials for\npatientswithlymphomasandmultiplemyelomas.Dr.Mason'slab\nmechanismsthatSETD2controlsmight provideanadditional\ntreatment option.\n\"This studygets us closertoa precisionmedicineforatypeof\nDr.Mason said.This is particularly important becausemost cancer\nresearchhasfocusedonly on European and Asian populations,\nthe investigators said.\nDr.Richards would be delighted to know that her research may be\ntribute to her that this study will be important to addressing these\nhealthdisparities.\"\nDr.ChristopherMasonisacofounderandboardmemberforBiotia\nandOnegevityHealthaswell asanadvisororcompensated\nspeakerforAbbvie,AcuamarkDiagnostics,ArcBio,Bio-Rad,DNA\nGenotek,Genialis,Genpro,Karius,llumina,New England\nBioLabs,Qiagen,WholeBiomeandZymoResearch.A.M.\nreceives research fundingfrom Epizyme,Janssen,Astra Zeneca\nSanofi,DaiichiSankyo,hasconsultedforEpizyme,Constellation\nExo-Therapeutics,Astra Zeneca,BMs,DaiichiSankyo,Janssen\nand isonthescientificadvisoryboard of KDAC.\nStory source:\nMaterials providedbyWeill cornell Medicine.Note:Contentmay\nbeeditedforstyleandlength.\nJournal Reference:\nWilfredLeung.MattTeater,CeydaDurmaz.\nCemMeydan\nAlexandraGChivu,AmyChadburn,EdwardJ.Rice,Ashlesha\nMuley,JeannieM.Camarillo,JaisonArivalagan,Ziyi Li.\nChristopherR.Flowers,Neil L.Kelleher,Charles G.Danko.\nMarcin Imielinski,SandeepS.Dave,ScottA.Amstrong.\nChristopherE.Mason,AriM.Melnick.SETD2\nAIcDAsomatichypermutationto driveBcell\nlymphomagenesis.CancerDiscovery.2022,DOl\n10.1158/2159-8290.CD-21-1514\nCite This Page:\nAPA\nMLA\nChicago\nWeill Cornell Medicine.\"studyreveals cause,potential precision\nScienceDaily.25May2022.\n\nFeatured Content\nfromNewScientist\nBrain cells that are linked to Parkinson's disease finally identified\nMay 5,2022-High-tech genetic sequencing has found the brain cells connected to the movement\ndisorder,which could lead tonewtreatments.\nVaccine may protect against the virus behind multiple sclerosis\nMay4,2022—The jabcouldwardoff Epstein-Barrvirus,whichcausesglandularfeverand is\nHow repealing Roe v Wade in the Us will lead to more women's deaths\nnumber ofabortions,onily increases theriskofdeathfor thosewhoneedthem.\nVisitNewScientistformoreglobalsciencestories>>>\nExplore More\nfrom ScienceDaily\nADVERTISEMENT\nRELATEDSTORIES", "live": "ScienceDaily\nFollow:\nSubscribe:\nYour source for the latest research news\nNew! Sign upfor our free email newsletter.\nQuirky \nSociety\nHealth \nTech \nEnviro\nSearch\nScience News\nfromresearchorganizations\ne Print\nEmail\nShare\nStudyreveals cause,potential precisiontherapiesfor\nBreaking\nthis hour\naggressivetypeof lymphoma\n>FireSalamanders Havea Secret Glow\nDate:May25,2022\n>ScientistsDiscoveraLostVolcanicSystem\nSource:Weill Cornell Medicine\n>TheHiddenTriggerBehind Earth's IceAges\nSummary:DNA mutations are essential to the rapid development of an array of\n>SurprisingRadiationLevels NeartheMoon\nantibody-producing immunecells called Bcellsthat collectively can\n>HowAutistic Brains ProcessFaces Differently\n>HowAnts ConqueredtheWorld\npeople with a mutation in a gene called SETD2, leading to a type of\naggressive blood cancer,according to a new study.\n>ImmuneCellsHaveaHiddenSenseofTouch\nCommonDrugsCan HelpVirusesSpread\nShare.\n>ALavaPlanetWitha GiantSunscreen\n>Scientists Recreate the Early Universe\nRELATEDTOPICS\nFULL STORY\nTrending Topics\nthis week\nHealth&Medicine\nDNAmutations are essential to the rapid\nHEALTH&MEDICINE\n>Lymphoma\ndevelopment of an array of antibody-producing\nImmuneSystem\nimmune cells called B cells that collectively\n>Breast Cancer\nPersonalized Medicine\ncanrecognizea vast numberof specific\nPharmacology\n>Pharmaceuticals\ntargets.But this process can go awry in\nMIND&BRAIN\nDiseasesand\npeople with a mutation in a gene called\nConditions\nSETD2,leadingtoatypeof aggressiveblood\nIntelligence\ncancer, according to a study by Weill Cornell\n>ImmuneSystem\nSocial Psychology\nMedicine investigators.\n>Pharmacology\nDepression\nLIVING&WELL\nGenes\nThestudy,publishedApril2oinCancerDiscovery,found\nthat having a mutation in one of the two copies of SETD2\nFitness\nWorkplaceHealth\nin B cells can lead to a proliferation of cells that don't\nNutrition\nreadily repair theirmutated DNA,causing an aggressive\nRELATEDTERMS\nSkin Care\ntypeofcancercalleddiffuselargeBcelllymphoma\nCancer\n(DLBCL).\nStrange &Offbeat\n\"However, when both copies of this gene are mutated in\nMonoclonalantibody\nthe cancer cell, it is fatal to the cell, suggesting that drugs\ntherapy\nHEALTH&MEDICINE\nthat target SETD2might offer an effective treatment option\n>Allele\nfor this type of lymphoma,\"said senior author Dr.Ari\nASimpleDailyFiberSupplementReduced\nArthritisPainand Improved Strength\nMelnick,theGebroeFamilyProfessorof\nGene\nHematology/Oncology in theDivision of Hematologyand\nASimpleLiquid Can Stop Cavities Without\nDrilling.Major Study Confirms\nDNA\nClinical Oncology and a member of the Sandra and\nEdwardMeyerCancerCenteratWeill Cornell Medicine.\nCould Lowering High Blood PressureBeas\nGene therapy\nSimple as Stimulating Your Ear?\nResearchers have previously foundthat the SETD2\nImmunesystem\nMIND&BRAIN\nmutationdisproportionatelyoccurs inDLBCLinpeopleof\nAfrican ancestry.\nThisMysteriousMushroomMakesPeopleSee\n>Telomere\nHundreds of Tiny Humans\n\"The finding points to a possible therapeutic intervention\nScientists Win 2026 Nobel Prize for Controlling\nforthesepatients,who don't otherwisehavegood\nBrainCells With Light\noptions,\"said Dr.Melnick.Thestrategy is nowbeing\nModernNeuroscienceIsRediscoveringa\ntested in a phase 1 clinical trial.\nSurprising Idea Freud Had 130Years Ago\nDiffuselargeBcelllymphomadevelopsinBcellsinthe\nLIVING&WELL\nlymph nodes of humans,dogs and someothermammals.\nScientistsTested39Sweetenersand\nTo understand the underlying causes,lead author Dr.\nUncoveredSurprising Gut Effects\nWilfred Leungexamined B cells of micegenetically\nThe Secret to Easier Exercise as an Adult May\nengineered to lackonecopyof SETD2.Hebeganthe\nStart in Childhood\nstudy as a doctoral candidate in thelaboratory of Dr.\nPopular Weight LossDrugs Linked toa\nKristyRichards,whowasanassociateprofessorwitha\nSurprisingFingernail Problem\njointappointment at the College of Veterinary Medicine at\nCornell UniversityandWeill Cornell Medicine.Her\nlaboratoryhad studied cancer in humans and caninesto\naccelerate the development of potential new treatments.\nDr. Leung joined Dr.Melnick's laboratory to complete the\nworkafterDr.Richardsdiedofbreastcancerin2019\nNormally,duringBcell productionmanymutations occur\nto churnout the specialized cells needed to fight a\nto churn out the specialized cells needed to fighta\nparticular infection, Dr.Leung said.\n\"The B cells have to be able to shuffle and mutate\nantibody genes to come upwithnew antibodies that\nprotect against a new type of pathogen,\"Dr.Melnick\nadded.\nSETD2 provides the ability of the genome tosense\ndamaged DNAbyadding chemical tags to DNA-support\nproteinscalled histones,thus monitoringtheintegrity of\nthe DNA, said co-senior author Dr.Christopher Mason,\nco-directoroftheWorldQuant InitiativeforQuantitative\nPredictionandprofessorofphysiologyandbiophysicsat\nWeill Cornell Medicine.Without two copiesof SETD2the\ncells lose the ability to sense DNA damage and repair it.\nAsaresult,mutations accumulateunchecked,andthe\ncellsbegintogrowuncontrollably.\n\"Wefounda newway cancerforms inside B cells,\"said\nDr.Mason,who is alsotheWorldQuant Research Scholar,\nprofessorofcomputational genomicsincomputational\nbiomedicineintheHRHPrinceAlwaleedBinTalal Bin\nAbdulazizAl-Saud InstituteforComputational Biomedicine\nandprofessor of neuroscience in the Feil Family Brain and\nMind Research Institute at Weill Cornell Medicine.\nThe experiments also revealed that having two mutated\ncopies ofSETD2 isfatal tothecancercells,suggesting\nthatdrugs targetingSETD2might bean effective\ntreatment option for peoplewiththis type of cancer.As\nluck would have it,a pharmaceutical company has already\ncreateda SETD2 inhibitorthat is in clinical trials for\npatientswithlymphomasandmultiplemyelomas.Dr.\nMason's lab is also studying whether treatments targeting\nthe repair mechanisms that SETD2 controls might provide\nanadditionaltreatment option.\n\"This study gets us closerto a precision medicine for a\ntype ofcancer thatdisproportionatelyaffects people of\nAfrican ancestry,\"Dr.Mason said.This is particularly\nimportantbecausemost cancerresearchhasfocused\nonly on European andAsian populations,the investigators\nsaid.\nDr Richards would bedelighted toknow that her research\nmaybeon thevergeofproducingaprecision therapyfor\nan underserved population of patients with cancer,Dr.\nMelnick said.\"lt's a great tribute to her that this study will\nbe importanttoaddressingthesehealthdisparities.\"\nDr.ChristopherMasonisa cofounderand board member\nfor Biotia and Onegevity Health as well as an advisoror\ncompensatedspeakerforAbbvie,AcuamarkDiagnostics,\nArcBio,Bio-Rad,DNAGenotek,Genialis,Genpro,Karius,\nIllumina,NewEnglandBioLabs,Qiagen,WholeBiome\nandZymoResearch.A.M.Mreceivesresearchfunding\nfromEpizymeJanssen,AstraZeneca,Sanofi,Daichi\nSankyo,has consultedforEpizyme,Constellation,Exo-\nTherapeutics,AstraZeneca,BMs,DaiichiSankyo\nJanssen and ison thescientific advisoryboardofKDAC.\nStory Source:\nMaterials provided byWeill Cornell Medicine.Note:Content may be editedfor styleand\nlength.\nJournal Reference:\n1.Wilfred Leung,Matt Teater,CeydaDurmaz,\nCemMeydan\nAlexandraG.Chivu,Amy\nChadburn,EdwardJ.Rice,AshleshaMuley,JeannieM.Camarillo,JaisonArivalagan\nZiyiLi,ChristopherR.Flowers,Neil L.Kelleher,CharlesGDanko,MarcinImielinski\nSandeepS.Dave,ScottA.Armstrong,ChristopherEMason,AriM.Meinick.sETD2\nhaploinsufficiency enhances germinal center-associated AicDA somatic\nhypermutation to driveBcell lymphomagenesis.CancerDiscovery,2022,DOl:\n10.1158/2159-8290.CD-21-1514\nCite This Page.\nMLA\nAPA\nChicago\nWeill Cornell Medicine.\"study reveals cause,potential precision therapies foraggressive\ntypeoflymphoma.\"ScienceDaily.ScienceDaily.25May2022." } }, { "id": "setd2-wcm", "study": "melnick", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Study Reveals Cause, Potential Precision Therapies for Aggressive Type of Lymphoma", "title_original": "Study Reveals Cause, Potential Precision Therapies for Aggressive Type of Lymphoma", "language": "English", "date": "2022-05", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2022/05/study-reveals-cause-potential-precision-therapies-for-aggressive-type-of-lymphoma", "archive_url": "https://web.archive.org/web/20220525175536/https://news.weill.cornell.edu/news/2022/05/study-reveals-cause-potential-precision-therapies-for-aggressive-type-of-lymphoma", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Weill Cornell release on a Cancer Discovery study showing one-copy SETD2 mutation in B cells impairs DNA repair and promotes aggressive diffuse large B-cell lymphoma, whereas losing both copies kills cells, pointing to SETD2-targeted therapy.", "topics": [ "setd2", "lymphoma", "dlbcl", "precision therapy", "b cells" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/setd2-wcm.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/setd2-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/setd2-wcm.txt", "ocr_text": { "archived": "Menu\nSkiptomaincontent\nNewsroom\nNews\nPublications\nVideo&Photography\nSocial Media\nPress Room\nAbout Us\nHome\nNews\nStudyRevealsCause,PotentialPrecisionTherapiesfor\nAggressive Typeof Lymphoma\nMAY25,2022\nBacktoNews\nin\nWeill CornellMedicine\nOfficeof External Affairs\n1300YorkAvenue\nOfficeofExternalAffairs\n1300YorkAvenue\nBox 314\nNewYork, NY10065\nPhone: (646) 962-9476\nJump To Top\nDiffuse large B-cell lymphoma. Photograph by CoRus13, distributed under a CC BY-SA 4.0 license\nDNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that\ncollectively can recognize a vast number of specific targets. But this process can go awry in people with a mutation in a\ngene called SETD2, leading to a type of aggressive blood cancer, according to a study by Weill Cornell Medicine\ninvestigators.\ncells can lead to a proliferation of cells that don't readily repair their mutated DNA, causing an aggressive type of cancer\ncalled diffuse large B cell lymphoma (DLBCL).\n\"However, when both copies of this gene are mutated in the cancer cell, it is fatal to the cell, suggesting that drugs that\ntarget SETD2 might offer an effective treatment option for this type of lymphoma,\"said senior author Dr. Ari Melnick, the\nGebroe Family Professor of Hematology/Oncology in the Division of Hematology and Clinical Oncology and a member of\nthe Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.\nResearchers have previously found that the SETD2 mutation disproportionately occurs in DLBCL in people of African\nancestry.\n\"The finding points to a possible therapeutic intervention for these patients, who don't otherwise have good options,\"\nsaid Dr. Melnick. The strategy is now being tested in a phase 1 clinical trial .\nDiffuse large B cell lymphoma develops in B cells in thelymph nodes of humans, dogs and some other mammals.To\nunderstand the underlying causes,lead author Dr.Wilfred Leung examined B cells ofmice genetically engineered to lack\none copy ofSETD2.Hebegan the studyasa doctoral candidate in thelaboratory of Dr.Kristy Richards,who was an\nassociate professor with a joint appointment at the College of Veterinary Medicine at Cornell University and Weill Cornell\nMedicine.Her laboratory had studied cancer in humans and canines to accelerate the development of potential new\n2019.\ninfection, Dr. Leung said.\n\"The B cells have to be able to shuffle and mutate antibody genes to come up with new antibodies that protect against a\nnew type of pathogen,\" Dr. Melnick added.\ncalled histones,thusmonitoring the integrityof theDNA,said co-senior author Dr.Christopher Mason,co-directorof the\nWorldQuant Initiativefor Quantitative Prediction and professor of physiology and biophysics at Weill Cornell Medicine.\nWithout two copies of SETD2 the cells lose the ability to sense DNA damage and repair it. As a result, mutations\naccumulate unchecked, and the cells begin to grow uncontrollably.\n\"Wefound a newway cancerforms inside B cells,\"said Dr.Mason, who is also the WorldQuant Research Scholar,\nprofessor of computational genomics in computational biomedicine in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz\nAl-Saud Institute for Computational Biomedicine and professor of neuroscience in the Feil Family Brain and Mind\nResearch Institute at Weill Cornell Medicine.\nThe experiments also revealed that having two mutated copies of SETD2 is fatal to the cancer cells, suggesting that drugs\npharmaceutical company has already created a SETD2 inhibitor that is in clinical trials for patients with lymphomas and\nmultiple myelomas.Dr.Mason's lab is also studying whether treatments targeting the repair mechanisms that SETD2\ncontrols might provide an additional treatment option.\n\"This study gets us closer to a precision medicine for a type of cancer that disproportionately affects people of African\nancestry,\" Dr. Mason said.This is particularly important because most cancer research has focused only on European\nand Asian populations, the investigators said.\nDr. Richards would be delighted to know that her research may be on the verge of producing a precision therapy for an\nimportant to addressing these health disparities.\"\nDr.Christopher Mason is a cofounder and board member for Biotia and Onegevity Health as well asan advisor or compensated\nspeakerforAbbvie,AcuamarkDiagnostics,ArcBio, Bio-Rad,DNA Genotek,Genialis,Genpro,Karius,llumina,NewEngland\nBioLabs, Qiagen,Whole Biome and Zymo Research.A.M.M receives research funding from Epizyme, Janssen, Astra Zeneca,\nSanofi,Daiichi Sankyo,has consulted for Epizyme,Constellation, Exo-Therapeutics,Astra Zeneca,BMS,Daichi Sankyo,Janssen\nandisonthescientificadvisoryboardofKDAC.", "live": "Weill Cornell Medicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpactMagazine\nAbout Us\nHome\nNews\nStudyRevealsCause,Potential Precision Therapies for\nAggressiveTypeofLymphoma\nMAY25,2022\nBack to News\nfxin\nWeill Cornell Medicine\nOfficeof External Affairs\nPhone:(646)962-9476\nDiffuse large B-cell lymphoma.Photograph by CoRus13, distributed under a CC BY-SA 4.0 license\nDNAmutations are essential to therapid development of an array of antibody-producing immune cells called B cells that\ngene called SETD2, leading to a type of aggressive blood cancer, according to a study by Weill Cornell Medicine\ninvestigators.\nThe study , published April 20 in Cancer Discovery, found that having a mutation in one of the two copies of SETD2 in B\ncells can lead to a proliferation of cells that don't readily repair their mutated DNA, causing an aggressive type of cancer\nCalled diffuse large B cell lymphoma (DLBCL).\n\"However, when both copies of this gene are mutated in the cancer cell, it is fatal to the cell, suggesting that drugs that\ntarget SETD2 might offer an effective treatment option for this type of lymphoma,\" said senior author Dr. Ari Melnick, the\nGebroe Family Professor of Hematology/Oncology in the Division of Hematology and Clinical Oncology and a member of\nthe Sandra and Edward Meyer Cancer Centerat Weill Cornell Medicine.\nResearchers have previously found that the SETD2 mutation disproportionately occurs in DLBCL in people of African\nancestry.\n\"The finding points to a possible therapeutic intervention for these patients, who don't otherwise have good options,\"\nDiffuse large B cell lymphoma develops in B cells in the lymph nodes of humans, dogs and some other mammals. To\nunderstand the underlying causes, lead author Dr. Wilfred Leung examined B cells of mice genetically engineered to lack\none copy ofSETD2.Hebegan the study asa doctoral candidatein thelaboratory ofDr.Kristy Richards,who was an\nassociate professor with a joint appointment at the College of Veterinary Medicine at Cornell University and Weill Cornell\nMedicine.Her laboratory had studied cancer in humans and canines to accelerate the development of potential new\ntreatments. Dr. Leung joined Dr. Melnick's laboratory to complete the work after Dr. Richards died of breast cancer in\n2019.\nNormally,during B cell production many mutations occur to churn out the specialized cells needed to fight a particular\ninfection, Dr. Leung said.\n\"The Bcellshaveto be ableto shuffle and mutate antibody genes to comeupwithnew antibodies thatprotect againsta\nnew type of pathogen,Dr.Melnick added.\nSETD2 provides the ability of thegenome to sense damaged DNA by adding chemical tags to DNA-support proteins\ncalled histones,thus monitoring the integrity of the DNA, said co-senior author Dr.Christopher Mason,co-director of the\nWorldQuant Initiative for Quantitative Prediction and professor of physiology and biophysics at Weill Cornell Medicine.\nWithout two copies of SETD2 the cells lose the ability to sense DNA damage and repair it. As a result, mutations\naccumulateunchecked, and the cells begin to grow uncontrollably.\n\"We found a new way cancerforms inside B cells,\"said Dr.Mason, who is also the WorldQuant Research Scholar,\nprofessor of computational genomics in computational biomedicine in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz\nAl-Saud Institute for Computational Biomedicine and professor of neuroscience in the Feil Family Brain and Mind\nResearch Institute at Weill Cornell Medicine.\nThe experiments also revealed that having two mutated copies of SETD2 is fatal to the cancer cells, suggesting that drugs\ntargeting SETD2might be an effectivetreatment optionfor peoplewith thistype of cancer.Asluck would have it,a\npharmaceutical company has already created a SETD2 inhibitor that is in clinical trials for patients with lymphomas and\ncontrols might provide an additional treatment option.\n\"This study gets us closer to a precision medicine for a type of cancer that disproportionately affects people of African\nancestry,\" Dr. Mason said. This is particularly important because most cancer research has focused only on European\nand Asian populations, the investigators said.\nDr. Richards would be delighted to know that her research may be on the verge of producing a precision therapy for an\nimportant to addressing these health disparities.\"\nDr.Christopher Mason is a cofounder and board member for Biotiaand Onegevity Healthas well as an advisor or compensated\nspeaker for Abbvie, Acuamark Diagnostics, ArcBio, Bio-Rad, DNA Genotek, Genialis, Genpro, Karius, Ilumina, New England\nBioLabs, Qiagen, Whole Biome and Zymo Research.A.M.M receives research funding from Epizyme, Janssen, Astra Zeneca,\nand is on the scientific advisory board of KDAC.\nDr.riMenick,Dr.ChriophrMaonDr.KristyRichards,Hematology/Medicalncoogy.RearchandraandEdwardMeyrCancrent\nSystemsand Computational Biomedicine,NewsfromwCM\nRELATED NEWS" } }, { "id": "setd2-cornell-chronicle", "study": "melnick", "outlet": "Cornell Chronicle", "outlet_original": "Cornell Chronicle", "outlet_score": 6, "title": "Study reveals potential therapies for aggressive lymphoma", "title_original": "Study reveals potential therapies for aggressive lymphoma", "language": "English", "date": "2022-05", "kind": "press-release", "url": "https://news.cornell.edu/node/324371", "archive_url": "", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Cornell Chronicle repost of the release on SETD2 mutations driving aggressive diffuse large B-cell lymphoma and suggesting precision treatment, notably for patients of African ancestry.", "topics": [ "setd2", "lymphoma", "dlbcl", "precision therapy", "cancer discovery" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/setd2-cornell-chronicle.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/setd2-cornell-chronicle--live.jpg", "saved_html": "", "saved_article_text": "media-archive/text/setd2-cornell-chronicle.txt", "ocr_text": { "live": "IMEDIARELATIONS\nCORNELL.EDU\nCORNELLCHRONICLE\nEDA.\nCampus & Community\nTopics\nAll Stories\nPodcast\nMedia Relations\nCornellians\nStudy reveals potential therapies for aggressive lymphoma\nBy Bridget Kuehn\nMay 26, 2022\nDNA mutations are essential to the rapid development of an array of\nantibody-producing immune cells called B cells that collectively can recognize\na vast number of specific targets. But this process can go awry in people with a\nmutation in a gene called SETD2, leading to a type of aggressive blood cancer,\naccording to a study by Weill Cornell Medicine investigators.\nThe study, published April 20 in Cancer Discovery, found that having a\nmutation in one of the two copies of SETD2 in B cells can lead to a\n“However, when both copies of this gene are mutated in the cancer cell, it is\nfatal to the cell, suggesting that drugs that target SETD2 might offer an\nAri Melnick, the Gebroe Family Professor of Hematology/Oncology in the\nDivision of Hematology and Clinical Oncology and a member of the Sandra\nand Edward Meyer Cancer Center at Weill Cornell Medicine.\nResearchers have previously found that the SETD2 mutation\n“The finding points to a possible therapeutic intervention for these patients,\nwho don't otherwise have good options,\" Melnick said. The strategy is now\nbeing tested in a phase 1 clinical trial.\nDiffuse large B cell lymphoma develops in B cells in the lymph nodes of\nhumans, dogs and some other mammals. To understand the underlying\ncauses, lead author Dr. Wilfred Leung examined B cells of mice genetically\ncandidate in the laboratory of Dr. Kristy Richards, who was an associate\nprofessor with a joint appointment at the College of Veterinary Medicine at\nCornell University and Weill Cornell Medicine. Her laboratory had studied\ncancer in humans and canines to accelerate the development of potential new\ntreatments. Leung joined Dr. Melnick's laboratory to complete the work after\nDr. Richards died of breast cancer in 2019.\nNormally, during B cell production many mutations occur to churn out the\nspecialized cells needed to fight a particular infection, Leung said.\n“The B cells have to be able to shuffle and mutate antibody genes to come up\nwith new antibodies that protect against a new type of pathogen,\" Melnick\nadded.\nadded.\nSETD2 provides the ability of the genome to sense damaged DNA by adding\nchemical tags to DNA-support proteins called histones, thus monitoring the\nintegrity of the DNA, said co-senior author Dr. Christopher Mason, co-\ndirector of the WorldQuant Initiative for Quantitative Prediction and\nprofessor of physiology and biophysics at Weill Cornell Medicine. Without\ntwo copies of SETD2 the cells lose the ability to sense DNA damage and repair\nit. As a result, mutations accumulate unchecked, and the cells begin to grow\nuncontrollably.\n\"We found a new way cancer forms inside B cells,\" said Mason, who is also the\nWorldQuant Research Scholar, professor of computational genomics in\ncomputational biomedicine in the HRH Prince Alwaleed Bin Talal Bin\nAbdulaziz Al-Saud Institute for Computational Biomedicine and professor of\nneuroscience in the Feil Family Brain and Mind Research Institute at Weill\nCornell Medicine.\nThe experiments also revealed that having two mutated copies of SETD2 is\nfatal to the cancer cells, suggesting that drugs targeting SETD2 might be an\neffective treatment option for people with this type of cancer. A\npharmaceutical company has already created a SETD2 inhibitor that is in\nclinical trials for patients with lymphomas and multiple myelomas. Mason's\nSETD2 controls might provide an additional treatment option.\n“This study gets us closer to a precision medicine for a type of cancer that\ndisproportionately affects people of African ancestry,\" Mason said. This is\nparticularly important because most cancer research has focused only on\nEuropean and Asian populations, the investigators said.\nRichards would be delighted to know that her research may be on the verge of\nproducing a precision therapy for an underserved population of patients with\ncancer, Melnick said. \"It's a great tribute to her that this study will be\nimportant to addressing these health disparities.\"\nDr. Christopher Mason is a cofounder and board member for Biotia and Onegevity\nHealth as well as an advisor or compensated speaker for Abbvie, Acuamark\nDiagnostics, ArcBio, Bio-Rad, DNA Genotek, Genialis, Genpro, Karius, Illumina,\nNew England BioLabs, Qiagen, Whole Biome and Zymo Research. A.M.M receives\nresearch funding from Epizyme, Janssen, Astra Zeneca, Sanof, Daichi Sankyo, has\nconsulted for Epizyme, Constellation, Exo-Therapeutics, Astra Zeneca, BMS,\nDaiichi Sankyo, Janssen and is on the scientific advisory board of KDAC.\nBridget Kuehn is a freelance writer for Weill Cormell Medicine.\nHealth,Nutrition&Medicine\nMEDIAINQUIRIESV\nGet Cornell news delivered right to your inbox.\nSUBSCRIBE\nYOU MIGHT ALSO LIKE" } }, { "id": "setd2-technetworks", "study": "melnick", "outlet": "Technology Networks", "outlet_original": "Technology Networks", "outlet_score": 5, "title": "New Genetic Cause of Aggressive B Cell Lymphoma Revealed", "title_original": "New Genetic Cause of Aggressive B Cell Lymphoma Revealed", "language": "English", "date": "2022-05", "kind": "news", "url": "https://www.technologynetworks.com/cancer-research/news/new-genetic-cause-of-aggressive-b-cell-lymphoma-revealed-361976", "archive_url": "https://web.archive.org/web/20221206135235/https://www.technologynetworks.com/cancer-research/news/new-genetic-cause-of-aggressive-b-cell-lymphoma-revealed-361976", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Technology Networks republishes the release on SETD2 mutation causing aggressive B-cell lymphoma and suggesting targeted therapy options.", "topics": [ "setd2", "lymphoma", "dlbcl", "precision therapy", "cancer discovery" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/setd2-technetworks.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/setd2-technetworks--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/setd2-technetworks.txt", "ocr_text": { "archived": "We've updated our Privacy Policyto make it clearer how we use your personal data.\nIUnderstand\nWe use cookies to provide you witha better experience.You can read our Cookie Policy here.\nFind the science...\nQSearch\nTechnologyNetworks\nfyoin\nCancerResearch\nCommunitiesy\nWebinars\nContent\nSubscribe\nNew Genetic Cause of Aggressive B-Cell Lymphoma Revealed\nNews Published: May 26, 2022 I Original story from Weill Cornell Medicine\nDownload Article\nReadtime:3minutes\nDNA mutations are essential to the rapid development of an array of antibody-\nproducing immune cells called B cells that collectively can recognize a vast number of\nSETD2, leading to a type of aggressive blood cancer, according to a study by Weill\nCornell Medicine investigators.\nThe study, published April 20 in Cancer Discovery, found that having a mutation in one\nof the two copies of SETD2 in B cells can lead to a proliferation of cells that don't readily\nrepair their mutated DNA, causing an aggressive type of cancer called diffuse large B\ncell lymphoma (DLBCL).\n\"However, when both copies of this gene are mutated in the cancer cell, it is fatal to the\ncell, suggesting that drugs that target SETD2 might offer an effective treatment option\nfor this type of lymphoma,\" said senior author Dr. Ari Melnick, the Gebroe Family\nProfessor of Hematology/Oncology in the Division of Hematology and Clinical Oncology\nand a memberofthe Sandra and Edward MeyerCancer Centerat Weill Cornell\nMedicine.\nResearchershavepreviouslyfoundthattheSETD2mutationdisproportionatelyoccurs\nin DLBCL in people of African ancestry.\n\"The finding points to a possible therapeutic intervention for these patients, who don't\na phase 1 clinical trial.\na phase 1 clinical trial.\nDiffuse large B cell lymphoma develops in B cells in thelymph nodes of humans,dogs\nand some other mammals. To understand the underlying causes, lead author Dr.\nWilfred Leung examined Bcells of mice genetically engineered to lack one copy of\nSETD2. He began the study as a doctoral candidate in the laboratory of Dr. Kristy\nRichards, who was an associate professor with a joint appointment at the College of\nVeterinary Medicine at Cornell University and Weill Cornell Medicine. Her laboratory\nhad studied cancer inhumans and canines to acceleratethe development of potential\nnew treatments. Dr. Leung joined Dr. Melnick's laboratory to complete the work after\nDr.Richards died of breast cancer in 2019.\nNormally, during B cell production many mutations occur to churn out the specialized\ncells needed to fight a particular infection, Dr. Leung said.\n\"TheB cells havetobeableto shuffleandmutateantibodygenes to comeupwith new\nantibodies that protect against a new type of pathogen,\" Dr. Melnick added.\nSETD2 provides the ability of the genome to sense damaged DNA by adding chemical\nfor Quantitative Prediction and professor of physiology and biophysics at Weill Cornell\nMedicine. Without two copies of SETD2 the cells lose the ability to sense DNA damage\nand repair it. As a result, mutations accumulate unchecked, and the cells begin to grow\nuncontrollably.\n\"We found a new way cancer forms inside B cells,\" said Dr. Mason, who is also the\nWorldQuant Research Scholar.professor of computational genomics in computational\nbiomedicine in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for\nComputational Biomedicineandprofessorof neuroscience intheFeil Family Brainand\nMind Research Instituteat Weill Cornell Medicine.\ncancer cells, suggesting that drugs targeting SETD2 might be an effective treatment\noption for people with this type of cancer. As luck would have it, a pharmaceutical\nlymphomas andmultiplemyelomas.Dr.Mason'slab is also studyingwhether\ntreatments targeting the repair mechanisms that SETD2 controls might provide an\nadditionaltreatmentoption.\n\"This study gets us closer to a precision medicine for a type of cancer that\ndisproportionately affects people of African ancestry\" Dr.Mason said.This is\nparticularly important because most cancer research has focused only on European\nand Asian populations, the investigators said.\nDr.Richards would be delighted toknow that her research may be on the verge of\nDr. Melnick said. \"lt's a great tribute to her that this study will be important to\naddressing thesehealth disparities.\"\nReference: Leung W, Teater M, Durmaz C, et al. SETD2 haploinsufficiency enhances\ngerminal center-associated AICDA somatic hypermutation to drive B cell\nlymphomagenesis. Cancer Discov.2022:candisc.1514.2021.doi: 10.1158/2159-8290.CD-\n21-1514\nThis article has been republished from the following materials.Note:material may have been edited for\nlength and content.For further information,please contact the cited source.\nRelated Topic Pages\nInfectious Diseases\nPersonalized Medicine\nThe Immune System", "live": "We'veupdated ourPrivacyPolicytomakeitclearerhowweuse\nyourpersonaldata.Weusecookiestoprovideyouwithabetter\nexperience.YoucanreadourCookiePolicyhere.\nIUnderstand\nTechnologyNetworks\nSearch...\nStay up to date on the topics\nSubscribe Now\nthat matter to you\nCancer Research\nScience News\nCommunitiesv\nContent v\n习 Log in\nNew Genetic Cause of Aggressive B-Cell\nChosen for you\nLymphoma Revealed\nHow Do WeTacklethe\nBiggest Challenges Facing\nNews Published: May 26, 2022\nOncology?\nSave forlater\nOriginal storyfromWeill Cornell Medicine\nArticle\nWhat Scientific\nAdvancements Are the\nMost Overlookedor...\nArticle\nOne Platform, Many\nOmes: Scaling Spatial\nTranscriptomics Resear...\nillumina\nWebinar\nDownload Article\nRegister or log ln for free to listen to this article\nListen with Speechify\n0:00\n Read time: 2 minutes\nDNA mutations are essential to the rapid development of an array of antibody-\nproducing immune cells called B cells that collectively can recognize a vast number of\nSETD2, leading to a type of aggressive blood cancer, according to a study by Weill\nCornell Medicine investigators.\nThe study. published April 20 in Cancer Discovery, found that having a mutation in one\nof the two copies of SETD2 in B cells can lead to a proliferation of cells that don't readily\nrepairtheirmutatedDNA,causinganaggressivetypeofcancercalleddiffuse largeB\ncell lymphoma (DLBCL).\n\"However,when both copies of this gene are mutated in the cancer cell, it is fatal to the\ncell, suggesting that drugs that target SETD2 might offer an effective treatment option\nfor this type of lymphoma,\" said senior author Dr.Ari Melnick, the Gebroe Family\nProfessor of Hematology/Oncology in the Division of Hematology and Clinical Oncology\nand a memberofthe Sandra and Edward Meyer Cancer Centerat Weill Cornell\nMedicine.\nContinue reading below...\nContinue reading below...\nResearchers have previouslyfound that the SETD2 mutation disproportionately occurs\nin DLBCL in people of African ancestry.\n\"The finding points to a possible therapeutic intervention for these patients, who don't\na phase 1 clinical trial.\nDiffuse large B cell lymphoma develops in B cells in the lymph nodes of humans, dogs\nand some other mammals. To understand the underlying causes, lead author Dr.\nSETD2. He began the study as a doctoral candidate in the laboratory of Dr. Kristy.\nRichards, who was an associate professor with a joint appointment at the College of\nVeterinary Medicine at Cornell University and Weill Cornell Medicine. Her laboratory\nhad studied cancer inhumans and canines to acceleratethe development of potential\nnew treatments.Dr.Leung joined Dr.Melnick's laboratory to complete the work after\nDr.Richardsdied of breast cancer in2019.\nNormally, during B cell production many mutations occur to churn out the specialized\ncells needed to fight a particular infection, Dr. Leung said.\n\"The B cells have to be able to shuffle and mutate antibody genes to come up with new\nantibodies that protect against a new type of pathogen, Dr. Melnick added.\nSETD2 provides the ability of the genome to sense damaged DNA by adding chemical\ntags to DNA-support proteins called histones, thus monitoring the integrity of the DNA,\nsaid co-senior author Dr.Christopher Mason, co-director of the WorldQuant Initiative\nforQuantitative Prediction andprofessorof physiologyand biophysics at Weill Cornell\nMedicine. Without two copies of SETD2 the cells lose the ability to sense DNA damage\nand repair it. As a result, mutations accumulate unchecked, and the cells begin to grow\nuncontrollably.\n\"We found a new way cancer forms inside B cells,\" said Dr. Mason, who is also the\nWorldQuant Research Scholar. professor of computational genomics in computational\nbiomedicine in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for\nComputational Biomedicine andprofessorofneuroscience in the Feil Family Brainand\nMind Research Institute at Weill Cornell Medicine.\ncancer cells, suggesting that drugs targeting SETD2 might be an effective treatment\noption for people with this type of cancer.As luck would have it, a pharmaceutical\nlymphomas and multiple myelomas. Dr. Mason's lab is also studying whether\ntreatments targeting the repair mechanisms that SETD2 controls might provide an\nadditional treatment option.\n\"This study gets us closer to a precision medicine for a type of cancer that\ndisproportionately affects people of African ancestry\" Dr.Mason said.This is\nparticularly important because most cancer research has focused only on European\nand Asian populations,the investigators said.\nDr.Richards would be delighted toknow that her research maybe on the verge of\nDr. Melnick said. \"lt's a great tribute to her that this study will be important to\naddressingthesehealthdisparities.\"\nReference: Leung W, Teater M, Durmaz C, et al. SETD2 haploinsufficiency enhances\ngerminal center-associated AICDA somatic hypermutation to drive B cell\nlymphomagenesis.Cancer Discov.2022:candisc.1514.2021.doi:10.1158/2159-8290.CD-\n21-1514" } }, { "id": "smc3-wcm", "study": "melnick", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Scientists Identify Gene that Plays Critical Role in Immune Cell Development", "title_original": "Scientists Identify Gene that Plays Critical Role in Immune Cell Development", "language": "English", "date": "2021-02", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2021/02/scientists-identify-gene-that-plays-critical-role-in-immune-cell-development", "archive_url": "https://web.archive.org/web/20210202215358/https://news.weill.cornell.edu/news/2021/02/scientists-identify-gene-that-plays-critical-role-in-immune-cell-development", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Release on a Nature Immunology study showing that SMC3 underpins the 3D genome architecture of antibody-producing B cells, and that its disruption impairs immune cell development and can lead to cancer.", "topics": [ "smc3", "3d genome", "b cells", "nature immunology", "lymphoma" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/smc3-wcm.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/smc3-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/smc3-wcm.txt", "ocr_text": { "archived": "considersupportingWeill Cornell Medicine's effortsagainstthepandemic.\nWeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nEXPLORETHISWEBSITE\nNewsroom\nSocial Media\nAbout Us\nPublications\nNews\nPressRoom\nVideo&Photography\nSocial Media\nAbout Us\nHome\nNews\nScientistsldentifyGenethatPlaysCriticalRolein\nImmuneCellDevelopment\nFEBRUARY1,2021\nBack.toNews\nin\nWeill Cornell Medicine\nOfficeof External Affairs\n1300YorkAvenue\nOfficeofExternalAffairs\n1300YorkAvenue\nBox 314\nNewYork,NY10065\nPhone:(646)962-9476\nis highly structured and functional, while the other canvas has lost its pattern and has open threads. Artist: Victoria Beguelin.\nMuch of the three-dimensional architecture of the genome in antibody-producing immune cells is dependent on a gene\ndisrupting how DNA is structured inside the cell nucleus, according to a team of researchers from Weill Cornell Medicine.\nThis research has broad implications, because 3D genome organization is a vital function across all cell types.\nIn order for immune cells called B cells to confront infections by making antibodies, they need to change the\nwhen SM3 is disrupted, the cells do not make these and other changes needed to mature; and become prone to\nmalignancy.\n\"lt's not like dumping spaghetti in a colander,\" said senior author Dr. Ari M. Melnick , the Gebroe Family Professor of\nHematology and Medical Oncology and amember of the Sandra and Edward Meyer Cancer Centerat Weill Cornell\nand coordinate with each other.\" It turns out the SMc3 gene encodes a protein that acts as a motor, working within a\nprotein complex to move the strands of DNA around and make sure that everything goes where it should.\nPrevious work from Dr.Melnick's lab showed that massive three-\ndimensional changes in DNA occur as part of the immune\nresponse, but there were no data on how these changes were\nregulated or controlled. In the new paper, his team has shown for\nRosa26YFP\nRosa26YFP\nthe first time that SMC3 is required for this activity. When they\nSmc3wt-:\nSmc3wt/wt\nstudied mice that had reduced levels of the SMC3 protein in their\nimmune cells, they found that the animals had defective B cells\nthat were unable to make critical genome alterations,including\nrearrangement of genes needed to produce antibodies. Further\nexperiments revealed that the organization of the DNA in the\nnucleus was disturbed.\nThe SMC3protein waspreviouslyknown to bepartof a group of\nproteins called the cohesin complex, which is essential for\nimportant role in gene regulation.SMc3 mutations arefound in\nMice withhaif asmuchSmc3asnormaldisplayenlarged\nsomehumancancers,andlowerlevelsoftheSMC3proteinin\ngerminal centers, the area where B cells undergo changes\nimmune system tumors are associated with more aggressive\nneeded to produceantibodies.Immunofluorescence images\ndisease.They are also found in a genetic disease called Cornelia\nof wildtypecells (Rosa26YFP;Smc3wt/wt)andcellswithonly\nonecopyof the Smc3gene (Rosa26YFP:Smc3wt/-) in mouse\nde Lange syndrome, which is characterized by slow growth,\nspleens.Germinalcenters and postgerminalcenters\nintellectual disability, abnormalities of the bones, and distinct\nexpresstheyellowfluorescentprotein (YFP)and samples\nfacialfeatures.\nwere alsostainedwithanti CD35fluorescentantibodyfor\nvisualizotion of the light zone of the germinal centers. Scale\n\"Disruptions in the motor functions of the SMC3 protein and loss\nbar represent 100 μm.\noffunction ofthecohesin complex makecells more prone\nbecoming malignant,\" said Dr. Melnick, who has consulted for\nEpizyme and Constellation and is on the scientific advisory board of KDAC pharmaceutical.\"Thecells appear to be\naffected in such a way that they are more likely to divide and mutate, since they become stuck in an intermediate stage\nof development proneto developing mutations.\"\nthat the levels of the SMC3 protein within cancer cells may affect how they respond to different drugs.\n\"We still know very little about these 3-D mechanisms,\" Dr.Melnick said.\"There are important implications not only for\ncancer, but for biology in general. I can't imagine that this process is not critical to every single cell in our bodies.\"\nDr.Ari Melnick, Research, Sandra and Edward Meyer Cancer Center,News from WCM", "live": "WeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpactMagazine\nAbout Us\nHome\nNews\nScientists Identify Gene that Plays Critical Role in\nImmuneCellDevelopment\nFEBRUARY1,2021\nBack to News\nWeill CornellMedicine\nOfficeofExternalAffairs\nPhone: (646)962-9476\nis highly structured and functional, while the other canvas has lost its pattern and has open threads. Artist: Victoria Beguelin.\nMuch of the three-dimensional architecture of the genome in antibody-producing immune cells is dependent on a gene\ndisrupting how DNA is structured inside the cell nucleus, according to a team of researchers from Weill Cornell Medicine.\nThis research has broad implications, because 3D genome organization is a vital function across all cell types.\nIn order for immune cells called B cells to confront infections by making antibodies, they need to change the\narrangement of their chromosomes. In a study published Jan. 11 in Nature Immunology, the investigators found that\nwhen SMc3 is disrupted, the cells do not make these and other changes needed to mature; and become prone to\nmalignancy.\nEvery cell in the body contains two meters of DNA, which needs to be organized in such a way that it fits into the nucleus.\n\"lt's not like dumping spaghetti in a colander,\" said senior author Dr. Ari M. Melnick , the Gebroe Family Professor of\nHematology and Medical Oncologyand a member of the Sandra and Edward Meyer Cancer Centerat Weill Cornell\nMedicine.\"There has to be order in the way the strands are arranged, so that different parts of the genome can talk to\nand coordinate with each other.\" It turns out the SMc3 gene encodes a protein that acts as a motor, working within a\nprotein complex to move the strands of DNA around and make sure that everything goes where it should.\nPreviousworkfromDr.Melnick'slabshowedthatmassivethree-\ndimensional changes in DNA occur as part of the immune\nresponse, but there were no data on how these changes were\nRosa26YFP\nregulated or controlled. In the new paper, his team has shown for\nRosa26YFP\nthe first time that SMC3 is required for this activity. When they\nSmc3wt-\nSmc3wt/wt\nstudied mice that had reduced levels of the SMC3 protein in their\nimmune cells, they found that the animals had defective B cells\nthat were unable to make critical genome alterations, including\nrearrangement of genes needed to produce antibodies. Further\nexperiments revealed that the organization of the DNA in the\nnucleus was disturbed.\nThe SMc3 protein was previously known to bepart of a group of\nproteins called the cohesin complex, which is essential for\nimportant role in gene regulation. SMC3 mutations are found in\nMice with half as much Smc3 as normal display enlarged\nsome human cancers,and lower levels of the SMC3 protein in\ngerminal centers, the area where B cells undergo changes\nneededto produceantibodies.Immunofluorescence\ndisease. They are also found in a genetic disease called Cornelia\nimagesofwildtypecells (Rosa26YFP;Smc3wt/wt)andcells\nwithonlyonecopyoftheSmc3gene(Rosa26YFP:Smc3wt/-)\nde Lange syndrome, which is characterized by slow growth,\nin mouse spleens.Germinal centers and post germinal\nintellectual disability,abnormalities ofthebones,and distinct\ncenters express the yellow fluorescent protein (YFP) and\nfacial features.\nsamples were alsostainedwith anti CD35 fluorescent\nantibody for visualizationof the light zone of thegerminal\n\"Disruptions in the motor functions of the SMC3 protein and loss\ncenters.Scalebarrepresent100μm.\noffunctionof thecohesincomplexmakecellsmoreprone\nbecoming malignant,\" said Dr. Melnick, who has consulted for\nEpizyme and Constellation and is on the scientific advisory board of KDAC pharmaceutical.\"The cells appear to be\naffected in such a way that they are more likely to divide and mutate, since they become stuck in an intermediate stage\nofdevelopmentpronetodevelopingmutations.\"\nFuture work will focus on learning more about the role of sMc3 in both immune cells and cancer cells. It's also possible\nthat the levels of the sMc3 protein within cancer cells may affect how they respond to different drugs.\n\"We still know very little about these 3-D mechanisms,\" Dr. Melnick said. \"There are important implications not only for\nCancer, but for biology in general. I can't imagine that this process is not critical to every single cell in our bodies.\"\nDr.Ari Melnick,Research,Sandra and Edward MeyerCancer Center,News from WCM\nRELATEDNEWS\nAUnifying Mechanismfor Cancer-Driving Mutations\nNoninvasiveFocused Ultrasound Treatment Can Ease MotorSymptoms of Parkinson'sDisease\n2026RituBangaAwardsSupport InnovativeResearch" } }, { "id": "smc3-cornell-chronicle", "study": "melnick", "outlet": "Cornell Chronicle", "outlet_original": "Cornell Chronicle", "outlet_score": 6, "title": "Gene critical to immune cell development identified", "title_original": "Gene critical to immune cell development identified", "language": "English", "date": "2021-02", "kind": "press-release", "url": "https://news.cornell.edu/stories/2021/02/gene-critical-immune-cell-development-identified", "archive_url": "https://web.archive.org/web/20210205180738/https://news.cornell.edu/stories/2021/02/gene-critical-immune-cell-development-identified", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "University story on a Nature Immunology study finding that SMC3 is needed for genome folding in B cells; faulty SMC3 disrupts immune development and can promote cancer.", "topics": [ "smc3", "3d genome", "b cells", "immune development", "cancer" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/smc3-cornell-chronicle.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/smc3-cornell-chronicle--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/smc3-cornell-chronicle.txt", "ocr_text": { "archived": "CORNELL.EDU\nMEDIARELATIONS\nCORNELLCHRONICLE\nCampus & Community\nAll Stories\nTopics\nIn theNews\nExpert Quotes\nEzra Magazine\nGene critical to immune cell development identified\nBy Julie Grisham [ February 5, 2021\nMuch of the three-dimensional architecture of the genome in antibody-\nis not working properly it can lead to improper immune cell development and\nto cancer, by disrupting how DNA is structured inside the cell nucleus,\naccording to a team of researchers from Weill Cornell Medicine.\nThis research, detailed in a study published\nJan. ll in Nature Immunology, has broad\nimplications, because 3D genome\norganization is a vital function across all\ncell types.\nIn orderfor immune cells called B cells to\nconfront infections by making antibodies,\nthey need to change the arrangement of\ntheir chromosomes. Investigators found\nthat when SMC3 is disrupted, the cells do\nnot make these and other changes needed\nto mature; and become prone to\nmalignancy.\nEvery cell in the body contains two meters\nof DNA, which needs to be organized in\nsuch a way that it fits into the nucleus. “It's\nnot like dumping spaghetti in a colander,\"\nsaid senior author Dr. Ari M. Melnick, the\nVictoria Beguelin/Provided\nGebroe Family Professor of Hematology\nThe two canvases represent the genome as folded in.cells with.normal\n(left) or reduced levels of SMC3. The.normal canvas is highly structured\nand Medical Oncology and a member of\nand functional, while the other canvas has lost its pattern and has open\nthe Sandra and Edward Meyer Cancer\nthreads.\nCenter at Weill Cornell Medicine.\n“\"There has to be order in the way the strands are arranged,\" Melnick said, “so\nthat different parts of the genome can talk to and coordinate with each other.\"\nIt turns out the SMC3 gene encodes a protein that acts as a motor, working\nwithin a protein complex to move the strands of DNA around and make sure\nthat everything goes where it should.\nPrevious work from Melnick's lab showed that massive three-dimensional\nchanges in DNA occur as part of the immune response, but there were no data\non how these changes were regulated or controlled. In the new paper, his\nteam has shown for the first time that SMC3 is required for this activity.\nWhen they studied mice that had reduced levels of the SMC3 protein in their\nWhen they studied mice that had reduced levels of the SMC3 protein in their\nimmune cells, they found that the animals had defective B cells that were\nunable to make critical genome alterations, including rearrangement of genes\nneeded to produce antibodies. Further experiments revealed that the\norganization of the DNA in the nucleus was disturbed.\nThe SMC3 protein was previously known to be part of a group of proteins\ncalled the cohesin complex, which is essential for chromosome segregation\nduring cell division and plays an important role in gene regulation. SMC3\nmutations are found in some human cancers, and lower levels of the SMC3\ndisease.\nThey are also found in a genetic disease called Cornelia de Lange syndrome,\nwhich is characterized by slow growth, intellectual disability, abnormalities of\nthe bones, and distinct facial features.\n“Disruptions in the motor functions of the SMC3 protein and loss of function\nof the cohesin complex make cells more prone becoming malignant,\" said\nMelnick, who has consulted for Epizyme and Constellation and is on the\nscientific advisory board of KDAC pharmaceutical. The cells appear to be\naffected in such a way that they are more likely to divide and mutate, since\nthey become stuck in an intermediate stage of development prone to\ndeveloping mutations.\"\nFuture work will focus on learning more about the role of SMC3 in both\nimmune cells and cancer cells. It's also possible that the levels of the SMC3\nprotein within cancer cells may affect how they respond to different drugs.\n\"We still know very little about these 3-D mechanisms,\" Melnick said. \"There\ncan't imagine that this process is not critical to every single cell in our\nbodies.\"\nJulie Grisham is a freelance writer for Weill Cornell Medicine.\nNew York City\nHealth, Nutrition & Medicine\nMEDIA INQUIRIES\nYOU MIGHT ALSO LIKE\nCOVID-19 spread extremely low at\nCross-campus team probes gene-\nNorth Carolina day camps\nenvironment interactions\nLINKS\nCONTACT\nSUBSCRIBE\nCornellChronicle\nAbout the Chronicle\nDaily and weekly newsletters\nMedia Relations Office\n312College Ave\nFeeds-RSS&JSON\nCopyright\nIthaca,NY14850\nWebAccessibilityAssistance\n607-255-4206\ncunews@cornelledu", "live": "CORNELL.EDU\nMEDIARELATIONS\nCORNELLCHRONICLE\nTopics\nCampus & Community\nAll Stories\nPodcast\nMedia Relations\nCornellians\nGene critical to immune cell development identified\nBy Julie Grisham\nFebruary 5,2021\nMuch of the three-dimensional architecture of the genome in antibody\nis not working properly it can lead to improper immune cell development and\nto cancer, by disrupting how DNA is structured inside the cell nucleus,\naccording to a team of researchers from Weill Cornell Medicine.\nThis research, detailed in a study published\nJan. ll in Nature Immunology, has broad\nimplications, because 3D genome\norganization is a vital function across all\ncell types.\nIn order for immune cells called B cells to\nconfront infections by making antibodies,\nthey need to change the arrangement of\ntheir chromosomes. Investigators found\nthat when SMC3 is disrupted, the cells do\nnot make these and other changes needed\nto mature; and become prone to\nmalignancy.\nEvery cell in the body contains two meters\nof DNA, which needs to be organized in\nsuch a way that it fits into the nucleus. “It's\nnot like dumping spaghetti in a colander,\"\nsaid senior author Dr. Ari M. Melnick, the\nVictoria Beguelin/Provided\nGebroe Family Professor of Hematology\nThe two canvases represent the genome as folded in cells with normal\n(left) or reduced levels of SMC3. The normal canvas is highly structured\nand Medical Oncology and a member of\nand functional, while the other.canvas has lost its pattern and has open\nthe Sandra and Edward Meyer Cancer\nthreads.\nCenter at Weill Cornell Medicine.\n“There has to be order in the way the strands are arranged,\" Melnick said, \"so\nthat different parts of the genome can talk to and coordinate with each other?\nIt turns out the SMC3 gene encodes a protein that acts as a motor, working\nwithin a protein complex to move the strands of DNA around and make sure\nthat everything goes where it should.\nPrevious work from Melnick's lab showed that massive three-dimensional\nchanges in DNA occur as part of the immune response, but there were no data\non how these changes were regulated or controlled. In the new paper, his\nteam has shown for the first time that SMC3 is required for this activity.\nteam has shown for the first time that SMC3 is required for this activity.\nWhen they studied mice that had reduced levels of the SMC3 protein in their\nimmune cells, they found that the animals had defective B cells that were\nunable to make critical genome alterations, including rearrangement of genes\nneeded to produce antibodies. Further experiments revealed that the\nOorganization of the DNA in the nucleus was disturbed.\nThe SMC3 protein was previously known to be part of a group of proteins\ncalled the cohesin complex, which is essential for chromosome segregation\nduring cell division and plays an important role in gene regulation. SMC3\nmutations are found in some human cancers, and lower levels of the SMC3\ndisease.\nThey are also found in a genetic disease called Cornelia de Lange syndrome,\nwhich is characterized by slow growth, intellectual disability, abnormalities of\nthe bones, and distinct facial features.\n“Disruptions in the motor functions of the SMC3 protein and loss of function\nof the cohesin complex make cells more prone becoming malignant,\" said\nMelnick, who has consulted for Epizyme and Constellation and is on the\nscientific advisory board of KDAC pharmaceutical. “The cells appear to be\naffected in such a way that they are more likely to divide and mutate, since\nthey become stuck in an intermediate stage of development prone to\ndeveloping mutations.\"\nFuture work will focus on learning more about the role of SMC3 in both\nimmune cells and cancer cells. It's also possible that the levels of the SMC3\n\"We still know very little about these 3-D mechanisms,\" Melnick said. “There\nare important implications not only for cancer, but for biology in general. I\ncan't imagine that this process is not critical to every single cell in our\nbodies.\"\nJulie Grisham is a freelance writer for Weill Cornell Medicine.\nHealth, Nutrition & Medicine\nNew York City\nMEDIA INQUIRIESY\nGet Cornell news delivered right to your inbox.\nSUBSCRIBE\nYOU MIGHTALSO LIKE\nCOVID-19 spread extremely low at\nCross-campus team probes gene-\nNorth Carolina day camps\nenvironment interactions\nLINKS\nCONTACT\nSUBSCRIBE\nAbout the Chronicle\nComell Chronicle\nDaily andweekly newsletters" } }, { "id": "pathomap-nyt-metasub-2021", "study": "metasub", "outlet": "The New York Times", "outlet_original": "The New York Times", "outlet_score": 10, "title": "Subway Swabbers Find a Microbe Jungle and Thousands of New Species", "title_original": "Subway Swabbers Find a Microbe Jungle and Thousands of New Species", "language": "English", "date": "2021-05-26", "kind": "news", "url": "https://www.nytimes.com/2021/05/26/science/microbes-subway-metasub-mason.html", "archive_url": "https://web.archive.org/web/20210527000624/https://www.nytimes.com/2021/05/26/science/microbes-subway-metasub-mason.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Covers the Cell paper from the MetaSUB consortium, an atlas of microbes from 60 cities on six continents built by 900-plus contributors, revealing a shared core urban microbiome and over 10,000 previously unknown viruses and bacteria.", "topics": [ "metasub", "urban microbiome", "global cities", "new species", "cell" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/pathomap-nyt-metasub-2021.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/pathomap-nyt-metasub-2021--archived.jpg", "saved_html": "media-archive/html/pathomap-nyt-metasub-2021--archived.html", "saved_article_text": "media-archive/text/pathomap-nyt-metasub-2021.txt", "ocr_text": { "archived": "SCIENCE\nCheNeworkCimes\nLOGIN\nADVERTISEMENT\nSubway Swabbers Find a Microbe Jungle\n- And Thousands of New Species\nA team of international researchers has assembled an atlas of\nmicroorganisms present in 60 cities around the world.\n42\nNew York City subwayriders in 2017.From2015 to 2017,researchers collected samples in 60 cities on six\ncontinents and found 4,246 known species of microorganisms.Benjamin Norman for The NewYork Times\nByEmilyAnthes\nMay26,2021,8:00p.m.ET\nFor centuries, naturalists have mapped the world's flora and fauna.\nThey have assembled atlases of migratory birds and cold-water\nfishes, sketched out the geography of carnivorous animals and\nalpine plants.\nNow,anenormousinternationalteamofresearchershasaddeda\nnew volume to the collection: an atlas of microorganisms that can\nnew volume to the collection: an atlas of microorganisms that can\nbe found in the world's subways. It contains data collected by more\nthan 900 scientists and volunteers in 60 cities on six continents,\nfrom Stockholm to shanghai, Sacramento to Sydney.\n\"We had a coordinated phalanx of people with swabs and masks,\ncollecting genetic material from cities around the world,' said\nChristopher Mason, a geneticist at weill Cornell Medicine who led\nthe research.\nAlthough each city had its own unique microbial profile, there was\na “core urban microbiome\" that all of the cities shared, they found.\nThe scientists, members of the international MetasUB consortium,\nalso discovered more than 1o,ooo previously unidentified species of\nviruses and bacteria. They published the findings in the journal\nCell on wednesday.\n“We have taken a deep dive into the urban centers to find a breadth\nand treasure trove of new life-forms, Dr. Mason said.“\"The railings\nand the benches of our cities have sometimes just as much or more\ndiversity than what you find in a rain forest.\"\nThe source and function of many of these microbes remains\nunknown, and the research reveals how much is left to learn about\nthe microorganisms that surround us. But the findings should not\nbe cause for alarm, the scientists stress.\n\"We don't see anything that we are worried about,' said David\nDanko, one of the paper's authors and the director of\nbioinformatics for MetasUB.“People are in contact with these all\nthe time,\" He added, \"We don't want people to be scared of these\nmicrobes, because these are just part of the ecosystem that we as\nhumans live in.\"\nSubway surveyors\nMicrococcusluteus,magnified10,00 times,produces\nThe colors in a MetaSUB heatmap indicate relative\nbody odor.It was one of 31 species of bacteria-the \"core\nabundance of thetaxa,in this case, Micrococcus\nurban microbiome\"-found in nearly every sample in\nluteus.MetasUB\neverycity.JaniceHaneyCarr/cDC\nSample collection for the new study began in 2015, after Dr.\nMason's research on the microbes of the New York City subway\nsystem drew international interest. In response, he created the\nMetasUB consortium to study the microbes present in cities\naround the world.\nTeams of researchers and volunteers fanned out across the mass\ntransitsystems of 6ocities,collectingthousandsof samplesfrom\n2015 to 2017. They swabbed a wide variety of surfaces, including\nturnstiles, railings, ticket kiosks and benches inside transit stations\nand subway cars. (In a handful of cities that did not have subway\nsystems, the teams focused on the bus or train system.)\nThe scientists' subterranean sampling expeditions often attracted\nattention. Some commuters grew so curious that they joined the\nvolunteer swabbing corps, while others insisted that they\nabsolutely did not want to know what was living on the subway\npoles. Passengers occasionally misunderstood what the\nresearchers were doing with their tiny swabs. “One man effusively\nthanked us for cleaning the subway, Dr. Mason said.\nThe researchers also collected air samples from the transit\nsystems of six cities - New York, Denver, London, oslo, Stockholm", "live": "To continue to The New York Times, please\nconfirm that you are human.\nSlide right to secure your access\nYour IP address is 157.139.64.11\nHaving trouble? Contact support.\nID:6cadff9b-3135-e44a-24be-2160eb46f206", "image": "42" } }, { "id": "metasub-wired-video", "study": "metasub", "outlet": "WIRED (video)", "outlet_original": "WIRED (video)", "outlet_score": 9, "title": "What Doctors Learned from Swabbing Subways in Different Countries", "title_original": "What Doctors Learned from Swabbing Subways in Different Countries", "language": "English", "date": "2021-07", "kind": "video", "url": "https://www.youtube.com/watch?v=euz5QpzNgXk", "archive_url": "https://web.archive.org/web/20210729185537/https://www.youtube.com/watch?v=euz5QpzNgXk", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "WIRED video on what lives on subway poles, turnstiles and seats: Christopher Mason's team swabbed every New York station and many around the world to map the microbes that travel with passengers.", "topics": [ "metasub", "subway", "urban microbiome", "video" ], "audience": "social-video", "thumbnail": "media-archive/thumbs/metasub-wired-video.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-wired-video--archived.jpg", "saved_html": "media-archive/html/metasub-wired-video--live.html", "saved_article_text": "", "ocr_text": { "archived": "YouTube\nSearch\nSIGN IN\nDr.MichioKaku Answers\nTheWayback Machinedoesnot havethis video archived.\nWasEinsginw\nPhysics Questions From...\nWIRED\n14Kviews2hoursago\nNew\nWILLMARRY\nWhy You Will Marry the Wrong\nTHEWRONG PERSON\nPerson\nGTHESCHOOLCELFE\nThe School of Life\n3.7Mviews·3yearsago\nHowNoiselessPropsAre\nMade For Movies And TV...\nReal\nSilent\nProp\nInsider\n3.7Mviews6daysago\nNew\nWorldRecord DominoRobot\n(100kdominoesin24hrs)\nMark Rober\n11Mviews·2daysago\nNew\nInsidethemind of a master\nprocrastinator|TimUrban\nTEDO\nWhatDoctorsLearnedfromSwabbingSubwaysinDifferentCountriesIWiRED\n41M views:5years ago\n77.712viewsJul26,2021\n139\nSHARE\n3.1K\n=+SAVE\nSLEOFDOGS\nSushi Master Rates 9Sushi\nScenes In Movies And TV I...\nInsider\nLimitedtimeoffer:S30offYouTubeTV\nSUBSCRIBE\n1.4Mviews.1weekago\nINSIOER HOWREALIST\nSaves10/monthfor3monthstoexplore85+livechannelsand\nIces?\nBADHANDSHAKE\nFormerFBIAgentBreaks\nYouTubeTV\non-demand hits-all summer long\nnany\nDown Body Language Pet...\nWIRED\n684Kviews3weeksago\nDISMISS\nCLAIM OFFER\nFormerFBIAgent Explains\nHow to Read Body Language ..\nFabzil 3 years ago\n\"'ve missed more than 9000 shots in my career. I've lost almost 300 games. 26 times, I've been trusted to take the\nWIREDO\n39Mviews-2yearsago\ngame winning shot and missed. I've failed over and over and over again in my life.And that is whyI succeed.\nTRADECRAFT\nOYGLNXGUASE\n-Michael Jordan\nAdam Savage's Guide to Drill\nREPLY\nBits!\nView19replies\nAdam Savage'sTested\n194Kviews-1weekag0\nHigh5Gaming2monthsago\nM.Night Shyamalan Answers\nAmazing talk.Thank you :)\nthe Web's Most Searched...\nREPLY\nWIREDO\n177Kviews-6daysago\nHeliosFTW3monthsago\nNew\nman this is freaking diamond right here...\nThe7DeadlySinsof3D\nPrinting Companies.\nREPLY\nvdeo frst?\nMaker's Muse\n38Kviews.6hoursago\nTommy-leeBarney4months ago\nNew\nBritish school kids did this regularly in theform of 'scratch'\nMagnificentStorytellerSoldier\nREPLY\nReveals What He Saw In..\nDavid Hoffman\nNatural40Rambo214monthsago\n12Mviews3yearsago\nUREROKE\nMilitarySurvival ExpertRates\nREPLY\n9 Ocean Survival Scenes In...\nInsider\nLiftPizzas3yearsago\n553Kviews-3weeksago\n\"In every job that must bedone there is an element of fun.Find the fun and snap, the job's a game.-Mary Poppins\nNSIOERHOWREA\nISIT\nREPLY\nTheSpring Paradox\nView25replies\nSteve Mould\nDOWN\n106Kviews3hoursago\nNew\nsambolester3months ago\nOne of the smartest dudes on the planet!!\nwoRLD'sWorldRecordChainFountain?\nTALLEST\nCHAIN\nREPLY\nThe Mould Effect Explained\nFOUNTAIN\nSteve Mould \n778K views·1week ago\nChanel Chung 4 months ago\nIwishhewasmyphysicsprofessorrn\n5LEVELSS1-E10\nTeen\nREPLY\nAstrophysicist Explains Gravity\nin5Levels of Difficulty...\nDJ Ravien3months ago\n5Leve\nDJ\nWIRED\nGravity\n6.1Mviews.1yearago\nREPLY\nInkCartridgesAreAScam\nAustinMcConnell\nREPLY\nInkCartridgesAreAScam\nAustinMcConnell\nMadi B4months ago\n9.2Mviews3yearsago\nAmazing thank you!!!\nSCAM\nREPLY\nMortician AnswersDead Body\nWhy-are.cottins so ex\nyali bury merar\nQuestionsFromTwitterITec...\n36Techniques2yearsago\nWIREDO\nlife is like supermario..we spend most of our time collecting gold coins, but if you eat mushrooms you go up a level\n12Mviews·2monthsago\n1.2K\nREPLY\nWHO'S RIGHT?\nAPhysicsProfBetMeS10,000\nView15replies\nI'm wrong\nVeritasium\nPhiro NoSurvivors 3monthsago\n6.9Mviews-4weeksago\n.. great speech..Iwonder though.. Howmany abandoned thetest\nNothing Ear(1) Review: See\nREPLY\nThrough the Hype!\nMarquesBrownlee\nVanitas Vanistatum3months ago\n775Kviews5hoursago\nItgivesmetheideatoapplySuperMarioonpianolearning\nNew\nREPLY\nAustinMychaelDuhon4monthsago\nYOUROCK!! MYMOMSABIOCHEMISTANDSHEAGREESYOUARETHECOOLESTSUPERFLYSCIENCEGUY!LOL\n4REALTHOU\nREPLY\n3monthsago\n\"Focus on the Princess not the pits, to stick with the task and learn more\"\nREPLY\nCooperWarren1year ago\nThis man just straight up admit that he clickbaits to teach people. If that's not wholesome,I don't know what is.\n面615\nREPLY\nView6replies\nOllyKing854monthsago\nLove how our brain thinks about the mario effect but still gets tricked to learningmore\nREPLY\nSerena Simdi 3months ago\nI love this, its funnytoo\nREPLY\nMaxWind3monthsago\nI didn't realize that was you untilI saw the sand filled hot tub. Nice work.\nREPLY\nJenna M4.months ago\nimagien if they used the super mario effect in school \nREPLY\nFabzil 3 years ago\n\"'ve missed more than 9000 shots in my career.I've lost almost 300 games.26 times, I've been trusted to take the\ngame winning shot and missed. I've failed over and over and over again in my life. And that is why I succeed.\nMichael Jordan\n面1.8K\nREPLY\nView19replies\nHigh5Gaming2monthsago\nAmazingtalk.Thank you:)\nREPLY\nHeliosFTW3monthsago\nman this is freaking diamond right here...\nREPLY\nTommy-leeBarney 4months ago\nBritish school kids did this regularly in theform of'scratch\"\nREPLY\nNatural40Rambo214monthsago\n1:510\nREPLY\nLift Pizzas 3 years ago\n\"In every job that must be done there is an element of fun. Find the fun and snap, the job's a game. - Mary Poppins\nREPLY\nView25replies\nsambo lester 3months ago\nOneofthesmartestdudesontheplanet!!!\nREPLY\nChanel Chung 4months ago\nIwishhewasmyphysicsprofessorrn\nREPLY\nDJ Ravien3months ago\nNow answer whyI can remember wherethe hidden stars and warps are over 20 years later.\nREPLY\nMadi B 4months ago\nAmazingthank youll!\nREPLY\n36Techniques 2 years ago\nlife is like super mario.. we spend most of our time collecting gold coins, but if you eat mushrooms you go up a level\nREPLY\nView15replies\nPhiro NoSurvivors 3 months ago\n... great speech..I wonder though.. How many abandoned the test\nREPLY\nVanitas Vanistatum3monthsago\nREPLY\nAustin Mychael Duhon 4months ago\n4REAL THOU\nREPLY\nl3months ago\n\"FocusonthePrincess notthepits,to stickwiththetask and learnmore\"\nREPLY\nCooper Warren1 year ago\nThis man just straight up admit that he clickbaits to teach people. If that's not wholesome, I don't know what is.\n#615\nREPLY\nView6replies\nollyking854monthsago\nLove how our brain thinks about the mario effect but still gets tricked to learning more\nREPLY\nSerena Simdi 3months ago\nIlovethis,itsfunnytoo@\nREPLY\nMaxWind3months ago\nI didn't realize that was youuntil I sawthe sand flled hot tub.Nice work.\nREPLY\nJenna M4months ago\nimagien if they used the super mario effect in school e\nREPLY\nFabzil 3 years ago\n\"I've missed more than 9000 shots in my career. I've lost almost 300 games.26 times, I've been trusted to take the\ngame winning shot and missed. I've failed over and over and over again in my life.And that is why I succeed.\n-Michael Jordan\n面 1.8K\nREPLY\nView19replies\nHigh5Gaming 2months ago\nAmazingtalk.Thankyou:)\nREPLY\nHeliosFTW3months ago\nman this is freaking diamond right here....\nREPLY\nTommy-lee Barney 4months ago\nBritish school kids did this regularly in the form of\"scratch\nBritishschoolkidsdidthisregularlyintheformof\"scratch'\nREPLY\nNatural40 Rambo21 4months ago\n1:51\nREPLY\nLift Pizzas3yearsago\n\"In every job that must be done there is an element of fun.Find the fun and snap,the job's a game.-Mary Poppins\n面3.1K\nREPLY\nView25replies\nsambolester3months ago\nOneofthesmartestdudesontheplanet!!!\nREPLY\nChanel Chung 4months ago\nIwishhewasmyphysicsprofessorrn\nREPLY\nDJ Ravien 3months ago\nNowanswerwhyIcanrememberwherethehiddenstarsandwarpsareover20yearslater.\nREPLY\nMadi B4monthsago\nAmazing thank you!!!!\nREPLY\n36Techniques2years ago\nlifeis like supermario..we spendmost of our time collecting gold coins, but if you eatmushrooms you goupa level\nREPLY\nView15replies\nPhiroNoSurvivors 3months ago\n... great speech..I wonder though.. How many abandoned the test \nREPLY\nVanitas Vanistatum 3 months ago\nIt gives me the idea to apply Super Mario on piano learning\nREPLY\nAustinMychaelDuhon4monthsago\nYOUROCK!! MYMOMSABIOCHEMISTANDSHEAGREESYOUARETHECOOLESTSUPERFLYSCIENCEGUY!LOL\n4REAL THOU\nREPLY\nl3monthsago\n\"Focus on the Princess not the pits, to stick with the task and learn more\"\nREPLY\nCooper Warren 1 year ago\nThis man just straight up admit that he clickbaits to teach people. If that's not wholesome,I don't know what is.\nREPLY\nView6replies\nOllyKing854monthsago\nLovehow our brain thinks about themario effectbut still gets tricked to learning more\nREPLY\nSerena Simdi 3months ago\nI love this, its funnytoo\nREPLY\nMaxWind3monthsago\nI didn't realize that was you until I sawthe sand flled hot tub.Nice work.\nREPLY\nJennaM4monthsago\nimagien if they used the super mario effect in school @\nREPLY", "live": "Search\nDYouTube\nSign in\nMicrobiologist\nDo you need to clean\nAnswers Microbiology\nyourmircowave?Can\nbacteriaevensurvive?\nQuestionsFrom...\nWIRED\nD3.1M2yago\nWIRED\n28:17\nTheOnlyDiseaseYou\nCan't Catch\nDoctorMike\n>6.3M10moago\nTHISIS\nSMALLI\n2038\nNew%DEATHRATE\nHowISurvived Late-\nStageCancer(AFun\nStory)\nKurzgesagt In a Nu..\nD4.1M1dago\n14:54\nWHY\nWhy Don't We Eat\nWhatDoctorsLearnedfromSwabbingSubwaysinDifferentCountries/WiRED\nDuck Eggs Everywhere\nIf Ducks Lay Almost ...\nWIRED\n 10K\nSubscribe\nSave\nMurph\n13M subscribers\nD1.3M2moago\n431K views 5years ago\n35:48\nA subway pole, a turnstile, a seat...what kinds of bacteria and microbes live on these surfaces? Dr. Christopher Mason and his\nWhy Cold Drinks Were\nSafe\nteam swabbed every subway station in New York City,and manyaround theglobe,to comeup with theanswers.\nLethal\nDeadly Before 1914\n...more\nVeritasium\n>12M8moago\n466Comments\n=Sort by\n30:17\nAdd acomment...\nNew\nWhat Really Happened\nWhenAlSolveda\n@infamousborg96345yearsago\nMillion-Dollar Math..\nV.u=0\nI'm outraged! Allthose\"species\"riding the subwayforfree??\nNew Scientist\nD9.4k4hago\n 1.6K\nReply\nLEARNED NOTHINQ:57\n13repliesV\nA100%FatalDisease\nJust Founda\n@eddiehopper24445yearsago\nTreatment\nLoll likehowNaples has ahigherconcentrateofmicroscopicpizza dough thanothercities\nDrBenMiles\n557\nReply\nD2.4M3wago\n22:04\n9 replies\nShe Lied\nNew\nLegaiEagleO\n@Sjalabais5years ago\nD1.1M1dago\nfascinating way.Ihopehe's teaching!\n 112\nReply\n29:27\n2repliesV\n15 Things a Retired\nNYPDDetective\n@RoyalKnightish5yearsago\nTeachesWomen...\nLol Tokyohasgotmoreantibioticsthanmicroorganismitself.\nJackie Shaw\nD246K2wago\n 318\nReply\n22:15\n1 reply\nElizabeth Holmes&\nTheranos|60Minutes\n@Discotechque 5 years ago\nArchive\nThetrain is soItalian it hasyeastforbakingpizza.\n60Minutes\n5 68\nReply\nD1.9M13dago\n13:38\n1 reply V\nWhy Does Fentanyl\nFeel So Good?\n@simple11g5yearsago\nKurzgesagt-In a Nu..\nOh man-that gives a whole NEwmeaning to that guy that licked all the poles and rails on the subway and busses. If you\n>12M1yago\nguysrememberduringthepandemic.\n 377\nReply\n14:58\n7 repliesV\nBiomedical scientist\nAnswers More\n7repliesV\nBiomedicalScientist\nAnswersMore\n@jimmycantor96025 years ago\nPseudoscience ...\nWIRED\nLong story short: don't hide in nyc. This dude will track you down better than the K-9 unit\nD1.6M1yago\n 490\nReply\n32:22\n10 repliesV\nThe Best Client of My\nNew\nEntire Pet Grooming\n@Rentaro895years ago\nCareer\nThe before and after of big events would be interesting. Like what was different in Rio? And how did it change after the start\nGirl WithTheDogs 2\nof the pandemic?Didthedesinfection of whole streetsdo something significant in Asia?\nD4.1M3dago\n 313\nReply\n28:41\n5 repliesV\nWhyHumans Can Eat\nAnything (But Animals\nCan't)\n@thirdeyeangel 5 years ago\nTp Dossier\nThis was extremely interesting!Thank you for covering this.It makes you look at the world a little different when you start\nD848K2wago\nthinkingaboutthemicrobiomesofeverywhereyouvisit\n23:25\n109\nReply\nThe Man WithThe\n@mathiasbekker2115yearsago\nMostValuableBlood\nBecky:\"so for commuters riding subways around the world, you might not wanna touch the poles, turnstiles and seats like\nOn Earth\nyou used to\"\nDoctorMike\nDr. Mason: ehhh..did you even listen, Becky?Iactually think it's okay to grab the subway pole\"\nD5.4M2yago\n41\nReply\n7:53\n3 repliesV\nDoctorAnswers\nVaccineQuestionsl\nTech Support / WIRED\n@rey619ih5yearsago\nWIREDO\nSo innycyoufindconstructiongerms\nD812K10moago\nInnaplesyou'llfindpizzagerms\nIngreeceyou'll findfishgerms\n25:17\nAnd inTokyoyou'll findOtakugerms?Got it\n 29\nScience Can't Ignore It\nReply\nAnymore\nTodayI LearnedScie..\n@chipkosboth32335yearsago\n>856K2moago\nMoral of thestory:buynewshoeswhen yougotoanewcitybeforecommittingcrimes\n188\nReply\n28:16\n9 repliesV\nNew\nWhy Elizabeth Holmes\nIs SOGOODat\n@TomNook. 5 years ago\nManipulation Body ...\nhaha,soItaliansubwaysaremadeofpizza.LookslikeSKoreanTVwasright:D\nDr.G Explains\nD230K1dago\n124\nReply\n16:05\n4 repliesV\nSurgeon Answers\nSurgeryQuestions\n@TathD5years ago\nFrom TwitterITech...\nCities they studied:\nWIREDO\nNew York\nD4.1M5yago\nNaples\nRio de Janeiro..\n12:13\nRead more\nBiomedical Scientist\n188\nReply\nDebunks The Biggest\nPeptide Myths on...\nWIREDO\n5 replies\nD563K3wago\n@Boo-pv4hn 5 years ago\n19:22\nWould love them to do this round the U.K., I'd be very intrigued\nPaleontologist\n 27\nReply\nAnswersFossil\nQuestions/Tech...\n2 replies V\nWIRED\nD1.2M1yago\n@iammaxhailme5yearsago\n27:52\nthe least surprising thing i've ever heard in my life is finding rat DNA on the subway\nMapping the Bacteria\nReply\nintheNYC Subway\nTheWall Street Journ..\n2 replies V\n22K11yago\n@CREAOOfficial5years ago\n6:26\nSo much science.Go science.\nMedical Historian\nReply\nAnswers History of\n@bonnieinla 5 years ago\nMedicine Questions ...\nWIREDO\nLearned something...morestories likethisplease!\nD1.2M5moago\nReply\n27:06\n@spawnymint 5 years ago\nThe Ridiculous\n@spawnymint 5 years ago\nThe Ridiculous\nThis was so interesting! Iwonder if this information can be used to trace some infections even if the bacteria itself isn't\nEngineeringOf Jet\ndangerous\nEngines\n 22\nReply\nVeritasium\nD16M11moago\n1 reply\n39:34\n@roksanabuller69195yearsago\nHow HIV Starteda\nwatchingthisat2amjusthitsdifferent\nCentury Before\nAnyone Noticed\nReply\nBe Smart \n@cheryi-lynnmehring86065yearsago\nYou have to be tough to make it in NY, even if you are a Microbe!\n28:10\nReply\nWhat a Stroke Looks\nLiketheDay Before It\n@sharrajab35045yearsago\nHits-Know This to...\nAttheend ofthevideo:I haveno confidencetoholdona subwaypoleeveragain.\nDr. William Parker Senior..\nD2.8M3moago\nReply\n26:45\n@LetoDK 5 years ago (edited)\nThe situation in Japan could be explained by the fact that although it's a very clean nation in many ways, the use of hand\nThe Insane\nsoap is very very limited.Most public restrooms don't have hand soap.\nEngineering of Fiber\nOptics\nReply\nVeritasium\nD13M2wago\n4 replies\n34:32\n@TheFiown5years ago\nTheProfessorWho\nManyyears agomy allergologist in Paristoldmenevertotakethe subway,he said thattheyhad even found the plagueand\nTaughtPeopleHowTo\nmany really terrible microbes that could give us many illnesses. Itook the bus or walked.\nThink (1962)\nABCScienceO\nReply\nan.\nD3.2M5moago\n@nadiamunday83515 years ago\n29:34\nFascinating!Wouldlovetoaccessthefull study\nImmunologist\nReply\nAnswersImmune\nSystem Questions...\n@zackangel17104years ago\nWIRED\nWhata wholesomedudelol\nD1M 3yago\nReply\n13:59\n@c10na735years ago\nThe Closest Thing We\nSooooo,I shouldn'tbe as grossed out as Iwas when my daughter put herface on the seat infront ofus in the bus today? She\nHave to Alien\njustexposed herself toagoodamount of probiotics?\nTechnology\nReply\nVeritasium\n64M9moago\n1 reply\n55:00\nNew\n@herazka5yearsago\nPumpkins Shouldn't\nExist\nInteresting.Thanks for sharing!\nPBS Eons\nReply\n432K1dago\n@jamesl9371 5 years ago\n14:03\nGreat project :Good job\nReply\nNew\nAI Crisis in Math:\nNavier-Stokes,\n@BigGroupHug 5 years ago\nRiemann Hypothesis..\nFascinating. Another!\nLex Fridman \nD698K 1dago\nReply\n3:34:27\n@lg29715years ago\nFascinating! Thank youl!\nThis Deep Sea Reptile\nShouldn't Exist\nReply\nStephanieSammann\n>1.6M3moago\n@Opioid-z5years ago\nDon't get scared peopoooo this is normal don't live in fear just ofc don't go around licking poles and similar stuff\n36:20\nReply\nThe Republican Party\nNew\n@danajaber2679 5 years ago\n& The Far Right: Last\nit soweird tobetold notto beafraid of touching public transportation polls after thepandemic\nWeek Tonight with...\nLastWeekTonight\nReply\nD5.3M2dago\n@Raphaelus135yearsago\n36:12\nExcellent.\nThe Secret to Mind\nReply\nControl-Nobel Prize\n2026EXPLAINED\n@doubtsshadow5yearsago\nDr Ben MilesO\n5:34 LoL why did ithink he was gonna talk about show style and fashion. Forgot what type of video I'm on\nD1.8M2wago\nReply\n20:32\nReply\n20:32\n@daveblack69515 years ago\nThe Mitochondria\nAmazing stuff!\nDoctor:This Reverses\nGray Hair, Makes Yo...\nReply\nTheDiaryOfACEOa.\n@roachtoasties 5 years ago (edited)\nInmypartofthe world(California)there'splentyof Barfovomitium,Bodyodorvorans,Neverwashedyourclothesbacillusom\n238:38\nThemost overlooked\nReply\ntaste inthe world\nRabbitHoleand50x..\n1 reply\nD683K2wago\n@ggcatbelladogantics29595yearsago\n39:54\nInevertouch subwaypoleswithmy handunlessIabsolutely haveto.\nReply\nIs AI Hiding Its Full\nPower? With Geoffrey\nHinton\n1 reply\nStarTalk\nD4.1M8moago\n@HuemorDGAP5yearsago\n133:33\nFascinating!!!\nGenius 10 Year Old's\nResearchShocks\n@Tim-57 5 years ago\nScientists Around th...\nExtremely interesting.\nACurious Birb\nD5.7M7moago\nReply\n14:02\nThisSecretCave\nCould Change How\nWe See Early Human...\nNOVAPBS OfficialO\nD646K3wago\n54:08", "image": "WIRED" } }, { "id": "metasub-smithsonian", "study": "metasub", "outlet": "Smithsonian Magazine", "outlet_original": "Smithsonian Magazine", "outlet_score": 9, "title": "Thousands of Unknown Microbes Found in Subways Around the World", "title_original": "Thousands of Unknown Microbes Found in Subways Around the World", "language": "English", "date": "2021-05", "kind": "news", "url": "https://www.smithsonianmag.com/smart-news/thousands-unknown-microbes-found-subways-around-world-180977851/", "archive_url": "https://web.archive.org/web/20210528224329/https://www.smithsonianmag.com/smart-news/thousands-unknown-microbes-found-subways-around-world-180977851/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Summarizes the Cell MetaSUB study of 60 transit systems, which found a core urban microbiome of 31 shared bacterial species and thousands of unidentified viruses and bacteria.", "topics": [ "metasub", "subway microbes", "core microbiome", "cell", "urban" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/metasub-smithsonian.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-smithsonian--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/metasub-smithsonian.txt", "ocr_text": { "archived": "Smithsonian\nSUBSCRIBE\nRENEW\nGIVEA GIFT\nMAGAZINE\nHISTORY\nSCIENCE\nPHOTOS\nVIDEO\nSMARTNEWS\nINGENUITY\nARTS & CULTURE\nTRAVEL\nAT THE SMITHSONIAN\nGAMES\nSUBSCRIBE\nSHOP\nHISTORY\nSCIENCE\nINNOVATION\nARTS&CULTURE\nTRAVEL\nPHOTO OF THE DAY\nSMARTNEWS\nKeeping you current\nA small European Honey bee\ncollecting pollen in the summer.\nThousands of Unknown Microbes Found in\nEuropean HoneyBee\nPHOTO OF THE DAY\"\nSubways Around the World\nMOST POPULAR\nAteam of morethan goo scientists andvolunteers swabbed the\n1.Tiffany Stained Glass at Art Institute of\nChicago\nsurfacesof6opublictransitsystems\n2. Park Ranger Stumbles Upon Treasure Trove\nof Several-Million-Year-OldFossilsinNorthern\nPEX\nCalifornia\n3.What ArchaeologyTells Us AbouttheAncient\nHistory of Eating Kosher\n4.How Tudor Women Saved Anne Boleyn's\nPrayer Book\n5.MadagascarMayBeStrongholdforAncient\nFish With420-Million-Year History\n6.Haydarpasa Station Excavations Reveal\nAncient Apse\n7.RosaryBeads Owned byMary,Queen of\nScots,Stolen in Heist at English Castle\n8. Spot the Difference\n9.Lost Scottish Village of Netherton Found\n10.TheTrue Storyof Pocahontas\n11.Biggest. Antlers.Ever.Meet the Irish Ek\n12.Looking Beyond the Female Firsts of Science\nHistory\n13.ABrief History of the Cheez-It\n14.14 Fun Facts About Cicadas\n15. Cicadas Fall Prey to a Psychedelic-Producing\nFungus That Makes Their Butts Fall Off\nPassengers ride the New York City subway on May 24, 2021.(Tayfun Coskun/Anadolu Agency via Getty\nADVERTISEMENT\nBy Theresa Machemer\nSMITHSONIANMAG.COM\nMAY28,202110:23AM\nesearch published this week in the journal Cell catalogues themicrobial makeup of 6o public\ntransportation systems around the globe.\nBetween 2015 and 2017,more than 900 scientists and volunteers on six continents swabbed\nthe benches, railings, turnstiles and ticket kiosks of subway and bus stops, Emily Anthes\nreports for the New York Times. The effort resulted in the discovery of the“core urban microbiome,\"or\n31 species of bacteria common to 97 percent of the samples gathered in the study. The research also\nrevealed the presence of almost 11,ooo viruses and over 70o bacteria species that have not yet been\nidentified.\nThe study is“fantastic,\"says Liverpool School of Tropical Medicine microbiologist Adam Roberts, who\nwas not involved in the research, to Cathleen O'Grady at Science magazine.They've done an amazing\njob bringing this all together. I think this data will be analyzed for decades to come.\"\nBecause the study covers dozens of cities instead of just one, it presents an opportunity to answer new\nquestions, Roberts tells Science. The research team was led by Christopher Mason, whose 2015 study\non the microbes of the New York subway system sparked other researchers'interest. The team grew as\npassersby seeing the scientists meticulously swabbing surfaces in the subway volunteered to help,\nreports the New York Times.\nBy swabbing surfaces, the researchers gathered DNA from the microbes that had lived and died there.\nSurfaces were swabbed for long enough to gather the DNA, but not so long that the researchers and\ncommuting crowds became too uncomfortable. Three minutes of swabbing per surface was“the perfect\nbalance between DNA yield and social discomfort,\"Mason tells Science.\nthird\nThe samples yielded 4,246 known species of microbes. Two-thirds were bacteria, while the other third\nwas a mix of fungi, viruses and other microbes. Thirty-one bacteria species were present in nearly every\ncity, earning them the title of the core urban microbiome. About half of those 3i bacteria species are\ncommon on the human body, especially on the skin. Other species are commonly found in dirt, water or\ndust.\nEach city had a different microbial makeup. That means that the researchers could predict with 88\npercent accuracy which city a random sample came from. Further research could establish recognizable\nurban fingerprints for use in forensics, Mason tells Science.\nBut the research also found 748 bacteria and 10,928 viruses that haven't yet been identified.\n\"We could see these were real-theyre microorganisms-but they're not anywhere in any database,\"\nsays University Hospital Tubingen biologist Daniela Bezdan, former executive director of MetasUB, the\nresearch consortium that ran the study, to the New York Times.\nThe mystery microbes are not a cause for concern, the researchers say.Most of the viruses are probably\nbacteriophages, which infect bacteria, not humans. The sample collection technique that they used also\ncan't differentiate between microbes that are living and dead-when bacteria, viruses and fungi die on\nthe subway surfaces, their DNA is left behind.\nThe research could open new methods for monitoring public health or new candidates for antibiotics.\n\"The amount of microbial diversity is just incomprehensibly vast,\" says Northwestern University\nmicrobiologist Erica Hartmann, who was not involved in the study, to the New York Times.\"There's so\nmuch out there that we just don't really understand, and there could be all kinds of nifty\nbiotechnologies and allkinds of fun chemistries that we're not aware of yet.\"\nLike this article? SIGN UP for our newsletter\nEmail\nSIGNUP\nPrivacyPolicy,Termsof Use\nTheresa Machemer is a freelance writer based in Washington DC.Her work has also appeared in National\nGeographicandScishow.Website:tkmach.com\nRead morefromthis authorIFollow@theresakmach\nTAGS\nCities\nDNAMicrobes,Bacteria,Viruses\nMicrobiome\nNewResearchNewYork\nCity\nTransportation\nRecommendedVideos\n00:00/03:45\nCOMMENTONTHISSTORY\nDisqus seems to be taking longer than usual. Reload?", "live": "Smithsonian magazine\nShop\nQ Search\nNewsletters\nRenew\nGivea Gift\nSubscribe\nMembership\nSubscribe to Smithsonian magazine and geta FREEtote.\nNewResearch\nThousands of Unknown Microbes Found in\nSubways Around the World\nA team of more than 900 scientists and volunteers swabbed the surfaces of 60 public transit\nsystems\nTheresa MachemerICorrespondent\nMay 28,2021\nd Sharev\nGAddas preferred source\nPEX\nResearch published this week in the journal Cell catalogues the microbial makeup of 60 public\ntransportation systems around the globe.\nBetween 2015 and 2017, more than 900 scientists and volunteers on six continents swabbed the\nbenches, railings, turnstiles and ticket kiosks of subway and bus stops, Emily Anthes reports for the\nNew York Times. The effort resulted in the discovery of the “core urban microbiome, or 31 species of\nbacteria common to 97 percent of the samples gathered in the study. The research also revealed the\npresence of almost 11,000 viruses and over 700 bacteria species that have not yet been identified.\nThe study is “fantastic,' says Liverpool School of Tropical Medicine microbiologist Adam Roberts, who\nwas not involved in the research, to Cathleen O'Grady at Science magazine. “They've done an amazing\njob bringing this all together. I think this data will be analyzed for decades to come.\"\nBecause the study covers dozens of cities instead of just one, it presents an opportunity to answer new\nquestions, Roberts tells Science. The research team was led by Christopher Mason, whose 2015 study\non the microbes of the New York subway system sparked other researchers interest. The team grew as\npassersby seeing the scientists meticulously swabbing surfaces in the subway volunteered to help,\nreports the New York Times.\nBy swabbing surfaces, the researchers gathered DNA from the microbes that had lived and died there.\nSurfaces were swabbed for long enough to gather the DNA, but not so long that the researchers and\ncommuting crowds became too uncomfortable. Three minutes of swabbing per surface was \"the\nperfect balance between DNA yield and social discomfort,' Mason tells Science.\nThe samples yielded 4,246 known species of microbes. Two-thirds were bacteria, while the other third\nwas a mix of fungi, viruses and other microbes. Thirty-one bacteria species were present in nearly\nevery city, earning them the title of the core urban microbiome. About half of those 31 bacteria species\nare common on the human body, especially on the skin. Other species are commonly found in dirt,\nwater or dust.\nEach city had a different microbial makeup. That means that the researchers could predict with 88\npercent accuracy which city a random sample came from. Further research could establish\nrecognizable urban fingerprints for use in forensics, Mason tells Science.\nBut the research also found 748 bacteria and 10,928 viruses that haven't yet been identified.\n\"We could see these were realthey're microorganisms-but they're not anywhere in any database,\nsays University Hospital Tubingen biologist Daniela Bezdan, former executive director of MetasUB,\nthe research consortium that ran the study, to the New York Times.\nThe mystery microbes are not a cause for concern, the researchers say. Most of the viruses are probably\nbacteriophages, which infect bacteria, not humans. The sample collection technique that they used also\ncan't differentiate between microbes that are living and dead-when bacteria, viruses and fungi die on\nthe subway surfaces, their DNA is left behind.\nThe research could open new methods for monitoring public health or new candidates for antibiotics.\n“The amount of microbial diversity is just incomprehensibly vast,' says Northwestern University\nmicrobiologist Erica Hartmann, who was not involved in the study, to the New York Times. “There's so\nmuch out there that we just don't really understand, and there could be all kinds of nifty\nbiotechnologies and all kinds of fun chemistries that we're not aware of yet\"\nYou Might Also Like\nEvery City Has a Unique Microbial “Fingerprint\"\nApril20,2016\nScientists Investigate the Bacteria That Colonized Extinct Mammoths-and Uncover the Oldest\nKnown Microbial DNA From a Host\nSeptember 8,2025\nThese Bees Fight Varroa Mites With Help From Special Engineered Bacteria\nFebruary 4,2020\nScientists Extract 15,000-Year-Old Viruses From Tibetan Glacier\nJuly26,2021\nScientists Find New Type of Antibiotics Hiding in the Human Nose\nJuly28,2016\nTheresaMachemer isa freelancewriterbased in Washington DC.Her work has alsoappeared in\nNational GeographicandSciShow.Website:tkmach.com", "image": "PEX\n212675-6600" } }, { "id": "metasub-cellpress", "study": "metasub", "outlet": "Cell Press (EurekAlert!)", "outlet_original": "Cell Press (EurekAlert!)", "outlet_score": 7, "title": "Global study of 60 cities' microbes finds each has a signature microbial fingerprint", "title_original": "Global study of 60 cities' microbes finds each has a signature microbial fingerprint", "language": "English", "date": "2021-05-26", "kind": "press-release", "url": "https://www.eurekalert.org/news-releases/734958", "archive_url": "https://web.archive.org/web/20211125030852/https://www.eurekalert.org/news-releases/734958", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Release on the largest global urban metagenomics study, sampling transit systems and hospitals in 60 cities, finding each city has a distinct microbial signature and cataloguing many unreferenced species.", "topics": [ "metasub", "urban microbiome", "metagenomics", "cell", "60 cities" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/metasub-cellpress.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-cellpress--archived.jpg", "saved_html": "media-archive/html/metasub-cellpress--archived.html", "saved_article_text": "media-archive/text/metasub-cellpress.txt", "ocr_text": { "archived": "EurekAlert!\nNAAAS\nSEARCHARCHIVE\nADVANCED SEARCH\nHOME\nNEWSRELEASES\nMULTIMEDIA\nMEETINGS\nLOGIN\nREGISTER\nNEWSRELEASE26-MAY-2021\nMedia Contact\nGlobal study of 60 cities' microbes finds\nCarly Britton\neach has a signature microbial\npress@cell.com\nfingerprint\nOffice:617-417-7053\nPeer-Reviewed Publication\nCELL PRESS\nMore on this News Release\nAninternationalconsortium hasreportedthelargest-everglobal metagenomicstudyof\nGlobalstudyof60cities\nurban microbiomes,spanningboththe airand the surfaces ofmultiple cities.The\nmicrobesfindseachhasa\ninternationalproject,whichsequencedand analyzedsamplescollectedfrompublictransit\nsignaturemicrobial fingerprint\nsystems and hospitals in 60 cities around the world,features comprehensive analysis and\nCELLPRESS\nannotation for all the microbial species identified--including thousands ofviruses and bacteria\nJOURNAL\nand two archaea notfound in reference databases.The study appears May26 in the journal\nCell\nCell.\nDOI\n\"Every city has its own 'molecular echo' of the microbes that define it,\" says senior author\n10.1016/j.cell.2021.05.002\nChristopherMason (@mason_lab),aprofessoratWeill Cornell Medicine(wCM)andthe\ndirector oftheWorldQuant Initiativefor Quantitative Prediction.\"if yougaveme yourshoe,l\nKEYWORDS\ncould tell you with about 90% accuracythe city inthe world from which you came.\nURBANSTUDIES\nThefindings are based on 4.728samplesfrom citieson six continentstaken over the course\nBACTERIAL SPECIES\nofthreeyears,characterizeregional antimicrobial resistancemarkers,and representthefirst\nANTIBIOTICRESISTANCE\nsystematic worldwide catalogue of the urban microbial ecosystem.In addition to distinct\nmicrobial signatures in various cities, the analysis revealed a core set of 31 species that were\nfound in 97% of samples across the sampled urban areas.The researchers identified 4,246\nknown species of urbanmicroorganisms,but theyalsofoundthatanysubsequent sampling\nrawpotential fordiscoveries related tomicrobial diversity and biological functions awaiting in\nurbanenvironments.\nThis project began in2013,whenMason started collecting and analyzingmicrobial samples in\nthe New York City subway system. After he published his first findings, he was contacted by\nresearchers from alloverthe world who wanted to do similar studies in theirown cities.He\ndevelopedaprotocolforcollectingthesamplesand postedan instructionalvideoon\nYouTube.The samples were collected with DNA-and RNA-free swabs and sent to a lab at\nWCMforanalysis,along withpositiveand negativecontrols.Muchoftheanalysis and\nEnvironment(XSEDE)supercomputerinPittsburgh,whichledtothediscoveryof10,928\nviruses and 748 bacteria that are not present in any referencedatabases.\nThe worldwide interest inspired Mason in 2015 to create the International MetasUB\nConsortium (shortforMetagenomicsand MetadesignofSubwaysandUrbanBiomes),which\nhas sinceexpandedto collectingsamplesfromair,water.andsewageinadditiontohard\nsurfaces.ThegroupoverseesprojectssuchasGlobalCitySamplingDay(gCsD),heldevery\nyear on june 21,and has donewide-ranging studies including a comprehensivemicrobial\nanalysis of Rio dejaneiro's city surfaces and its mosquitoes before, during,and afterthe 2016\nprevalence of sARS-cov-2 and other coronaviruses in domestic cats, and a project also is\nplannedforthe2021TokyoOlympics.\nThenew research has implicationsfor detecting outbreaks of bothknown and unknown\ninfections and for studying the prevalenceof antibiotic resistant microbes in differenturban\nenvironments.It also can contributeto newdiscoveries about the evolution of microbial life.\nMetasUB researchers in Switzerland (AndreKahles and Gunnar Ratsch)also released a\nsearchable,globalDNAsequenceportal(MetaGraph,https://metagraph.ethz.ch/search)that\nindexed allknown genetic sequences (including MetasUB data), which maps any known or\nnewmicrobial interactionsandputativefunctions.\n\"There are millions of species on Earth,but we have a complete,solid genome reference for\nonly100.000 to200.000 at this point,\"Masonsays,explaining that the discovery of new\nspecies can help withthe building ofmicrobialfamily trees to see how different species are\nrelatedto oneanother.\nThefindlings alsohavemanypotential practicalapplications.\"Based onthesequencedata\nthat we've collected so far,we've alreadyfound more than 800000 new CRiSPRarrays.\"he\nsays.Additionally.thefindings indicatethe presence of newantibiotics and smallmolecules\n\"One of the next steps is to synthesize and validate some of these molecules and predicted\nBGCs,and then see whatthey domedically ortherapeutically.\"Mason says.\"People often\nthink a rainforest is a bounty ofbiodiversity and new molecules for therapies, but the same is\ntrueofasubwayrailingorbench.\"\nthink a rainforest is a bounty of biodiversity and new molecules for therapies, but the same is\ntrueofasubwayrailingorbench.\"\n###\nPlease see the acknowledgements in the paper for fullfunding information.Arelated paper\n(\"Characterization of thepublictransit airmicrobiomeand resistomereveals geographical\nspecificity)publishes in the journal Microbiome on May26.\nCell,Danko etal.:\"Aglobal metagenomic mapofurban microbiomes andantimicrobial\nresistance\"https://www.cell.com/cell/fulitext/S0092-8674(21)00585-7DOl:\n10.1016/j.cell.2021.05.002\nCell (@CellCellPress),theflagshipjournalofCell Press,isabimonthly journalthatpublishes\nfindings of unusual significance in any area ofexperimental biology,including but not limited\nto cell biology,molecularbiology.neuroscience,immunology.virologyand microbiology.\ncancer, human genetics, systems biology,signaling, and disease mechanisms and\ntherapeutics.Visit:http:/www.cell.com/cell.ToreceiveCell Pressmedia alerts,contact\npress@cell.com.\nJOURNAL\nCell\nDOI\n10.1016/j.cell.2021.05.002C\nDisclaimer:AAAS and EurekAlert!arenot responsiblefor the accuracy of news releases\npostedto EurekAlert! by contributing institutions orfor theuse of any information through\nthe EurekAlert system.\nHelp /FAQ\nfacebook.com/EurekAlert\nTerms&Conditions\nEurekAlert!\nNAAAS\nServices\nPrivacy Policy\n@EurekAlert\nEligibility Guidelines\nDisclaimer\nCopyright2021by theAmericanAssociation forthe\nyoutube.com/EurekAlert\nContact EurekAlert!\nAdvancementofScience (AAAS)", "live": "EurekAlert!\nNAAAS\nWebsite Unavailable\nThe EurekAlertl website is currently unavailablefor scheduled maintenance or due to unexpected technical\nissues.Please try again later or contact webmaster@eurekalert.org for an estimated outageduration.\nEurekAlert!AAAS\nNAAAS\n1200NewYorkAvenueNWIWashington,DC20005/USA\nPhone:1-202-326-6716|Fax:1-202-898-0391\nCopyright@2023AmericanAssociationfortheAdvancementof Science" } }, { "id": "covid-wcm-metasub-2021", "study": "metasub", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Global Microbiome Study Discovers Thousands of New Species, Maps Urban Antimicrobial Resistance", "title_original": "Global Microbiome Study Discovers Thousands of New Species, Maps Urban Antimicrobial Resistance", "language": "English", "date": "2021-05", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2021/05/global-microbiome-study-discovers-thousands-of-new-species-maps-urban-antimicrobial", "archive_url": "https://web.archive.org/web/20210527000533/https://news.weill.cornell.edu/news/2021/05/global-microbiome-study-discovers-thousands-of-new-species-maps-urban-antimicrobial", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Weill Cornell release on the Cell MetaSUB study: about 12,000 unseen bacteria and viruses across 60 cities, urban antimicrobial resistance maps, and new drug candidates.", "topics": [ "metasub", "urban microbiome", "antimicrobial resistance", "new species", "drug candidates" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/covid-wcm-metasub-2021.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-wcm-metasub-2021--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-wcm-metasub-2021.txt", "ocr_text": { "archived": "nsidersupportingWeill Cornell Medicine's effortsagainstthepandemic.\nSkiptomaincontent\nWeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nNewsroom\nPublications\nNews\nVideo&Photography\nSocial Media\nPressRoom\nAbout Us\nHome\nNews\nGlobalMicrobiomeStudyDiscoversThousandsofNew\nSpecies,MapsUrbanAntimicrobialResistanceand\nRevealsNewDrugCandidates\nMAY 26,2021\nBack toNews\nWeill CornellMedicine\nWeill Cornell Medicine\nOfficeofExternalAffairs\n1300YorkAvenue\nBox 314\nNewYork,NY10065\nPhone: (646) 962-9476\nLeft:Heba Shabaan, a third-year medical student at Weill Cornell Medical College, (left) and Dr.Christopher Mason (right)\nprepare to swab for microbes in the NYC subway system on June21,2020.Right:Subway turnstile being swabbed.Credit:\nImages courtesy of Dr.Mason.\nNEWYoRK (May 26,2021)—About 12,000 bacteria and viruses collected in a sampling from public transit systems and\nhospitals around theworldfrom2015to2017had never beforebeen identified,according toastudybythe\nInternational MetaSUB Consortium, a global effort at tracking microbes that is led by Weill Cornell Medicine investigators.\nFor the study, published May 26 in Cell, international investigators collected nearly 5,000 samples over a three-year\nperiod across 60 cities in 32 countries and six continents. The investigators analyzed the samples using a genomic\nsequencing technique called shotgun sequencing to detect the presence of various microbes, including bacteria, archaea\n(single-celled organisms that are distinct from bacteria),and viruses that use DNA as their genetic material, (Other types\nof viruses that use RNA as their genetic material, such as SARS-CoV-2,the virus that causes COVID-19, would not have\nbeen detected with the DNA analysis methods used in this pre-pandemic study.)\nThis field of researchhas important implications for detecting outbreaks of\nboth known and unknown infections and for studying the prevalence of\nantibiotic-resistant microbes in different urban environments.\nBogota\nOffa\nHanoi\n\"Every time you sit down in the subway,you are likely commuting with an\nlorin\nentirelynew species,\"said seniorauthor Dr.Christopher Mason,co-director of\nRio De Janeiro\nKuala Lumpur\nthe WorldQuant Initiative for Quantitative Prediction and a professor of\nBerlin\nphysiology and biophysics at Weill Cornell Medicine. Dr. Mason is also co-\nLisbon\nSantiago\nfounder and a paid consultant of Biotia and Onegevity Health, and a paid\nBarcelona\nTokyo\nspeaker for WorldQuant LLC.\nFairbanks\nVienna\nThe current study led to the discovery of 10,928 viruses and 748 bacteria that\nNew York City\nHamilton\nare not present in any reference databases.\nBaltimore\nLondon\nDr.Mason founded MetaSUB (shortforMetagenomics and Metadesign of\nMinneapolis\nSubways and Urban Biomes)in2015,along with Dr.EvanAfshin, who was then\nDoha\nSingapore\nan undergraduate student at Macaulay Honors College at Queens College and\nZurich\nRibeirao Preto\nis now a clinical fellow in physiology and biophysics at Weill Cornell Medicine\nAuckland\nand a paid consultant for Onegevity Health. The newly released study was led\nSydney\nSofia\nby Drs. Mason, David Danko, a Weill Cornell Graduate School doctoral student\nKyiv\nSan Francisco\nin Dr. Mason's lab during the study,and Daniela Bezdan, who was a research\nHong Kong\nassociate in computational biomedicine at Weill Cornell Medicine at that time.\nNaples\nSao Paulo\nSendal\nBy collecting samples of microbes and analyzing their genes-collectively\nMarseille\nknown as themicrobiome-the researchers hope to learn more about the\nPorto\nTaipei\nbacteria, viruses and other microorganisms that live among humans. For\nOslo\nexample, the research may help to identify the emergence of antibiotic-\nBrisbane\nDenver\nresistant strains.Predicting antibiotic resistancefrom genetic sequences alone\nParis\nSeoul\nSacramento\nlinked to resistance, quantify their abundance and confirm the genetic markers'\nStockholm\n10\n100\nability to confer resistance. They found that some cities had more resistance\nNumber of AMRs Detected\ngenes than others, and that there might be city-specific signatures for some of\nNumber of antimicrobial resistance\nthese genes.\ngenes detected by city. Courtesy of\nAntimicrobial resistance remains a major global health challenge. \"While further\nCell Press.\nresearch is needed, this dataset demonstrates the value and potential for\nmicrobiome mapping and monitoring, and the insights it can provide physicians, scientists and public health officials,\" Dr.\nAfshin said.\nMoreover, learning about the small molecules and proteins made by microbes could also lead to the discovery of new\nantibiotics as well as othermolecules that have the potential to be developed as drugs. Many antibiotics and drugs that\nare currently in use have been derived frommicrobial sources. Discoveries made about newmicrobial species could also", "live": "WeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPress Room\nVideo&Photography\nSocial Media\nImpactMagazine\nAbout Us\nHome\nNews\nGlobal Microbiome Study Discovers Thousandsof New\nSpecies,MapsUrbanAntimicrobialResistanceand\nRevealsNewDrugCandidates\nMAY26,2021\nBack to News\nfX in\n20\nWeill CornellMedicine\nOfficeofExternalAffairs\nPhone:(646)962-9476\nLeft: Heba Shabaan, a third-year medical student at Weill Cornell Medical College, (left) and Dr. Christopher Mason (right)\nprepare to swab for microbes in the NYC subway system on June 21,2020. Right: Subway turnstile being swabbed. Credit:\nImagescourtesyof Dr.Mason.\nNEW YoRK (May 26,2021)— About 12,000 bacteria and viruses collected in a sampling from public transit systems and\nInternational MetasUB Consortium,a global effort at tracking microbes that is led by Weill Cornell Medicine investigators.\nperiod across 60 cities in 32 countries and six continents. The investigators analyzed the samples using a genomic\nsequencing technique called shotgun sequencing to detect the presence of various microbes, including bacteria,archaea\n(single-celled organisms that are distinct from bacteria), and viruses that use DNA as their genetic material. (Other types\nof viruses that use RNA as their genetic material, such as SARS-CoV-2, the virus that causes COVID-19, would not have\nbeen detected with the DNA analysis methods used in this pre-pandemic study.)\nThis field of research has important implications for detecting outbreaks of\nbothknown and unknown infections andfor studying the prevalence of\nantibiotic-resistant microbes in different urban environments.\nBogota\nOffa\nHanoi\n\"Every time you sit down in the subway,you are likely commuting with an\nllorin\nentirely new species,\"said senior author Dr.Christopher Mason, co-director of\nRio De Janeiro\nKuala Lumpur\nthe WorldQuant Initiative for Quantitative Prediction and a professor of\nBerlin\nLisbon\nphysiology and biophysics at Weill Cornell Medicine. Dr. Mason is also co-\nSantiago\nfounder and a paid consultant of Biotia and Onegevity Health, and a paid\nBarcelona\nspeaker for WorldQuant LLC.\nTokyo\nFairbanks\nVienna\nThe current study led to the discovery of 10,928 viruses and 748 bacteria that\nNewYork City\nHamilton\nare not present in any reference databases.\nBaltimore\nLondon\nDr.Mason founded MetasUB (short for Metagenomics and Metadesign of\nMinneapolis\nDoha\nSubways and Urban Biomes) in 2015,along with Dr.Evan Afshin,whowas then\nSingapore\nan undergraduate student at Macaulay Honors College at Queens College and\nZurich\nRibeirao Preto\nis now a clinical fellow in physiology and biophysics at Weill Cornell Medicine\nAuckland\nand a paid consultantfor Onegevity Health.The newly released studywas led\nSydney\nSofia\nby Drs.Mason, David Danko, a Weill Cornell Graduate School doctoral student\nKyiv\nSan Francisco\nin Dr. Mason's lab during the study, and Daniela Bezdan, who was a research\nHong Kong\nassociate in computational biomedicine at Weill Cornell Medicine at that time.\nNaples\nSao Paulo\nSendai\nBy collecting samples of microbes and analyzing their genes-collectively\nMarseille\nknown as the microbiome-the researchers hope to learn moreabout the\nPorto\nTaipel\nbacteria, viruses and other microorganisms that live among humans. For\nOslo\nexample, the research may help to identify the emergence of antibiotic-\nBrisbane\nDenver\nresistant strains. Predicting antibiotic resistance from genetic sequences alone\nParis\nis challenging, but the researchers were able to map some genes known to be\nSeoul\nSacramento\nlinked to resistance, quantify their abundance and confirm the genetic markers'\nStockholm\n10\n100\nability to confer resistance.Theyfound that some cities had more resistance\nNumber of AMRs Detected\ngenes than others, and that there might be city-specific signatures for some of\nNumber ofantimicrobial resistance\nthese genes.\ngenes detected by city. Courtesy of\nCell Press.\nAntimicrobial resistance remains a major global health challenge.\"Whilefurther\nresearch is needed, this dataset demonstrates the value and potential for\nAfshin said.\nMoreover, learning about the small molecules and proteins made by microbes could also lead to the discovery of new\nantibiotics as well as other molecules that have the potential to be developed as drugs. Many antibiotics and drugs that\nare currently in use have beenderivedfrom microbial sources.Discoveries madeabout new microbial species could also\nlead to new laboratory tools and approaches, such as novel ways to use the molecular editing tool known as CRiSPR. In\nthis study,the researchers found 838,532 novel CRISPR arrayssnippets of viral DNA found inside bacteria-and 4.3\nmillion new peptides (small proteins).\nDue to these sampling efforts, Dr. Mason said that he can predict with about 90 percent accuracy where a person lives,\njust by sequencing the DNA on their shoes. Many factors were found to influence a city's microbiome, including overall\nsignatures could enablefutureforensic studies." } }, { "id": "metasub-sciencedaily", "study": "metasub", "outlet": "ScienceDaily", "outlet_original": "ScienceDaily", "outlet_score": 6, "title": "Global microbiome study discovers thousands of new species, maps urban antimicrobial resistance and reveals new drug candidates", "title_original": "Global microbiome study discovers thousands of new species, maps urban antimicrobial resistance and reveals new drug candidates", "language": "English", "date": "2021-05-27", "kind": "news", "url": "https://www.sciencedaily.com/releases/2021/05/210527112616.htm", "archive_url": "https://web.archive.org/web/20210528013636/https://www.sciencedaily.com/releases/2021/05/210527112616.htm", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports that about 12,000 previously unknown bacteria and viruses were found in nearly 5,000 samples from 60 cities in 32 countries by the MetaSUB Consortium in a Cell study.", "topics": [ "metasub", "urban microbiome", "new species", "antimicrobial resistance", "cell" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/metasub-sciencedaily.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-sciencedaily--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/metasub-sciencedaily.txt", "ocr_text": { "archived": "ScienceDaily\nFollow\nSubscribe\nYour source for the latest research news\nNew:How and When the Milky Way Came Together\nADVERTISEMENT\nFollowall ofScienceDaily's\nlatest research news and\ntop science headlines!\nSociety\nQuirky\nHealth\nTech \nEnviro\nSearch\nScience News\nfromresearchorganizations\n Print\nEmail\nShare\nGlobal microbiome study discovers thousands of new\nADVERTISEMENT\nspecies,maps urban antimicrobialresistanceand reveals\nnew drug candidates\nMost Popular\nthis week\nDate:\nMay27.2021\nPLANTS&ANIMALS\nSource:\nWeill Cornell Medicine\nMammals Can Use Their Intestines\nto Breathe\nSummary.\nAbout 12,000bacteria and viruses collected ina sampling frompublic transit systems\nand hospitals around the world from2015to2017had never before been identified.\naccording to a new study.\nWhichAnimalsWill SurviveClimate\nChange?\nShare:\nHarvesting Light LikeNatureDoes\nRELATEDTOPICS\nFULL STORY\nHealth&Medicine\nAbout 12,o00 bacteria and viruses collected ina\nEARTH&CLIMATE\n>Genes\nsamplingfrompublictransitsystemsandhospitals\nAntarctic Ice Sheet Retreat Could\naround theworld from2015to2017had never\n>Human Biology\nTrigger Chain Reaction\nbefore been identified, accordingto a study by the\n>Personalized Medicine\nInternational MetasUB Consortium,a global effort\nGenetic Effects of Chermobyl\n>MedicalTopics\nattracking microbes that is led by Weill Cornell\nRadiation\nPlants&Animals\nMedicine investigators.\nEnvironmental Impactsof theCOVID-19\nMicrobesandMore\nForthestudy.publishedMay26 inCell,internationalinvestigators\nPandemic,asObservedfromSpace\n>NewSpecies\ncollectednearly5,000samplesovera three-yearperiodacross60\nFOSSILS&RUINS\n>Biology\ncities in 32 countries and six continents.The investigators\nanalyzedthe samples usinga genomic sequencingtechnique\nBoy or Gir? It's in the Father's Genes\nBiotechnology and\ncalled shotgun sequencing to detect the presence of various\nThe'Great Dying\"\nBioengineering\nmicrobes,includingbacteria,archaea (single-celledorganisms that\nare distinct from bacteria), and viruses that use DNA as their\nTheCerebellumMayHavePlayed\ngenetic material. (Other types of viruses that use RNA as their\nan Important Role in theEvolution\ngenetic material, such as SARs-CoV-2, the virus that causes\nRELATEDTERMS\nof the Human Brain\nCOVID-19,wouldnothavebeendetectedwiththeDNAanalysis\nADVERTISEMENT\nVirus\nmethods used in this pre-pandemic study.)\nRotavirus\nThis fieldof researchhas important implications fordetecting\noutbreaks ofbothknownandunknown infections andfor studying\nEpidemiology\nStrange&Offbeat\nthe prevalence ofantibiotic-resistant microbes in different urban\nFish\nenvironments.\nPLANTS&ANIMALS\nMicroorganism\nParasites as Fountains of Youth:Study Finds\nInfectedAntsLiveMuchLonger\nDecade Voicanoes\nMason,co-directoroftheWorldQuant InitiativeforQuantitative\nPrediction anda professorof physiology andbiophysics at Weill\nLymph node\nDiveBombingKillerFliesAreSoFast They Lose\nSteering Control\n》Biology\nCornell Medicine.Dr.Mason is also co-founder anda paid\nconsultant of Biotia and Onegevity Health,and a paid speakerfor\nHow'Non-Professional Cells Can Trigger\nWorldQuant LLC\nimmuneResponse\nThe current study led to the discovery of 10,928 viruses and 748\nEARTH&CLIMATE\nbacteria that are not present in any reference databases.\nNewFishingTechMayPoseRiskstoFisheries\nDr.MasonfoundedMetasUB(shortforMetagenomicsand\nTellingUp fromDown:How MarineFlatworms\nMetadesignofSubwaysandUrbanBiomes)in2015,alongwith\nLeamto SenseGravity\nDr. Evan Afshin, who was then an undergraduate student at\nSwiftsSetNewRecordforSwiftness\nMacaulayHonorsCollegeat Queens Collegeand is nowa clinical\nfellow in physiology and biophysics at Weill Cornell Medicineanda\nFOSSILS&RUINS\npaidconsultantforOnegevity Health.Thenewly released study\nDental Crowding:Ancient Baleen WhalesHada\nwasledbyDrs.Mason,DavidDanko,aWeill Cornell Graduate\nMouthFull\nSchooldoctoral student in Dr.Mason's labduring the study,and\nPandemicPaleo:AWayward Skull,at-Home\nDaniela Bezdan,who wasaresearch associate in computational\nFossilAnalyses,aFirstforAntarcticAmphibians\nbiomedicine at Weill Comell Medicine at that time.\nStudy on BizarreRodent Genetics Soivesa\nBycollectingsamplesofmicrobesandanalyzingtheirgenes--\nMysteryandRevealsAnother\ncollectivelyknownasthemicrobiome--theresearchershopeto\nlearnmoreabout thebacteria,viruses and othermicroorganisms\nthat live among humans.Forexample,theresearch may help to\nidentify the emergence of antibiotic-resistant strains.Predicting\nantibiotic resistancefromgeneticsequencesalone is challenging.\nlinked toresistance,quantifytheirabundanceand confirm the\ngeneticmarkers'ability to conferresistance.They found that some\nbe city-specific signaturesfor some of these genes.\nAntimicrobial resistanceremainsamajorglobal healthchallenge.\nAntimicrobial resistanceremains a majorglobalhealth challenge.\n\"Whilefurtherresearchis needed,this datasetdemonstrates the\nvalue and potential for microbiome mapping and monitoring,and\nofficials.\"Dr.Afshin said.\nwellasothermoleculesthat havethepotential tobedevelopedas\nbeen derivedfrommicrobial sources.Discoveriesmade about new\nmicrobial speciescouldalso lead tonewlaboratorytools and\napproaches,suchasnovel waystousethemoleculareditingtool\nknownasCRiSPR.Inthisstudy,theresearchersfound838,532\nnovel CRISPRarrays--snippets of viral DNAfound insidebacteria\n--and4.3million newpeptides (small proteins).\nDue to these sampling efforts, Dr. Mason said that he can predict\ninfluencea city'smicrobiome,includingoverall populationand\npopulation density,elevation, proximity to the ocean and climate.\nThefindings about these distinct signatures could enable future\nforensic studies.\n\"Amicrobiome containsmolecularechoesoftheplacewhere it\nwas collected.Acoastalsamplemay contain salt-lovingmicrobes\nbiodiversity.\"Dr.Danko said.\npublishedtheirfirstfindings,dubbedPathoMap,theywere\ncontactedbyresearchersfromaroundtheworldwhowantedtodo\nsimilar studies for their own cities.The international interest\ninspiredDrMason'slabtocreateMetaSUBandrecruitedDaniela\nBezdan as the research director.\"We needed internationally\nacceptedprotocols,logisticsandcollaborationagreements with\nscientists,vendors,governmentoffices andphilanthropic\nfoundationsforpotentially100citiesin20countries,Bezdansaid.\nToday MetasUB continuesto growand has expanded to collecting\nhardsurfaces.Thishas ledtoas5milliongrantonwastewater\nsequencing and viraltracking across threestates (Florida,New\nYorkand Wisconsin).and which is part of the Centerfor Disease\nControlandPrevention'snewNational WastewaterSurveillance\nSystem (NWss).\nThe group also oversees projects such as Global City Sampling\nranging studies includinga comprehensivemicrobial analysis of\nRiode Janeirobefore,duringandafterthe2016Summer\nOlympics.Many of the samples analyzed in the current study were\ncollectedonGlobal CitySamplingDay in2016and2017.TheNew\nYork Citysamplingeffortwasconductedwithsupportfromthe\nWeill Cornell Medicine ClinicalandTranslational Science Center\nyear's event.\n\"When westarted in2015,theconsortiumconsistedof16 cities,\nsix years laterwe have more than 100 cities. It's great to have this\ngroup of curious,self-starting andenthusiastic co-investigators,\"\nsaid Dr.Mason,who isalso professorofcomputationalgenomics\nin computational biomedicine in the HRH Prince Alwaleed Bin Talal\nBin Abdulaziz Al-Saud Institutefor Computational Biomedicine at\nWeill Cornell Medicine.\n\"Although samplesarecollected all overtheworld,muchofthe\nanalysis is done right here in New York City at Weill Cornell\nMedicine,\"said Dr.Mason.Theanalysis and assemblageof\nsequences also leveraged Bridges and Bridges-2, Extreme\nScienceandEngineering Discovery Environment (XSEDE)\nsupercomputersat thePittsburghsupercomputingCenter.\nMetaSUBresearchersinSwitzerland(Drs.AndreKahlesand\nGunnarRatsch) usedtheseassembliesand rawdatatobuilda\nsearchable,global DNA sequence portal (MetaGraph)that indexed\nlocationon Earthandcanaid inthediscoveryofnewmicrobial\ninteractionsandputativefunctions.\nfromZymoResearchandPromega,andsequenced in\ncollaboration with Dr.Shawn Levy at the HudsonAlpha Institutefor\nBiotechnology,Dr.KlasUdekwufromStockholmUniversityand\ntheNew York Genome Center.Future and ongoing studieswill\nlookatRNAandDNAwith longreadsandspatial-imaging\nmethods, as well as trace the metabolites from the global sites.\nand continue to update the planetary-scale genetic map.\nStory Source:\nMaterials providedbyWeill Cornell Medicine.Note:Contentmay", "live": "ScienceDaily\nFollow:\nSubscribe:\nYour source forthe latest research news\nNew! Sign upfor our free email newsletter.\nQuirky \nSociety\nHealth \nTech \nEnviro\nSearch\nScience News\nfromresearchorganizations\ne Print\nEmail\nShare\nGlobal microbiomestudy discovers thousandsof new\nBreaking\nthis hour\nspecies,maps urban antimicrobial resistance and reveals\nnew drug candidates\n>CommonDrugsCanHelpVirusesSpread\n>ALava PlanetWitha GiantSunscreen\nDate:May 27,2021\n>ScientistsRecreatetheEarlyUniverse\nSource:Weill Cornell Medicine\n>DoSpidersDream?ScientistsFindNewClues\nSummaryAbout 12,ooobacteria andviruses collected in a samplingfrompublictransit\nWhySomeBrainsResistAlzheimer's\nsystemsand hospitalsaroundtheworld from2015to2017had neverbefore\n>Mayo Clinic Uncovers New Secrets of Aging\nbeen identified,according to a new study.\n>AncientDiscovery Rewrites Human History\nShare:\nin\n>ScientistsSolve30-YearIBDMystery\n>Exercise Changes the Heart's Hidden Wiring\n>AncientEclipseReveals Earth'sFasterSpin\nRELATEDTOPICS\nFULL STORY\nTrending Topics\nthis week\nHealth&Medicine\nAbout12,000bacteriaandvirusescollected in\na sampling from public transit systems and\n>Pharmacology\nPLANTS&ANIMALS\nhospitalsaround the world from2015to2017\nBiology\n>Viruses\nhad neverbefore been identified,according to\nNature\n>InfectiousDiseases\na study by the International MetaSUB\nEndangered Plants\n>PersonalizedMedicine\nConsortium, a global effort at tracking\nEARTH&CLIMATE\nmicrobes that is led byWeill Cornell Medicine\nPlants&Animals\nTsunamis\ninvestigators.\nAir Qualty\n> New Species\nForthestudy,publishedMay26inCell,international\nSnowandAvalanches\n>Virology\ninvestigatorscollectednearly5,oo0samplesoverathree-\nFOSSILS&RUINS\nBiotechnology and\nyear period across 60 cities in 32countries and six\ncontinents.The investigators analyzed the samples using\nBioengineering\nHuman Evolution\na genomic sequencing techniquecalled shotgun\nDinosaurs\nCRISPRGeneEditing\nsequencing to detectthe presence of various microbes,\nAncient Civilizations\nincluding bacteria, archaea (single-celled organisms that\nRELATEDTERMS\nare distinct from bacteria),and viruses that use DNAas\ntheirgenetic material. (Othertypes of viruses that use\nStrange &Offbeat\n>Antibioticresistance\nRNA as their genetic material, such as SARS-CoV-2, the\n>Virus\nvirusthatcausesCOViD-19,wouldnothavebeen\nPLANTS&ANIMALS\ndetected with the DNA analysismethods used in this pre-\nDoSpiders Dream?ScientistsJust Founda\nMicroorganism\npandemic study.)\nSurprising Clue\nBiology\nThis field ofresearchhas important implicationsfor\nChinese Scientists Discover\"D-Rex,\"a Giant\nFungus With Roots Stretching Back65Million\ndetectingoutbreaks of bothknownandunknown\nMMRvaccine\nYears\ninfections and for studying the prevalence of antibiotic-\nNew EvidenceSuggests SpinosaurusSpent\n>HurricaneKatrina\nresistantmicrobes in different urbanenvironments.\nMostof Its Life Underwater\n>Commercialfishing\n\"Every timeyou sitdown in the subway,you are likely\nEARTH&CLIMATE\n>BlackRhinoceros\ncommutingwith anentirelynewspecies,\"said senior\nSomething Strange Is Happening Beneatha\nauthor Dr.Christopher Mason,co-directorof the\nVolcanoNear2MillionPeople\nWorldQuant InitiativeforQuantitativePredictionanda\nNew\"plantArmorMoreThan Triples\nprofessorofphysiologyandbiophysicsatWeill Cornell\nStrawberryYields\nMedicine.Dr.Masonisalsoco-founderandapaid\nEarth'sDayIsn't Exactly24Hours.The\nconsultant of Biotia and Onegevity Health, and a paid\nReason May Lie Deep Insidethe Planet\nspeakerforWorldQuantLLC.\nFOSSILS&RUINS\nThe current study led to the discovery of 10,928 viruses\nArchaeologists MayHave Just Found the\nand748 bacteria that arenot present inany reference\nWorld'sOldestShipwreck\ndatabases.\nThis 150-Million-Year-Old Bird Had Dinosaur\nDrMasonfoundedMetasUB(shortforMetagenomics\nTeeth anda Strange Secret\nandMetadesignofSubwaysandUrbanBiomes)in2015,\nScientists Discovera Bizarre Jurassic\"squid\"\nUnlikeAnythingEverSeen\nalong with Dr.EvanAfshin,who wasthen an\nundergraduatestudentatMacaulayHonorsCollegeat\nQueens College and is nowa clinicalfellow in physiology\nand biophysics at Weill Cornell Medicineand apaid\nconsultant for Onegevity Health.The newly released study\nwasledbyDrs.Mason,DavidDanko,aWeill Cornell\nGraduate School doctoralstudent inDr.Mason'slab\nduring the study, and Daniela Bezdan, who was a\nresearch associate in computational biomedicine at Weill\nwilowasa\nresearch associate in computational biomedicine at Weill\nCornell Medicine at that time.\nBy collecting samples of microbes and analyzing their\ngenes--collectivelyknownas themicrobiome--the\nresearchers hope to learn more about the bacteria,\nviruses and other microorganisms that live among\nhumans.Forexample,theresearchmayhelptoidentify\nthe emergence of antibiotic-resistant strains. Predicting\nantibioticresistancefromgenetic sequencesaloneis\nchallenging,but the researchers wereable to map some\ngenesknown tobe linkedtoresistance,quantify their\nabundance and confirm the genetic markers'abilityto\nconfer resistance.Theyfoundthat some cities had more\nresistance genes than others, and that there might be city-\nspecific signatures for some of these genes.\nAntimicrobial resistanceremainsamajorglobalhealth\nchallenge.\"Whilefurther research is needed, this dataset\ndemonstrates the valueand potentialformicrobiome\nmappingand monitoring,andthe insights it can provide\nphysicians,scientistsand public healthofficials,Dr.\nAfshinsaid.\nMoreover,learningabout thesmall moleculesand\nproteins madeby microbes could also lead to the\ndiscoveryofnewantibioticsaswell asothermolecules\nthat have the potential to be developed as drugs.Many\nantibiotics and drugs that are currently in use have been\nderivedfrommicrobial sources.Discoveries made about\nnew microbial species could also lead to new laboratory\ntoolsandapproaches,suchasnovelwaystousethe\nmolecular editing tool known as CRISPR.In this study,the\nresearchersfound838,532novelCRiSPRarrays-\nsnippetsof viral DNAfound insidebacteria--and 4.3\nmillionnewpeptides(small proteins).\nDue to these sampling efforts, Dr.Mason said that he can\npredict with about 90 percentaccuracy where a person\nlives, justbysequencingtheDNAontheirshoes.Many\nfactors were found to influence a city's microbiome,\nincluding overallpopulation and populationdensity,\nelevation, proximity to the ocean and climate. The findings\nabout these distinct signatures could enable future\nforensic studies.\n\"Amicrobiome contains molecularechoes of the place\nwhere it was collected.Acoastal sample may contain salt-\nlovingmicrobes whilea samplefromadenselypopulated\ncitymay show strikingbiodiversity,\"Dr.Danko said.\nDrs.Mason and Afshin began collecting and analyzing\nmicrobial samplesintheNewYork Citysubwaysystem in\nPathoMap,theywerecontactedbyresearchersfrom\naround the world who wanted todo similar studies fortheir\nown cities.The international interest inspired Dr. Mason's\nlab tocreateMetaSUBand recruited Daniela Bezdan as\nthe research director.\"We needed internationally\nacceptedprotocols,logisticsandcollaboration\nagreements with scientists,vendors,governmentoffices\nand philanthropic foundationsforpotentially100 cities in\n20 countries,\"Bezdan said.\nToday MetasUB continues to grow and has expanded to\ncollectingRNAandDNAsamplesfromair,waterand\nsewage, in addition to hard surfaces.This has led to a $5\nmillion grant on wastewater sequencing and viral tracking\nacross three states (Florida, New York and Wisconsin),\nand whichispartoftheCenterforDiseaseControl and\nPrevention's newNational Wastewater Surveillance\nSystem (NWSS).\nThegroupalso overseesprojects such as Global City\nSamplingDay (gcsD),held every year on June21, and\nhas done wide-ranging studies including a comprehensive\nmicrobial analysisof Riode Janeiro before,during and\nafterthe2016SummerOlympics.Manyof thesamples\nanalyzed inthecurrentstudywerecollectedonGlobal\nCitySamplingDay in2016and2017.TheNewYork City\nsampling effort was conducted with support from the Weill\nCornell Medicine Clinical andTranslational Science\nCenter (CTSC),in collaborationwithseniorCTSC\nprogram manager Jeff Zhu.Dr.Mason and his colleagues" } }, { "id": "metasub-medicalxpress", "study": "metasub", "outlet": "Medical Xpress", "outlet_original": "Medical Xpress", "outlet_score": 6, "title": "Global microbiome study discovers thousands of new species", "title_original": "Global microbiome study discovers thousands of new species", "language": "English", "date": "2021-05", "kind": "news", "url": "https://medicalxpress.com/news/2021-05-global-microbiome-thousands-species.html", "archive_url": "https://web.archive.org/web/20210527154928/https://medicalxpress.com/news/2021-05-global-microbiome-thousands-species.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports that about 12,000 previously unknown bacteria and viruses turned up in nearly 5,000 samples from 60 cities across 32 countries, in a Cell study by the MetaSUB Consortium.", "topics": [ "metasub", "urban microbiome", "new species", "antimicrobial resistance", "cell" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/metasub-medicalxpress.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-medicalxpress--archived.jpg", "saved_html": "media-archive/html/metasub-medicalxpress--archived.html", "saved_article_text": "media-archive/text/metasub-medicalxpress.txt", "ocr_text": { "archived": "Medical press\nWeek's top\nSubscribe\nUnread news\nLatestnews\nTopics\nConditions\nHome / Medical research\nFeatured\nLast Comments\nPopular\nMAY27,2021\nMicewithT-cell acutelymphoblastic\nShare\nGlobal microbiome studydiscovers\nleukemia benefitedfrom atargeted therapy\n①1HOURAGO\nthousandsof new species\nTwit\nby Well Cornell Medical College\n153yearsafterdiscoveryoftheimmune\nShare\nsystem's dendritic cells,scientists uncovera\nRio De Janeiro\nnew subset\nEmail\nKuala Lumpur\n①2HOURSAGO\nBerlin\nLisbon\nSantiago\nRussiansinfectedwithcrossoverfluvirus\nBarcelona\nsuggests possibilityof anotherpandemic\nTokyo\nFairbanks\nMAY21,2021\nVienna\nNew York City\nHamilton\nThe First Cell:Jump-starting the global\nBaltimore\ncancerrevolution\nLondon\n①MAY14,2021\nMinneapolis\nDoha\nSingapore\nRemapping and realignment in the\nhippocampalformation predictcontext-\nRibeiraoPreto\nAuckland\ndependent spatial behavior\nSydney\n①MAY122021\neyos\nKyiv\nSan.Francisco\nHong Kong\nDelaying lung cancer surgery\nNaples\nassociated with higherrisk of\nSao Paulo\nSendai\nrecurrence, death\nMarseille\n①49MINUTESAGO\nPorto\nTaipel\nRoots of majordepression\nBrisbane\nrevealed in all its genetic\nDenver\ncomplexity\nNumber of antimicrobial resistance genes detected by city.Credit:Cell...\n①49MINUTESAGO\nAbout 12,000 bacteriaand viruses collected ina samplingfrom\nStudy:Sinopharm CoVID-19\nvaccines appear safe,\npublic transit systems and hospitals around the world from2015\neffective\nto 2017 had never before been identified, according to a study by\n① 1 HOUR AGO\nthe International MetaSUB Consortium,a global effort at tracking\nmicrobes that is led by Weill Cornell Medicine investigators.\nLow on antibodies, blood\ncancer patients can fight off\nCOVID-19withTcells\nForthe study,published May26in Cell, international\n①1HOURAGO\ninvestigatorscollected nearly5,000samplesoverathree-year\nNewtool helps'tune'cochlear\nperiod across 60 cities in 32 countries and six continents. The\nimplantsto improve hearing\ninvestigators analyzedthe samples using a genomic sequencing\n①1HOURAGO\ntechniguecalled shotgunsequencingtodetectthepresenceof\nvariousmicrobes,includingbacteria,archaea(single-celled\nSmoking during pregnancy\norganisms that are distinct from bacteria),and viruses that use\nassociated with child'srisk of\nDNA as their genetic material. (Other types of viruses that use\ncongenital heart disease\nRNA as their genetic material, such as SARS-CoV-2, the virus that\n1HOURAGO\ncauses COVID-19, would not have been detected with the DNA\nSometimes, even three-year-\nanalysis methods used in this pre-pandemic study.)\nolds just wanttofit in with\nthe group\n①1HOURAGO\nThisfield of research has important implications for detecting\noutbreaksof bothknownandunknown infectionsandfor\nstudying the prevalence of antibiotic-resistant microbes in\ndifferent urban environments.\n\"Every time you sit down in the subway, you are likely commuting\nwith anentirely new species'said seniorauthorDr.Christopher\nMason,co-director oftheWorldQuant InitiativeforQuantitative\nCornell Medicine.Dr.Mason is also co-founder and a paid\nconsultant of Biotia and Onegevity Health,and a paid speaker for\nWorldQuant LLC.\nThe current study led to the discovery of 10,928 viruses and 748\nbacteria that arenot present in anyreferencedatabases.\nbacteria that are not present in any reference databases.\nDr.MasonfoundedMetasUB(shortforMetagenomicsand\nMetadesign of Subways and Urban Biomes)in 2015,along with\nDr. Evan Afshin, who was then an undergraduate student at\nMacaulayHonorsCollegeatQueensCollegeandisnowa\nclinical fellow in physiology and biophysics at Weill Cornell\nMedicineand a paid consultant for Onegevity Health.The newly\nreleased study was led by Drs. Mason, David Danko, a Weill\nCornell Graduate School doctoral student in Dr.Mason's lab\nduring the study,and Daniela Bezdan, who was a research\nassociate in computational biomedicineat Weill Cornell\nMedicineatthattime.\nBy collectingsamplesofmicrobesand analyzingtheirgenes-\ncollectivelyknownasthemicrobiome-theresearchershopeto\nlearnmoreaboutthebacteria,virusesandothermicroorganisms\nthatliveamong humans.For example,the researchmay helpto\nidentify the emergence of antibiotic-resistant strains.Predicting\nantibiotic resistancefrom genetic sequences alone is\nchallenging, but the researchers were able to map some genes\nknowntobe linkedtoresistance,quantifytheirabundanceand\nconfirm the genetic markersability to confer resistance.They\nfound that some cities had more resistance genes than others,\nand that there might be city-specific signatures for some of\nthese genes.\nAntimicrobial resistance remains a majorglobal health\nchallenge.\"Whilefurtherresearch is needed,thisdataset\ndemonstrates the valueand potentialformicrobiome mapping\nand monitoring,and the insights it can providephysicians,\nscientists and publichealth officials,Dr.Afshin said.\nGlobal microbiome study discovers thousands of new species\nThecoremicrobiome.Taxonomictreeshowing31coretaxa,coloredb..\nMoreover,learningaboutthesmall molecules andproteins made\nbymicrobes couldalso leadtothe discoveryof newantibiotics\nas well as other molecules that havethepotentialto be\ndeveloped as drugs.Many antibiotics and drugs that are\ncurrently in use have been derived from microbial sources.\nDiscoveriesmadeabout newmicrobial speciescouldalso lead\nto new laboratory tools and approaches, such as novel ways to\nuse the molecular editing toolknown as CRISPR.In this study,\ntheresearchers found838,532novel CRISPRarrays-snippetsof\nviral DNA found inside bacteria-and 4.3million new peptides\n(small proteins).\nDue to these sampling efforts,Dr.Mason said that he can predict\nwith about 90 percent accuracy where a person lives, justby\nsequencing the DNA on their shoes. Many factors were found to\ninfluencea city'smicrobiome, including overall population and\npopulation density,elevation,proximity to the ocean and climate.\nThe findings about these distinct signatures could enable future\nforensicstudies.\n\"A microbiome contains molecular echoes of the place where it\nwas collected. A coastal sample may contain salt-loving\nmicrobes while a sample from a densely populated city may\nshow strikingbiodiversity'Dr.Dankosaid.\nDrs.Mason and Afshin began collecting and analyzing microbial\nsamples in the New York City subway system in 2013.After they\npublishedtheirfirstfindings,dubbed PathoMap,they were\ncontacted by researchersfrom around theworld whowantedto\nosimiar", "live": "Justaquickcheck\nWe'recheckingyourconnectiontopreventautomatedabuse\nVerify you are human\nCLOUDFLARE\nPrivacr * Hele\nWhyam I seeing this?\nHaving probiems? Contact support", "image": "Bogota\nOffa\nHanoi\nIlorin\nRio De Janeiro\nKuala Lumpur\nBerlin\nLisbon\nSantiago\nBarcelona\nTokyo\nFairbanks\nVienna\nNew York City\nHamilton\nBaltimore\nLondon\nMinneapolis\nDoha\nSingapore\nZurich\nRibeiraoPreto\nAuckland\nSydney\nSofia\nKyiv\nSan Francisco\nHong Kong\nNaples\nSao Paulo\nSendai\nMarseille\nPorto\nTaipei\nBrisbane\nDenver\nParis\nSeoul\nSacramento\nStockholm\n10\n100\nNumberofAMRsDetected" } }, { "id": "metasub-cornell-chronicle", "study": "metasub", "outlet": "Cornell Chronicle", "outlet_original": "Cornell Chronicle", "outlet_score": 6, "title": "Weill Cornell study: New species are all around us", "title_original": "Weill Cornell study: New species are all around us", "language": "English", "date": "2021-05", "kind": "press-release", "url": "https://news.cornell.edu/stories/2021/05/weill-cornell-study-new-species-are-all-around-us", "archive_url": "https://web.archive.org/web/20210527200850/https://news.cornell.edu/stories/2021/05/weill-cornell-study-new-species-are-all-around-us", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports an international MetaSUB Consortium study in Cell that sampled transit systems and hospitals in 60 cities, finding roughly 12,000 previously unknown bacteria and viruses and mapping urban antimicrobial resistance, with implications for outbreak surveillance.", "topics": [ "metasub", "urban microbiome", "metagenomics", "new species", "antimicrobial resistance" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/metasub-cornell-chronicle.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-cornell-chronicle--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/metasub-cornell-chronicle.txt", "ocr_text": { "archived": "CORNELL.EDU\nMEDIARELATIONS\nCORNELLCHRONICLE\nED A.\nCampus & Community\nTopics\nAll Stories\nExpert Quotes\nIntheNews\nEzra Magazine\nDr.ChristopherMason/Provided\nLeft: Heba Shabaan,athird-yearmedical student at Well Cornell Medical Collegeand Dr.Christopher Mason prepare to swab formicrobes in the NC subway systemon June 21,\n2020. Right: Subway turnstile being swabbed.\nWeill Cornell study: New species are all around us\nBy Julie Grisham I May 27, 2021\nAbout 12,o00 bacteria and viruses collected in a sampling from public transit\nsystems and hospitals around the world from 2015 to 2017 had never before\nbeen identified, according to a study by the International MetaSUB\nConsortium, a global effort at tracking microbes that is led by Weill Cornell\nMedicine investigators.\nFor the study, published May 26 in Cell, international investigators collected\nnearly 5,000 samples over a three-year period across 60 cities in 32 countries\nand six continents. The investigators analyzed the samples using a genomic\nsequencing technique called shotgun sequencing to detect the presence of\nvarious microbes, including bacteria, archaea (single-celled organisms that\nare distinct from bacteria), and viruses that use DNA as their genetic\nmaterial. (Other types of viruses that use RNA as their genetic material, such\nas SARS-CoV-2, the virus that causes COVID-19, would not have been\ndetected with the DNA analysis methods used in this pre-pandemic study.)\nboth known and unknown infections and for studying the prevalence of\nantibiotic-resistant microbes in different urban environments.\n“Every time you sit down in the subway, you are likely commuting with an\nentirely new species,\" said senior author Dr. Christopher Mason, co-director\noftheWorldQuantInitiativeforQuantitativePredictionandaprofessorof\nof the WorldQuant Initiative for Quantitative Prediction and a professor of\nphysiology and biophysics at Weill Cornell Medicine. Mason is also co-\nfounder and a paid consultant of Biotia and Onegevity Health, and a paid\nspeaker for WorldQuant LLC.\nThe current study led to the discovery of 10,928 viruses and 748 bacteria that\nare not present in any reference databases.\nMason founded MetasUB (short for Metagenomics and Metadesign of\nSubways and Urban Biomes) in 2015, along with Dr. Evan Afshin, then an\nundergraduate student at Macaulay Honors College at Queens College and\nand a paid consultant for Onegevity Health. The newly released study was led\nby Mason, Dr. David Danko, a Weill Cornell Graduate School doctoral student\nin Mason's lab during the study, and Daniela Bezdan, who was a research\nassociate in computational biomedicine at Weill Cornell Medicine at that\ntime.\nBy collecting samples of microbes and analyzing their genes - collectively\nknown as the microbiome - the researchers hope to learn more about the\nbacteria, viruses and other microorganisms that live among humans. For\nexample, the research may help to identify the emergence of antibiotic-\nalone is challenging, but the researchers were able to map some genes known\nto be linked to resistance, quantify their abundance and confirm the genetic\nmarkers' ability to confer resistance. They found that some cities had more\nresistance genes than others, and that there might be city-specific signatures\nfor some of these genes.\nfurther research is needed, this dataset demonstrates the value and potential\nfor microbiome mapping and monitoring, and the insights it can provide\nphysicians, scientists and public health officials,\" Afshin said.\nMoreover, learning about the small molecules and proteins made by microbes\ncould also lead to the discovery of new antibiotics as well as other molecules\nthat are currently in use have been derived from microbial sources.\nDiscoveries made about new microbial species could also lead to new\nlaboratory tools and approaches, such as novel ways to use the molecular\nediting tool known as CRISPR. In this study, the researchers found 838,532\nnovel CRISPR arrays - snippets of viral DNA found inside bacteria - and 4.3\nmillion new peptides (small proteins).\nDue to these sampling efforts, Mason said he can predict with about 90%\naccuracy where a person lives, just by sequencing the DNA on their shoes.\nMany factors were found to influence a city's microbiome, including overall\npopulation and population density, elevation, proximity to the ocean and\nclimate. The findings about these distinct signatures could enable future\nforensic studies.\n“A microbiome contains molecular echoes of the place where it was collected.\nA coastal samplemay contain salt-loving microbes while a samplefrom a\ndensely populated city may show striking biodiversity,\" Danko said.\nMason and Afshin began collecting and analyzing microbial samples in the\n2013\nhlishedtheirfrs", "live": "CORNELL.EDU\nMEDIARELATIONS\nCORNELLCHRONICLE\nTopics\nCampus & Community\nAll Stories\nPodcast\nMedia Relations\nCornellians\nDr.ChristopherMason/Provided\nLeft: Heba Shabaan,athird-yearmedical student at Well Cornell Medical Collegeand Dr.Christopher Mason prepare to swab formicrobes in the NC subway systemon June 21,\n2020. Right: Subway turnstile being swabbed.\nWeill Cornell study: New species are all around us\nBy Julie Grisham\nMay 27,2021\nAbout 12,000 bacteria and viruses collected in a sampling from public transit\nsystems and hospitals around the world from 2015 to 2017 had never before\nbeen identified, according to a study by the International MetasUB\nConsortium, a global effort at tracking microbes that is led by Weill Cornell\nMedicine investigators.\nFor the study, published May 26 in Cell, international investigators collected\nnearly 5,000 samples over a three-year period across 60 cities in 32 countries\nvarious microbes, including bacteria, archaea (single-celled organisms that\nare distinct from bacteria), and viruses that use DNA as their genetic\nmaterial. (Other types of viruses that use RNA as their genetic material, such\nas SARS-CoV-2, the virus that causes COVID-19, would not have been\ndetected with the DNA analysis methods used in this pre-pandemic study.)\nThis field of research has important implications for detecting outbreaks of\nboth known and unknown infections and for studying the prevalence of\nantibiotic-resistant microbes in different urban environments.\n“Every time you sit down in the subway, you are likely commuting with an\nentirely new species, said senior author Dr. Christopher Mason, co-director\nentirely new species,\"said senior author Dr. Christopher Mason, co-director\nof the WorldQuant Initiative for Quantitative Prediction and a professor of\nphysiology and biophysics at Weill Cornell Medicine. Mason is also co-\nfounder and a paid consultant of Biotia and Onegevity Health, and a paid\nspeaker for WorldQuant LLC.\nThe current study led to the discovery of 10,928 viruses and 748 bacteria that\nare not present in any reference databases.\nMason founded MetasUB (short for Metagenomics and Metadesign of\nSubways and Urban Biomes) in 2015, along with Dr. Evan Afshin, then an\nundergraduate student at Macaulay Honors College at Queens College and\nnow a clinical fellow in physiology and biophysics at Weill Cornell Medicine\nand a paid consultant for Onegevity Health. The newly released study was led\nby Mason, Dr. David Danko, a Weill Cornell Graduate School doctoral student\nin Mason's lab during the study, and Daniela Bezdan, who was a research\nassociate in computational biomedicine at Weill Cornell Medicine at that\ntime.\nBy collecting samples of microbes and analyzing their genes - collectively\nknown as the microbiome - the researchers hope to learn more about the\nbacteria, viruses and other microorganisms that live among humans. For\nexample, the research may help to identify the emergence of antibiotic-\nalone is challenging, but the researchers were able to map some genes known\nto be linked to resistance, quantify their abundance and confirm the genetic\nmarkers' ability to confer resistance. They found that some cities had more\nresistance genes than others, and that there might be city-specific signatures\nfor some of these genes.\nfurther research is needed, this dataset demonstrates the value and potential\nfor microbiome mapping and monitoring, and the insights it can provide\nphysicians, scientists and public health officials,\" Afshin said.\nMoreover, learning about the small molecules and proteins made by microbes\ncould also lead to the discovery of new antibiotics as well as other molecules\nthat have the potential to be developed as drugs. Many antibiotics and drugs\nthat are currently in use have been derived from microbial sources.\nDiscoveries made about new microbial species could also lead to new\nlaboratory tools and approaches, such as novel ways to use the molecular\nediting tool known as CRISPR. In this study, the researchers found 838,532\nnovel CRISPR arrays - snippets of viral DNA found inside bacteria - and 4.3\nmillion new peptides (small proteins).\nDue to these sampling efforts, Mason said he can predict with about 90%\naccuracy where a person lives, just by sequencing the DNA on their shoes.\nMany factors were found to influence a city's microbiome, including overall\npopulation and population density, elevation, proximity to the ocean and\nclimate. The findings about these distinct signatures could enable future\nforensic studies.\n“A microbiome contains molecular echoes of the place where it was collected.\nA coastal sample may contain salt-loving microbes while a sample from a\ndensely populated city may show striking biodiversity,\" Danko said.\nMason and Afshin began collecting and analyzing microbial samples in the" } }, { "id": "metasub-technetworks", "study": "metasub", "outlet": "Technology Networks", "outlet_original": "Technology Networks", "outlet_score": 5, "title": "Global Microbiome Study Identifies Thousands of New Species", "title_original": "Global Microbiome Study Identifies Thousands of New Species", "language": "English", "date": "2021-05", "kind": "news", "url": "https://www.technologynetworks.com/immunology/news/global-microbiome-study-identifies-thousands-of-new-species-349279", "archive_url": "https://web.archive.org/web/20210623063131/https://www.technologynetworks.com/immunology/news/global-microbiome-study-identifies-thousands-of-new-species-349279", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports an international MetaSUB Consortium study in Cell that sampled transit systems and hospitals in 60 cities, finding roughly 12,000 previously unknown bacteria and viruses and mapping urban antimicrobial resistance, with implications for outbreak surveillance.", "topics": [ "metasub", "urban microbiome", "metagenomics", "new species", "antimicrobial resistance" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/metasub-technetworks.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-technetworks--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/metasub-technetworks.txt", "ocr_text": { "archived": "We've updated our Privacy Policyto make it clearer how we use your personal data.\n1Understand\nWe use cookies to provide you with a better experience. You can read our Cookie Policy here.\nFind the science...\nQ search\nTechnologyNetworks\nImmunology&Microbiology\nContent \nWebinars\nCommunitiesy\nSubscribe\nNews\nGlobal Microbiome Study Identifies Thousands of New Species\nMay 27 20211 Original story from Weill Cornell Medicine\nCredit:Pixabay.\nRead time:5minutes\nAbout 12,o00 bacteria andviruses collected in a samplingfrom publictransit systems\nand hospitals around theworld from 2015 to 2017 had never before been identified,\naccording to a study by the International MetasUB Consortium, a global effort at\ntracking microbes that is led by Weill Cornell Medicine investigators.\nFor the study, published May 26 in Cell, international investigators collected nearly\n5,o00samples overa three-year period across 60 cities in32 countries and six\ncontinents. The investigators analyzed the samples using a genomic sequencing\nincluding bacteria, archaea (single-celled organisms that are distinct from bacteria),\nand viruses that use DNA as their genetic material. (Other types of viruses that use RNA\nas their genetic material, such as SARS-CoV-2, the virus that causes COvID-19, would\nnot havebeendetected withtheDNAanalysismethodsused inthispre-pandemic\nstudy.)\nThis field of research has important implications for detecting outbreaks of both\nknownandunknown infectionsandfor studying theprevalenceofantibiotic-resistant\nmicrobes in different urban environments.\n\"Everytime you sit down in the subway,youare likely commuting with an entirely new\nspecies,\"said senior author Dr.Christopher Mason,co-director of theWorldQuant\nInitiativeforQuantitativePredictionandaprofessorofphysiologyandbiophysicsat\nWeill Cornell Medicine.Dr.Mason is also co-founder and a paid consultant of Biotia\nand Onegevity Health, and a paid speaker for WorldQuant LLC.\nThe current study led to the discovery of 10,928 viruses and 748 bacteria that are not\npresent in any reference databases.\nDr.MasonfoundedMetasUB(shortforMetagenomicsand MetadesignofSubways\nand Urban Biomes) in 2015,along with Dr.EvanAfshin, whowas then an\nundergraduatestudentat Macaulay Honors Collegeat QueensCollegeandisnowa\nclinicalfellow inphysiologyandbiophysics at Weill Cornell Medicineanda paid\nconsultant for Onegevity Health.The newly released study was led by Drs.Mason,\nDavid Danko,a Weill Cornell Graduate School doctoral student in Dr.Mason's lab\nduring the study,and Daniela Bezdan,who was a researchassociate in computational\nbiomedicine at Weill Cornell Medicine at that time.\nBy collecting samples of microbes and analyzing theirgenes--collectivelyknown as the\nmicrobiome-the researchers hope to learn more about the bacteria, viruses and other\nmicroorganisms thatliveamong humans.Forexample,theresearch mayhelpto\nidentify the emergence of antibiotic-resistant strains. Predicting antibiotic resistance\nfromgenetic sequences alone is challenging, but the researchers were able to map\nfrom genetic sequences alone is challenging, but the researchers were able to map\nsome genes known to be linked to resistance, quantify their abundance and confirm\nthe genetic markers'ability to confer resistance. They found that some cities had more\nresistance genes than others, and that there might be city-specific signatures for some\nofthesegenes.\nresearch is needed,this dataset demonstrates the value and potential for microbiome\nmapping and monitoring, and the insights it can provide physicians, scientists and\npublic health officials,\" Dr. Afshin said.\nMoreover,learningaboutthesmall moleculesandproteinsmadebymicrobescould\nalso lead to the discovery of new antibiotics as well as other molecules that have the\npotential to be developed as drugs. Many antibiotics and drugs that are currently in\nuse havebeenderivedfrommicrobial sources.Discoveriesmadeaboutnewmicrobial\nspecies could also lead to new laboratorytools and approaches,such as novelwaysto\nuse the molecular editing tool known as CRiSPR. In this study, the researchers found\n838,532novel CRISPR arrays--snippets of viral DNAfound inside bacteria--and 4.3\nmillionnewpeptides (small proteins).\nDueto these sampling efforts, Dr.Mason said that he can predict with about 90\npercent accuracy where a person lives, just by sequencing the DNA on their shoes.\nMany factors were found to influence a city's microbiome, including overall population\n\"A microbiome contains molecular echoes of theplace where it was collected.A coastal\nmay show striking biodiversity,\" Dr.Danko said.\nDrs. Mason and Afshin began collecting and analyzing microbial samples in the New\nYork City subway system in 2013. After they published their first findings, dubbed\nPathoMap, they were contacted by researchers from around the world who wanted to\ndo similar studies for their own cities.The international interest inspired Dr.Mason's\nlab tocreateMetasUBand recruitedDaniela Bezdanas the research director.\"We\nneeded internationallyaccepted protocols, logistics and collaborationagreements with\nscientists, vendors, government offices and philanthropic foundations for potentially\n100 cities in 20 countries, Bezdan said.\nToday MetasUB continues to grow and has expanded to collecting RNA and DNA\nsamples from air, water and sewage, in addition to hard surfaces.This hasled to a s5\nmillion grant on wastewater sequencing and viral tracking across three states (Florida,\nNew York and Wisconsin),and which is part ofthe Center for Disease Control and\nPrevention's new National Wastewater SurveillanceSystem (NwsS).\nThe group also oversees projects such as Global City Sampling Day (gCSD), held every\nyearon June21,andhasdone wide-ranging studies includingacomprehensive\nmicrobial analysis of Rio deJaneiro before, during and after the 2016 Summer\nOlympics.Manyofthesamplesanalyzed inthecurrentstudywerecollectedonGlobal\nCity Sampling Day in 2016 and 2017. The New York City sampling effort was conducted\nwithsupport from theWeill Cornell MedicineClinicalandTranslational ScienceCenter\n(CTSC), in collaboration with senior CTSC program manager Jeff Zhu. Dr.Mason and his\n\"when we started in 2015, the consortium consisted of 16 cities; six years later we have\nmore than 100 cities. It's great to have this group of curious, self-starting and\nenthusiastic co-investigators,\" said Dr. Mason, who is also professor of computational\nAbdulaziz Al-Saud Institute for Computational Biomedicine at Weill Cornell Medicine.\n\"Although samples are collected all over the world, much of the analysis is done right\nhere in New York City at Weill Cornell Medicine,\" said Dr. Mason. The analysis and\nassemblage of sequences also leveraged Bridges and Bridges-2, Extreme Science and\nEngineeringDiscovery Environment (XSEDE)supercomputersatthePittsburgh\nSupercomputing Center.MetasUBresearchers in Switzerland (Drs.AndreKahles and\nGunnar Ratsch)used these assemblies and raw data to build a searchable,global DNA\nsequence portal (MetaGraph) that indexed all known genetic sequences (including\ntheir location on Earth and can aid in the discovery of new microbial interactions and\nputativefunctions.\nand Promega, and sequenced in collaboration with Dr. Shawn Levy at the HudsonAlpha\nInstitute for Biotechnology,Dr.Klas Udekwu from Stockholm University andthe New", "live": "We'veupdated ourPrivacyPolicytomakeitclearerhowweuse\nyourpersonaldata.Weusecookiestoprovideyouwithabetter\nexperience.You can read ourCookiePolicyhere.\nIUnderstand\nTechnologyNetworks\nSearch...\nStayuptodateon thetopics\nSubscribe Now\nthat matter to you\nScience News\nCommunitiesv\nContent v\n习 Log in\nGlobal Microbiome Study Identifies Thousands of\nChosen for you\nNew Species\nHowAreEvolvingPFAS\nRegulations Reshaping\nNewsPublished:May27,2021\nEnvironmental Testing?\nSaveforlater\nPFAI\nOriginal storyfromWeill Cornell Medicine\nArticle\nCirculating Long RNA: At\nthe Frontier of Liquid\nBiopsy Diagnostics\nArticle\nAcceleratingPrecision\nMedicine Through\nAntibody Discovery\nListicle\nCredit: Pixabay.\n Download Article\nRegister or log In for free to listen to this article\nListen with Speechify\n0:00\n Read time:4 minutes\nTo continue reading this article,sign up for FREE to\nTechnologyNetworks\nBreaking\nExploring the Science That Matters to You\nMembership isFREEandprovidesyouwith instantaccessto\nemailnewsletters,digital publications,ourfullcontentcatalogue&\nmore...\nUnlockforFREE\nAlready have an account? Log in here" } }, { "id": "metasub-umaryland", "study": "metasub", "outlet": "University of Maryland School of Medicine", "outlet_original": "University of Maryland School of Medicine", "outlet_score": 5, "title": "Global study of microbes in 60 cities finds each has unique fingerprint of viruses and bacteria", "title_original": "Global study of microbes in 60 cities finds each has unique fingerprint of viruses and bacteria", "language": "English", "date": "2021-05", "kind": "press-release", "url": "https://www.medschool.umaryland.edu/news/2021/global-study-of-microbes-in-60-cities-finds-each-has-unique-fingerprint-of-viruses-and-bacteria.html", "archive_url": "https://web.archive.org/web/20210610095418/https://www.medschool.umaryland.edu/news/2021/global-study-of-microbes-in-60-cities-finds-each-has-unique-fingerprint-of-viruses-and-bacteria.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "University of Maryland release on the Cell MetaSUB paper, the largest global urban metagenomic survey to date. It says each city has a distinct microbial fingerprint and highlights the Baltimore sampling led by a UMSOM co-author.", "topics": [ "metasub", "urban microbiome", "baltimore", "metagenomics", "city fingerprint" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/metasub-umaryland.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/metasub-umaryland--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/metasub-umaryland.txt", "ocr_text": { "archived": "SOMHomeQUICKLINKSEMAIL\nMAP\nINTRANET\nMYUMB\nDIRECTORY\nCALENDAR\nSite Search\nJNIVERSITYofMARYLAND\nSCHOOLOFMEDICINE\nAbout Us I Departments |\nResearch\nEducationPatientCare FacultyNewsAlumni&Donors\nGive\nGlobal Study of Microbes in 60 Cities Finds Each Has\nUnique Fingerprint of Viruses and Bacteria\nJune09,2021DeborahKotz\nResearchers turn now to see how covID-i9 pandemicaffected microbiome in each city\nEach city has its own unique microbiome, a\"fingerprint”of viruses and bacteria that\nservesastypeofcityprofile,accordingtoa new studyfroman international consortium\nof researchers that included a team from theUniversity of Maryland School of Medicine\n(UMsoM).The international project,which sequenced and analyzed samples collected\nfrompublictransit systems and hospitals in 60 cities around the world,was published\ntoday in the journal Cell.\nThe research is considered to be the largest-ever global metagenomic study ofurban\nmicrobiomes,spanning both the air and the surfaces of multiple cities. It features a\ncomprehensive analysis forall the microbial species identified--including thousands of\nviruses and bacteria and two newly identified single-cell organisms not found in\nreference databases.\nStudyco-authorLynnSchriml,PhD,UMSOMAssociateProfessorintheDepartmentof\nEpidemiology&Public Healthand Scientist at the Institutefor GenomeSciences (IGS),\nled the study sampling efforts for Baltimore's transit systems.“Baltimore's distinct\nmicrobial signature reveals a unique,fascinating, anddiverse world, providing\ninsights into geographical variation and previously unknown microbial genomes,\"she\nsaid.\nLynn M. Schriml, Ph.D.\nAdded study seniorauthor Christopher Mason,PhD,a professor at Weill Cornell\nMedicineand thedirectoroftheWorldQuant\nInitiative for Quantitative Prediction:“Every city has its ownmolecularecho'ofthe microbes that\ndefine it. If you gave me your shoe, Icould tell you with about go percent accuracy the city in the\nworld from which you came.\"\nThestudy was conducted beforethe COVID-19 pandemic shut down citiesthroughout the world,so\nthe researchers are now looking at how the pandemic affected the microbiome fingerprint of each\ncity.\"lt's a good question,\" Schriml said,\"and we are addressing this in follow-up research.\"The\nconsortiumlaunched theMetacoVproject in2o20to investigatethechangeinurbanmetagenomes\nand isolate the presence of the SARS-CoV-2 virus (the virus that causes COVID-19) in urban\nFindings in the latest research are based on an analysis of 4,728 samples from cities on six continents,\nChristopher Mason, PhD\ntaken over the course of three years, and represent thefirst systematic worldwide catalogue of the\nurban microbial ecosystem. In addition to distinct microbial signatures in various cities, the analysis revealed a core set of 31 species that were\nfound in 97 percent of samples across the sampled urban areas. The researchers identified 4,246 known species of urban microorganisms,but\nthey also found that any subsequent sampling will still likely continue to find species that have never been seen before, which highlights the\nraw potential fordiscoveries relatedto microbial diversityand biological functions awaiting inurban environments.\nIn thefuture, thefindings also have many potential practical applications, including identifying potential new compounds that can be used as\nantibiotics and small moleculesannotated frombiosyntheticgeneclusters (BGCs)that havepromisefordrugdevelopment.\nDr.Schriml joined the International Metagenomics andMetadesign of Subways and Urban Biomes\n(MetasUB) consortium in 2016 to gain greater insight on urban built environments through studying\nthecomposition and variation ofmicrobes across Baltimoreand Washington D.C.mass transit\nsystems.The MetasUB consortium has expanded sincethen to include projects sampling diverse\nbuilt environments, including sewers, monuments and hospitals with Dr.Schriml sampling biofilms\nbuilt environments, including sewers, monuments and hospitals with Dr.Schriml sampling biofilms\non the Orpheus Monument at Fort McHenry and the Soldiers'National Monument at Gettysburg in\nofMicrobiology and Immunologyat UMSOM and IGS faculty member.Lastyear, heleft the UMSOMto\nbecome a program director at the National Heart, Lung, and Blood Institute.\n\"This is a fascinating study, and it is fitting that our researchers played an integral role in\nidentifyingthemicrobiomefingerprintof Baltimore,\"said E.Albert Reece, MD,PhD,MBA,\nExecutive Vice President for Medical Affairs, UM Baltimore,and the John Z.and Akiko K.Bowers\nDistinguished Professor and Dean, University of Maryland School of Medicine.\"Basic research is at\nthe core ofour medical school mission and using the information we glean will be crucial for\nE.Albert Reece,MD,PhD,MBA\nimproving our global health in the future.\"\nCell,Danko et al.:\"Aglobalmetagenomicmap ofurbanmicrobiomes and antimicrobial resistance\"https://www.cell.com/cell/fulltext/soo92-\n8674(21)00585-7D0l:10.1016/j.cell.2021.05.002\nAbouttheUniversityof Maryland Schoolof Medicine\nNow in its third century,the University of Maryland School of Medicinewas chartered in 1807 as thefirst public medical school in the United\nStates. It continues today as one of thefastest growing, top-tier biomedical research enterprises in the world -- with 45 academic\ndepartments, centers,institutes, and programs; and a faculty ofmore than 3,ooo physicians, scientists, and allied health professionals,\nincluding members of the National Academy of Medicine and the National Academy of Sciences,and a distinguished two-time winner ofthe\nAlbert E. Lasker Award in Medical Research. With an operating budget of more than S1.2 billion, the School of Medicine works closely in\npartnershipwith the University of Maryland Medical Centerand Medical System to provideresearch-intensive,academic and clinicallybased\ncare for nearly 2million patients each year.The School of Medicine has more than s563 million in extramural funding, with most ofits\nacademic departments highly ranked amongall medical schools inthenation in researchfunding.As one ofthe seven professional schools\nthat make up the University of Maryland, Baltimore campus,the School of Medicine has a total population of nearly 9,ooo faculty and staff,\nincluding 2,500 student trainees,residents, and fellows. The combined School of Medicine and Medical System (University of Maryland\nMedicine\")has an annual budget of nearly s6 billion and an economic impact more than s15 billion on the state and local community. The\nSchool of Medicine,whichranks as the 8th highest among publicmedical schools in researchproductivity,is an innovatorin translational\nmedicine,with600 activepatents and24 start-up companies.TheSchool ofMedicine works locally,nationally,and globally,with researchand\ntreatment facilities in 36 countries around the world.Visit medschool.umaryland.edu\nCONTACT\nDeborah Kotz\n410-706-4255\ndkotz@som.umaryland.edu\nRelatedstories\nTuesday, March 16, 2021\nNewStudyFinds HealthcareSettings DoNot PoseAdded Risk FactorforCovid-19\nInfectionSpreadAmongU.S.HealthcarePersonnel\nHealthcarepersonnel who were infected with cOVID-19facedstrongerriskfactors outside of the\nworkplacethan in theirhospitalorhealthcaresettings.That is thefinding ofa new studypublishedtoday\nin the Journal of theAmerican Medical association's JAMANetwork Open conductedby University of\nPrevention (CDC) and three other universities.\nThursday, January 21,2021\nFAITH,SCIENCE&LOVE\nAFRICANAMERICANCLERGYAND\nUM School of MedicineHosted MediaAvailabilityforEnsuringTrust in CoViD-19\nCOMMUNITYCONVERSATION ON\nCOVID-19\nVaccine Event\nFRIDAY, JAN.22,2021\nOn January 22,2021at 2 p.m., the University of Maryland School of Medicine (UMSOM) hosted Black\nKEYNOTE\nfaith-based leaders, COVID-19 research volunteers, and\"America's Doctor,Anthony Fauci, MD.The event\nprovided straight talk aboutfears,trust issues, and why we need our Black and Brown communityto bea\nANTHONYFAUCI,MD\nDrector,National institite\npart of cOVID-19 vaccine research.\nNationa Institutes of Health\nTuesday,January05,2021\nDr.KathleenNeuzil,World-renownedLeaderinVaccineResearch,Receives\nModerna Vaccine\nKathleen Neuzil, MD, MPH, FIDSA, the Myron M. Levine, MD, DTPH, Professor of Vaccinology and Director\nofthe University of Maryland School of Medicine's (UMSOM)'s CenterforVaccine Developmentand\nGlobal Health (CVD),receivedherfirst injectionoftheModerna vaccineforCoVID-19onDecember31.\nResearchers at theUniversityof Maryland Schoolof Medicine (UMSOM)played an integral part in the\ndedicated work that led to the U.S. Food and Drug Administration issuing an Emergency Use", "live": "UNIVERSITYof MARYLAND\nSCHOOL OFMEDICINE\nUMSOMAssistant\n2021 Archive\nHome>News>PressReleases>2021Archive\nGlobal Study of Microbes in 60 Cities Finds Each Has Unique\nFingerprint of Viruses and Bacteria\nJune09,2021DeborahKotz\nResearchers turn now to see how COViD-19 pandemicaffected microbiome in each city\nEach city has its own unique microbiome,a“fingerprint\"of viruses and bacteria that serves as\ntype ofcity profile,accordingto a new study froman international consortium of researchers\nthatincluded a team from the University of Maryland School of Medicine(UMSOM).The\ninternational project,which sequenced and analyzed samples collected from publictransit\nsystems and hospitals in 6o citiesaround the world,was publishedtoday in thejournal Cell.\nThe research is consideredto be the largest-everglobalmetagenomic study ofurban\nmicrobiomes, spanning both the air and the surfaces of multiple cities. It features a\ncomprehensive analysis for all themicrobial species identified-including thousands of viruses\nand bacteria and two newly identified single-cell organisms not found in referencedatabases.\nStudy co-authorLynn Schriml,PhD,UMsOM AssociateProfessor in theDepartmentof\nEpidemiology&Public Healthand Scientistat the InstituteforGenomeSciences (IGS),led the\nstudy sampling efforts for Baltimore's transit systems.“Baltimore's distinct microbial signature\nreveals a unique,fascinating, and diverse world, providing insights into geographical\nvariation andpreviouslyunknown microbial genomes,\"she said.\nAdded study senior author Christopher Mason,PhD,a professor at Weill Cornell Medicine and\nthedirectorof theWorldQuant Initiativefor Quantitative Prediction:\"Every city has its own\n'molecular echoof the microbes that define it. if you gave me your shoe, I could tell you with\nabout 9o percent accuracy the city in the worldfrom which you came.\"\nLynn M.Schriml,Ph.D.\nThestudy was conducted beforetheCoviD-19 pandemic shutdowncitiesthroughout theworld,\nsotheresearchersarenowlookingathowthe\naddressing this infollow-upresearch.\"The consortium launched the MetaCOV project in 2020 to investigate the\nchangeinurbanmetagenomesand isolatethepresenceoftheSARS-CoV-2virus (thevirus thatcauses CovID-19)\nin urban environments (e.g.ATMmachines, wastewater, hospitals,transit systems).\nFindingsinthelatest researcharebasedonananalysisof 4,728samplesfromcitiesonsixcontinents,takenover\nthecourse of three years,andrepresent thefirst systematic worldwide catalogue of the urban microbial\necosystem.In addition to distinctmicrobial signatures invarious cities,theanalysisrevealed a core setof31\nspeciesthat werefound in 97percentofsamples acrossthesampled urban areas.Theresearchers identified\ncontinueto find species that haveneverbeen seen before,whichhighlightstherawpotentialfordiscoveries\nrelated to microbial diversity and biological functions awaiting in urban environments.\nChristopherMason,PhD\nInthefuture,thefindings alsohavemanypotential practical applications,includingidentifyingpotential new compoundsthatcan beusedas antibiotics\nand smallmoleculesannotatedfrombiosyntheticgeneclusters (BGCs)thathavepromisefordrugdevelopment.\nDr.Schriml joined theInternational Metagenomics and Metadesignof Subways and Urban Biomes (MetasUB)consortium in 2016togaingreaterinsighton\nMetasUB consortium has expanded sincethen to includeprojects sampling diversebuiltenvironments,including sewers,monuments and hospitalswith\nDr.Schriml sampling biofilms on the Orpheus Monument at Fort McHenryandthe Soldiers'National MonumentatGettysburg in2018.Shehad been\njoined bystudyco-author Emmanuel Mongodin,PhD,formerAssistantProfessorof Microbiologyand ImmunologyatUMsOMand IGSfacultymember.\nLast year,heleft theUMsoM to becomea program director at the National Heart, Lung,and Blood Institute.\n“This is a fascinating study, and it is fitting that our researchers played an integral role in identifying the microbiome fingerprintof Baltimore,\"said E.\nAlbertReece,MD,PhD,MBA,ExecutiveVicePresidentforMedicalAffairs,UMBaltimore,andtheJohnZ.and AkikoK.BowersDistinguishedProfessorand\nDean,University of Maryland School of Medicine.\"Basic research is at thecore ofour medical school mission and using the information we glean will be\ncrucial for improving our global health in the future.\"\nCell,Dankoetal.:\"Aglobalmetagenomicmapofurbanmicrobiomesandantimicrobial resistance\"https://www.cell.com/cell/fulltext/soo92-\n8674(21)00585-7D01:10.1016/j.cell.2021.05.002\nAbout theUniversity of Maryland School of Medicine\nNow in its third century,the University of Maryland Schoolof Medicinewas chartered in1807 as thefirst public medical school in the United States.It\ncontinues today as one of thefastest growing,top-tier biomedical research enterprises in the world --with 46 academic departments, centers, institutes,\nMedicineand the National Academy of Sciences, and a distinguished two-timewinner of the Albert E.Lasker Award in Medical Research.With an\noperatingbudgetofmorethanS1.2billion,theSchool of Medicineworks closely inpartnershipwith the Universityof Maryland Medical Centerand\nMedical Systemto provideresearch-intensive,academic and clinically based carefor nearly2million patients each year.TheSchool ofMedicine hasnearly" } }, { "id": "covid-forbes", "study": "covid", "outlet": "Forbes", "outlet_original": "Forbes", "outlet_score": 9, "title": "Is Coronavirus In The NYC Subway? How Swabbing Doors And Trains Is Shaping The Fight Against COVID-19", "title_original": "Is Coronavirus In The NYC Subway? How Swabbing Doors And Trains Is Shaping The Fight Against COVID-19", "language": "English", "date": "2020-03-28", "kind": "news", "url": "https://www.forbes.com/sites/johncumbers/2020/03/28/is-coronavirus-in-the-nyc-subway-how-swabbing-doors-and-trains-is-shaping-the-fight-against-covid-19/", "archive_url": "https://web.archive.org/web/20200328230707/https://www.forbes.com/sites/johncumbers/2020/03/28/is-coronavirus-in-the-nyc-subway-how-swabbing-doors-and-trains-is-shaping-the-fight-against-covid-19/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Forbes contributor piece on a town hall about environmental sequencing of surfaces, describing efforts to test NYC transit for the coronavirus using targeted sequencing enrichment.", "topics": [ "covid-19", "subway", "environmental sequencing", "metasub", "sars-cov-2" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/covid-forbes.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-forbes--archived.jpg", "saved_html": "media-archive/html/covid-forbes--archived.html", "saved_article_text": "media-archive/text/covid-forbes.txt", "ocr_text": { "archived": "Forbes\nBusiness\nLifestyle Lists Advisor\nBillionaires\nSmall Business\nInnovation\nLeadership\nMoney\nBreaking\nMore\nFeatured\nEDITORSPICK/535Views/Mar28,2020,12:04amEDT\nIsCoronavirus In TheNYC\nSubway? How Swabbing Doors And\nTrainsIs ShapingTheFight\nAgainst COVID-19\nJohn Cumbers Senior Contributor\nManufacturing\nSynthetic biology & space settlement connector,founder amd investor.\nKE ATLAS ON UNSPLASH\nNew Yorkers know the subway can be nasty,but coviD-19 has\nmade riding the rails dicier than usual.\nAs I write this, New York City is getting hit harder than any other metropolis. In\nthe past 24 hours, 365 residents died of COVID-19. \"The rate in the next few\ndays [will] continue to go up,” Francisco Moya, a New York City councilmen,\ntold The Guardian.\nHow much coronavirus is out there? Are handrails, Amazon packages, and\nelevator buttons all contaminated? How would we know?\nIt turns out that several industries-commercial kitchens and breweries, for\nexample-rely on what's called “environmental sequencing\" of surfaces and\ndoor handles. They do this to keep dangerous bacteria and viruses from getting\nanywhere near your food to begin with. Experts are now applying this\ntechnology in the search for the new coronavirus.\nI spoke with three such experts this morning during an online town hall I\nhosted to understand how we can track and respond to coronavirus within our\nbuilt world. Weill Cornell Medicine professor Christopher Mason has swabbed\nthe NYC subway system before with surprising results. Now, with help from\nTwist Bioscience's NGS Target Enrichment tools for coronavirus, Chris is\nsampling the public transit system to see if and where the novel coronavirus is\nresiding. Chris was in conversation with Twist CEO Emily Leproust, as well as\nJosh Perfetto, founder and CEO of Chai Bio, which makes tools like Open qPCR\naccessible to researchers everywhere.\nHere's what they had to say.\nToday In: Manufacturing\nHow do we detect viruses in theenvironment?\nHow do wedetectviruses intheenvironment?\n\"Everywhere we go is a living ecosystem,\"explained Mason, who famously\nstudied astronaut poop to look for differences in the microbes of people living\non and off Earth. (Yes, even the International Space Station is home to various\ngerms.)\nPROMOTED\nMason has been swabbing different parts of the New York City subway since\n2013. His motivation? \"When my daughter got old enough to ride the subway,\nshe did actually one day lick a subway pole, which I was terrified about. So I\nreally wanted to know what was there.\"\nMason is now part of a consortium of\nscientists who are swabbing urban\nenvironments around the world. In 2019\nthey nabbed 9521 samples from every\ncontinent except Antarctica, including 647\nThe transmission and genetic evolution of\nsamples from New York City.Normally\nthe SARS-CoV-2,as of March 26, 2020.\nsamples are collected as a snapshot every\nThe virus's genome [+]NEXTSTRAIN.ORG\nsummer. This year, the swabbing has started\nearly.\nWe don't have any good, solid evidence that there is SARS-CoV-2 [the virus\nthat cases COVID-19] in the subway,” Mason reported this morning. \"We just\nhave a very limited data set so far, but the collection has ramped up.\"\nCollections to monitor SARS-CoV-2 began two months ago and has expanded\nto 59 cities.\nan increasingly popular wayfor scientists to quickly share their findings before\nthey have gone through the lengthy peer-review process.\"I was hoping it would\nbe online by today, but it is probably going to go on early next week.\"\nOnce collected, samples from the\nenvironment can be studied in different\nways. Depending on how a lab does the\nprocessing, it can take 30 minutes, three\nhours or up to three days to get a result.\nResearchersgenerally scrutinizethegenetic\nmaterial in a given sample, then attempt to\nback-calculate which microbes or viruses it\ncame from.To detect the presence of SARS-\nIcohelix buccal swabs are used to collect\nCoV-2 in a subway swab,a so-called RT-PCR\ngenetic material from the environment.\nprotocol is often performed. This test takes a\nISOHELIX.COM\nfew hours and can give a definitiveansweras\nto whether intact genes from the virus were present at the time the sample was\ncollected. The same technique is used to detect the virus in patients.\nThe biggest danger of swabbing in public places is that some people think\ncorrectly that you are just collecting a sample [while] other people think you are\nleaving something,which can be technically a crime.\"\nSynthetic DNA to the Rescue\nCritical to this work are reliable controls. In orderfor Mason to know that his\ninstruments are working properly, and that their findings can be trusted, the\nteam relies on synthetic DNA molecules made by Twist. If those positive\ncontrols fail to produce a signal, something must have gone wrong inside one of\nthe sample processing labs.\n\"At Twist we have built a platform based on silicon to write DNA,\"explained\nTwist CEo Leproust.\"There are a number of applications for that. One of them", "live": "Forbes\nVerification Required\nSlideright to secureyour access\nWhy is this step needed?\nWe detected unusual activity from your device or network.Reasons may include:\n-Rapidtapsorclicks\n-JavaScriptdisabledornotworking\n-Automated (bot) activity on your network (IP157.139.64.11)\n-Useofdeveloperorinspectiontools\nNeedhelp?Submitfeedback.\nID:5eefe68f-d932-38d7-b9b4-73b8c1067758" } }, { "id": "covid-wired-microbe-mappers", "study": "covid", "outlet": "WIRED", "outlet_original": "WIRED", "outlet_score": 9, "title": "Microbe Mappers Are Tracking Covid-19's Invisible Traces", "title_original": "Microbe Mappers Are Tracking Covid-19's Invisible Traces", "language": "English", "date": "2020", "kind": "news", "url": "https://www.wired.com/story/microbe-mappers-are-tracking-covid-19s-invisible-traces/", "archive_url": "https://web.archive.org/web/20201028203957/https://www.wired.com/story/microbe-mappers-are-tracking-covid-19s-invisible-traces/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Feature on scientists swabbing New York transit and sequencing samples to look for coronavirus traces in the city, building on earlier subway microbiome work.", "topics": [ "covid-19", "metagenomics", "subway", "surveillance", "environmental sampling" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/covid-wired-microbe-mappers.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-wired-microbe-mappers--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-wired-microbe-mappers.txt", "ocr_text": { "archived": "WIRED\nBACKCHANNEL\nSECURITY\nSIGN IN\nBUSINESS\nCULTURE\nGEAR\nIDEAS\nSCIENCE\nSUBSCRIBE\nCORONAVIRUS\nFAOS\nFACE HASKS\nESSENTIALS\nHOW TO DISINFECT EVERYTHING\nSYHPTOMS AND TESTING\nWHAT HAPPENS NEXT?\nNEWSLETTER\nLATEST\nHEGAN HOLTENI\nSCIENCE\n84.29.282887:88AM\nMicrobe Mappers Are Tracking Covid-19's Invisible\nTraces\nArmiesofmicrobiologistsareswabbingsubways,ATMs,andhospitalsinsearchofthenovel coronavirus.Theirdatacouldhelp\ncitiesreopenresponsibly.\nWith Covid-19 testing stll woefully lagging in the Us, even as some states are already starting to relax safety measures, passive disease surveillance\nGetWIRED\nDURING THE SEcoND Week ofMarch,as theWorld Health Organization\nAccess\ndeclaredCovid-19aglobalpandemic,ateamoflatex-glovedscientists\nfrom Cornell Weill Medical School fanned out across Penn Stationarmed\nwith packs of sterile,long-armed swabs and a tripod-mounted\nSUBSCRIBE\ninstrument for capturing air samples. In New York City,the 1ooth person\nhad just tested positive for SARS-CoV-2, the coronavirus that causes the\ndeadly new respiratory disease, but the subways remained open and\npacked with daily commuters. The researchers were there, in one of the\nmost crowded areas of the city, to see if the coronavirus was, too.\nNearly a decade ago, after watching his\nyoung daughter lick a pole in a subway\ncar,computationalbiologistChristopher\nMason got the idea to start regularly\nswabbing the handrails, turnstiles, seats,\nandfloors insideNewYorkCity'smetro\nsystem. Sequencing of these samples\nHow Long Does the\nback inhislabat Cornell Weill led tothe\nCoronavirus Liveon\nfirst map of the microbes that call the\nCoronavirus Liveon\nfirst map of the microbes that call the\nSurfaces?\ncity's transit system home. Mason, who's\nPlus: What It means to \"flatten\nperhaps better known for his work on the\nthe curve,and everything else\nyou need to knowabout the\nNASAtwin studyand his“500-yearplan\"\ncoronavirus.\nfor space colonization, soon found other\nscientists similarly obsessed with\nconducting a regular census of all the\nviruses, bacteria, and fungi making their way through metropolitan public\ntransit. In 2015,they launched MetasUB-a network of scientists in more\nthan ioo cities who keep a running annual tally on the bugs in their\nrespective urban biomes.\nOver theyears,criticshavepanned theprojectas too esoteric and too\nexpensive to be anything more than a splashy publication play. Mason's\noriginal NYC-subway-mapping paper was later corrected after health\nofficials disputed the headline-grabbing findings, which included trace\nevidence of anthrax and the bugs that cause bubonic plague. But when\nSARS-CoV-2 began spreading out of China and around the world,\nMetasUB's teams were ready to spring into action.\nNormally, they conduct sampling in the summer. But in 17 pilot cities,\nMetasUB scientists started swabbingfor tracesof geneticmaterial from\nSARS-CoV-2 as early as the first week of February.When subways shut\ndown,they switched to otherhigh-touch surfaces,likeATMs and park\nbenches.So far,they'vecollected 3,600 samples,with1,000 of those\nhaving made it to the Mason lab foranalysis.And asmore cities within\nMetaSUB's network come online, Mason expects data from at least 10,o00\nsamples to flow into the group's open-access repository.\nNews of the future, now.\nGet WIRED for as low as $5.\nSubscribe Now\nThegoal of all this swabbing and sequencing is twofold:One, to better\nunderstand the virus's transmission dynamics. How long does it stayalive\nOn surfaces? How much of it is in the air? How risky is riding the subway.\nreally? Answers to thosekinds of questions can helppublic health\nofficials make decisions now to protect citizens during the early stages of\nthe pandemic. But the second aim is more long-term: detecting potential\nhot spots of infection in highly trafficked areas before people start\nshowing up in emergency rooms.\nWith Covid-i9 testing still woefully lagging in the US, even as some states\nare already starting to relax safety measures, passive disease surveillance\nmay be an important part of the next phase of the pandemic--learning to\nlive with the virus. In addition to subways, scientists have started looking\nfor signs of the virus in other parts of the public infrastructure, including\nhospitals and wastewater treatmentplants.Last month, Ginkgo Bioworks,\nthe largest synthetic biology company in the US, committed s25 million of\nin-kind work to academic and industry projects focused on combating\nCovid-19, including free sequencing. At present, the company is\nsequencing a few hundred patient samples each week to bolster\nepidemiological investigations in hard-hit areas, but it plans to scale up to\n10,oo0 samplesa day to support widespread environmental surveillance\nin the future.\n\"The appetite for molecular monitoring has really increased, because\npeople are now seeing what the cost of its absence looks like,\" says\nMason. That cost is especially high in New York City, where the", "live": "THE WIRED APP IS HERE\nDOWNLOAD NOW\nWIRED\nSECURITY\nPOLITICS\nTHE BIG STORY\nBUSINESS\nSCIENCE\nCULTURE\nREVIEWS\nNEWSLETTERS\nSUBSCRIBE\nHEGAN MOLTENI\nSCIENCE\nAPR29.28287:88AM\nMicrobe Mappers Are Tracking Covid-19's Invisible Traces\nArmies of microbiologists are swabbing subways, ATMs, and hospitals in search of the novel coronavirus. Their data could help\ncities reopen responsibly.\nGetyourfirstmonthfreewithunlimitedaccess,plus 5premiumnewsletters-cancelanytime.STARIFREETRIAL\nWith Covid-19 testing still woefully lagging in the Us, even as some states are already starting to relax safety measures, passive disease\nsurveillance maybe an important part of the next phase of the pandemic--learning to live with the virus.PHOTOGRAPH:GARY\nHERSHDRN/GETTY IMAGES\nAllproductsfeaturedonWIRED areindependentlyselectedbyoureditors.However,wemay\nrecelvecompensationfromretailersand/orfrompurchasesofproductsthroughtheselinks.\nYou'vereadyourlastfreearticle.\nMOST POPULAR\nPOLITICS\nA28-Year-OldDOGEOperative\nGuttedUSAID.HRHadNoRecord\nof Him Working There\nBY HOLLY KNIGHT RASKIN\nPRIVACY\nThe US Government Is Hiding a\nSecret Court Ruling About How It\nGetyourfirstmonthfreewithunlimited access,plus5premium\nSpies on Americans\nnewsletters-cancelanytime\nBY DELL CAMERON\nDIGITAL CULTURE\nSTART FREE TRIAL\nGrok Says Its Al-Generated Version\nof The Odyssey Is 'Not Historically\nAccurate\nAre you already a subscriber? Log ln\nBY HILES KLEE\nGEAR\nITested EveryMajorAl Agentfora\nDay.Here's the Best One\nBY REECE ROGERS\nMegan Molteni is a science writer at STAT News.Previously.she\nwas a staff writer at WIRED, covering biotechnology. public\nhealth, and genetic privacy. She studied biology and ultimate\nfrisbee at Carleton College and has a graduate degree in\njournalism from the University of California,Berkeley...Read\nMore\nTOPICS\nCORONAVIRUS\nCOVID-19\nHICROBIOME\nPUBLIC HEALTH\nWIRED's Guide to How\nthe Universe Works\nYourweeklyroundup ofthebeststories onhealth care,the\nclimate crisis,new scientific discoveries, and more.\nSIGN UP\nBy signing up, you agree to our user agreement (including class action waiver and arbitration\nprovisions), and acknowledge our privacy.policy.\nREAD MORE\nMeet the Vendors Selling\nI've Tested the 3 Mac\nThese Midterm Races Will\nA Mysterious Nonprofit Run\n\"Cornell Seven'Merch\nDesktops That Apple Makes,\nDecideDataCenters'Political\nbySpaceXAl'sTopLawyerIs\nand There's a Clear Winner\nFate\nPaying the Salaries of...\nBrands, influencers, and Etsy sellers\nApple's Mac desktops have become\nclaim they're hawking T-shirts, mugs.\nFrom the Senate to governors'\nThe National Design Studio has been\nmansions, candidates are trying to\nand buttons out of solidaritywith the\nsome of themost sought-after\nsomething of a successor agency to\ncomputers this year, driven by surging\nwomanwhoaccusedsevenmale\noutcompeteeachothertobethemost\nDOGE.A WIRED investigation finds\ninterest in agentic Al. Here's which\nclassmatesofsexual assault.Some\nanti-datacenter inracesacrossthe\nsome ofitsmembers are onloan from\nsay it's shameless.\nmodel to buy depending on your use\nUS.\na nonprofit run by SpaceXAI's general\ncase.\nHOLLY TAFT\ncounsel.\nEJ DICKSON\nLUKE LARSEN\nVITTORIA ELLIOTT\nWhatsAr\nWhatsApp Help Pages Leaked\nArtificial Roasts Al's Creators\n9 WIRED-Approved Gifts for\nAStartup Has aPlan toMake\nHidden Instructions fora\n-and Sends a Dark Warning\ntheTechieinYourLife\nWater From Air Using Data\nMeta Chatbot\nAbout Its Dangers\nCenters'Waste Heat\nDon't buya loved one something you" } }, { "id": "covid-wired-wisconsin", "study": "covid", "outlet": "WIRED", "outlet_original": "WIRED", "outlet_score": 9, "title": "A Wisconsin City Experiments With a Faster, DIY Covid-19 Test", "title_original": "A Wisconsin City Experiments With a Faster, DIY Covid-19 Test", "language": "English", "date": "2020", "kind": "news", "url": "https://www.wired.com/story/a-wisconsin-city-experiments-with-a-faster-diy-covid-19-test/", "archive_url": "https://web.archive.org/web/20201104143939/https://www.wired.com/story/a-wisconsin-city-experiments-with-a-faster-diy-covid-19-test/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "In Racine, Wisconsin, firefighters turned a city building into a COVID-19 lab to try a saliva test that is simpler and cheaper than PCR, and WIRED asks whether faster, do-it-yourself testing could change how the virus is screened.", "topics": [ "covid-19", "diy testing", "rapid test", "wisconsin" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/covid-wired-wisconsin.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-wired-wisconsin--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-wired-wisconsin.txt", "ocr_text": { "archived": "WIRED\nBACKCHANNEL\nGEAR\nIDEAS\nSIGN IN\nBUSINESS\nCULTURE\nSCIENCE\nSECURITY\nCORONAVIRUS\nFAOS\nFACE HASKS\nHOW TO DISINFECT EVERYTHING\nSYMPTOMS AND TESTING\nWHAT HAPPENS NEXT?\nESSENTIALS\nNEWSLETTER\nLATEST\nGREGORY BARBER\nSCIENCE\n87.23.282887:88AM\nA Wisconsin City Experiments With a Faster, DIY Covid-\n19 Test\nIn a former boxing gym in Racine, firefighters are trying out a spit test that's simpler and cheaper than PCR. Could it change\nhowwe screen forthevirus?\nPHOTOGRAPH:GETTY IMAGES\nEAcH MoRNING AT7, Brian Wolf,thefire chief of Racine,Wisconsin,\narrivesforwork inaneglectedcornerofabuildingcalledtheCityHall\nAnnex.A stately,Depression-era brick structure on a not-so-stately\nstretch of parking lots and auto glass shops, the space once held the\nworkshopsofavocational college.Later,itbecamehometothecity's\nboxing club-a sign still hangs in the room that held the old ring. More\nrecently,thespacewasusedforstorage.\"It'sbasicallyawarehouse,\"Wolf\nsays. But a few weeks ago, the Annex's ancillary purpose became an asset.\nOld items were cleared out, the walls and floors scrubbed down, and\nrooms stocked with an array of lab tools and boxes of test tubes and\npipettes. The result is perhaps the world's most unassuming Covid-19\ntesting lab, where Wolf now presides over his fire crew as pipetter-in-\nchief.\nAt the start of a shift, the firefighters don\ngowns, goggles, and medical masks. Then\ntheyawaitastreamofcityworkers-\npermit issuers, police officers, lifeguards\n-whodropbyontheirwaytowork.\nUnder careful supervision, each visitor\nUndercarefulsupervision,eachvisitor\nspits into a vial. And for the rest of the\nEverything You Need\nday, the firefighters perform the tests,\nto Know About the\nheating up the samples and pipetting\nCoronavirus\nliquids from one test tube to the next.\nHere's all theWIREDcoverage In\n\"We're slow at it,\" says Wolf.\"But like any\none place,from how to keep your\nchildren entertained to how this\nemergency we respond to, we have to\noutbreak is affecting the\nwork together. No bickering. No errors.\neconomy.\nWe get it done.\" If all goes well, they'll\nhave results by lunch. They await a\nsimple change of color in the test tubes: Pink is the all-clear; no virus\ndetected. Yellow is evidence of SARS-CoV-2.\nThe technology used in the tests is called LAMP,or loop-mediated\nisothermal amplification. It's similar to PCR--or polymerase chain\nreaction-the common way of diagnosing Covid-19, in that it looks for\ngenetic traces of the virus. But it's a stripped-down process, requiring\nfewer chemical ingredients, test tubes, and equipment. Typically, the\nmethod is used to test for diseases like Zika and dengue fever in places\nthat don't have labaccess-or else by farmers who want tofind out what\npathogen ails their soybeans. But in Racine, it's part of an experiment: to\nseehowa cheaper, simpler test,ifdonefrequently enough, mighthold\noutbreaks at bay. Instead of sending samples off to a hospital or lab, and\npotentially waiting days for results, could you test for Covid-19 from the\nback of a van, or outside a school, or in a city-owned former boxing gym?\nThe tests had found their way to the shores of Lake Michigan by way of\nChris Mason, a professor at Cornell-Weill Medical School, Racine native,\nand younger brother of the city's mayor. Earlier this spring, Mason had\npublishedapreprint ofhis work on LAMP,and then posted it on Facebook\nand Twitter. It caught his brother's attention.Their hometown, much like\neverywhere else, lacked adequate testing for the new virus, and in April,\nMason's brother called, inquiring about his research.The mayor told him\nthat cases were surging, and asked if the test could be put to use.\nThe idea behind LAMP testing, according to Mason, is to give every town\nor city its own capacity to test closer to home. While few places have their\nown clinically certified labs, “everybody has a fire department' he says.\nBecausepeoplecan havea Covid-19infectionwithout symptoms,the\nmajor barrier to any return to a semblance of normal life-back to school,\nto work-is the need to test lots of people, regularly,whether they show\nsigns of Covid-19 or not. An estimate from Paul Romer, a Nobel Prize-\nwinning economist at New York University, puts the requirement for\ndoing so safely at more than 35 million tests per day.\nADVERTISEMENT\nFrequent testing would allow for the use of slightly less accurate-and\npotentially cheaper-tests, since missed infections would likely be caught\nby subsequent rounds of testing. The key is to return results within hours\nor even minutes, says Jeremy Kamil, a microbiologist at Louisiana State\nUniversity.That's useful for quashing outbreaks before they spread, and\nalso critical for avoiding too much disruption.“The savior test will be\nsomething that's economical and reliable in onehour directlyfrom\nsaliva,\" he says. You could intercept infected people before they spend\nmany hours together at work or to pack the gym for the high school\nbasketball game.If they tested positive, they would be asked to self-", "live": "THE WIRED APP IS HERE\nDOWNLOAD NOW\nWIRED\nSECURITY\nPOLITICS\nTHE BIG STORY\nBUSINESS\nSCIENCE\nCULTURE\nREVIEWS\nNEWSLETTERS\nSUBSCRIBE\nGREGORY BARBER\nSCIENCE\nJUL23.28287:88AM\nA Wisconsin City Experiments With a Faster, DIY Covid-19 Test\nIn a former boxing gym in Racine, firefighters are trying out a spit test that's simpler and cheaper than PCR. Could it change\nhowwe screen forthe virus?\nGetyourfirstmonth freewith unlimitedaccess.plus5premiumnewsletters-cancelanytime.STARTFREE TRIAL\nPHOTOGRAPH:GETTY IMAGES\nMOST POPULAR\nWIRED'sGuidetoHowtheUniverseWorks\nYourweeklyroundupofthebest storiesonhealthcare,theclimatecrisis,newscientiflc\nPOLITICS\ndiscoveries, and more.\nA28-Year-OldDOGEOperative\nSIGN UP\nGuttedUSAID.HRHadNoRecord\nof Him Working There\nBy signing up. youagree to our user agreement (including class action waiver andarbitration\nBY HOLLY KNIGHT RASKIN\nprovisions),andacknowledgeourprivacy_policy\nPRIVACY\nThe Us Government Is Hiding a\nAlreadya subscriber? Sign In\nSecret Court Ruling About How It\nSpies on Americans\nRead this story for free.\nBY DELL CAMERON\nDIGITAL CULTURE\nTo continue reading, sign up for the newsletter for innovative\nGrok SaysItsAl-GeneratedVersion\njournalism and more.\nof The Odyssey Is'Not Historically\nAccurate\nBY HILES KLEE\nEnter your email\nGEAR\nI Tested EveryMajorAl Agentfora\nUnlock Article\nDay.Here's the Best One\nBY REECE ROGERS\nBY REECE ROGERS\nSee offers\nBy signing up you agree to our User Agreement (including the class action waiver and arbitration\nprovisions),our Privacy Policy& Cookie Statement and to receive marketing and account-related\nemails from The Wired. You can unsubscribe at any time.This site is protected by reCAPTCHA and the\nGoogle Privacy Policy and Terms of Service apply.\nGregory Barber is a journalist in San Francisco who previously\ncovered energy and climate for WIRED.... Read More\nCONTRIBUTOR\nTOPICS\nCORONAVIRUS\nC0VI0-19\nEPIDEMIOLOGY\nTESTING\nPUBLIC HEALTH\nWIRED's Guide to How\nthe Universe Works\nYourweeklyroundupofthebeststoriesonhealthcare,the\nclimate crisis,new scientific discoveries,and more.\nSIGN UP\nBy signing up. you agree to our user agreement (including class action waiver and arbitration\nprovisions),and acknowledgeourprivacy.policy.\nREAD MORE\nALSDEALSDEALSDEALS DEA\nSIXTy HERR\nDEALS DEALS\nLSD\nLS\nDEA\nRonBtarTrekCh\nDEA\nSD\nCOUPONS\nDEA\nJEALSDEALS\nS DEALS DEALS DEALSDEALS\nThe Sixty-Year Mission Brings\nTheSecrets ofaUsSpyware\nOurGo-ToPowerBanksAre\nHome Depot Promo Codes:\nKing\nStar Trek's Legacy to a New\nOn Sale Right Now\n30% Off in October 2026\nGeneration\nInan exclusiveinterviewwith\nYou can never have too many\nSaveupto50%todaywiththelatest\nWIRED, Paragon Solutions CEO\nportable chargers, especiallywhen\nThedocumentarychronicleshowStar\nHome Depot promo codesfor\nTrek'spositions oneverythingfrom\nAndrewBoyd revealsthe limits of the\nthey're this discounted.\nappliances,powertools,andmore\ncompany's promisetokeepbad\nrace to Al were wayahead of their\nthis October.\nLOURYN STRAMPE\ntime.\nactors from abusing its powerful\nHOLLY HIGGINS\nespionage tool.\nHAX EVRY\nKIM ZETTER" } }, { "id": "covid-indyturk-test", "study": "covid", "outlet": "The Independent (Turkish edition)", "outlet_original": "Independent Türkçe", "outlet_score": 6, "title": "New coronavirus test gives results in 30 minutes", "title_original": "Yeni koronavirüs testi, 30 dakikada sonucu veriyor", "language": "Turkish", "date": "2020", "kind": "news", "url": "https://www.indyturk.com/node/197341/sa%C4%9Flik/yeni-koronavir%C3%BCs-testi-30-dakikada-sonucu-veriyor-g%C3%BCnde-1-milyondan-fazla-test", "archive_url": "https://web.archive.org/web/20201026154352/https://www.indyturk.com/node/197341/sa%C4%9Flik/yeni-koronavir%C3%BCs-testi-30-dakikada-sonucu-veriyor-g%C3%BCnde-1-milyondan-fazla-test", "names_meydan": true, "meydan_context": "Interviewed as a Weill Cornell researcher on the LAMP test who explains how it works, its sensitivity and the related city-mapping work.", "passage_naming_meydan": "Dr. Cem Meydan of Weill Cornell Medicine, who works on the LAMP test, said the new test shows within 30 minutes whether the virus is present.", "summary": "Turkish-language article on an FDA-authorized LAMP COVID-19 test that is cheap and returns results in about 30 minutes without special equipment, tied to subway microbiome mapping work in New York.", "topics": [ "covid-19", "lamp test", "rapid diagnostics", "subway microbiome", "fda" ], "audience": "major-news", "thumbnail": "media-archive/thumbs/covid-indyturk-test.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-indyturk-test--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-indyturk-test.txt", "ocr_text": { "archived": "INDEPENDENT\nTurkce\nSiYASET\nDUNYA\nBiLiM\nEKONOMi\nSPOR\nKORONAViRUS\nKULTUR\nHABER\nYASAM\nYAZARLAR\nTURKIYE'DENSESLER\nDUNYADANSESLER\nSAGLIK\nROPORTAJ\nDOSYA\nViDEO\nHome》SAGLIK Yenikoronavirus testi,3o dakikada sonucu veriyor:Gunde1milyondan fazla test yapilabilecek\nYeni koronaviris testi, 30 dakikada\nsonucu veriyor: Ginde 1 milyondan\nfazla test yapilabilecek\nFDA'den onay alan ve 30 dakikada sonuc veren yeni LAMP testi uzerinde arastirma yapan Weill\nCornell TipFakultesi'nden\nDr.CemMeydan\n\"Butestucuz,hizh vekolay sonucveriyor\"dedi\nEsra Oz| @fesraoz \nCarsamba 17 Haziran 202011:39\nFotograf: Independent Turkce\nABD Gida ve ilac idaresi (FDA), ucuz, hizl ve kolay sonuc veren yeni bir\nKovid-19 testine onay verdi.\nENCOKOKUNANLAR\nGunumuzde koronaviruis icin genellikle RT-PCR testleri uygulaniyor.\nAncak bu testlerin bazi sikintilari var.\nSONHABERLER\nOzellikle ornek alindiginda test kapasitesine gore bekleme siresi cok uzun\nCHP Sozcusu Oztrak: Birileri\noluyor.\nelciyi cekiyorsa o zaman siz\nBelli aletlere bagll sekilde calisilmas1 zorunlu oldugu icin cok sik herkes test\nde ne yapacaginizi\ndustineceksiniz\nedilemiyor,ekipmanvekimyasallaracisindankapasitevestoksorunuda\nvar.\nThe Independent, binlerce\nmedyaorganini inceleyen\nFDA'den onay alan LAMP testi ise RT-PCR testlerinden farkli olarak,\ngozlemci kurulustan yizde\n100gtivenpuanialdi\nFDAdenonay alanLAMPtestiiseRT-PCRtestlerindenfarkli olarak,\n100given puanialdi\nherhangifarkli bir ekipmana ihtiyag duyulmadan kolayca uygulanarak,ucuz\nve hizli sonuca ulasma imkani veriyor.\nCiplak kor farelerin\nbirbirinin yavrularini calip\nLAMP testi uzerinde arastirma yapan New York'taki Weill Cornell Tip\nkolelestirdigi ortaya gikti\nFakiltesi'nde calisanDr.Cem Meydan\nyenitestinise30dakikadahizlica\nSaype'nin\"Dunyanin en\nviruisun olup olmadigini gosterdigini belirtti.\nbuyuk insan zinciri\"projesi\nistanbul'da\nIndependent Turkce'ye konusan\nDr.CemMeydan\nyeni LAMP\ntestinin biuyuk cihazlar olmadan her yerde uygulanabilecegini soyledi.\nSaglik Bakani Koca'dan\nistanbul icin kritik uyari\nCemMeydan.jpg\nYAZARLAR\nCharlie Mitchell\nKovid'in Hindistan'daki yikici\netkisi Modi'nin basarisizhiginin\nisareti\nQuhramaana Kakar\nAfganistan'da kadinlar\nmizakerelere dahil edilmedigi\nsurece baris imkansiz\nKim Sengupta\nDonald Trump icin Rudy\nGiuliani'ye givenmek neden\nartik bu kadar riskli?\nVome Aghoghovbia-Gafaar\nGeng Nijeryalilarin degisime yon\nvermesinden gururluyum:Artik\nyok sayilmayacagiz\nChris Stevenson\nTrump'in en sadik destekcileri\nonu islevsiz birkampanyadan\nhala kurtarabilir\nTURKiYE'DENSESLER\nProf. Dr.Mehmet Celik\nTopraga givenmek\nCelalettin Can\nPandemi kosullarinda sanat...\nOzgur Kaya\nFazla calisma ve hafta tatili\ncalismalarinin icret\nDr.Cem Meydan\nFotograf:Independent Turkce\nhesaplamalari nasil yapilir?\nEyup Kaan Yoksu\n'Sehrin mikrobiyom haritasiyla, salginlarin\nTurk sinemasinda \"darbe\"\nyayilmasi durdurulabilir\"\ntemasiyla cekilmis 13 film\nSehirlerin mikrobiyomunu arastirarak,salginlarin olmasinin onune\ngecilmesi icin uzun yllardir calisan Dr.Meydanve arkadaslari,bu\nBenan Kepsutlu\ncalismasiyla New York'un mikrobiyom haritasini olusturdu.\nNATO'nun da atis alani olarak\nkullandigiGirit'teki askeri\nBu calismasiyla ilgili olarak Dr.Meydan New York ve lo0 kadar uluslararasi\ntesiste.Yunanistan'in S-300\ndenemelerine iliskin detaylar\nsehirde son 4-5 senedir metro duraklarindan test ornekleri alarak\nincelediklerini anlattr:\nDUNYADAN SESLER\nHazim Sagiye\nSadece Nero York'ta bilebir ginde 5milyondanfazla kisi metroya\nLibnan:Kesfedilmesi zor yalan\nbiniyor.Eger birmetrodabirka hasta kisi gelmissebile gok riskli bir ortam.\nSiztemizledik deseniz bilegelen birkackisibinlerce insanabulastirabilir Bu\nortamlarda insanlarin dokundugu yerlerden ornekler almak gerekiyor.\nHuseyin Subuksi\ninsanlarin dokundugu metrodaki kapilar, digmeler, ekranlargibi yerlerden\n'Kuzeye' go mevsimi!\nOrnek alarak timmikroorganizmalarn haritasingikardik.Kovid-19 salgin!\nsirastndada metroda viris takibine basladik.\nViris takibi haritasiyla elde edilen orneklerde genetik sekanslama yaninda\nAbdurrahman Salkam\nLAMP ya da PCR ile test yapilmasi gerektigini soyleyenDr.Meydan\nFransiz ogretmeni kim oldurdu?\n\"Sekanslama bu tur arastirmalar icin nispeten cok yavas ve pahal bir\nyontem.LAMP ise guinde binlerce ornegi alip.hizlica bakmaniza olanak", "live": "INDEPENDENT\nTurkce\nSiYASET\nDUNYA\nBiLiM\nKULTOR\nEKONOMi\nSAGLIK\nHABER\nYASAM\nTURKIYE'DENSESLER\nDUNYADANSESLER\nSPOR\nROPORTAJ\nYAZARLAR\nDOSYA\nViDEO\nYeni koronaviriis testi, 30 dakikada\nsonucu veriyor: Ginde 1 milyondan\nfazla test yapilabilecek\nFDA'den onay alan ve 3O dakikada sonuc veren yeni LAMP testi uzerinde arastirma yapan Weill\nCornell Tip Fakultesi'nden\nDr.Cem Meydan\n\"Butestucuz,hizli vekolay sonuc veriyor\"dedi\nEsraO/@fesraoz1Carsamba17Haziran202011:39\nFotograf:Independent Turkce\nABD Gida ve ilac idaresi (FDA), ucuz,hizl vekolay sonuc veren yeni bir Kovid-19 testine\nonay verdi.\nENCOKOKUNANLAR\nGinimizde koronaviris icin genellikle RT-PCR testleri uygulaniyor.Ancak bu testlerin\n33 yillik senaryo Netflix filmi\nbazi sikintilari var.\noluyor: Basrolde Keanu\nReeves\nOzellikle ornek alindiginda test kapasitesine gore bekleme stiresi cok uzun oluyor.\nUc haftada 20,3 milyon saat\nBelli aletlere bagl sekilde calisilmasi zorunlu oldugu igin cok sik herkes test edilemiyor,\nizlenen diziye onay geldi\nekipman vekimyasallar agisindan kapasite ve stok sorunu da var.\nFDAden onay alan LAMP testi ise RT-PCR testlerinden farkli olarak, herhangi farkli bir\nYonetmeni yanitladr:\nekipmana ihtiyag duyulmadan kolayca uygulanarak,ucuz ve hizli sonuca ulasma imkani\nMatthewPerrybelgeselinde\nveriyor.\nFriends yildizlari neden yok?\nLAMP testi uzerinde arastirma yapan New York'taki Weill Cornell Tip Fakiltesi'nde\nRobert Pattinson'dan The\ncalisan Dr.Cem Meydan yeni testin ise 30 dakikada hizlica virtisin olup olmadigni\nBatman2aciklamasi\ntestiuzerindearastirmayapanNew\nTipFakultesinde\nRobert Pattinson'dan The\nDr.Cem Meydan\ncalisan\nyeni testin ise30dakikada hizlicavirisunolupolmadigmi\nBatman2aciklamasi\ngosterdigini belirtti.\nIndependent Turkge'yekonusan\nDr.CemMeydan\nyeniLAMPtestininbuyikcihazlar\nGalaksinin Koruyucular'ni\nolmadan her yerde uygulanabilecegini soyledi.\nreddeden Oscar adayl yildiz:\n\"Bufilm tutmaz\"\n4 Emmy adayhgi, sifir zam:\nMeshur sitcomun yildizindan\nsitem\nBilim insanlari tarihin ilk\nkurumsal psikopatini\nbelirledi\nCall of Duty'nin yonetmeni\nfilmin odagimi acikladi\nYeni korku dizisi ll ginde\n1,3 milyar dakika izlendi\n\"Basyapit\"savasfilmi.\nkahramanlik hayallerini yerle\nbir ediyor\nSONHABERLER\nKisa haberler\nR4 ulkelerinden istanbul'da\nortak bildiri: israil\npolitikalarina tepki,iki\ndevletli cozum cagrisi\nTrump'tan iran'a yeni saldiri\niddiasina yanit: Haberim yok\nTurkiye-Kanada serbest\nticaret anlasmas\nmizakereleri 30Kasim'da\nbasliyor\nZonguldak'ta coken binayla\nilgili gozaltina alinan5\nsupheliden 3'u tutuklandi\nDr.Cem Meydan\nFotograf:Independent Turkce\nYAZARLAR\nDr Sidharth Kaushal\n\"Sehrin mikrobiyom haritasiyla, salgimlarin\nGizemli Rus uydusu uzayda\nyayilmasi durdurulabilir\nsavas baslatabilir mi?\nSehirlerin mikrobiyomunu arastirarak, salginlarin olmasinm onine gecilmesi icin uzun\nyllardir galisan Dr.Meydan ve arkadaslari,bu calismasiyla New York un mikrobiyom\nVictoria Richards\nharitasini olusturdu.\nDonald Trump kendini daha\nfazla batiramaz saniyorduk ki\nBu galismasiyla ilgili olarakDr.Meydan New York ve 100 kadar uluslararasi sehirde son\n\"Yorkshirekaplaniyla\"cikageldi\n4-5 senedir metro duraklarindan test ornekleri alarak incelediklerini anlattr:\nNevzat Cicek\nSadece New York'ta bile bir ginde 5milyondan fazla kisi metroya biniyor.Eger\nMeclis Baskan Kurtulmus:\nbirmetroda birkag hastakisi gelmisse bile gokriskli bir ortam.Sis temizledik deseniz\nHirsizik yapanin,yanlishk\nyapanin dinlisi dinsizi olmaz\nbilegelenbirkag kisi,binlerce insanabulastirabilir.Bu ortamlarda insanlarin\ndokundugu yerlerden Ornekler almak gerekiyor.Iinsanlarn dokunduigu metrodaki\nkapilar,digmeler, ekranlargibi yerlerden ornek alarak tim mikroorganizmalarn\nRobert Fox\nharitasingikardik.Kovid-19 salgim sirasinda dametroda viristakibinebasladik.\nPutin'in savasi yogun\nbakimdaydi: Trump ona hayat\nVirus takibi haritasiyla elde edilen orneklerde genetik sekanslama yaninda LAMP ya da\nopicugu verdi\nPCR iletest yapilmasi gerektigini soyleyen Dr.Meydan\n\"Sekanslama bu tur arastirmalar\nigin nispeten cok yavas ve pahali bir yontem.LAMP ise gunde binlerce ornegi alip.hizlica\nJessica Barrett\nbakmaniza olanak sagliyor\"dedi.\nDinya o kadar tuhaf bir hal aldi\nki Tom Cruise artik normal\ngorinuyor\n\"30 dakikada hzlca virisin olup olmadigim\nTURKiYE'DENSESLER\ngosteriyor\"\nProf.Dr. Levent Eraslan\nLAMP bazli kimyasal teknikli bu testin birkac sene once Zika viruisine uygulandigim\nCocuklarimizin dikkati kimin\nbelirten Meydan LAMP testini,laboratuvar ortaminda arastirma yapmak icin degil.\nelinde?\n\"hizlica bir salgin hastaligi bulabilir miyiz diye yaptiklarini vurgulad." } }, { "id": "covid-wcm-2021", "study": "covid", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Researchers Create Rapid Diagnostic Tests and Multi-Omics Analytics Platforms for SARS-CoV-2 Infection", "title_original": "Researchers Create Rapid Diagnostic Tests and Multi-Omics Analytics Platforms for SARS-CoV-2 Infection", "language": "English", "date": "2021-03", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2021/03/researchers-create-rapid-diagnostic-tests-and-multi-omics-analytics-platforms-for-sars", "archive_url": "https://web.archive.org/web/20210330180120/https://news.weill.cornell.edu/news/2021/03/researchers-create-rapid-diagnostic-tests-and-multi-omics-analytics-platforms-for-sars", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Release on a Nature Communications study presenting two rapid diagnostic tests, an RNA sequencing host/pathogen platform and spatial tissue mapping as alternatives to RT-PCR, used to map early New York infections.", "topics": [ "sars-2", "diagnostics", "rt-lamp", "sequencing", "spatial mapping" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/covid-wcm-2021.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-wcm-2021--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-wcm-2021.txt", "ocr_text": { "archived": "considersupportingWeill Cornell Medicine's effortsagainstthepandemic.\nWeill CornellMedicine\nDiscover\nCare\nTeach\nMenu\nEXPLORETHISWEBSITE\nNewsroom\nSocial Media\nAbout Us\nNews\nPublications\nPressRoom\nVideo&Photography\nSocial Media\nAbout Us\nHome\nNews\nResearchersCreateRapidDiagnosticTestsandMulti-\nOmicsAnalyticsPlatformsforSARS-CoV-2Infection\nMARCH30,2021\nBacktoNews\nWeill Cornell Medicine\nOfficeof External Affairs\n1300YorkAvenue\nOfficeofExternalAffairs\n1300YorkAvenue\nBox314\nNewYork,NY10065\nPhone:(646)962-9476\nAnillustrationoftheSARS-CoV-2virus.Credit:Shutterstock\nTwo distinct diagnostic tests, a host/pathogen RNA sequencing platform, and spatially-resolved tissue mapping tools\nand used to map SARS-CoV-2 infections at the height of the initial COVID-19 outbreak in New York City. These\nalternatives to the gold standard RT-PCR test expand the repertoire of tools available to the public health community and\nThe multi-disciplinary study , published March 12 in Nature Communications, demonstrates that a test called reverse\nCoV-2 in patient samples using simple equipment, while a second approach that captures and sequences the viral RNA\nallows investigators to identify and track the evolution of variants.The investigators further demonstrated that total RNA\nsequencing yields insights into both viral sequence evolution as well as human responses to the viral infection.\n\"We are entering a new era of fast and accurate tools that can tell us when and how viral variants arise and move in\nspecific populations, said senior author Dr.Christopher Mason ,co-director of the WorldQuant Initiative for\nQuantitative Prediction and a professor of physiology and biophysics at Weill Cornell Medicine.\"We hopeour innovations\nwill be used likea weather reportto identify viral outbreaks,improve tracking and tracing effortsto protect peoplefrom\ninfection,andimprovetreatmentinterventionsforpatients.\"\nDr.Mason developed the RT-LAMP test in collaboration with genomic testing firm Color and reagent supplier New\nEngland Biolabs.The single-tubetest reveals apositive result from a nasopharyngeal swab specimen in about30\nminutes by changing color from yellow to pink. The RT-LAMP test was shown to have a sensitivity of 96 percent and\nspecificity of 99 percent compared to the gold standard reverse transcription polymerase chain reaction (RT-PCR) test.\nBased on these and other results, the U.S. Food and Drug Administration (FDA) issued an emergency use authorization\n(EUA)to Colorfor therapid diagnostictest in May2020.\nThe RT-LAMP test, which can potentially be scaled to great numbers, offers an alternative to the standard RT-PCR test,\n\"This project was a great collaboration between the clinical pathology lab and the research labs at Weill Cornell\nMedicine,said co-senior author Dr. Hanna Rennert ,professor of pathology and laboratory medicine and director of\nthemolecularpathologylaboratory atWeill Cornell MedicineandNewYork-Presbyterian/Weill Cornell Medical Center.\n\"We were able to work with Dr. Mason's lab to validate the RT-LAMP test quickly using the in-house RT-PCR test we\ndeveloped just two weeks earlierfor patient testing.\"\nOne way the team confirmedtheaccuracy of theRT-LAMPtestwasto compare the results to thosefrom another viral\ndetection assaythey developed in collaboration with Twist Bioscience,a synthetic biology company and Biotia,a\ngenomics and artificial intelligence company. This technique combines a method called hybridization (hybrid) capture,\nwhich uses specially designed \"bait probes\" to trap all of the SARS-CoV-2 RNA in a sample, with next-generation\nsequencing, which provides detailed information about the viral strain and any mutations it has acquired. The U.s. FDA\nissued an EUA on March 24 for the advanced RNA sequencing platform,the first hybrid capture and sequencing platform\nfor SARS-CoV-2 to receive a FDA EUA and also the first test with an FDA-authorized, cloud-based analytics platform.\ncomputational analysis is used to map the data to all known species.They used the platform to profile all human, viral,\nwho were treated at NewYork-Presbyterian/Weill Cornell Medical Center during Marchand April 2020.\nThe analysis allowed the investigators to understand how SARS-CoV-2 affected the human body as the new virus was\nrapidly sickening people worldwide. They found that SARS-CoV-2 infection significantly altered gene expression in 757\ngenes and was associated with a wide range ofresponses in patients. Specific genes (SHFL, IFI6, IFI27,and IFIT1)in the\ninterferon pathway,a network of genes that control the immune response,were upregulated across all viral load levels\nand theyalso showed significantly higher expression than observed with other respiratory viruses.Othergenes showed\nreduced expression, such as olfactory genes, which could help explain why the loss of smell (anosmia) is a common\nCoVID-19 symptom.\n\"Our collaboration came together quickly to generate and analyze a large amount of data that would typically require an\ninternational consortium and a much longer time frame,\" said co-senior author Dr.Marcin Imielinski , assistant\nprofessor of pathology and laboratory medicine and member of the Englander Institute for Precision Medicine and\nthe Sandra and Edward Meyer Cancer Centerat Weill Cornell Medicine.\"Our findings about the origins of the virus in\nNYC outbreak and the host responses continue to hold today:\"", "live": "Weill Cornell Medicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPressRoom\nVideo&Photography\nSocial Media\nImpact Magazine\nAboutUs\nHome\nNews\nResearchersCreateRapidDiagnosticTestsandMulti-\nOmicsAnalyticsPlatforms for SARS-CoV-2Infection\nMARCH30,2021\nBack to News\nin\nWeill Cornell Medicine\nOfficeof External Affairs\nPhone:(646)962-9476\nAn illustrationoftheSARS-CoV-2virus.Credit:Shutterstock\nwere created by a multidisciplinary team of Weill Cornell Medicine and NewYork-Presbyterian Hospital-led researchers\nand used to map SARS-CoV-2 infections at the height of the initial COVID-19 outbreak in New York City.These alternatives\nto the gold standard RT-PCR test expand the repertoire of tools available to the public health community and together\noffer the benefits of speed, simplicity,and in-depth knowledge about the virus.\nThe multi-disciplinary study , published March 12 in Nature Communications, demonstrates that a test called reverse\ntranscription loop-mediated isothermal amplification (RT-LAMP)can quickly andaccuratelydetectthe presenceof SARS-\nCoV-2 in patient samples using simple equipment, while a second approach that captures and sequences the viral RNA\nallows investigators to identify and track the evolution of variants. The investigators further demonstrated that total RNA\n\"We are entering a new era of fast and accurate tools that can tell us when and how viral variants arise and move in\nspecific populations,\"said seniorauthor Dr.Christopher Mason,co-director ofthe WorldQuant Initiative for Quantitative\nPrediction and a professor of physiology and biophysics at Weill Cornell Medicine.\"We hope our innovations will beused\nand improve treatment interventions for patients.\"\nEngland Biolabs.The single-tube test reveals a positive result from a nasopharyngeal swab specimen in about 30\nspecificity of 99 percentcompared to thegold standard reversetranscription polymerase chain reaction (RT-PCR)test.\nBased on these and other results, the U.S. Food and Drug Administration (FDA) issued an emergency use authorization\n(EUA) to Color for the rapid diagnostic test in May 2020.\nThe RT-LAMP test, which can potentially be scaled to great numbers, offers an alternative to the standard RT-PCR test,\nwhich uses reagents that were in short supply during the height of the initial outbreak, as well as different equipment.\n\"This project was a great collaboration between the clinical pathology lab and the research labs at Well Cornell\nMedicine,said co-senior author Dr.Hanna Rennert,professor of pathology and laboratory medicine and director of the\nmolecular pathologylaboratory at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center.\"We\nwere able to work with Dr.Mason's lab to validate the RT-LAMP test quickly using the in-house RT-PCR test we developed\njust two weeks earlier for patient testing.\"\nOne way the team confirmed the accuracy of the RT-LAMP test was to compare the results to thosefrom another viral\ndetection assay they developed in collaboration with Twist Bioscience, a synthetic biology company and Biotia, a\ngenomics and artificial intelligence company. This technique combines a method called hybridization (hybrid) capture,\nwhich uses specially designed \"bait probes\"to trap all of the SARS-CoV-2 RNA in a sample, with next-generation\nsequencing, which provides detailed information about the viral strain and any mutations it has acquired. The U.s. FDA\nfor SARS-CoV-2 to receive a FDA EUA and also the first test with an FDA-authorized, cloud-based analytics platform.\n\"shotgun RNA sequencing\". In this method, many small fragments of the RNA specimen are sequenced, and\ncomputational analysis is used to map the data to all known species. They used the platform to profile all human, viral,\nwho were treated at NewYork-Presbyterian/Weill Cornell Medical Center during March and April 2020.\nThe analysis allowed the investigators to understand how SARS-CoV-2 affected the human body as the new virus was\nrapidly sickening people worldwide.Theyfound that SARS-CoV-2 infection significantly altered gene expression in757\ngenes and was associated with a wide range of responses in patients. Specific genes (SHFL, IFI6, IFI27, and IFIT1) in the\ninterferon pathway,a network of genes that control the immune response, were upregulated across all viral load levels\nreduced expression,suchas olfactory genes,which could help explain why the loss of smell (anosmia) is a common\nCoVID-19symptom.\n\"Our collaboration came together quickly to generate and analyze a large amount of data that would typically require an\nof pathology and laboratory medicine and member of the Englander Institute for Precision Medicine and the Sandra and\nEdward Meyer Cancer Center at Weill Cornell Medicine.\"Our findings about the origins of the virus in NYC outbreak and\nthe host responses continue to hold today.\"\nSince the researchers observed increased ACE2 expression in patients with high viral loads, and SARS-CoV-2 uses the\nAcE2 receptor to enter cells, they then investigated whether patients taking medications commonly taken for\nhypertension-angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs)-were\nprotective against developing severe CovID-19. The research team, including Dr.Nicholas Tatonetti , associate\npatient records frommore than 50,oo0 patients treated at NewYork-Presbyterian/Weill Cornell Medical Center and\nNewYork-Presbyterian/Columbia University Irving Medical Center.They observed that taking ACE inhibitors or ARBs was" } }, { "id": "covid-wcm-tackles", "study": "covid", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Weill Cornell Medicine Tackles COVID-19", "title_original": "Weill Cornell Medicine Tackles COVID-19", "language": "English", "date": "2020-05", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2020/05/weill-cornell-medicine-tackles-covid-19", "archive_url": "https://web.archive.org/web/20200508144454/https://news.weill.cornell.edu/news/2020/05/weill-cornell-medicine-tackles-covid-19", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Institutional overview of Weill Cornell and NewYork-Presbyterian COVID-19 research, including work to map virus hot spots and other basic and translational projects launched in the first months of the pandemic.", "topics": [ "covid-19", "weill cornell", "hotspot mapping", "translational research" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/covid-wcm-tackles.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-wcm-tackles--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-wcm-tackles.txt", "ocr_text": { "archived": "consider supporting Weill Cornell Medicine's efforts against the pandemic.\nWeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nNewsroom\nEXPLORETHISWEBSITE\nHome\nNews\nPressRoom\nPublications\nVideo&Photography\nSocial Media\nAbout Us\nNews\nPublications\nVideo&Photography\nPressRoom\nSocial Media\nAbout Us\nHome\nNews\nWeillCornellMedicineTacklesCOVID-19\nMAY7,2020\nBackto News\nWeill Cornell Medicine\nOffice of External Affairs\n1300YorkAvenue\nBox314\nNewYork,NY10065\nPhone: (646)962-9476\nCOVIDO\nMultiexposure background of covID-19 infected blood sample and background of blood cells and pulse signal. Credit:\nShutterstock\nPhysicians and scientists at Weill Cornell Medicine and NewYork-Presbyterian have rapidly mobilized to confront the\nworkersandpublichealthofficials.\nAs COVID-19 spreads across the United States, state and county governments require new tools to track the disease, and\nmost other research activity,investigators in infectious disease and a range of other specialties have swiftly changed\ngears to meet the new challenge.\nWith numerous studies underway in both the translational and clinicalarenas, weare dividing our coverage of cOviD-19\nresearch into multiple stories. Below is a snapshot of some of the activities going on in the basic and translational\nresearch community.\nTrackingtheOutbreak\nOne of the keys to preventing the spread of any infectious disease and preparing for outbreaks\nis knowing where hotspots are emerging. In the absence of very large-scale testing, researchers\nare looking for other clues that the virus is present in a community. To rapidly acquire that\ninformation,Dr.Olivier Elemento,director oftheCaryl andIsrael EnglanderInstitutefor\nPrecision Medicine and a professor of physiology and biophysics at Weill Cornell Medicine,\nsubmit symptoms as well as information such as travel patterns and known exposures to\ninfected individuals. The team is also gathering state public health data to determine if the\nsurvey information is predictive of the reported coviD-19 cases.\"The hope is that we can\nDr.Olivier Elemento\nidentify which counties are poised for potential outbreaks earlier,\" said Dr.Elemento.\nTo preserve anonymity, the survey only requires the first three digits of the person's zip code, and the data are analyzed\nMedicine team has partnered with a nationwide consortium called the How We Feel Project to expand the disease-\ntrackingcapabilities evenfurther.\nDiagnosingtheDisease\nWhile experts in data analysis craft a portrait of the disease landscape,Dr. Christopher\nMason , an associate professor of physiology and biophysics and co-director of the\nWorldQuant Initiativefor Quantitative Prediction at Weill Cornell Medicine,is developing a\ndiagnostic test that is designed to complement most currently used methods. Based on a\nmethod called loop-mediated isothermal amplification, or LAMP, the test looks for evidence\nof the virus in samples collected from a swab of the inner cheek. Using a simple set of\nchemicals,it makes millions of copies of a portion of thevirus'sgenetic material,which can\nthen be easily detected by a color change. In contrast to polymerase chain reaction (PCR)\nbased tests, which require sophisticated machinery that cycles between high and low\nDr.ChristopherMason\nequipment.\n\"People can be asymptomatic for about five days, and yet they'll be carrying tens of thousands of copies of the virus, or\nmillions of copies, in their mouth,\" said Dr.Mason, who is also an associate professor of computational genomics in\ncomputational biomedicine in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational\nBiomedicine at Weill Cornell Medicine.\"We need a way to increase testing capacity to include asymptomatic potential\ncarriers. The test needs to be fast, cheap and performed entirely at the site of administration. We currently have capacity\nto test only symptomatic patients and healthcare workers, so this method is a potential way to scale up.\"", "live": "WeillCornellMedicine\nCare\nDiscover\nTeach\nMenu\nSearch\nNewsroom\nNews\nPressRoom\nVideo&Photography\nSocial Media\nImpactMagazine\nAboutUs\nHome\nNews\nWeillCornell Medicine Tackles COVID-19\nMAY7.2020\nBacktoNews\nWeill Cornell Medicine\nOffice of External Affairs\nPhone:(646)962-9476\nCOVID\n19\nMultiexposurebackground of coviD-19 infected blood sampleand background of blood cells and pulse signal.Credit:\nShutterstock\nPhysicians and scientists at Weill Cornell Medicine and NewYork-Presbyterian have rapidly mobilized to confront the\nCOVID-19 pandemic, focusing a broad spectrum of expertise on the critical issues the disease is posing to healthcare\nworkersandpublichealthofficials.\nAs CovID-19 spreads across the United States, state and county governments require new tools to track the disease, and\nphysicians urgently need effective treatments for their patients. While social distancing required rapidly ramping down\nmost other research activity, investigators in infectious disease and a range of other specialties have swiftly changed\ngears to meet the new challenge.\nWith numerous studies underway in both the translational and clinical arenas, we are dividing our coverage of coVID-19\nresearch into multiple stories. Below is a snapshot of some of the activities going on in the basic and translational\nresearch community.\nTrackingthe Outbreak\nOne of the keys to preventing the spread of any infectious disease and preparing for outbreaks\nare looking for other clues that the virus is present in a community. To rapidly acquire that\ninformation, Dr.Olivier Elemento,director ofthe Caryl and Israel Englander Institutefor\nPrecision Medicine and a professor of physiology and biophysics at Weill Cornell Medicine,and\nhis collaborators are asking people to participate in a daily online survey in which they submit\nsymptoms as well as information such as travel patterns and known exposures to infected\nindividuals. The team is also gathering state public health data to determine if the survey\ninformation is predictive of the reported COVID-19 cases.\"The hope is that we can identify\nDr.Olivier Elemento\nwhich counties are poised for potential outbreaks earlier\" said Dr.Elemento.\nTo preserve anonymity,the survey only requires the first three digits of the person's zip code, and the data are analyzed\nand reported on a HiPAA-compliant website available to all. As interest in this approach has grown, the Weill Cornell\nMedicineteam has partnered with a nationwide consortium called the How WeFeel Project to expand the disease-\ntracking capabilities even further.\nDiagnosing the Disease\nWhile experts in data analysis craft a portrait of the disease landscape, Dr.Christopher\nMason, an associate professor of physiology and biophysics and co-director of the\nWorldQuant Initiativefor Quantitative Predictionat Weill Cornell Medicine, is developing a\ndiagnostic test that is designed to complement most currently used methods. Based on a\nmethod called loop-mediated isothermal amplification, or LAMP, the test looks for evidence\nof the virus in samples collected from a swab of the inner cheek. Using a simple set of\nchemicals, it makes millions of copies of a portion of the virus's genetic material, which can\nthen be easily detected by a color change. In contrast to polymerase chain reaction (PCR)-\nbased tests, which require sophisticated machinery that cycles between high and low\nDr.ChristopherMason\nequipment.\n\"People can be asymptomatic for about five days, and yet they'll be carrying tens of thousands of copies of the virus, or\nmillionsof copies,in theirmouth,said Dr.Mason,who is also an associateprofessor of computational genomics in\nBiomedicine at Weill Cornell Medicine.\"We need a way to increase testing capacity to include asymptomatic potential\ncarriers.The test needs to be fast, cheap and performed entirely at the site of administration. We currently have capacity\nto test only symptomatic patients and healthcare workers, so this method is a potential way to scale up.\"\nThe diagnostic may soon be submitted to the FDAfor emergency use approval.\n\"lf we perfect these methods and make them cheap enough, theyre going to be part of a broader surveillance, like a viral\nweather map,Dr.Mason said.\nFindingDrugstoFighttheVirus\nDoctors on the front lines of caring for COViD-19 patients have very limited tools to fight the\ndisease. So scientists are mobilizing to find drugs that stop coronavirus infection.\nMost virus research is conducted with monkey cells, and whilethese cells are useful for\nstudying how the virus replicates, they may poorly mirror human cells and their response to\ninfection.To address that problem,Weill Cornell Medicine investigators haveteamed up to\ncreate a more realistic drug screening platform." } }, { "id": "covid-wcm-citadel", "study": "covid", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "$2 Million Gift from the Partners of Citadel and Citadel Securities to Fund New COVID-19 Advances", "title_original": "$2 Million Gift from the Partners of Citadel and Citadel Securities to Fund New COVID-19 Advances", "language": "English", "date": "2020-04", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2020/04/2-million-gift-from-the-partners-of-citadel-and-citadel-securities-to-fund-new-covid-19", "archive_url": "https://web.archive.org/web/20200426120504/https://news.weill.cornell.edu/news/2020/04/2-million-gift-from-the-partners-of-citadel-and-citadel-securities-to-fund-new-covid-19", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Weill Cornell announcement of a $2 million Citadel gift to fund a trial of an antimalarial drug for protecting health workers and the rollout of a rapid COVID-19 test.", "topics": [ "covid-19", "philanthropy", "rapid test", "clinical trial", "funding" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/covid-wcm-citadel.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-wcm-citadel--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-wcm-citadel.txt", "ocr_text": { "archived": "considersupportingWeill Cornell Medicine'seffortsagainstthepandemic.\nWeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nNewsroom\nEXPLORETHISWEBSITE\nHome\nNews\nPressRoom\nPublications\nVideo&Photography\nSocial Media\nAbout Us\nNews\nPublications\nVideo&Photography\nPressRoom\nSocial Media\nAbout Us\nHome\nNews\nS2MillionGiftfromthePartnersofCitadelandCitadel\nSecuritiestoFundNewCOVID-19AdvancesatWeill\nCornell Medicine\nAPRIL17,2020\nBack toNews\nWeillCornell Medicine\nOfficeofExternalAffairs\n1300YorkAvenue\nBox 314\nNewYork,NY10065\nPhone:(646)962-9476\nWith the goal of advancing the fight against COVID-19, the Partners of Citadel and Citadel Securities have made a $2\nmillion gift to Weill Cornell Medicine to develop new approaches to protect people from the disease and identify new\ncases of it.\nThe giftfrom Citadel-led by longtimeWeill Cornell Medicine benefactor Kenneth C.Griffin-will support two initiatives:\na futurenational, randomized clinical trial evaluating whether an anti-malaria medication can protect front-line\nhealthcare workers from COviD-19, and the accelerated development and national rollout of a rapid-response test for\nthe infection.\nGriffin is the founder and CEO of Citadel, one of the world's leading alternative investment managers, and the founder of\nthan two decades and include nearly s$10 million in support of numerous institutional initiatives.\n\"As the number of cOVID-19 cases continues to surge, we must battle the virus on multiple fronts so that we can slow\nthe spread of infection, reduce its burden on our healthcare system, and save lives,\"said Dr.Augustine M.K. Choi ,the\nStephen and Suzanne Weiss Dean of Weill Cornell Medicine.\"This generous gift from Ken Griffin and the partners of\nCitadel and Citadel Securities will advance our efforts to achieve these goals.\"\n\"Clinical research has never been more important to advance the healthcare and\npublic healthresponseto COVID-19,saidDr.Rainu Kaushal ,senior associate\ndean of clinical research and chair of population health sciences at Weill Cornell\nMedicine and physician-in-chief of population health sciences at NewYork-\nPresbyterian/Weill Cornell Medical Center.\n\"We are grateful for these gifts from Citadel that will allow us to advance COVID-19\ntesting and better protect our front-line healthcare workers.\"\n\"Thefortitude and compassion of ourfrontline responders is heroic. Doctors,\nnurses and countless others continue to relentlessly battle the virus and selflessly\ncare for the sick, while our nation's researchers pursue the science needed to\nultimately lead us out of this pandemic\" Griffin said.\"Collaboration and\nDr, Rainu Kaushal\nphilanthropic support are essential to accelerate medical solutions and will be the\ndifference in protecting as many lives as possible.\"\nsuggests that approximately 20 percent of these workers become infected as a result of their efforts to care for sick\npatients, with rates higher in areas where there is a limited supply of protective equipment, such as masks and gowns.\nWhile healthcare workers continue to use this equipment-considered the best line of defense-at all times, there is\ncurrently no existing therapy that can prevent healthcare workers from acquiring the SARS-CoV-2 virus that causes\nCOVID-19 - or from asymptomatically spreading it to others, including their own families.\nClinical Trial to Test Anti-Malaria Medications'Protective Qualities\nThe national clinical trial, expected to launch in the coming weeks, will evaluate\nwhether hydroxychloroquine -an anti-malaria drug that has been identified as\npotentially effective against COviD-19-can protect front-line healthcare workers\nfrom contracting the virus.Investigators plan to enroll into the trial 15,000\nhealthcare workers,including 1,500 from New York City,from intensive careunits,\nemergency departments and cOVID-19 wards nationwide over a two-week period,\nwith the randomized clinical trial lasting a month. The gift will support increased\nNew York City enrollment of healthcare workers into this study.", "live": "WeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPressRoom\nImpactMagazine\nVideo&Photography\nSocial Media\nAboutUs\nHome\nNews\nS2 MillionGift from the Partners of Citadel and Citadel\nSecuritiesto FundNewCOVID-19 AdvancesatWeill\nCornell Medicine\nAPRIL17,2020\nBack toNews\nfXin\nWeill Cornell Medicine\nOfficeofExternalAffairs\nPhone:(646)962-9476\nWith the goal of advancing the fight against COVID-19, the Partners of Citadel and Citadel Securities have made a $2\nmillion gift to Weill Cornell Medicine to develop new approaches to protect people from the disease and identify new\ncases of it.\nThe gift from Citadel-led by longtime Weill Cornell Medicine benefactor Kenneth C. Griffin-will support two initiatives: a\nfuture national,randomized clinical trial evaluating whether an anti-malaria medication can protect front-line healthcare\nworkers from COViD-19, and the accelerated development and national rollout of a rapid-response test for the infection.\nGriffin is the founder and CEO of Citadel, one of the world's leading alternative investment managers, and thefounder of\nthan two decades and include nearly $10 million in support of numerous institutional initiatives.\n\"As the number of coViD-19 cases continues to surge, we must battle the virus on multiple fronts so that we can slow\nthe spread ofinfection, reduce its burden on our healthcare system, and save lives,\" said Dr. Augustine M.K. Choi, the\nStephen and Suzanne Weiss Dean of Weill Cornell Medicine.This generous gift from Ken Griffin and the partners of\nCitadel and Citadel Securities will advance our efforts to achieve these goals.\"\n\"Clinical research has neverbeen more important to advance the healthcare and\npublic healthresponse to COVID-19,\"said Dr.Rainu Kaushal, senior associate dean\nof clinical research and chair of population healthsciences at Weill Cornell Medicine\nand physician-in-chief of population health sciences at NewYork-Presbyterian/Weill\nCornellMedical Center.\n\"We are grateful for these gifts from Citadel that will allow us to advance COVID-19\ntesting and better protect our front-line healthcare workers.\"\n\"The fortitude and compassion of our frontline responders is heroic. Doctors,\nnurses and countless others continue to relentlessly battle the virus and selflessly\ncare for the sick, while our nation's researchers pursue the science needed to\nultimately lead us out of this pandemic,\" Griffin said.\"Collaboration and\nDr, RainuKaushal\nphilanthropic support are essential to accelerate medical solutions and will be the\ndifference in protecting as many lives as possible.\"\nWhile healthcare workers continue to use this equipment-considered the best line of defense- at all times, there is\nClinical Trial toTest Anti-Malaria Medications'ProtectiveQualities\nThe national clinical trial, expectedto launch in the coming weeks,will evaluate\nwhether hydroxychloroquine -an anti-malaria drug that has been identified as\npotentially effective against COVID-19 - can protect front-line healthcare workers\nfrom contracting the virus: Investigators plan to enroll into the trial 15,000\nhealthcare workers, including 1,50o from New York City,from intensive care units,\nemergency departments and COVID-19 wards nationwide over a two-week period,\nwith the randomized clinical trial lasting a month. The gift will support increased\nNew York City enrollment of healthcare workers into this study.\nThe study is funded nationally by the non-profit healthcare organization PCORl\nand will be implemented through the PCORnet Network. INSIGHT , run by Dr.\nKaushal, is a unique partnership of more than five highlyranked academicmedical\nDr.Timothy Wilkin\ncenters in the New York City and will be the work's regional hub. INSIGHT trial sites\nwill be led by Dr.Timothy Wilkin,an associate professor of medicineand infectious diseasespecialist atNewYork-\nPresbyterian/Weill CornellMedicalCenter.\n\"This trial represents a critical stepforward in protecting this vulnerablepopulation while we work on thefront lines\nfighting COVID-19, Dr. Wilkin said.\"We are extraordinarily grateful for Citadel's generosity and their contribution to this\nvaliant effort to stop thisglobal pandemic.\nRapidTesttoDetectCOVID-19\nThe rapid-response test for CovID-19, developed by Dr.Christopher Mason, an\nassociateprofessorofphysiologyandbiophysicsandco-directorof theWorldQuant" } }, { "id": "covid-ieee", "study": "covid", "outlet": "IEEE Spectrum", "outlet_original": "IEEE Spectrum", "outlet_score": 7, "title": "Swabbing the World's Cities for Coronavirus", "title_original": "Swabbing the World's Cities for Coronavirus", "language": "English", "date": "2020", "kind": "news", "url": "https://spectrum.ieee.org/swabbing-the-worlds-cities-for-coronavirus", "archive_url": "https://web.archive.org/web/20210731013743/https://spectrum.ieee.org/swabbing-the-worlds-cities-for-coronavirus", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Describes how MetaSUB researchers swab transit kiosks, benches and other surfaces in cities worldwide to detect SARS-CoV-2 and build models that could give early warning of outbreaks, including a 15-city effort.", "topics": [ "covid-19", "metasub", "environmental surveillance", "sars-cov-2", "urban surfaces" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/covid-ieee.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-ieee--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-ieee.txt", "ocr_text": { "archived": "SIGN IN\nMORE SITES\nIEEE.ORG\nIEEE XPLORE DIGITAL LIBAARY\nIEEE STANDARDS\nJOIN IEEE\nIEEE\nIEEESpectrum\nQTypeto search\nExplorebytopicv\nNEWS\nBIOMEDICAL\nRelated Stories\nSwabbing the World's Cities for\nCoronavirus >Computational modeling of\nFEATURE\nSENSORS\nthousands of genetic samples takenfrom city\nCOVID-19ForcedUsAllto\nExperiment.What Have We\ncentersyield newinformation aboutCOVID-\nLearned?\n19\nINTERVIEW\nBIOMEDICAL\nExclusive QgA:Neuralink's\nBYEMILYWALIZI30MAR 20213MIN READ\nQuesttoBeattheSpeedof\nType\nNEWS\nTHE INSTITUTE\nFreeAccesstoThousandsof\nCOVID-19Research\nDocuments\nILLUSTRATION:ISTOCKPHOTO\nIn cities around the world, an army of researchers has been busy\nSHARE THIS STORY\nswabbing mass transit kiosks, public benches, hospital floors\nin\nand other high traffic urban surfaces. They're looking for genetic\nevidence of SARS-CoV-2, the virus that causes COVID-19,and\nTAGS\nusing the data to build computational models that could warn\nMEDICAL DEVICES\nus of impending viral outbreaks.\nCOVID-19\nGENETIC SEQUENCING\n“Instead of reactive epidemiology, it's proactive tracing,\" says\nChristopher Mason, a professor at Weill Cornell Medicine, who\nknown viruses once or twice a week in every city, you could\ncatch an outbreak well before it becomes a big problem.\"\nThe project, dubbed METACoV, spans 15 cities, including New\ndBerlinIt'soneof\nYork, Sao Paolo, Hong Kong, Tel Aviv and Berlin. It's one of\nseveral such swabbing ventures by the international consortium\nMetagenomics and Metadesign of Subways and Urban Biomes,\nor MetasUB. Since 2016, the organization has been collecting\ngenetic samples from more than a hundred cities and studying\nwhat kind of microbial life exists on our most shared surfaces.\nWhen the pandemic hit, MetasUB's global network got to work.\nThe research groups send their postdocs, grad students, and\nmedical students out into their cities to collect the samples.\nAt public transit hubs, for example, they target features universal\nacross nearly all cities: kiosks, benches, and turnstiles or other\nentry barriers. Then, for three awkward minutes, the researchers\nbrush the surface with a nylon swab that looks like a Q-tip and is\nconfirmed to be DNA and RNA free.\ncovid sampling\nWeill Cornell associate professor Christopher Mason and medical student Heba\nShaaban take samples from a kiosk in a New York City subway station. CHRIsTOPHER\nMASON\n\"Three minutes is the perfect balance between getting enough\nyield of DNA or RNA and minimizing the amount of social\ndiscomfort,\" says Mason.“Pre-CovID, it always looked weird to\nbe out there swabbing with gloves and a mask on, but the\npandemic has really normalized our behavior.\"\nThe researchers place the samples in a storage medium that\npreserves the genetic material, and then transport them back to\nthe lab where the DNA or RNA is extracted, prepped, and\nsequenced. They use a range of bioinformatics tools to identify\nwhat viruses or species are present, and with what mutations.\nThe data enable researchers to create an atlas of sorts that\nshows where high risk variants of SARS-CoV-2 are emerging.\nThis can help public health oficials stay on top of the spread of\nthevirus, and makedecisions on wheretofocus vaccine\nsupplies. Computational models also indicate where the virus\nmight be headed genetically and geographically.\nThe data have yielded useful public health information. SARS-\nCoV-2 hasn't shown up much on public transit surfaces, Mason\nsays. But it is plentiful on hospital surfaces, including in rooms\nwhere people are negative for COVID-19, the researchers have\nfound.\nThe team tested hospital samples to see how readily they could\ninfect human cells. Luckily, none of the samples were\nsuccessful.\"It's sitting on a hard surfacethat may havebeen\nbleached the night before. It's a rough environment for anything\nto try to survive,\" says Mason.\nThey also found SARS-CoV-2 on the ceilings of hospital\ntingwhilere\nadingthis.", "live": "This website utilizes technologies such as cookies to enable essential site functionality,as well as foranalytics,\npersonalization,andtargetedadvertising.Tolearnmore,viewthefollowing link:PrivacyPolicy\nMANAGE PREFERENCES\nAccessThousandsofArticles-\nCompletely Free\nCreate an account and get exclusive content and features:Savearticles,download\ncollections,andpostcomments-all free!Forfull accessandbenefits,subscribeto\nSpectrum.\nCREATE AN ACCOUNT\nSIGN IN\nNEWS\nBIOMEDICAL\nRelatedStories\nSwabbing the World's Cities for\nCoronavirus >Computational modeling of\nNEWS\nBIOMEDICAL\nthousands of genetic samples taken from city\nFDAClarifiesWearable\nDevice Rules\ncentersyieldnewinformation aboutCOVID-\n19\nANALYSIS\nBIOMEDICAL\nSoftwareFlawsRiskPatient\nSafety\nEmily Waltz is the power and energy editor at IEEE Spectrum.\nNEWS\nBIOMEDICAL\nPressure-ReliefEyeTech\nAdvances TowardApproval\nILLUSTRATION:ISTOCKPHOTO\nSHARE THIS STORY\nIn cities around the world, an army of researchers has been busy\nswabbing mass transit kiosks, public benches, hospital floors\nand other high trafic urban surfaces.They'relooking forgenetic\nevidenceofSARS-CoV-2,thevirusthat causesCOVID-19,and\nTAGS\nusing the data to build computational models that could warn\nGENETIC SEQUENCING\nusing the data to build computational models that could warn\nGENETIC SEQUENCING\nus of impending viral outbreaks.\nCOVID-19\nMEDICAL DEVICES\n\"Instead of reactive epidemiology, it's proactive tracing,\" says\nChristopher Mason, a professor at Weill Cornell Medicine, who\nknown viruses once or twice a week in every city, you could\ncatch an outbreak well before it becomes a big problem.\"\nThe project, dubbed METACoV, spans 15 cities, including New\nYork, Sao Paolo, Hong Kong, Tel Aviv and Berlin. It's one of\nseveral such swabbing ventures by the international consortium\nMetagenomics and Metadesign of Subways and Urban Biomes,\nor MetasUB. Since 2016, the organization has been collecting\ngenetic samples from more than a hundred cities and studying\nwhat kind of microbial life exists on our most shared surfaces.\nWhen the pandemic hit, MetasUB's global network got to work.\nThe research groups send their postdocs, grad students, and\nmedical students out into their cities to collect the samples.\nAt public transit hubs, for example, they target features universal\nacross nearly all cities: kiosks, benches, and turnstiles or other\nentry barriers. Then, for three awkward minutes, the researchers\nbrush the surface with a nylon swab that looks like a Q-tip and is\nconfirmed to be DNA and RNA free.\nCEuclidA" } }, { "id": "covid-cornell-chronicle-2021", "study": "covid", "outlet": "Cornell Chronicle", "outlet_original": "Cornell Chronicle", "outlet_score": 6, "title": "Researchers create rapid tests, analytics for COVID-19", "title_original": "Researchers create rapid tests, analytics for COVID-19", "language": "English", "date": "2021-03", "kind": "press-release", "url": "https://news.cornell.edu/stories/2021/03/researchers-create-rapid-tests-analytics-covid-19", "archive_url": "https://web.archive.org/web/20210331193003/https://news.cornell.edu/stories/2021/03/researchers-create-rapid-tests-analytics-covid-19", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Describes a Nature Communications study from Weill Cornell and NewYork-Presbyterian presenting RT-LAMP and viral RNA capture sequencing as alternatives to RT-PCR, plus RNA sequencing and spatial tissue mapping of SARS-CoV-2.", "topics": [ "rt-lamp", "sars-cov-2", "rna sequencing", "variants", "covid-19" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/covid-cornell-chronicle-2021.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-cornell-chronicle-2021--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-cornell-chronicle-2021.txt", "ocr_text": { "archived": "IMEDIARELATIONS\nCORNELL.EDU\nCORNELLCHRONICLE\nCampus & Community\nAll Stories\nTopics\nIn theNews\nExpert Quotes\nEzra Magazine\nResearchers create rapid tests, analytics for COVID-19\nByJaneLanglle/March31,2021\nTwo distinct diagnostic tests, a host/pathogen RNA sequencing platform, and\nspatially resolved tissue mapping tools, were created by a multidisciplinary\nteam of Weill Cornell Medicine and NewYork-Presbyterian Hospital-led\nresearchers and used to map SARS-CoV-2 infections at the height of the initial\nCOVID-19 outbreak in New York City.\nThese alternatives to the gold standard RT-PCR test expand the repertoire of\ntools available to the public health community and together offer the benefits\nof speed, simplicity and in-depth knowledge about the virus.\nThe multidisciplinary study, published March 12 in Nature Communications,\ndemonstrates that a test called reverse transcription loop-mediated\nisothermal amplification (RT-LAMP) can quickly and accurately detect the\npresence of SARS-CoV-2 in patient samples using simple equipment, while a\nsecond approach that captures and sequences the viral RNA allows\ninvestigators to identify and track the evolution of variants. The investigators\nfurther demonstrated that total RNA sequencing yields insights into both viral\nsequence evolution as well as human responses to the viral infection.\nWe are entering a new era of fast and accurate tools that can tell us when and\nhow viral variants arise and move in specific populations,\" said senior author\nDr. Christopher Mason, co-director of the WorldQuant Initiative for\nQuantitative Prediction and a professor of physiology and biophysics at Weill\nCornell Medicine. We hope our innovations will be used like a weather\nreport to identify viral outbreaks, improve tracking and tracing efforts to\nprotect people from infection, and improve treatment interventions for\npatients.\"\nMason developed the RT-LAMP test in collaboration with genomic testing\nfirm Color and reagent supplier New England Biolabs. The single-tube test\nreveals a positive result from a nasopharyngeal swab specimen in about 30\nminutes by changing color, from yellow to pink. The RT-LAMP test was\nshown to have a sensitivity of 96% and specificity of 99% compared to the\ngold standard reverse transcription polymerase chain reaction (RT-PCR) test.\nBased on these and other results, the Food and Drug Administration (FDA)\nissued an emergency use authorization (EUA) to Color for the rapid\ndiagnostic test in May 2020.\nThe RT-LAMP test, which can potentially be scaled to great numbers, offers\nan alternative to the standard RT-PCR test, which uses reagents that were in\nshort supply during the height of the initial outbreak, as well as different\nequipment.\nequipment.\n“This project was a great collaboration between the clinical pathology lab and\nthe research labs at Weill Cornell Medicine,\" said co-senior author Dr. Hanna\nRennert, professor of pathology and laboratory medicine and director of the\nmolecular pathology laboratory at Weill Cornell Medicine and NewYork-\nPresbyterian/Weill Cornell Medical Center. We were able to work with Dr.\nMason's lab to validate the RT-LAMP test quickly using the in-house RT-PCR\ntest we developed just two weeks earlier for patient testing.\"\nOne way the team confirmed the accuracy of the RT-LAMP test was to\ncompare the results to those from another viral detection assay they\ndeveloped in collaboration with Twist Bioscience, a synthetic biology\nThis technique combines a method called hybridization (hybrid) capture,\nRNA in a sample, with next-generation sequencing, which provides detailed\ninformation about the viral strain and any mutations it has acquired. The FDA\nissued an EUA on March 24 for the advanced RNA sequencing platform, the\nFDA EUA and also the first test with an FDA-authorized, cloud-based\nanalytics platform.\nMason and colleagues also developed a large-scale total RNA sequencing\ncomputational analysis is used to map the data to all known species. They\nmicrobial RNA in samples obtained from 669 patients with confirmed or\nsuspected COVID-19 who were treated at NewYork-Presbyterian/Weill\nCornell Medical Center during March and April 2020.\nThe analysis allowed the investigators to understand how SARS-CoV-2\naffected the human body as the new virus was rapidly sickening people\nworldwide. They found that SARS-CoV-2 infection significantly altered gene\nexpression in 757 genes and was associated with a wide range of responses in\npatients. Specific genes (SHFL, IFI6, IFI27, and IFIT1) in the interferon\npathway, a network of genes that control the immune response, were\nupregulated across all viral load levels and they also showed significantly\nhigher expression than observed with other respiratory viruses. Other genes\nshowed reduced expression, such as olfactory genes, which could help explain\nwhy the loss of smell (anosmia) is a common COVID-19 symptom.\namount of data that would typically require an international consortium and a\nassistant professor of pathology and laboratory medicine and member of the\nEnglander Institute for Precision Medicine and the Sandra and Edward\nMeyer Cancer Center at Weill Cornell Medicine. “Our findings about the\norigins of the virus in [the] New York City outbreak and the host responses\ncontinue to hold today.\"\nSince the researchers observed increased ACE2 expression in patients with\nhigh viral loads, and SARS-CoV-2 uses the ACE2 receptor to enter cells, they\nthen investigated whether patients taking medications commonly taken for", "live": "I MEDIARELATIONS\nCORNELL.EDU\nCORNELL CHRONICLE\nEDA.\nCampus & Community\nTopics\nAll Stories\nPodcast\nMedia Relations\nCornellians\nResearchers create rapid tests, analytics for COVID-19\nBy Jane Langille\nMarch 31, 2021\nTwo distinct diagnostic tests, a host/pathogen RNA sequencing platform, and\nteam of Weill Cornell Medicine and NewYork-Presbyterian Hospital-led\nresearchers and used to map SARS-CoV-2 infections at the height of the initial\nCOVID-19 outbreak in New York City.\nThese alternatives to the gold standard RT-PCR test expand the repertoire of\ntools available to the public health community and together offer the benefits\nof speed, simplicity and in-depth knowledge about the virus.\nThe multidisciplinary study, published March 12 in Nature Communications,\ndemonstrates that a test called reverse transcription loop-mediated\nisothermal amplification (RT-LAMP) can quickly and accurately detect the\npresence of SARS-CoV-2 in patient samples using simple equipment, while a\nsecond approach that captures and sequences the viral RNA allows\ninvestigators to identify and track the evolution of variants. The investigators\nfurther demonstrated that total RNA sequencing yields insights into both viral\nsequence evolution as well as human responses to the viral infection.\n‘We are entering a new era of fast and accurate tools that can tell us when and\nhow viral variants arise and move in specific populations,\" said senior author\nDr.Christopher Mason, co-director of the WorldQuant Initiativefor\nQuantitative Prediction and a professor of physiology and biophysics at Weill\nCornell Medicine. “We hope our innovations will be used like a weather\nreport to identify viral outbreaks, improve tracking and tracing efforts to\nprotect people from infection, and improve treatment interventions for\npatients.\"\nMason developed the RT-LAMP test in collaboration with genomic testing\nfirm Color and reagent supplier New England Biolabs. The single-tube test\nreveals a positive result from a nasopharyngeal swab specimen in about 30\nminutes by changing color, from yellow to pink. The RT-LAMP test was\nshown to have a sensitivity of 96% and specificity of 99% compared to the\ngold standard reverse transcription polymerase chain reaction (RT-PCR) test.\nBased on these and other results, the Food and Drug Administration (FDA)\nissued an emergency use authorization (EUA) to Color for the rapid\ndiagnostic test in May 2020.\nThe RT-LAMP test, which can potentially be scaled to great numbers, offers\nan alternative to the standard RT-PCR test, which uses reagents that were in\nshort supply during the height of the initial outbreak, as well as different\nht of the initial outbreak, as well as different\nequipment.\n“This project was a great collaboration between the clinical pathology lab and\nthe research labs at Weill Cornell Medicine,\" said co-senior author Dr. Hanna\nRennert, professor of pathology and laboratory medicine and director of the\nmolecular pathology laboratory at Weill Cornell Medicine and NewYork-\nPresbyterian/Weill Cornell Medical Center. “We were able to work with Dr.\nMason's lab to validate the RT-LAMP test quickly using the in-house RT-PCR\ntest we developed just two weeks earlier for patient testing.\"\nOne way the team confirmed the accuracy of the RT-LAMP test was to\ncompare the results to those from another viral detection assay they\ndeveloped in collaboration with Twist Bioscience, a synthetic biology\ncompany, and Biotia, a genomics and artificial intelligence company.\nThis technique combines a method called hybridization (hybrid) capture,\nwhich uses specially designed “bait probes\" to trap all of the SARS-CoV-2\nRNA in a sample, with next-generation sequencing, which provides detailed\ninformation about the viral strain and any mutations it has acquired. The FDA\nissued an EUA on March 24 for the advanced RNA sequencing platform, the\nFDA EUA and also the first test with an FDA-authorized, cloud-based\nanalytics platform.\nMason and colleagues also developed a large-scale total RNA sequencing\nmethod, many small fragments of the RNA specimen are sequenced, and\nused the platform to profile all human, viral, bacterial, fungal and other\nmicrobial RNA in samples obtained from 669 patients with confirmed or\nsuspected COVID-19 who were treated at NewYork-Presbyterian/Weill\nCornell Medical Center during March and April 2020.\nThe analysis allowed the investigators to understand how SARS-CoV-2\naffected the human body as the new virus was rapidly sickening people\nworldwide. They found that SARS-CoV-2 infection significantly altered gene\nexpression in 757 genes and was associated with a wide range of responses in\npatients. Specific genes (SHFL, IFI6, IFI27, and IFIT1) in the interferon\npathway, a network of genes that control the immune response, were\nupregulated across all viral load levels and they also showed significantly\nhigher expression than observed with other respiratory viruses. Other genes\nshowed reduced expression, such as olfactory genes, which could help explain\nwhy the loss of smell (anosmia) is a common COVID-19 symptom.\n\"Our collaboration came together quickly to generate and analyze a large\namount of data that would typically require an international consortium and a\nmuch longer time frame,\" said co-senior author Dr. Marcin Imielinski,\nassistant professor of pathology and laboratory medicine and member of the\nEnglander Institute for Precision Medicine and the Sandra and Edward\nMeyer Cancer Center at Weill Cornell Medicine. “Our findings about the\norigins of the virus in [the] New York City outbreak and the host responses\ncontinue to hold today.\"\nSince the researchers observed increased ACE2 expression in patients with\nhigh viral loads, and SARS-CoV-2 uses the ACE2 receptor to enter cells, they" } }, { "id": "covid-spreaker-podcast", "study": "covid", "outlet": "Podcast (Spreaker)", "outlet_original": "Spreaker (podcast)", "outlet_score": 4, "title": "Dr. Cem Meydan on the new coronavirus test and microbiome maps of cities", "title_original": "Dr. Cem Meydan, yeni coronavirüs testini ve şehirlerin mikrobiyom haritasını anlattı", "language": "Turkish", "date": "2020", "kind": "audio", "url": "https://www.spreaker.com/episode/dr-cem-meydan-yeni-coronavirus-testini-ve-sehirlerin-mikrobiyom-haritasini-anlatti--39860346", "archive_url": "", "names_meydan": true, "meydan_context": "Featured as the guest who discusses the new test, the microbiome map and his career path.", "passage_naming_meydan": "Dr. Cem Meydan of Weill Cornell Medicine described the new coronavirus test, the microbiome map of cities, and a site that collects COVID-19 data.", "summary": "Turkish-language podcast episode describing a new coronavirus test, the city microbiome map project, and a site collecting COVID-19 data.", "topics": [ "covid-19", "lamp test", "urban microbiome", "podcast" ], "audience": "social-video", "thumbnail": "media-archive/thumbs/covid-spreaker-podcast.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-spreaker-podcast--live.jpg", "saved_html": "media-archive/html/covid-spreaker-podcast--live.html", "saved_article_text": "media-archive/text/covid-spreaker-podcast.txt", "ocr_text": { "live": "Spreaker?\nSearchover1oMpodcastepisod.\nSign up\nFromHeart\nDiscover\nViralogy>CoronavirusNYC Scientists SwabtheSubway in Search of SARS-CoV-2\nO THE NEXI STOPIS\nVirology\nOMICS\nGenomics\nCoronavirus\nInsights\nNYC Scientists Swab the Subway in\nSearchof SARS-CoV-2\nBy Julianna LeMieux,PhD-April 1,2020\nShare\nin\nCOVID-19Candidates\nFor New Yorkers, signs of COVID-19 are everywhere: the near-constant sound of\nambulance sirens, the otherwise unsettling empty avenues, and the white tents erected in\nCentral Park that represent an emergency field hospital to treat COVID patients. The\nPpresence of the SARS-CoV-2 virus has taken over the city. But, is the virus actually\nCOVID\neverywhere? A team at Cornell Weill Medical School set out to answer that question.\nCOVID-19 Drug &Vaccine Candidate\nSpecifically, they wanted to find out if the virus is present in one of the most crowded areas\nTracker\nof the city-the NYC subway.\nIt all started with his daughter, noted Christopher Mason, PhD, associate professor at\nCornell Weill Medical School. One day, when traveling on the subway, she did something\nAll GEN Edge Stories\nthat got Mason thinking. She licked the subway pole. After that, he explained, he \"just got\ncurious\" and wanted to know what was there. His daughter's taste for subway poles\nbecame the motivation for a research project that has grown into the MetaSUB\n(metagenomics of subways and urban biomes) International Consortium. Founded in 2015\nby Mason and Ebrahim Afshinnekoo, who serves as the director of metagenomics, the large\nconsortium normally performs sampling of cities during the summer, but have moved it up\nRecentlyFeatured\nthis year.\ncoronavirus2019-nCoV spreading\nAt a virtual town hall hosted by John Cumbers,\nfounder of the synthetic biology network\nSynbiobeta, Mason (who appeared alongside\nEmilyLeproust, CEOof Twist Bioscience and Josh\nAstraZeneca,J&JResumingPhase\nEmily Leproust, CEO of Twist Bioscience and Josh\nAstraZenecaJ&JResumingPhase\nPerfetto, founder and CEOof Chai Bio) asserted\nII COVID-19VaccineTrials\nSo, he asked, why not identify what is out there-\nPaTest\nin NYC and around the globe?\nLysogene Confirms Child's Death in\nJosh Perfetto, John Cumbers, Emily Leproust, and\ntube with\nChris Mason\nPhase I/llI GeneTherapy Trial\nDNA\nMetaSUB's teams started swabbing for SARS-CoV-\n2 almost two months ago in pilot cities around the\nHow a Virus Can Trigger Diabetes\nworld. Those cities are Baltimore, Bangkok, Berlin, Buenos Aires, Daegu, Hong Kong,\nKolkata, Warsaw, London, New York City, Oslo, Sao Paulo, Seattle, Singapore, Tokyo and\nKanagawa-Prefecture, Washington, DC, and Zurich. The pilot included 1632 samples but,\nFucolD: Fast, Precise Tool Identifies\nthey anticipate thousands of samples coming in over the next few weeks-projecting over\nTumor-TargetingTCells\n10,000 swab samples in the project, representing 59 cities, in 25 countries, on six continents.\nPlant Compound Improves Cognitive\nSo, is SARS-CoV-2 in the NYC subway? According to Mason, no. At least, they have not\nDeficits in Mouse Modelof Down\nSyndrome\nfound any signs of it yet. But they have only been swabbing since March 16th and have\ncollected a small number of samples, with numbers ramping up quickly.\nSubway swabbing\nHow does someone swab the NYC subway? In order to obtain the RNA samples, an\nIsohelix buccal swab is used to collect the sample, which is then stored in Zymo's\nDNA/RNA shield to protect the RNA from degradation.\nLike the clinical samples that are being processed at Cornell Weill Medical School, the\nsubway samples go through six assays which can take anywhere from 20-30 minutes to up\nto three days. Mason attributes the large number of assays to the idea that this is\n(hopefully) a once in a century pandemic, and there is a lot to be learned from these\nthe RNA from the sample and gain as much information as possible.\"\nA portion of the RNA (10 ng) goes into the standard qRT-PCR assay that is being widely\nused to detect the presence of the viral RNA. The RNA also goes into various different\nmethods to sequence the viral genome, including PolyA RNA-seq (capturing of RNAs with\npolyA tails), Ribodepletion RNA-seq (removal of ribosomal RNAs), and MeRIP-Seq (which\ngeneration cDNA sequencing.\nDirect RNA sequencing using Oxford Nanopore's MinIONis also performed. In order to\ndo this, 500 ng (a lot) of polyadenylated RNA is required. The SARS-CoV-2 RNA genome,\nluckily, has a 33 nucleotide poly-A tail, so it can be sequenced directly.\nThe Loop-mediated isothermal amplification (LAMP) assay, a colorimetric assay that works\nin 30 minutes to test for the presence of the virus, is also performed on the samples. First\npublished by a Japanese group in 2014, and commercialized by New England Biolabs,\nMason asserts that this very quick and easy to read test may allow them to set up quick\ntesting pop-up labs to test people quickly, easily, and rapidly. For these assays, the viral\nRNA positive control is provided by the DNA writing company Twist Biosciences.\nThe sequencing data is uploaded into GISAID (Global Initiative on Sharing All Influenza\nData) which is a public-private partnership that provides public access to the genetic\nsequence data of influenza viruses and other viruses, including SARS-CoV-2.\nSo, what RNA is strap-hanging under the streets of NYC? The team found 10% human\nRNA and 1-2% viral RNA-including the genome of influenza virus. The other 88% are of\nunknown origin. But, Mason explains, that large number is \"not as crazy as it sounds.\" The\ndata are from only a handful of samples and many DNA sampling studies routinely see\nunknown percentages in the range of 50-70%.\nThinking beyond this pandemic, into a post-pandemic world, could this type of\nenvironmental sampling potentially lead to a partitioning of our spaces into \"green zones,\"\nwhich would be safe for people to enter, and \"red zones\" where there is still a risk of\ninfection? Or, a scenario where, in order to board a plane, surveillance would take place\nand testing would be required for boarding?\nUp until this point, Mason noted, the cost of doing routine environmental surveillance has\nbeen too high for this idea to enter into a realistic conversation. But, the current cost may\nmake it possible. And, he follows, the cost of not doing it-as evidenced by the current\npandemic-is probably far worse.", "live": "in\nGEN\nGenetic Engineering\n&BiotechnologyNews\nTopics v\nMultimediay\nResourcesV\nSubscribev\nGEN EdgeV\nContent V\nMagazine V\nHome > Topics > Coronavirus > NYC Scientists Swab the Subway in Search of SARS-CoV-2\nZ)THE NEYTSTOPIS\nNYC Scientists Swab the Subway in\nSearch of SARS-CoV-2\nJuliannaLeMieuxPhDApril 1,2020\nFor New Yorkers, signs of COVID-19 are everywhere: the near-constant sound of\nBCGVaccine-InducedTrained ImmunityMay\nambulance sirens, the otherwise unsettling empty avenues, and the white tents\nHelpProtectAgainstDementia\nerected in Central Park that represent an emergency field hospital for COVID\ntreatment. The presence of the SARS-CoV-2 virus has taken over the city. But is the\nEQTtoAcquireQiagenforS12.1B,Plansto\nTakeTools,DiagnosticsProviderPrivate\nvirus actually everywhere? A team at Cornell Weill Medical School set out to answer\nHowAlzheimer'sRiskGeneAPOE4Disrupts\nmost crowded areas of the city-the NYC subway.\nMyelination\nDiasome'sHDV-Insulin forT1D Finalizing\nIt all started with his daughter, noted Christopher Mason, PhD, associate professor at\nPhase Ill PlansAfterPromisingData\nCornell Weill Medical School. One day, when traveling on the subway, she did\nsomething that got Mason thinking. She licked the subway pole. After that, he\nAnthropicIPODisclosesPlansforLife\nSciencesGrowth\nexplained, he \"just got curious\" and wanted to know what was there. His daughter's\ntaste for subway poles became the motivation for a research project that has grown\nResources\ninto the MetaSUB (metagenomics of subways and urban biomes) International\nConsortium.Founded in 2015 by Mason and Ebrahim Afshinnekoo, who serves as\nRecommended ForYou\nthe director of metagenomics, the large consortium normally performs sampling of\ncities during the summer, but have moved it up this year.\nAt a virtual town hall hosted by John\nCumbers, founder of the synthetic biology\nCumbers,founderofthesyntheticbiology\nnetwork Synbiobeta, Mason (who appeared\nalongside Emily Leproust, CEO of Twist\nBioscience and Josh Perfetto, founder and\nVitamin Derivative Pantethine Alleviates Psoriasis\nSymptoms in SmallHuman Trial\nCEO of Chai Bio) asserted that \"we are all in\nJoshPerfetto,John Cumbers, EmilyLeproust,\nthis nucleic acid soup together.\" So, he\nand Chris Mason\nArtiva Axes94%of Workforce,Weighs Strategic\nasked, why not identify what is out there-\nAlternativesAfterTwoPatients inPhasella Trial\nin NYC and around the globe?\nDie\nMetaSUB's teams started swabbing for SARS-CoV-2 almost two months ago in pilot\nBonjour Genomics: A Video from ASHG\ncities around the world. Those cities are Baltimore, Bangkok, Berlin, Buenos Aires,\nDaegu, Hong Kong, Kolkata, Warsaw, London, New York City, Oslo, Sao Paulo,\nASHG:NabsysLinksCytogeneticsand Genomics\nSeattle, Singapore, Tokyo and Kanagawa-Prefecture, Washington, DC, and Zurich.\ntoMapHematologicCancers\nThe pilot included 1632 samples but they anticipate thousands of samples coming in\nover the next few weeks-projecting over 10,000 swab samples in the project,\nrepresenting 59 cities, in 25 countries, on six continents.\nSo, is SARS-CoV-2 in the NYC subway? According to Mason, no. At least, they have\n16th and have collected a small number of samples, with numbers ramping up\nquickly.\nSubway swabbing\nHow does someone swab the NYC subway? In order to obtain the RNA samples, an\nIsohelix buccal swab is used to collect the sample, which is then stored in Zymo's\nDNA/RNA shield to protect the RNA from degradation.\nLike the clinical samples that are being processed at Cornell Weill Medical School,\nthe subway samples go through six assays which can take anywhere from 20-30\nminutes to up to three days. Mason attributes the large number of assays to the idea\nthat this is (hopefully) a once in a century pandemic, and there is a lot to be learned\nfrom these samples. In turn, they are doing everything they can to \"aliquot and\npreserve as much of the RNA from the sample and gain as much information as\npossible.\"\nA portion of the RNA (10 ng) goes into the standard qRT-PCR assay that is being\nwidely used to detect the presence of the viral RNA. The RNA also goes into various\ndifferent methods to sequence the viral genome, including PolyA RNA-seq\n(capturing of RNAs with polyA tails), Ribodepletion RNA-seq (removal of ribosomal\nRNAs), and MeRIP-Seq (which maps m6A-methylated RNA)--all of which are\nvarious methods to perform next-generation cDNA sequencing.\nDirect RNA sequencing using Oxford Nanopore's MinION is also performed. In\norder to do this, 500 ng (a lot) of polyadenylated RNA is required. The SARS-CoV-2\nRNA genome, luckily, has a 33 nucleotide poly-A tail, so it can be sequenced directly.\nThe Loop-mediated isothermal amplification (LAMP) assay, a colorimetric assay that\nworks in 30 minutes to test for the presence of the virus, is also performed on the\nsamples. First published by a Japanese group in 2014, and commercialized by New\nEngland Biolabs, Mason asserts that this very quick and easy to read test may allow\nthem to set up quick testing pop-up labs to test people quickly, easily, and rapidly.\nFor these assays, the viral RNA positive control is provided by the DNA writing\ncompany Twist Biosciences.\nThe sequencing data is uploaded into GISAID (Global Initiative on Sharing All\nInfluenza Data) which is a public-private partnership that provides public access to\nthe genetic sequence data of influenza viruses and other viruses, including SARS-\nCoV-2.\nSo, what RNA is strap-hanging under the streets of NYC? The team found 10%", "image": "(7)THENEXTSTOPIS\nascar" } }, { "id": "covid-gen-lamp", "study": "covid", "outlet": "GEN (Genetic Engineering & Biotechnology News)", "outlet_original": "GEN (Genetic Engineering & Biotechnology News)", "outlet_score": 6, "title": "LAMP Lights Up COVID-19 Testing", "title_original": "LAMP Lights Up COVID-19 Testing", "language": "English", "date": "2020", "kind": "news", "url": "https://www.genengnews.com/topics/coronavirus/lamp-lights-up-covid-19-testing/", "archive_url": "https://web.archive.org/web/20240527163645/https://www.genengnews.com/topics/coronavirus/lamp-lights-up-covid-19-testing/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports two preprints, one from Weill Cornell and one from the Technion, showing LAMP can give a simple, inexpensive, single-tube COVID-19 test, and explains how the method works.", "topics": [ "lamp", "covid-19", "rapid testing", "preprint", "diagnostics" ], "audience": "trade", "thumbnail": "media-archive/thumbs/covid-gen-lamp.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-gen-lamp--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/covid-gen-lamp.txt", "ocr_text": { "archived": "GENI\nGeneticEngineering\n&BiotechnologyNews\nMayAnliet,Ine ofalliaen\nGEN Edge*\nNews\nMultimedia\nTopics\nMagazine\nResourcesY\nSubscribe\nHomeTopics>Coronavirus>LAMPLightsUpCOViD-19Testing\nLAMP Lights Up COVID-19 Testing\nApril292\nThe COVID-19 tests in use today are laborious and complicated. They require a skilled\nprofessional to take samples, perform the reaction and analyze the results. Also, there is the\nneed for dedicated machines, chemical reagents, sophisticated transport logistics, etc. But,\nwhat if COVID-19 testing didn't have to be so cumbersome?\nTwo preprints published within the last week suggest that the science is already here to\nresearchers at Weill Cornell Medical School in NYC-the epicenter of the epidemic in the\nRead the Digital Edition\nUnited States. The other is from a group at the Technion - Israel Institute of Technology in\nHaifa, Israel.\nGEN\nAt the heart of the technique reported in both papers is loop-mediated isothermal\nMultispecific\nAntibodies\namplification, or LAMP. Developed by a Japanese group of researchers at the Osaka\nCometoGrips iwithManifoldTargets\nUniversity Medical School in Japan two decades ago, LAMP is performed in a single tube,\nTop10\nat a constant temperature for very little cost, to detect DNA. The technique amplifies DNA\nSellingCel\nand Gene Therapies\nU.5.HUPO2024\nLAMP relies on DNA polymerase and a set of four to six primers, designed to recognize a\nCell Therapy Industry\ntotal of six distinct sequences on the target DNA. One of the inner primers initiates strand\ndisplacement and amplification. A strand displacing DNA polymerase displaces the two\noriginal DNA strands while creating a new strand. A separate primer then displaces the\noriginal DNA strands while creating a new strand. A separate primer then displaces the\nnewly made strand, and a loop is formed due to complementary sequences on the primers.\nThe process of displacement, amplification, and forming loops continues until the DNA\nforms a dumbbell structure. It is the accumulation of these amplification byproducts that\ncan be easily detected. (For a visual explanation on how LAMP works, please see the video\nat the end of this article.) Add to the above protocol a reverse transcriptase step, and\ndetection of RNA can be done in a similar way-using RT-LAMP.\nThe work from Isreal is published as a Preprint in MedRxiv. The title of the preprint (a\nPaper that has not yet gone through the peer review process) is \"SARS-CoV-2 On-the-Spot\nVirus Detection Directly from Patients.\"\nThe authors developed RT-LAMP for the detection of SARS-CoV-2 RNA directly from\nclinical diagnostic swabs of human patients, without RNA purification steps. They spent\ntime adjusting the protocol, tweaking it for SARS-CoV-2 specifically. After the first round of\ntests, there were no false positives, but the rate of true positives was very low. They\ncontinued adjusting conditions, to find the optimal conditions. Once the protocol was\nvalidated on nasal swabs, they moved on to saliva samples. Using a very small set of self-\ncollected samples-from three different confirmed patients and one suspected negative\nsubject-the confirmed patients were found positive in bothRT-LAMP and RTqPCR from\nsaliva, and the suspected negative subject was confirmed negative.\n\"The simplicity of detecting SARS-CoV-2 without an elaborated RNA extraction and\npurification step and the fact that this method can significantly reduce the number of\nprofessionals required for SARS-CoV-2 detection tests\" are what Naama Geva-Zatorsky,\nPhD, professor of nanobiotechnology & nanomedicine at the Technion-Israel Institute of\nTechnology, and senior author on the article, finds most exciting.\nGeva-Zatorsky added that they envision the RT-LAMP test used as a surveillance test for a\nbelieve,\" they continued, \"that a simple and easy detection method, preferably one that can\nbe performed and interpreted on-the-spot could relieve some of the current limitations, and\nhelp execute an efficient and safe exit strategy from lockdowns.\"\nLAMP tracks SARS-CoV-2 around NYC\nThe Mason lab at Weill Cornell reported last week the development of a similar LAMP-\nbased colorimetric test that can identify the presence of SARS-CoV-2 from both oral and\nnasopharyngeal samples.\nThis COVID-19 pandemic, they wrote, highlighted a pressing need for \"rapid, scalable\ndiagnostics that can detect SARS-CoV-2 infection, interrogate strain evolution, and map\nhost response in patients.\"\nTheir work was published in a preprint last week in bioRxiv titled, \"Host, Viral, and\nEnvironmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome\nCoronavirus 2 (SARS-CoV-2).\"\nThe team designed and optimized the rapid LAMP assay to\ndetect SARS-CoV-2 infection from nasopharyngeal swab\nspecimens and oropharyngeal swab lysates. When tested for\nefficacy on 201 clinically-annotated samples, the assay had 99%\nspecificity and 95% sensitivity. The team then developed a\nlarge-scale shotgun metatranscriptomics platform to\ncomprehensively profile nasopharyngeal swab samples\n collected from patients with RNA-seq.\nBoth technologies were used to profile 338 clinical specimens\nChrisMason,PhD\ntested for SARS-CoV-2 and 86 environmental samples collected\nfrom high-transit areas in the NYC subway in early March", "live": "in\nGEN\nGenetic Engineering\n&BiotechnologyNews\nGEN Edge V\nSubscribev\nTopics v\nContent V\nMagazinev\nMultimediav\nResourcesV\nHome > Topics > Coronavirus > LAMP Lights Up COVID-19 Testing\nLAMP Lights Up COVID-19 Testing\nApril 29, 2020\nTop5\nThe COVID-19 tests in use today are laborious and complicated. They require a\nBCG Vaccine-Induced Trained Immunity May\nskilled professional to take samples, perform the reaction and analyze the results.\nHelpProtectAgainstDementia\nAlso, there is the need for dedicated machines, chemical reagents, sophisticated\ntransport logistics, etc. But, what if COVID-19 testing didn't have to be so\nEQTtoAcquireQiagenforS12.1B,Plansto\nTakeTools,DiagnosticsProviderPrivate\ncumbersome?\nHowAlzheimer'sRiskGeneAPOE4Disrupts\nTwo preprints published within the last week suggest that the science is already here\nMyelination\nto make a simple, easy to read COVID-19 test a possibility. One study is from a\nDiasome'sHDV-Insulin forT1D Finalizing\ngroup of researchers at Weill Cornell Medical School in NYC-the epicenter of the\nPhaseIlI PlansAfterPromising Data\nepidemic in the United States. The other is from a group at the Technion - Israel\nAnthropic IPO Discloses PlansforLife\nInstitute of Technology in Haifa, Israel.\nSciences Growth\nAt the heart of the technique reported in both papers is loop-mediated isothermal\nResources\namplification, or LAMP. Developed by a Japanese group of researchers at the Osaka\nUniversity Medical School in Japan two decades ago, LAMP is performed in a single\nRecommended ForYou\ntube, at a constant temperature for very little cost, to detect DNA. The technique\nLAMP relies on DNA polymerase and a set of four to six primers, designed to\nrecognize a total of six distinct sequences on the target DNA. One of the inner\nrecognize a total of six distinct sequences on the target DNA. One of the inner\nprimers initiates strand displacement and amplification. A strand displacing DNA\npolymerase displaces the two original DNA strands while creating a new strand. A\nseparate primer then displaces the newly made strand, and a loop is formed due to\nVitaminDerivativePantethineAlleviatesPsoriasis\ncomplementary sequences on the primers. The process of displacement,\nSymptoms in Small Human Trial\namplification, and forming loops continues until the DNA forms a dumbbell\nArtiva Axes94%of Workforce,Weighs Strategic\nstructure. It is the accumulation of these amplification byproducts that can be easily\nAlternativesAfterTwoPatients inPhasella Trial\ndetected. (For a visual explanation on how LAMP works, please see the video at the\nDie\nend of this article.) Add to the above protocol a reverse transcriptase step, and\ndetection of RNA can be done in a similar way-using RT-LAMP.\nBonjour Genomics: A Video from ASHG\nThe work from Isreal is published as a preprint in MedRxio. The title of the preprint\nASHG:Nabsys Links Cytogenetics and Genomics\n(a paper that has not yet gone through the peer review process) is \"SARS-CoV-2 On-\ntoMapHematologicCancers\nthe-Spot Virus Detection Directly from Patients.\"\nThe authors developed RT-LAMP for the detection of SARS-CoV-2 RNA directly\nThey spent time adjusting the protocol, tweaking it for SARS-CoV-2 specifically.\nAfter the first round of tests, there were no false positives, but the rate of true\npositives was very low. They continued adjusting conditions, to find the optimal\nconditions. Once the protocol was validated on nasal swabs, they moved on to saliva\nsamples. Using a very small set of self-collected samples-from three different\nconfirmed patients and one suspected negative subject-the confirmed patients were\nfound positive in both RT-LAMP and RIqPCR from saliva, and the suspected\nnegative subject was confirmed negative.\n\"The simplicity of detecting SARS-CoV-2 without an elaborated RNA extraction and\npurification step and the fact that this method can significantly reduce the number of\nprofessionals required for SARS-CoV-2 detection tests\" are what Naama Geva-\nZatorsky,PhD, professor of nanobiotechnology & nanomedicine at the Technion \nIsrael Institute of Technology, and senior author on the article, finds most exciting.\nGeva-Zatorsky added that they envision the RI-LAMP test used as a surveillance test\nfor a large number of people in the community.\"Detection is key,\" the authors\npreferably one that can be performed and interpreted on-the-spot could relieve some\nof the current limitations, and help execute an efficient and safe exit strategy from\nlockdowns.\"\nLAMP tracks SARS-CoV-2 around NYC\nThe Mason lab at Weill Cornell reported last week the development of a similar\nLAMIP-based colorimetric test that can identify the presence of SARS-CoV-2 from\nboth oral and nasopharyngeal samples.\nscalable diagnostics that can detect SARS-CoV-2 infection, interrogate strain\nevolution, and map host response in patients.\"\nTheir work was published in a preprint last week in bioRxiv titled, Host, Viral, and\nEnvironmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome\nCoronavirus 2 (SARS-CoV-2).\"\nThe team designed and optimized the rapid LAMP assay\nto detect SARS-CoV-2 infection from nasopharyngeal\nswab specimens and oropharyngeal swab lysates. When\ntested for efficacy on 201 clinically-annotated samples,\nthe assay had 99% specificity and 95% sensitivity. The\nteam then developed a large-scale shotgun\nmetatranscriptomics platform to comprehensively profile" } }, { "id": "covid-glp", "study": "covid", "outlet": "Genetic Literacy Project", "outlet_original": "Genetic Literacy Project", "outlet_score": 5, "title": "'Microbe maps': Swabbing subways, ATMs and park benches to find coronavirus hot spots", "title_original": "'Microbe maps': Swabbing subways, ATMs and park benches to find coronavirus hot spots", "language": "English", "date": "2020-05-05", "kind": "news", "url": "https://geneticliteracyproject.org/2020/05/05/microbe-maps-swabbing-subways-atms-and-park-benches-to-find-coronavirus-hot-spots/", "archive_url": "https://web.archive.org/web/20201024165615/https://geneticliteracyproject.org/2020/05/05/microbe-maps-swabbing-subways-atms-and-park-benches-to-find-coronavirus-hot-spots/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Genetic Literacy Project piece on 'microbe maps': swabbing subways, ATMs and park benches to locate coronavirus hot spots in New York (archived copy).", "topics": [ "covid-19", "microbe maps", "surface swabbing", "hot spots" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/covid-glp.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-glp--archived.jpg", "saved_html": "media-archive/html/covid-glp--archived.html", "saved_article_text": "", "ocr_text": { "archived": "MENU\nABOUTGLP\nTOPICS\nGLPARTICLES\nSPECIALSECTIONS\nRESEARCH\nQ SEARCH\nGenetic Literacy Project\nSCIENCE NOT IDEOLOGY\nNewsletter Sign Up\nDonate\n61.0K\n17.7K\nGlobal Gene EditingRegulation Tracker\nAnti-GMOAdvocacy Funding Tracker\nOur interactive GLP global map explains the status of each country's\nThis GLP project maps contributions byfoundations to anti-biotech\nregulations for human and agricultural gene editing and gene drives.\nactivists and compares itto pro-GMo industryspending.\nMicrobe maps': Swabbing subways, ATMs and parkbenches\nto find coronavirus hot spots\nTRENDING\nMegan Molteni I Wired I May 5,2020\nAre Sudanese Arabs?\nrpdtibahnnh iviw efr uyzq\nComparing White and Black\nMTA personnel clean a subway car in the Coney Island Yard.Credit: Sam Costanza/New York Daily News\nbrains: Turns out'genetics','race'\nand ancestrymatterwhen\ndiagnosing disorders\nThis article or excerpt is included in the GLP's daily curated selection of ideologically diverse news.\nopinionand analysisofbiotechnology innovation.\nGlyphosate on trial: California\nSupreme Court rejects request\nfromBayertoreviewfirst\nNearly a decadeago,afterwatchinghisyoungdaughter licka polein a subway car,\nRoundup-cancerverdict\ncomputational biologist ChristopherMasongot the idea to start regularly swabbingthe\nDotheMAOAand CDH13'human\nhandrails,turnstiles,seats,andfloors inside New York City's metro system. Sequencing of\nwarriorgenes'make violent\nthese samples back in his lab at Cornell Weill led to the first map of themicrobes that call the\ncriminals-and what should\ncity's transit system home.\nsociety do?\nUSandSouthKoreareportedfirst\nCoVID casesonthesameday.\nThey managed the pandemic; Us\n[1]n17pilot cities,MetasUB scientists started swabbingfor tracesofgeneticmaterial from\ndidn't. Here's why\nSARS-CoV-2as earlyas thefirst week ofFebruary.When subways shut down,they switched\nViewpoint:Thechilling impactof\nto other high-touch surfaces, like ATMs and park benches. Sofar, they've collected 3,6o0\nSCTENTFEL\nthe virulent spread of anti-science\nsamples.\nthinking\nAGAIN\nPodcast: Regulate all food\nRelated article:Livingat high altitudes may offernatural defenseagainst CoViD-\nchemicals? Gin and tonics going\nextinct:GMOpineappleis here!\nImmunotherapy as a lastresort\nforterminal cancer patients\nThegoal ofall this swabbingand sequencingis twofold:One,to betterunderstand the\nvirus'stransmission dynamics.Howlong does it stay alive on surfaces?Howmuch of itis in\nthe air?How riskyis riding the subway,really?Answers to thosekinds ofquestions can help\nCoffee appears to offer\npublic health officials makedecisionsnow to protect citizens duringthe early stages of the\nwidespread protection against\npandemic. But the second aim is more long-term: detecting potential hot spots of infection\nParkinson's disease\nin highlytraffickedareas beforepeoplestart showing up in emergency rooms.\nScare talk debunked:GMOs,\nRead the original post\npesticides and antibiotics don't\nmake conventionalfood unsafe\nThe GLP Needs Your Help\nIt is easierthan ever for advocacygroups to spread disinformation on pressingscience\nissues, such as the ongoing coronavirus pandemic,No,vaccines arenot harmful Yes,\nthe use of biotechnology,GMOs orgene editing todevelop antigens for treatments\nincluding vaccines are part of the solution.To inform the public about what's really\ngoing on,wepresentthefactsand challengethosewho don't We can'tdothis work\nsupport our vital myth-busting efforts.\nDONATE\nCOMMENTS:CLICKHERETOREADORPOST\nOutbreak\nBiomedicine, Vaccines\n&Policy Solutions\nRichard Williams\nHow to assess the real safetyrisks of getling a COvIDvaccine shol\nPeterWamboga-Mugirya\nViewpoint: Uganda baules anti-GMO,anti-vaccine coalition agitating against COVID-\n19immunizalion\nDavid Gorski\nVicwpoint: Great Barrington Declaralion arguing for herd immunitytakes page from\ndenialistpropaganda playbook'\nMore...\nOutbreak Daily Digest\nABC NewS\nAsindependentscientists'do-it-yourself-CoviD-vaccines proliferate.bioethicislscounler\nwith warnings\nSustainableAgricultural Innovation &Food\nViewpoint:Rush to develop COvID vaccine highlights failure of Europe's GM crop regulalions\nScience\n1in7COVIDpatientshavegenetic flaws thatdramaticallyincreasetheirvulnerabilily\nWall Street Journal\nUS and South Korea reported first COvID cases on the same day.They managed the\npandemic; US didn't. Here's why\nMore..\nGLPPodcasts\nMore...\nSCIENCE\nPodcast:Regulate allfood chemicals?Gin and tonics going extinct; GMO\nFacts&\npineapple is here!\nFallacies\nCameron English, Kevin Folta | October 21,2020\nTalking\nPodcast:Activism's dark side--EarthLiberationFront bombs'GMO'tree\nBiotech\nlab,destroysendangeredplantsinstead\nKevin Folta,Toby BradshawAugust 28,2020\ngenetics\nPodcast:The Human Genome Project is30 years old.What havewe\nunzipped\nlearnedsinceits inception?\nEricGreen, KatArneyOctober22,2020\nVideos\nMore..\nVideo:How to boost your immune system to guard against coviD and other illnesses\nScientists have recently developed ways to measure your immune age.Fortunately,it turns out your immune age\ncan go down ...\nBees &Pollinators\nMore...\nDisaster interrupted:Whichfarming system better preserves insect\npopulations:Organicor conventional?\nA three-year run of fragmentary Armageddon-like studies had primed the journalism pumps\nand settled the media framing about the future ..\nArewefacing an'lnsect Apocalypse'causedby'intensive.industrial'farming\nand agricultural chemicals?Themedia say yes;Science says'no\nThe media call it the'lnsect Apocalypse. In the past three years,the phrase has become an\naccepted truth of ...\nInfographics\nMore...\n188\n34\n167\n515\n105\n(77433)\n(127202)\n(21132)\n(28-38)\nSinkfrom\nin:theatmosphere.\nSinkin.soils\nFossifuel\nInfographic:Cowscause climate change?Agriculture scientistsays‘belchingbovinesgettoo\nmuchblame\nArecent interview by Caroline Stocks, a UK joumalist who writes aboutfood, agriculture and the environment, of air\nquality...\nGMO FAQs\nMore...\nOrganic vconventional using GMos:Which is the more sustainable\nfarming?\nMany consumers spend more for organicfood to avoid genetically modified\nproducts in partbecause they believe that“industrial agriculture\"\nAremostGMOsafetystudiesfundedbyindustry?\nThe assertion that biotech companies do the research and the government just\nsigns off on itis false ..\nDo GMo Bt (insect-resistant) crops pose a threat to human health or the\nenvironment?\nBt is a bacterium found organically in the soil.It is extremelyeffective in repelling\nor killing target insects but...\nGLP Profiles\nMore...\nEnvironmental WorkingGroup:EWGchallengessafetyofGMOs,foodpesticide\nresidues\nKnown by someas the\"Environmental Worrying Group,\"EWG lobbies for tighterGMO legislation\nand famously puts out annual \"dirty dozen\" list of fruits and...\nENVIRONMENTAL\nNORKINGGROUR\nMichael Hansen:Architect of Consumers Union ongoing anti-GMOcampaign\nMichael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing\ncampaign against agricultural biotechnology at ConsumerReports.He is an..\nAbout Us\nSpecial Sections\nTopics\nGLP Articles\nResearch\nMission,Financial\nDailyFood&Agriculture\nGLPHuman Genetics\nBees&Butterflies\nSearchGLPLibrary\nTransparency.Governorship\nGLPFood&Agriculture\nDaily Human\nGLPBiotechProfiles\nSearch Infographics\nFairUseof Articles&Images\nAgricultural Laws&Regulations\nGMoBeyond theScience\nSearch Videos\nOurTeam\nAncestry&Evolution\nGMO FAQS\nBrowseAuthors\nGLPBoards\nBiomedicalRegulations&Ethics\nInfographics\nBrowseSources\nWrite for the GLP\nBiomedicine&Disease\nPesticides and Food\nGLPRSSFeeds\nDonate\nBiotechCommunications\nPodcasts\nCopyright\nBrain/Neuroscience\nVideos\nContact\nChemicals&Pesticides\nPrivacy Policy\nCrops&Food\nEpigenetics\nGene Therapy\nHealth&Wellness\nHuman Gene Editing/CRISPR\nNewBreedingTechniques\n(NBTs)\nPersonal Genomics\nScience of the Future\nSustainability/GreenGenes\nSynthetic Biology\n2012-2020IGENETICLITERACYPROJECT|Registered501(c)(3).EIN:52-1844456\nSELECT LANGUAGE\nSELECTLANGUAGE\nGLPARTICLES\nGLP Food &Agriculture\nGLP Human Genetics\nTOPICS\nDaily Food&Agriculture\nDaily Human\nAgricultural Laws &Regulations\nAncestry&Evolution\nBiomedical Regulations &Ethics\nBiomedicine&Disease\nBiotech Communications\nBrain/Neuroscience\nChemicals & Pesticides\nCrops&Food\nEpigenetics\nGene Therapy\nHealth&Wellness\nHuman Gene Editing/CRISPR\nPersonal Genomics\nNew Breeding Techniques (NBTs)\nPersonal Genomics\nSustainability / GreenGenes\nSynthetic Biology\nSPECIALSECTIONS\nBees & Butterflies\nEpigenetics FAQs\nGeneTherapy FAQS", "live": "Forbidden\nYou don't have permission to access this resource" } }, { "id": "covid-tubitak-seminar", "study": "covid", "outlet": "TÜBİTAK, Turkish science agency (YouTube)", "outlet_original": "TÜBİTAK (YouTube)", "outlet_score": 4, "title": "Transcriptomic, spatial and viral molecular characterization of SARS-CoV-2 infection (seminar)", "title_original": "SARS-CoV-2 Enfeksiyonunun Transkriptomik, Uzamsal ve Viral Olarak Moleküler Karakterizasyonu (seminar by Dr. Meydan)", "language": "Turkish", "date": "2021", "kind": "talk", "url": "https://www.youtube.com/watch?v=gwNJAmujQV0", "archive_url": "https://web.archive.org/web/20250408211616/https://www.youtube.com/watch?v=gwNJAmujQV0", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Recorded talk by Dr. Meydan in TÜBİTAK's Biological Sciences Seminar Series on transcriptomic, spatial and viral characterization of SARS-CoV-2 infection.", "topics": [ "sars-cov-2", "transcriptomics", "seminar", "covid-19" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/covid-tubitak-seminar.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/covid-tubitak-seminar--archived.jpg", "saved_html": "media-archive/html/covid-tubitak-seminar--live.html", "saved_article_text": "", "ocr_text": { "archived": "DE\nSearch\nSign in\nTheWaybackMachinedoesnothavethisvideoarchived.\nLive chat replayis not available for this video.\nGlobal View of theProtein\nUniverseINir Ben-Tal\nTUBiTAK TBAE\n1:07:55\n1.1K viewsStreamed4years ago\nQuantum\nStrangeTechfromtheQuantum\nTunneling!\nRealm!\nLawrence Livermore National Labor..\n413Kviews5daysago\n23:59\nNew\nIt's mind-blowing!New Starship\nRefueling Method Revealed...\nALPHA TECH\n14:43\n3.1K views-9hoursago\nNew\nPROTEINPUZZLE\nHow AI Cracked the Protein\nFolding Codeand Won a Nobel...\nQuanta Magazine\n22:20\n443Kviews-5monthsago\nSARS-CoV-2EnfeksiyonununTranskriptomik,Uzamsal veViralOlarakKarakterizasyonu\nCem Meydan\nTRUMPTARIFF CHAOS\nJonStewartonTrump's\nTUBiTAKTBAE\nBotchedTariffRollout&The...\nSubscribe\nLike\nShare\nSave\n5.24Ksubscribers\nTheDaily Show\n4Mviews-18 hoursago\n19:14\nNew\n741viewsStreamed4yearsago\nThe Most Misunderstood\nTUBiTAKTBAEBiologicalSciencesSeminarSeries\nConcept in Physics\nENTROPY\nSARS-CoV-2Enfeksiyonunun Transkriptomik,Uzamsal veViral olarakMolekulerKarakterizasyonu ...more\nVeritasium\n20Mviews-1yearago\n27:15\nPhysicist BrianCoxexplains\nCommentsareturned off.Learn more\nQUANTUM\nquantum physics in22minutes\n101\nBig Think\n529Kviews·5daysago\nBT\n22:19\nNew\n\"Godfather of Al\" Geoffrey\nHinton: The 60 Minutes...\n60Minutes\n13:12\n2.7Mviews1yearago\nTheTipping Points of Climate\nChange-and where We Stan...\nTED\n18:36\n1.2Mviews·7monthsago\nCURPAST\nTrump's Tariffs Murder Wall\nStreet, Dodgers Go to The Whi...\nJimmy Kimmel Live\nQUENTINTARIFF15:25\n1.8Mviews17hoursago\nNew\nGeheimakte Rudolf Steiner:\nAnthroposoph,okkultist...\nSTEINERS\nARTEde\nUMSTRITTENE\n205Kviews12daysago\nDEEN\n1:30:32\nWE FINALLY\nMicrosoftAnnounces World's\nDID IT\nFirst Topological Quantum Chi...\nDr Ben Miles\n1.6Mviews·1monthago\n22:29\nComputerScientistExplains\nOneConcept in5Levelsof...\nWIRED\n6.9M views..3 years ag0\nZERO-KNOWLEDGE\n22:36\nPROOF\n\"American Empire Is in Decline\":\nEconomist RichardWolff on...\nDemocracyNow!\n3.7Mviews5daysago\nNOW.\nNew\nHitler: From Homeless to\nMonster\nBest Documentary\n1:44:07\n1.6Mviews..3weeks ago\n1.6Mviews..3weeks ago\n1:44:07\nTheManWhoAlmostBroke\nMath (And Himself...)\nVeritasium\n33:01\n6.1Mviews6daysago\nNew\nhello?\nWhy DidThe Mars Helicopter\nDisappear?\nVeritasium\n29:08\n5Mviews·2weeks ago\nThe Insane Engineering of MRI\nMachines\nReal Engineering\n3.3Mviews·1yearago\n17:53\nNEWS\nHas ElonMuskruinedTesla?IIif\nYou're Listening\nTUSTENNG\nTESLABOYCOTT\nABC News In-depth\n473Kviews4daysago\n18:22\nNew\nDouglas\nROUND\nDouglas Murray: Putin,\nMurray\nZelensky.Trump, israel...\n#463\nLexFridman\nLex\n751Kviews9daysag0\nFridman\n3:09:05", "live": "Search\nDYouTube\nSign in\nGlobal Viewofthe\nProtein UniverseNir\nBen-Tal\nTUBITAKTBAE\nD1.1K Streamed6yago\nNir Ben-Tal\n1:07:55\nDay 5-Lecture 3:\nNew Space\nPhieteconpanesdeedopinglowcest\nTowardsSecure&\ncommeciulydriwnipprachiestospaceegploration\nSustainableNTNs ..\n+ Subarital\nTUBITAKTBAE\n- Orbitat\nD686moago\nDeep Space\nCrphasosmaaetcompettonreyaabnty\n1:27:41\nStatistics and Biology\nof Human MutationI\nShamil R. Sunyaev\nTUBiTAK TBAE\nD1.1K Streamed4yago\nShamil R.Sunyaev\n1:00:50\nNew\nBeyond\nAcknowledgment:\nTHE RESILIENTNURSEPOOCAST\nMaking Resilience a...\nCem Meydan\nJohns Hopkins Universit..\nTUBiTAK TBAE\n023minago\nSubscribe\n Like\nShare\nSave\n5.62Ksubscribers\nEpisode:37\n41:42\n845viewsStreamed6yearsago\nThe Earthing Movie\nTUBiTAKTBAEBiological SciencesSeminarSeries\nThe\nDocumentary 2018\nEarthing\nFree withads TV-PG\nSARS-CoV-2Enfeksiyonunun Transkriptomik,Uzamsal veViralOlarakMolekulerKarakterizasyonu..more\nMovie\nTHE REMARKABLE\nSCIENCE OF GROUNDING\n1:15:33\nComments are turned off. Learn more\nPhlebotomy\nCerticationPrep#CPT\nWhich of the following additives is used to\nprevent the breakdown ofglucose?\n#NPSCertification...\nMedical Assisting wit.@\nA.EDTA\n27KStreamed1yago\nB.Heparin\nC. Sodium fluoride\n51:44\nD.Sodium citrate\nTURKEY COILAPSE!\nTurkey's S20 Billion\nFund Collapse\nExplained\nPatrick Boyle\nD1.7M3wago\n33:35\nYour Brain\nHallucinates Your\nConscious Reality ...\nTEDO\nD11M9yago\n17:01\nNew\nPhysics for Sixth\nPreparatory Scientific\nIChapter Three ..\nD11K15hago\n1:00:30\nEmotional\nIntelligence:The #1\nability for leaders ...\nLeadership Lessons | Big..\nD2M2yago\n11:55\nPBSNOVA\nEinstein's\"Biggest\nBlunder\"Was Actually\nRight|NOVAIPBS\nNOVA PBS Official\n672K5moago\nWHATISSPACE-TIME\n14:26\n0921\n0921\nD7K3wago\nAuto-dubbed\n59:52\nGalapagos Finch\nEvolution-HHMI\nBiolnteractive Video\nbiointeractive\nD2.4M12yago\n16:09\nLongevity Edge Deep\nNew\nDiveEp009Dr.Dawn\nMussallem x Jean ...\nFountain Life\nD1hago\n1:01:50\nBahadir Ozgur:\nNew\n\"They've looted Turkey\nuntil it can barely ...\n“BUFONCULAR\nSADECEHIRSIZDEGIL\nBirGUn TVO\nBIRERVATAN HAINIF\nD351K3dago\nTIMURSOYKAN\nBAHADIR47:58\nTimur Soykan\nexplains:\"The fund\nSARAYDACOK\nscam is unraveling t.\nBUYUK BIR GUC\nBirGUn TVO\nKAVGASIVAR!\nD458K2wago\nTIMURSOYKAN\n19:07\nThis is how you treat\nADHDbasedoff\nscience, Dr Russell...\nAdhd Videos\nD5M12yago\n13:47\nNew\nFrom Story to Action:\nHowPolicy Works and\nWhere Advocates Fit..\nHemophilia Federation o.\nD3hago\n54:30\nNew\nWhat Really Happened\nWhenAlSolveda\nMillion-Dollar Math ...\nNew Scientist\nD9.4K4hago\n40:57\nTIMARHANEDE BU\nHAFTA-211\nSOYGUNUN...\nSule AYDIN \nD1M2wago\nAuto-dubbed\n13:26", "image": "SARS-CoV-26eads\nCemMeydan\nCornell University,USA" } }, { "id": "cell2020-wcm", "study": "cell2020", "outlet": "Weill Cornell Medicine", "outlet_original": "Weill Cornell Medicine", "outlet_score": 7, "title": "Studies Reveal Clues about Preventing Spaceflight-Related Risks", "title_original": "Studies Reveal Clues about Preventing Spaceflight-Related Risks", "language": "English", "date": "2020-11-25", "kind": "press-release", "url": "https://news.weill.cornell.edu/news/2020/11/studies-reveal-clues-about-preventing-spaceflight-related-risks", "archive_url": "https://web.archive.org/web/20201125165036/https://news.weill.cornell.edu/news/2020/11/studies-reveal-clues-about-preventing-spaceflight-related-risks", "names_meydan": true, "meydan_context": "Credited with noticing that astronaut stress signatures, including IL-6 activation, resembled those in COVID-19 patients.", "passage_naming_meydan": "…nd NewYork-Presbyterian patients with cancer and other conditions like COVID-19 to help match them with personalized therapies. That work led Dr. Cem Meydan, a senior staff scientist in Dr. Mason’s lab, to a startling discovery: Many of the stress signatures seen in astronauts were similar to COVID-19 patients. For example, an immune system protein…", "summary": "Release on a package of Cell studies finding that spaceflight, COVID-19 and Everest climbing trigger similar stress responses, with maps of blood-cell mutations and immune changes that may help protect travelers.", "topics": [ "spaceflight", "stress response", "cell", "covid-19", "immune system" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/cell2020-wcm.jpg", "passage_image": "media-archive/mentions/cell2020-wcm.jpg", "full_screenshot": "media-archive/shots/cell2020-wcm--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-wcm.txt", "ocr_text": { "archived": "considersupportingWeillCornell Medicine's efforts againstthepandemic.\nWeillCornellMedicine\nCare\nDiscover\nTeach\nMenu\nNewsroom\nEXPLORETHIS.WEBSITE\nHome\nNews\nPressRoom\nPublications\nVideo&Photography\nSocial Media\nAbout Us\nPressRoom\nNews\nPublications\nVideo&Photography\nSocial Media\nAbout Us\nHome\nNews\nStudiesRevealCluesaboutPreventingSpaceflight-\nRelatedRisks\nNOVEMBER25,2020\nBack toNews\nin\nWeill Cornell Medicine\nOfficeof External Affairs\n1300YorkAvenue\nBox 314\nNewYork,NY10065\nPhone:(646)962-9476\nThe Earth'satmosphere viewed from the International Space Stationfeaturing the Aurora Borealis.Photograph by Scott Kelly\nSpace travel, illnesses like CoviD-19, and climbing Mount Everest can trigger the body's stress response systems in\ndiscoveries ,including new maps of the abundance of mutations and immune changes found in blood cells during\nspaceflight,may lead to new ways to protect space travelers.They may also provide insights on caring for Earth-bound\nDr.Christopher Mason ,an associateprofessorof physiologyandbiophysics at Weill Cornell Medicine, led multiple\nAeronauticsand SpaceAdministration (NASA),JapanAerospaceExplorationAgency (AXA),EuropeanSpaceAgency(ESA)\nand Russia's ROScOSMOS-as well as academic institutions and industry groups.The teams investigated genetic,\nbiochemical, and physiological changes in 56 astronauts, which is the largest study of astronauts to date (581 total have\nbeen to space since 1961). Dr.Mason's laboratory members, including Weill Cornell Graduate School of Medical Sciences\n student Kirill Grigorev, also built an online portal, called an APl, to analyze data from NASA's GeneLab Repository.\nwhich contains animal, plant and microbial data collected during NASA's space missions since the 1960s.\nTogether, the Weill Cornell Medicine and global teams on Nov. 25 published 20 studies in special, coordinated issues and\nsimultaneously featured on the covers of Cell, Cell Reports and iscience, as well as highlighted in Cell Systems and Patterns.\nThe large effort details the effects of space travel on the human body and revealed potential prevention and treatment\napproaches that may allow longer term spaceflight, such as missions to Mars.\nInitiativeforQuantitative Prediction and theWorldQuant ResearchScholar at Weill Cornell Medicine.\"We can start\nthinking at the molecular and cellular level about longer term missions, and also what drugs, countermeasures and\ntherapies could be tried to minimizethe risks for astronauts.\"\nThe effort built on theresults of NASA's Twins Study of astronauts Scott and Mark Kelly from2014-2019, which looked\nat genetic, physiologic and behavioral characteristics in the identical twins before, during and after Scott completed a\none-year mission in space.Mark Kelly,who was recently elected to the U.S.Senate, stayed on Earth during the mission.\nThat study revealed that Scott's body underwent thousands of molecular and physical changes both while in space and\nafter returning to Earth.Among them was that the ends of his chromosomes,called telomeres, lengthened in spaceand\nshortened after his return.Lengthened telomeres have been linked to longer life,while shortened ones have been linked\nto a greater risk of disease.\nIn the new studies,Dr.Mason and his colleagues were able to confirm that those same telomere changes happened in\nall 11 otherastronautsforwhichtheyhad samples,andtheyalso exarmined changes in telomere length and DNA\ndamageusing urine and plasma samples.They examined the unique microbiomesfor each twin as well as their\ndistinct clonal hematopoiesis ,which is a measure of the number of blood cells that carry specificmutations and could\ncompared to patients with cancer at Memorial Sloan Kettering(MSK), the astronauts had larger changes. The\nincreased when back on Earth.\nDr. Mason's team, including Daniela Bezdan, a research associate at the time of the studies, applied new techniques \nsuch as single cell and cell-free DNA sequencing to study changes in individual cells like immune cells (B cells and T cells),\nMelnickand David Lyden atWeill Cornell Medicine.This helped showthat spaceflight was associated with\ndysfunction in mitochondria ,which provide the cells with energy,suggesting that the immune cells may have\ndisrupted functions. These signatures could be found in the blood as well as in urine, and utilized technology that is now\nspace.\n\"The immune system is under a lot of stress when youare in space,\"said Dr.Mason,who is also an associateprofessor\nof computational genomics in computational biomedicinein the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud", "live": "WeillCornellMedicine\nDiscover\nCare\nTeach\nMenu\nSearch\nNewsroom\nNews\nPressRoom\nVideo&Photography\nSocial Media\nImpact Magazine\nAbout Us\nHome\nNews\nStudies Reveal Clues about Preventing Spaceflight-\nRelatedRisks\nNOVEMBER25.2020\nBack to News\nfxin\nWeill Cornell Medicine\nOffice of External Affairs\nPhone:(646)962-9476\nsimilar ways, according to new studies by Weill Cornell Medicine, space agencies and many other investigators.The\npatients with illnesses that trigger similar physiological responses.\nDr.Christopher Mason,an associate professor of physiology and biophysics at Weill Cornell Medicine, led multiple\nstudies by teams of investigators spanning four of the largest space agencies in the world-the United States National\nAeronautics and Space Administration (NASA), Japan Aerospace Exploration Agency JAXA), European Space Agency (ESA)\nand Russia's ROSCOSMOS-as well as academic institutions and industry groups. The teams investigated genetic,\nbiochemical, and physiological changes in 56 astronauts, which is the largest study of astronauts to date (581 total have\nbeen to space since 1961). Dr.Mason's laboratory members, including Weill Cornell Graduate School of Medical Sciences\nstudent Kirill Grigorev,alsobuiltanonlineportal, called anAPl,to analyze datafromNASA's GeneLab Repository,which\ncontains animal, plant and microbial data collected during NASA's space missions sincethe 1960s.\nTogether, the Weill Cornell Medicine and global teams on Nov.25 published 20 studies in special, coordinated issues and\nsimultaneously featured on the covers of Cell, Cell Reports and iScience, as well as highlighted in Cell Systems and Patterns.\nThe large effort details the effects of space travel on the human body and revealed potential prevention and treatment\napproaches that may allow longer term spaceflight, such as missions to Mars.\n\"lt's a turning point in space biology and aerospace medicine,\"said Dr. Mason, who is also co-director of the WorldQuant\nInitiativefor Quantitative Prediction and the WorldQuant Research Scholar at Weill Cornell Medicine.\"We can start\nthinking at the molecular and cellular level about longer term missions, and also what drugs, countermeasures and\ntherapies could be tried to minimize the risks for astronauts.\"\nThe effort built on the results of NASA's Twins Study of astronauts Scott and Mark Kelly from2014-2019, which looked at\ngenetic,physiologic and behavioral characteristics in the identical twins before, during and after Scott completed a one-\nyear mission in space. Mark Kelly, who was recently elected to the U.s. Senate, stayed on Earth during the mission. That\nstudy revealed that Scott's body underwent thousands of molecular and physical changes both while in space and after\nreturning to Earth. Among them was that the ends of his chromosomes, called telomeres, lengthened in space and\nshortened after his return. Lengthened telomeres have been linked to longer life,while shortened ones have been linked\ntoagreaterriskof disease.\nIn the new studies, Dr.Mason andhis colleagues were ableto confirmthat those sametelomere changes happened in\nall 11 other astronauts for which they had samples, and theyalso examined changes in telomere length and DNA\ndamage using urine and plasma samples.They examined the unigue microbiomes for each twin as well as their\ndistinct clonal hematopoiesis ,which is a measure of the number of blood cells that carry specific mutations and could\nrepresent a precancerous condition.Each twin showed distinct mutations in their blood and their genomes,and when\ncompared to patients with cancer at Memorial Sloan Kettering(MSK), the astronauts had larger changes. The\ninvestigators also found that spaceflight reduced the abundance of these types of mutations, but that they then\nincreasedwhenbackonEarth.\nDr.Mason's team,including Daniela Bezdan,aresearchassociate at the time of the studies,applied new techniques\nsuch as single cell and cell-free DNA sequencing to study changes in individual cells like immune cells (B cells and T cells),\nas well as exosome profiling, in collaboration with Dr.Iwijin De Vlaminck at Cornell's Ithaca campus and Drs. Ari\nMelnick and David Lyden at Weill Cornell Medicine.This helped show that spaceflight was associated with dysfunction in\nThese signatures could be found in the blood as well as in urine, and utilized technology that is now being used for some\nkidney transplant patients . The team confirmed that similar changes occur in mice and rats in space.\n\"The immune system is under a lot of stress when you are in space,\"said Dr.Mason, who is also an associate professor\nof computational genomics in computationalbiomedicine in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud\nInstitutefor Computational Biomedicine,and an associateprofessorof neuroscience intheFeil Family Brainand Mind\nResearch Instituteat Weill Cornell Medicine.\nNot all of the changes they saw were unique to astronauts. Dr. Mason worked with a Nepalese team and Daniel Butler at\nWeill Cornell Medicine to obtain blood samples from climbers at the top of Mount Everest and bring them back by\nhelicopter,wheretheywere compared with samples from the climbers'twins who wereat sea level.Notably,individuals\nwho climb Mount Everest experience similar molecular changes ,such as lengthened telomeres and oxidative stress.\nThis discovery suggests that some drugs used to treat extreme athletes may be useful for astronauts, and that medicines\ndesigned for astronauts might be useful for those undergoing stress on Earth. Among the existing drugs they\ncataloged and compared with the stress profiles are thosethat reduce inflammation or control muscle growth.\n\"There are some conserved responses to really severe physiological stress, whether you are in a space station or on top\nof theworld'stallestmountain,said Dr.Mason,who is also amember of the Sandra and Edward Meyer Cancer Center." } }, { "id": "cell2020-mittr", "study": "cell2020", "outlet": "MIT Technology Review", "outlet_original": "MIT Technology Review", "outlet_score": 9, "title": "Spaceflight does some weird things to astronauts' bodies", "title_original": "Spaceflight does some weird things to astronauts' bodies", "language": "English", "date": "2020-11-25", "kind": "news", "url": "https://www.technologyreview.com/2020/11/25/1012628/spaceflight-astronauts-bodies-genetics-effects-scott-kelly-twins-study/", "archive_url": "https://web.archive.org/web/20201125234357/https://www.technologyreview.com/2020/11/25/1012628/spaceflight-astronauts-bodies-genetics-effects-scott-kelly-twins-study/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Covers new spaceflight biology studies, building on the NASA Twins Study, on how weightlessness and radiation change astronaut genetics and physiology.", "topics": [ "spaceflight", "twins study", "astronaut genetics", "cell", "nasa" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/cell2020-mittr.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/cell2020-mittr--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-mittr.txt", "ocr_text": { "archived": "MIT\nSignin\nSubscribe\nTechnology\nReview\nMagazine\nNewsletters\nEvents\nTopics\nLABIPS\nNASA\nSpace\nSpaceflight does some\nweird things to\nastronauts'bodies\nThe biggest-ever study of astronaut health gives us clues on what\nto look for in future long-haul space missions.\nby NeelV.Patel\nNovember25,2020\nAstronautScottKellyfamouslylivedandworkedontheInternationalSpace\nPopular\nHismissiongavescientists somevital insight intowhat happenstothe\nhuman body during long-duration stays in orbit. That's because Kelly has\n01\nan identical twin, Mark (also an astronaut, and now soon to be a us\nThe way we train Alisfundamentally flawed\nsenator). The Kelly twins offered scientists a rare opportunity: as they\nstudied what happened to Scott's body during his year in space, they had\nthe benefit of a control subject, Mark, who stayed on Earth.\nBidennamesJohnKerryclimateczarin\nrecommitmenttoglobalcooperation\nrecommitmenttoglobalcooperation\nThe NASA Twins Study provided more evidence for what we already\n03.\nsuspected. In a confined capsule under microgravity and prolonged\nAlhascrackedakeymathematicalpuzzlefor\nexposure to radiation, the immune system takes a hit, the eye changes\nunderstandingourworld\nshape for the worse, and there's some significant loss in muscle and bone\nmass.\n04.\nAfter Trump fires CISA's director,the agency\nispoisedtobecomeevenmorepowerful\nBut we also learned about some surprising effects. Kelly experienced\nchanges in his gut microbiome, his cognitive abilities slowed down, certain\ngenes would turn off and on, and his chromosomes experienced structural\nchanges.\nSignupforTheAirlock-Yourgateway tothefuture of space\ntechnology\nEnteryouremail,getthenewsletter\nSign up\nStay updatedon MIT Technology Reviewinitiativesandevents?\nOYesONo\n\"The Twins Study gave us a first sketch of the human body's molecular\nresponses to spaceflight, but these outlines needed to be filled in,' says\nChristopher Mason, an associate professor of physiology and biophysics at\nWeill Cornell Medicine.\"The changes we saw needed more context and\nreplication. We needed additional studies to map out the frequency of the\nchanges we observed in other astronauts, and other organisms, that go into\nspace, and also to see if the degree of change was similar for shorter\nmissions.\"\nThat brings us to a new package of research that builds on the Twins Study.\nreanalyzing some of the original data with new techniques and providing\ncomparisons with other astronauts. In a set of 19 studies published today in\na slew of different journals (along with lo preprints still under peer review),\nresearchers like Mason (a senior author on 14 of the papers) studied the\nphysiological, biochemical, and genetic changes that occurred in 56\nastronauts (including Kelly) who have spent time in space--the largest\nstudy of its kind ever conducted.\nThe new papers, which incorporate results from cell-profiling and gene-\nsequencing techniques that have become easier to run only recently, reveal\nthat \"there are some features of spaceflight that consistently appear in\nhumans, mice, and other animals when they go to space,' says Mason.\n\"There appears to be a core mammalian set of adaptations and responses\nto the rigors of spaceflight.\"\nThe good, the bad, and the inexplicable\nThe researchers highlight six biological changes that occur in all astronauts\nduring spaceflight: oxidative stress (an excessive accumulation of free\nradicals in the body's cells), DNA damage, dysfunction of the\nmitochondria, changes in gene regulation, alterations in the length of\ntelomeres (the ends of chromosomes, which shorten with age), and\nchanges in the gut microbiome.\nOf these six changes, the biggest and most surprising one for scientists\nwas mitochondrial dysfunction. Mitochondria play a critical role in\nproducing the chemical energy necessary to keep cells-and by extension,\ntissue and organs-functional. Researchers found irregular mitochondrial\nperformance in dozens of astronauts and were able to broadly characterize\nthese changes thanks to new genomics and proteomics techniques. Afshin\nBeheshti, a bioinformatician at NASA and senior author of one study, says\nmitochondrial suppression helps explain how many of the problems\nastronauts experiment (like immune system deficiencies, disrupted\ncircadian rhythm, and organ complications) are actually holistically related\nto each other, since they all rely on the same metabolic pathways.\n\"When you'rein space,it's not just oneare or organ that's affected.it's the", "live": "MIT Technology Review\n三Menu\nSign in\nSUBSCRIBE\nThe Big Story\nClimate&energy\nAl Hype Index\nArtificialintelligence\nBiotech&health\n1oBreakthroughTechnologies\nThe Impossible issue\nSPACE\nSpaceflightdoessomeweirdthingstoastronauts'bodies\nThebiggest-ever study of astronauthealthgives us clues on what tolook for in futurelong-\nhaulspacemissions.\nBy Nee/ V.Patel\nNovember25,2020\nAstronautKarenNyburgusesafundoscopeforaneyeexaminationaboardtheInternationalSpaceStation.\nNASA\nAstronautScottKellyfamouslylivedandworkedontheInternational\nSpaceStationfor340daysthelongesttimeanAmericanhasspent\nin space.His mission gave scientists some vital insight into what\nPOPULAR\nhappens to the human body during long-duration stays in orbit.That's\nbecause Kelly has an identical twin, Mark (also an astronaut, and now\nDon'tbefooled-LLMsdon'treason\nsoon to be a US senator).The Kelly twins offered scientists a rare\nThoreGraepel\nopportunity: as they studied what happened to Scott's body during his\nyear in space, they had the benefit of a control subject, Mark, who\n\"Wewerelookingatitwrong\":Theexplosive\nstayed on Earth.\nclaim that'supendedtheAlworld\nWill Douglas Heaven\nThe NASA Twins Study provided more evidence for what we already\nDon'tbefooledbythissummerofAlhype\nsuspected.In a confined capsule under microgravityand prolonged\nTimnitGebru&EmilyM.Bender\nexposureto radiation, the immune system takes a hit, the eye changes\nshape for the worse, and there's some significant loss in muscle and\nAnAl\"mind-reading\"toolcanreconstruct\nbone mass.\nwhatyou'relookingatfromabrainscan\nJessicaHamzelou\nbonemass.\nJessicaHamzelou\nBut we also learned about some surprising effects. Kelly experienced\nchanges in his gut microbiome, his cognitive abilities slowed down,\ncertain genes would turn off and on, and his chromosomes\nexperienced structural changes.\n\"The Twins Study gave us a first sketch of the human body's\nmolecular responses to spaceflight, but these outlines needed to be\nfilled in,\" says Christopher Mason, an associate professor of\nphysiology and biophysics at Weill Cornell Medicine.\"The changes\nwe saw needed more context and replication. We needed additional\nstudies to map out the frequency of the changes we observed in other\nastronauts, and other organisms, that go into space, and also to see if\nthe degree of change was similar for shorter missions.\"\nThat brings us to a new package of research that builds on the Twins\nStudy, reanalyzing some of the original data with new techniques and\nproviding comparisons with other astronauts. In a set of 19 studies\npublished today in a slew of different journals (along with 10 preprints\nstill under peer review),researchers like Mason (a senior author on 14\nof the papers) studied the physiological, biochemical, and genetic\nchanges that occurred in 56 astronauts (including Kelly) who have\nspent time in space-the largest study of its kind ever conducted.\nThe new papers, which incorporate results from cell-profiling and\ngene-sequencing techniques that have become easier to run only\nrecently,reveal that\"there are some features of spaceflight that\nconsistently appear in humans, mice, and other animals when they go\nto space,\" says Mason. \"There appears to be a core mammalian set of\nadaptations and responses to the rigors of spaceflight.\"\nThe good, the bad, and the inexplicable\nThe researchers highlight six biological changes that occur in all\nastronauts during spaceflight: oxidative stress (an excessive\naccumulation of free radicals in the body's cells), DNA damage,\ndysfunction of the mitochondria, changes in gene regulation,\nalterations in the length of telomeres (the ends of chromosomes,\nwhich shorten with age), and changes in the gut microbiome.\nOf these six changes, the biggest and most surprising one for\nscientists was mitochondrial dysfunction. Mitochondria play a critical\nby extension, tissue and organs-functional. Researchers found\nirregularmitochondrialperformanceindozens ofastronauts and\nwere able to broadly characterize these changes thanks to new\ngenomics and proteomics techniques. Afshin Beheshti, a\nbioinformatician at NASA and senior author of one study, says\nmitochondrial suppression helps explain howmany oftheproblems\nastronauts experienced (like immune system deficiencies, disrupted\ncircadian rhythm,and organ complications)are actually holistically\nrelated to each other, since they all rely on the same metabolic\npathways.\n\"When you're in space, it's not just one are or organ that's affected,\nit's the whole body that's affected,\" says Beheshti.\"We started\nconnectingthedots.\"\nOther research homed in on problems observed at the genetic level.\nThe Twins Study showed that Kelly's telomeres got longer in space\nbefore shrinking back to normal or even shorter lengths soon after he", "image": "LAB1P3" } }, { "id": "cell2020-nasa", "study": "cell2020", "outlet": "NASA", "outlet_original": "NASA", "outlet_score": 9, "title": "Mitochondrial Changes Key to Health Problems in Space", "title_original": "Mitochondrial Changes Key to Health Problems in Space", "language": "English", "date": "2020-11", "kind": "press-release", "url": "https://www.nasa.gov/humans-in-space/mitochondrial-changes-key-to-health-problems-in-space/", "archive_url": "https://web.archive.org/web/20240111105922/https://www.nasa.gov/humans-in-space/mitochondrial-changes-key-to-health-problems-in-space/", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "NASA summary of a Cell study of data from 59 astronauts and animal studies, concluding that altered mitochondrial activity may be a common driver of health problems in space.", "topics": [ "mitochondria", "spaceflight", "cell", "genelab", "astronaut health" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/cell2020-nasa.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/cell2020-nasa--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-nasa.txt", "ocr_text": { "archived": "NASA\nMultimedia \nNews&Eventsv\nExplore\nSearch...\nNASA+LIVE\n4MINREAD\nMitochondrial Changes Key to\nHealth Problems in Space\nFrankTavares\nNOV25,2020\nARTICLE\nAstronautScottKellyisworkingwiththeMicrogravitySciencesGloveboxduringaRodent ResearchsessionwithBone\nDensitometer.\nNASA\nLiving in space isn't easy.Therearenotable impacts on thebiologyof living things intheharsh\nenvironment of space.Ateamof scientists has now identified a possibleunderlyingdriver of\nthese impacts:the powerhouse of the cell, called mitochondria, experiences changes in activity\nduring spaceflight.\nRecentlypublished inthejournal Cell,theseresults useddatacollectedoverdecadesof\nexperimental researchontheInternational SpaceStation, includingsamples from59\nastronauts.Studies such as these are critical to understanding the effects of lowgravity.\nradiation,confined spaces,andmore as NAsA sends astronauts deep into spacefor extended\nmissionstotheMoon,Mars,andbeyond.\n\"We'vefound a universal mechanism that explains thekinds of changes we see to thebodyin\nspace,and in a place we didn't expectsaid Afshin Beheshti the leadauthor on thepaperanda\nCalifornia's Silicon Valley.“Everything gets thrown out of whack and it all starts with the\nmitochondria.\"\nValery Boyko. lead of NASA GeneLab's SampleProcessing Lab.is setting upautomated liquid handling instrument toquantify\nValeryBoyko.lead ofNASA GeneLab'sSampleProcessing Lab.is setting upautomated liquid handling instrumenttoquantify\nthe amount of sequencing material ina sample.\nNASA/Dominic Hart\nThe research alsomade use of a comprehensive database of animal studies collected on the\nGeneLabplatformatAmes,aswellastheNASAtwinstudycomparingidentical twinsMarkand\nScott Kellyoverthecourseof ayear.TheGeneLabplatformisthefirst of itskind tocapture\nlarge amounts of spacebiology\"omicsdata that can be used to characterize and quantify\nbiological molecules-suchasDNA,RNA,and proteins-andtheir systematiceffectsonthe\nstructuresandfunctions of organisms.GeneLab'sAnalysisWorkingGroup drew inscientists\nfrom all over the world to collaborate on the studyand get themost out of the datahoused on\nthe open-source platform.\nMitochondria are tiny structures within cells that produce energy for the basic units of biology\nthat make up our bodies. When that energy production breaks down, many of the body's key\norgansand its immunesystemcanbeput in jeopardy.Thisnewresearch indicatesthis\nbreakdown inactivity ofmitochondria might contributetohealth or performance challenges\nfaced by humans in space.\nThe firstclue about theconnection betweenmitochondria and spaceflight came fromresearch\nusing rodents.\n\"When we started comparing thetissuesfrommiceflownon separate spacemissions,we\nnoticedthatmitochondrialdysfunctionkept poppingup,\"said Beheshti.\"Whetherwe were\nlooking atproblems inthe eyes orinthe liver,thesamepathwaysrelated tomitochondria were\nthe source of theproblem.\"\nNAsA'sdata on humans backedthis hypothesis up.Thechanges identified in astronaut Scott\nKelly's immune systemduring hisyear in space starting in2015maybeexplained bythe\nchanges observed in theactivity of his mitochondria as well.Blood and urine samples from\ndozens of otherastronauts showed further evidence that, in various types of cells,being in\nspace led to altered mitochondrial activity.\n\"This is a big step toward figuring out how our bodies can live healthily off-world,said Beheshti.\n\"And the good news is, this is a problem we can already start to tackle.We can look at\ncountermeasures and drugs we alreadyuse to deal withmitochondrial disorders on Earth to see\nhowtheymightwork inspace, tostart.\"\nFrom issues as wide-ranging as disrupted circadian rhythms to cardiovascular alterations,\nscientists cannowturntothis small but essential structurein cells asaplaceto continue\nresearchand look for solutions.Mitochondria are indeed the powerhouseof the cell,andmay\nalso power the future of space biologyresearch-pointing the way toward discoveries that will\nhelpastronauts live safely in orbit and beyond.\nFor news media:\nMembers of the news media interested in covering thistopic shouldreachout to the NASA\nAmes.newsroom.\nAuthor:FrankTavares,NASA'sAmesResearchCenter\nNASA\nHome\nHumans in Space\nAeronautics\nThe National Aeronautics and\nFollowNASA\nNews&Events\nEarth&Climate\nTechnology\nSpace Administration\nMultimedia\nThe Solar System\nLeaning Resources\nNASAexplorestheunknown in airand space,\nNASA+IVE\nThe Universe\nAbout NASA\ninnovates for the benefit of humanity,and inspires the\nMoreNASASocial Accounts\nScience\nMissions\nNASA en Espanol\nworldthroughdiscovery.\nNASANewsletters\nAboutNASA'sMission\nJoin Us\nPrivacy Policy\nSitemap\nFor Media\nFOIA\nNo FEAR Act\nOfficeof theIG\nBudget&Annual Reports\nAgency Financial Reports\nContact NASA\nAccessibility", "live": "NASA\nMultimedia v\nExplore\nNews&Eventsv\nSearch\nNASA+LIVE\n4MINREAD\nMitochondrial Changes Key to\nHealth Problems in Space\nFrank Tavares\nNOV25,2020\nARTICLE\nAstronaut Scott Kelly is working withtheMicrogravity Sciences Glovebox during a Rodent Research session withBone\nDensitometer.\nNASA\nLiving inspace isn'teasy.Therearenotable impacts onthebiologyof livingthings intheharsh\nenvironmentof space.Ateamof scientists has nowidentified a possibleunderlyingdriverof\nthese impacts: the powerhouse of the cell, called mitochondria, experiences changes in activity\nduring spaceflight.\nRecently published inthejournal Cell,theseresults used data collected overdecadesof\nexperimental researchon theInternational SpaceStation,includingsamples from59\nastronauts. Studies such as these are critical to understanding the effects of low gravity,\nradiation,confined spaces,andmoreasNAsAsends astronautsdeepinto spaceforextended\nmissions to the Moon, Mars,and beyond.\n\"We'vefoundauniversalmechanismthatexplainsthekindsofchangesweseetothebody in\nspace,and in a place we didn't expect'said Afshin Beheshti the lead author on the paper and a\nresearcherwithKBR,whichprovidescontractsupporttoNASA'sAmesResearchCenterin\nCalifornia's silicon Valley.\"Everything gets thrown out of whack and it all starts with the\nmitochondria\"\nValeryBoyko,teadofNASAGeneLab's SampleProcessing Lab.issettingupautomated liquid handlinginstrumenttoquantify\ntheamount of sequencing materialina sample.\nNASA/Dominic Hart\nTheresearch alsomadeuse ofacomprehensivedatabase of animal studies collected onthe\nGeneLabplatformatAmes,as wellastheNASAtwinstudycomparing identicaltwinsMark and\nScott Kelly over the course of a year. The GeneLab platform is the first of its kind to capture\nlarge amounts of spacebiology\"omicsdata that can be used to characterize andquantify\nbiological molecules-suchasDNA,RNA,and proteins-andtheir systematiceffectson the\nstructuresandfunctions oforganisms.GeneLab'sAnalysisWorking Groupdrewin scientists\nfrom all over the world to collaborate on the study and get the most out of the data housed on\nthe open-source platform.\nMitochondria are tiny structures within cells that produce energy for the basic units of biology\nthat make up our bodies. When that energy production breaks down,many of the body's key\norgansand its immune system can beputin jeopardy.This newresearchindicates this\nbreakdown in activity of mitochondria might contributeto healthor performance challenges\nfaced by humans in space.\nThe first clue about the connection betweenmitochondriaand spaceflight came fromresearch\nusing rodents.\n\"When we started comparing the tissues from mice flown on separate space missions, we\nnoticed that mitochondrial dysfunction kept popping up,\"said Beheshti.\"Whether we were\nlooking at problems in the eyes or in the liver,the samepathwaysrelated tomitochondria were\nthe sourceof theproblem.\"\nNAsA'sdata on humans backed this hypothesis up.Thechanges identified inastronaut Scott\nKelly's immunesystemduringhisyearinspacestarting in2015maybeexplainedbythe\nchanges observed in the activity of his mitochondria as well.Blood andurine samples from\ndozens of otherastronauts showed further evidence that,invarioustypes of cells,being in\nspace led to altered mitochondrial activity.\n\"This is a big steptoward figuring out howourbodies can live healthily off-world,\"said Beheshti.\n\"And the good news is, this is a problem we can already start to tackle. We can look at\ncountermeasures anddrugs wealreadyusetodeal withmitochondrialdisorders on Earthto see\nhow they might work inspace,to start.\"\nFrom issues as wide-ranging as disrupted circadian rhythms to cardiovascular alterations,\nscientistscannowturntothis small butessential structureincells asaplaceto continue\nresearch and look for solutions.Mitochondria are indeed the powerhouseof the cell,andmay\nalso power the future of space biologyresearch-pointing the way toward discoveries that will\nhelp astronauts live safely in orbit and beyond.\nFor news media:\nMembers of thenewsmedia interested in covering this topic shouldreachout to theNAsA\nAmesnewsroom.\nAuthor:FrankTavares,NASA'sAmesResearchCenter\nNASA\nHome\nHumans in Space\nAeronautics\nNational AeronauticsandSpace\nFollowNASA\nEarth\nNews&Events\nTechnology\nAdministration\nMultimedia\nThe Solar System\nLearningResources\nNASA explores theunknown in air and space,\nNASA+ [LIVE\nThe Universe\nAbout NASA\nMoreNASASocial Accounts\ninnovatesforthebenefitofhumanity,and inspiresthe\nScience\nMissions\nNASA en Espanol\nNASANewsletters\nworld throughdiscovery.\nAboutNASA's Mission\nJoin Us\nPrivacy Policy\nSitemap\nFor Media\nNo FEAR Act\nOffice of the IG\nFOIA\nAgency Financial Reports\nBudget&AnnualReports\nContact NASA\nAccessibility", "image": "ONONONE\nEVOLUTIONO\nCAUTION\nCANGER\nNOTICE" } }, { "id": "cell2020-cornell-chronicle", "study": "cell2020", "outlet": "Cornell Chronicle", "outlet_original": "Cornell Chronicle", "outlet_score": 6, "title": "Studies offer tips on lessening spaceflight-related risk", "title_original": "Studies offer tips on lessening spaceflight-related risk", "language": "English", "date": "2020-12", "kind": "press-release", "url": "https://news.cornell.edu/stories/2020/12/studies-offer-tips-lessening-spaceflight-related-risk", "archive_url": "https://web.archive.org/web/20201213004212/https://news.cornell.edu/stories/2020/12/studies-offer-tips-lessening-spaceflight-related-risk", "names_meydan": true, "meydan_context": "Credited with noticing that astronaut stress signatures, including IL-6 activation, resembled those in COVID-19 patients.", "passage_naming_meydan": "…ne and NewYork-Presbyterian patients with cancer and other conditions like COVID-19 to help match them with personalized therapies. That work led Cem Meydan, a senior staff scientist in Mason’s lab, to a startling discovery: Many of the stress signatures seen in astronauts were similar to COVID-19 patients. For example, an immune system protein cal…", "summary": "University story on Cell studies showing spaceflight, COVID-19 and high-altitude climbing provoke similar stress responses, with mutation and immune maps that could inform protection of space travelers.", "topics": [ "spaceflight", "stress response", "cell", "covid-19", "immune system" ], "audience": "institutional", "thumbnail": "media-archive/thumbs/cell2020-cornell-chronicle.jpg", "passage_image": "media-archive/mentions/cell2020-cornell-chronicle.jpg", "full_screenshot": "media-archive/shots/cell2020-cornell-chronicle--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-cornell-chronicle.txt", "ocr_text": { "archived": "MEDIARELATIONS\nCORNELL.EDU\nCORNELLCHRONICLE\nEDA.D\nCampus & Community\nTopics\nAll Stories\nExpert Quotes\nInthe News\nEzra Magazine\nScott Kelly/NASA\nThe Earth's atmosphere,featuring the aurora borealis, is picturedfrom the International Space Station.\nStudies offer tips on lessening spaceflight-related risk\nByBridget Kuehn|December4,2020\nSpace travel, illnesses like COVID-19 and climbing Mount Everest can trigger\nthe body's stress response systems in similar ways, according to new studies\nby Weill Cornell Medicine, space agencies and other investigators.\nThe discoveries, including new maps of the abundance of mutations and\nEarth-bound patients with illnesses that trigger similar physiological\nresponses.\nChristopher Mason, an associate professor of physiology and biophysics at\nWeill Cornell Medicine, led multiple studies by teams of investigators\nspanning four of the largest space agencies in the world - NASA; the Japan\nAerospace Exploration Agency (JAXA); the European Space Agency (ESA);\nand Russia's ROSCOSMOS - as well as academic institutions and industry\ngroups.\nThe teams investigated genetic, biochemical and physiological changes in 56\nastronauts, making it the largest study of astronauts to date; 581 total have\nCornell Graduate School of Medical Sciences student Kirill Grigorev, also\nbuilt an online portal, called an API, to analyze data from NASA's GeneLab\nRepository, which contains animal, plant and microbial data collected during\nNASA's space missions since the 1960s.\nTogether, the Weill Cornell Medicine and global teams on Nov. 25 published\n20 studies in special, coordinated issues and simultaneously featured on the\ncovers of the journals Cell, Cell Reports and iScience, as well as highlighted in\nCell Systems and Patterns. The large effort details the effects of space travel\non the human body and revealed potential prevention and treatment\napproaches that may allow longer term spaceflight, such as missions to Mars.\nwho also is co-director of the WorldQuant Initiative for Quantitative\nPrediction and the WorldQuant Research Scholar at Weill Cornell Medicine.\n\"We can start thinking at the molecular and cellular level about longer term\nmissions, and also what drugs, countermeasures and therapies could be tried\nto minimize the risks for astronauts.\"\nThe effort built on the results of NASA's Twins Study of astronauts Scott and\nMark Kelly from 2014-19, which looked at genetic, physiologic and behavioral\ncharacteristics in the identical twins before, during and after Scott completed\na one-year mission in space. Mark Kelly, who was recently elected to the U.S.\nSenate, stayed on Earth during the mission. That study revealed that Scott's\nbody underwent thousands of molecular and physical changes both while in\nspace and after returning to Earth. Among them was that the ends of his\nchromosomes, called telomeres, lengthened in space and shortened after his\nreturn. Lengthened telomeres have been linked to longer life, while shortened\nones have been linked to a greater risk of disease.\nIn the new studies, Mason and his colleagues were able to confirm that those\nsame telomere changes happened in all ll other astronauts for which they\nhad samples, and they also examined changes in telomerelength and DNA\ndamage using urine and plasma samples. They examined the unique\nmicrobiomes for each twin, as well their distinct clonal hematopoiesis,\nwhich is a measure of the number of blood cells that carry specific mutations\nand could represent a precancerous condition.\nEach twin showed distinct mutations in their blood and their genomes, and\nwhen compared to patients with cancer at Memorial Sloan Kettering (MSK),\nthe astronauts had larger changes. The investigators also found that\nthen increased when back on Earth.\nMason's team, including Daniela Bezdan, a research associate at the time of\nthe studies, applied new techniques such as single cell and cell-free DNA\nsequencing to study changes in individual cells like immune cells (B cells and\nT cells), as well as exosome profiling, in collaboration with Iwijn De\nVlaminck, the Robert N. Noyce Assistant Professor in Life Science and\nMelnick and David Lyden at Weill Cornell Medicine.\nThis helped show that spaceflight was associated with dysfunction in\nmitochondria, which provide the cells with energy, suggesting that the\nimmune cells may have disrupted functions. These signatures could be found\nin the blood as well as in urine, and utilized technology that is now being used\nfor somekidney transplantpatients.\nThe team confirmed that similar changes occur in mice and rats in space.\nThe team confirmed that similar changes occur in mice and rats in space.\n“The immune system is under a lot of stress when you are in space,\" said\nMason, who also is an associate professor of neuroscience in the Feil Family\nBrain and Mind Research Institute at Weill Cornell Medicine.\nNot all of the changes they saw were unique to astronauts. Mason worked\nwith a Nepalese team and Daniel Butler at Weill Cornell Medicine to obtain\nblood samples from climbers at the top of Mount Everest and bring them back\nby helicopter, where they were compared with samples from the climbers'\ntwins who were at sea level. Notably, individuals who climb Mount Everest\nexperience similar molecular changes, such as lengthened telomeres and\noxidative stress. This discovery suggests that some drugs used to treat\nextreme athletes may be useful for astronauts, and that medicines designed\nfor astronauts might be useful for those undergoing stress on Earth. Among\nthose that reduce inflammation or control muscle growth.\n“\"There are some conserved responses to really severe physiological stress,\nwhether you are in a space station or on top of the world's tallest mountain,\"\nsaid Mason, who's also a member of the Sandra and Edward Meyer Cancer\nCenter.\nIn addition to their work with NASA, Mason and the other members of his lab\nperform clinical and molecular profiling of Weill Cornell Medicine and\nNewYork-Presbyterian patients with cancer and other conditions like COVID-\n19 to help match them with personalized therapies. That work led\nCem\nMeydan\na senior staff scientist in Mason's lab, to a startling discovery: Many\nof the stress signatures seen in astronauts were similar to COVID-19 patients.\nheavily activated in both COVID-19 patients and astronauts, as well as many\ngenes related to the immune system. This molecule helps stimulate the\nregeneration of muscles after returning to Earth and gravity, but is also\ninvolved in inflammation.\n“Landing back on Earth, going from zero gravity to Earth's gravity after a year\nmay trigger some of the same stress responses on the body as having COVID-\n19, like IL-6, which has also been associated with severe inflammation,\"\nMason said.\nIn addition to other Weill Cornell Medicine faculty, graduate students and\npost-doctoral fellows, three medical students participating in the Aerospace\nMedicine Area of Concentration (AOC) program co-authored some of the\npapers, including Sonia Iosim, Nicholas Vernice and Timothy Donahoe.\nBased on their observations, Mason said he believes some of the long-term\nmolecular monitoring used on the astronauts might also be useful for\nmonitoring patients health. For example, if a cancer patient begins\naccumulating mutations similar to the way astronauts do in space, that may\nbe cause for concern. To answer this question, Mason is now leading along-\nterm study on clonal hematopoiesis for astronauts and comparing with other\ncohorts, with an inter-disciplinary team from Weill Cornell, Cornell, MSK,\nNASA (Afshin Beheshti) and Colorado State University (Susan Bailey).\n“These genetic and molecular studies help us better understand stress - not\njust for astronauts and people climbing Mount Everest, but for people for\npeople undergoing any type of extreme stress, like coronavirus, a heart attack,\npeople undergoing any type of extreme stress, like coronavirus, a heart attack,\nor sepsis,\" Mason said, “Or even for healthy people who want to be vigilant\nabout their long-term cardiovascular and cancer risk. The body's myriad\nmolecules all tell a story, and if you listen to them, they reveal the trajectory\nof both health and disease.\"\nBridget Kuehn is a freelance writer for Weill Cornell Medicine.\nCoronavirus\nGlobal Reach\nHealth, Nutrition & Medicine\nMEDIAINQUIRIESY\nYOU MIGHT ALSO LIKE\nWeill-NASA study of Kelly twins\nStress-fighting proteins could lead\nyields new insights, DNA sequencing\nto asthma treatments\ntools\nLINKS\nCONTACT\nSUBSCRIBE\nAbout the Chronicle\nCorhell Chronicle\nMDailyand weekly newsletters\nMedia Relations Office\n312 College Ave\nFeeds-RSS&JSON\nCopyright\nIthaca,NY 14850\nWebAccessibility Assistance\n607-255-4206\ncunews@cornell.edu", "live": "MEDIARELATIONS\nCORNELL.EDU\nCORNELLCHRONICLE\nEDA.\nCampus & Community\nTopics\nAll Stories\nPodcast\nMedia Relations\nCornellians\nScott Kelly/NASA\nThe Earth's atmosphere,featuring the aurora borealis, is picturedfrom the International Space Station.\nStudies offer tips on lessening spaceflight-related risk\nBy Bridget Kuehn\nDecember4,2020\nSpace travel, llnesses like COVID-19 and climbing Mount Everest can trigger\nthe body's stress response systems in similar ways, according to new studies\nby Weill Cornell Medicine, space agencies and other investigators.\nThe discoveries, including new maps of the abundance of mutations and\nimmune changes found in blood cells during spaceflight, may lead to new\nways to protect space travelers. They may also provide insights on caring for\nEarth-bound patients with llnesses that trigger similar physiological\nresponses.\nChristopher Mason, an associate professor of physiology and biophysics at\nWeill Cornell Medicine, led multiple studies by teams of investigators\nspanning four of the largest space agencies in the world - NASA; the Japan\nand Russia's ROSCOSMOS - as well as academic institutions and industry\ngroups.\nThe teams investigated genetic, biochemical and physiological changes in 56\nastronauts, making it the largest study of astronauts to date; 581 total have\nCornell Graduate School of Medical Sciences student Kirill Grigorev, also\nbuilt an online portal, called an API, to analyze data from NASA's GeneLab\nRepository, which contains animal, plant and microbial data collected during\nNASA's space missions since the 1960s.\nTogether, the Weill Cornell Medicine and global teams on Nov. 25 published\n20 studies in special, coordinated issues and simultaneously featured on the\ncovers of the journals Cell, Cell Reports and iScience, as well as highlighted in\nCell Systems and Patterns. The large effort details the effects of space travel\non the human body and revealed potential prevention and treatment\napproaches that may allow longer term spaceflight, such as missions to Mars.\nwho also is co-director of the WorldQuant Initiative for Quantitative\nPrediction and the WorldQuant Research Scholar at Weill Cornell Medicine.\nWe can start thinking at the molecular and cellular level about longer term\nmissions, and also what drugs, countermeasures and therapies could be tried\nto minimize the risks for astronauts.\nThe effort built on the results of NASA's Twins Study of astronauts Scott and\nMark Kelly from 2014-19, which looked at genetic, physiologic and behavioral\ncharacteristics in the identical twins before, during and after Scott completed\na one-year mission in space. Mark Kelly, who was recently elected to the U.s.\nSenate, stayed on Earth during the mission. That study revealed that Scott's\nbody underwent thousands of molecular and physical changes both while in\nspace and after returning to Earth. Among them was that the ends of his\nchromosomes, called telomeres, lengthened in space and shortened after his\nreturn. Lengthened telomeres have been linked to longer life, while shortened\nones have been linked to a greater risk of disease.\nIn the new studies, Mason and his colleagues were able to confirm that those\nsame telomere changes happened in all 1l other astronauts for which they\nhad samples, and they also examined changes in telomere length and DNA\ndamage using urine and plasma samples. They examined the unique\nmicrobiomes for each twin, as well their distinct clonal hematopoiesis,\nwhich is a measure of the number of blood cells that carry specific mutations\nand could represent a precancerous condition.\nEach twin showed distinct mutations in their blood and their genomes, and\nwhen compared to patients with cancer at Memorial Sloan Kettering (MSK),\nthe astronauts had larger changes. The investigators also found that\nspaceflight reduced the abundance of these types of mutations, but that they\nthen increased when back on Earth.\nMason's team, including Daniela Bezdan, a research associate at the time of\nthe studies, applied new techniques such as single cell and cell-free DNA\nsequencing to study changes in individual cells like immune cells (B cells and\nT cells), as well as exosome profiling, in collaboration with Iwijn De\nVlaminck, the Robert N. Noyce Assistant Professor in Life Science and\nTechnology in the Meinig School of Biomedical Engineering, and Drs. Ari\nMelnick and David Lyden at Weill Cornell Medicine.\nThis helped show that spacefight was associated with dysfunction in\nmitochondria, which provide the cells with energy, suggesting that the\nimmune cells may have disrupted functions. These signatures could be found\nin the blood as well as in urine, and utilized technology that is now being used\nfor somekidney transplantpatients.\nThe team confirmed that similar changes occur in mice and rats in space.\n\"The immune system is under a lot of stress when you are in space,\" said\nMason, who also is an associate professor of neuroscience in the Feil Family\nBrain and Mind Research Institute at Weill Cornell Medicine.\nNot all of the changes they saw were unique to astronauts. Mason worked\nwith a Nepalese team and Daniel Butler at Weill Cornell Medicine to obtain\nblood samples from climbers at the top of Mount Everest and bring them back\nby helicopter, where they were compared with samples from the climbers'\ntwins who were at sea level. Notably, individuals who climb Mount Everest\nexperience similar molecular changes, such as lengthened telomeres and\noxidative stress. This discovery suggests that some drugs used to treat\nextreme athletes may be useful for astronauts, and that medicines designed\nfor astronauts might be useful for those undergoing stress on Earth. Among\nthe existing drugs they cataloged and compared with the stress profiles are\nthose that reduce inflammation or control muscle growth.\n“There are some conserved responses to really severe physiological stress,\nsaid Mason, who's also a member of the Sandra and Edward Meyer Cancer\nCenter.\nIn addition to their work with NASA, Mason and the other members of his lab\nperform clinical and molecular profiling of Weill Cornell Medicine and\nNewYork-Presbyterian patients with cancer and other conditions like COVID-\n19 to help match them with personalized therapies. That work led\nCem\nMeydan\na senior staff scientist in Mason's lab, to a startling discovery: Many\nof the stress signatures seen in astronauts were similar to COVID-19 patients.\nFor example, an immune system protein called interleukin-6 (IL-6) was\nheavily activated in both COVID-19 patients and astronauts, as well as many\ngenes related to the immune system. This molecule helps stimulate the\nregeneration of muscles after returning to Earth and gravity, but is also\ninvolved in inflammation.\n\"Landing back on Earth, going from zero gravity to Earth's gravity after a year\nmay trigger some of the same stress responses on the body as having COVID-\n19, like IL-6, which has also been associated with severe inflammation,\nMason said.\nIn addition to other Weill Cornell Medicine faculty, graduate students and\npost-doctoral fellows, three medical students participating in the Aerospace\nMedicine Area of Concentration (AOC) program co-authored some of the\npapers, including Sonia Iosim, Nicholas Vernice and Timothy Donahoe.\nBased on their observations, Mason said he believes some of the long-term\nmolecular monitoring used on the astronauts might also be useful for\nmonitoring patients' health. For example, if a cancer patient begins\naccumulating mutations similar to the way astronauts do in space, that may\nbe cause for concern. To answer this question, Mason is now leading along-\nterm study on clonal hematopoiesis for astronauts and comparing with other\ncohorts, with an inter-disciplinary team from Weill Cornell, Cornell, MsK,\nNASA (Afshin Beheshti) and Colorado State University (Susan Bailey).\n“These genetic and molecular studies help us better understand stress - not\njust for astronauts and people climbing Mount Everest, but for people for\njust for astronauts and people climbing Mount Everest, but for people for\npeople undergoing any type of extreme stress, like coronavirus, a heart attack,\nor sepsis,\" Mason said, \"Or even for healthy people who want to be vigilant\nabout their long-term cardiovascular and cancer risk. The body's myriad\nmolecules all tell a story, and if you listen to them, they reveal the trajectory\nof both health and disease.\"\nBridget Kuehn is a freelance writer for Weill Cornell Medicine.\nGlobal Reach\nCoronavirus\nHealth, Nutrition & Medicine\nMEDIAINQUIRIESY\nGet Cornell news delivered right to your inbox.\nSUBSCRIBE\nYOU MIGHT ALSO LIKE\nWeill-NASA study of Kellytwins\nStress-fighting proteins could lead\nyields new insights, DNA sequencing\ntoasthmatreatments\ntools\nLINKS\nCONTACT\nSUBSCRIBE\nAbout the Chronicle\nComell Chronicle\nMDailyandweekly newsletters\nSitemap\n120 Maple Ave.\nFeeds-RSS&JSON\nCopyright\nIthaca,NY14850\n@Podcasts\nWebAccessibilityAssistance\ncunews@cornell.edu\nUniversity Relations" } }, { "id": "cell2020-nrg", "study": "cell2020", "outlet": "Nature Reviews Genetics", "outlet_original": "Nature Reviews Genetics", "outlet_score": 7, "title": "Spaceflight causes mitochondrial stress", "title_original": "Spaceflight causes mitochondrial stress", "language": "English", "date": "2020-12", "kind": "news", "url": "https://www.nature.com/articles/s41576-020-00322-8", "archive_url": "https://web.archive.org/web/20211102080638/https://www.nature.com/articles/s41576-020-00322-8", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Research highlight of the Cell paper integrating multi-omics data from NASA GeneLab and 59 astronauts, implicating mitochondrial stress as a central driver of spaceflight risk, partly confirmed using Twins Study data.", "topics": [ "mitochondria", "multi-omics", "genelab", "spaceflight", "cell" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/cell2020-nrg.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/cell2020-nrg--archived.jpg", "saved_html": "media-archive/html/cell2020-nrg--archived.html", "saved_article_text": "media-archive/text/cell2020-nrg.txt", "ocr_text": { "archived": "naturereviewsgenetics\nView all journals\nSearchQ\nLogin@\nAbout the journal y\nSubscribe\nExplore content\nSign up for alerts \nPublish with usy\nRSS feed\nnature >nature reviews genetics >in brief >article\nIn BriefPublished:15December2020\nGENOMICS\nSpaceflightcauses mitochondrial stress\nDorothy Clyde\nNatureReviews Genetics 22,69(2021)Citethisarticle\n482Accesses2AltmetricMetrics\nIn this Cell article, the health risks of spaceflight are investigated by a wide-ranging analysis\nof transcriptomic,epigenomic, proteomic and metabolomic data from NASA's GeneLab.\nGeneLabcontainsdatafor59astronautsandhundredsofsamplesthathavebeenflownin\nspace, including mouse strains, human cell models,and mouse and humantissues.Pathway\nanalysesimplicatedmitochondrialstress anddysregulationasmajordriversofhealthrisks,\nandsomekeyfindingswereconfirmedusingdatafromtheNASATwinstudy\nAccessoptions\nRent or Buy\nSubscribeto\narticle\nJournal\nGet time limited orfull article\nGet full journal access for 1\naccess on ReadCube.\nyear\n$8.99\nfrom\n$59.00\nonly $4.92perissue\nRent or Buy\nSubscribe\nAllprices are NET prices.\nAll prices are NET prices.\nVAT will be added later in thecheckout.\nTax calculation will be finalised during checkout.\nAdditionalaccessoptions:\nLogin\nLearn about institutional subscriptions\nReferences\nOriginal article\nda Silveira, W.A. et al. Comprehensive multi-omics analysis reveals mitochondrial stress as\na central biological hub for spaceflight impact. Cell183, 1185-1201 (2020)\nArticle Google Scholar\nDownload references\nAuthorinformation\nAffiliations\nNatureReviews Genetics\nDorothy Clyde\nCorresponding author\nCorrespondence to Dorothy Clyde.\nRights and permissions\nReprintsandPermissions\nAbout this article\nCite this article\nCheck for\nClyde, D. Spaceflight causes mitochondrial stress. Nat Rev Genet 22, 69 (2021).\nupdates\nhttps://doi.org/10.1038/s41576-020-00322-8\nDownload citation\nPublished\nIssue Date\n15December2020\nFebruary 2021\nhttps://doi.org/10.1038/s41576-020-00322-8\nSubjects\nEpigenomics\nGenomics\nMetabolomics\nProteomics\nTranscriptomics\nNature Reviews Genetics (Nat Rev Genet)ISSN 1471-0064 (online)ISSN 1471-0056 (print)\nnatureportfolio\nAboutus Pressreleases Pressoffice\nContactus\nDiscover content\nPublishing policies\nAuthor&Researcherservices\nLibraries&institutions\nJournals A-Z\nNature portfolio policies\nReprints &permissions\nLibrarianservice&tools\nResearchdata\nArticles by subject\nOpenaccess\nLibrarian portal\nNano\nLanguage editing\nOpen research\nProtocol Exchange\nScientific editing\nRecommendto library\nNature Index\nNature Masterclasses\nNatureResearchAcademies\nAdvertising&partnerships\nRegional websites\nCareerdevelopment\nLegal & Privacy\nAdvertising\nNature Africa\nNature Careers\nPrivacy Policy\nPartnerships & Services\nNature Conferences\nNature China\nUse of cookies\nMedia kits\nNatureevents\nNature India\nManagecookies/Donot sell mydata\nBranded content\nNature Italy\nLegal notice\nNature Japan\nAccessibilitystatement\nNature Korea\nTerms&Conditions\nNature Middle East\nCalifornia Privacy Statement\nSPRINGERNATURE\n2021SpringerNatureLimited\nnature briefing\nEmail address\ne.g.jo.smith@university.ac.uk\nSign up\nSignupfortheNatureBriefingnewsletter\nwhat matters in science,freeto your\nIagree my information will be processed in accordance with the Natureand\ninbox daily.\nSpringer Nature Limited Privacy Policy.", "live": "naturereviewsgenetics\nSaved research\nView all journals\nSearch\nLog in\nSign up for alerts \nAbout thejournal v\nPublish with usv\nExplore content v\nRSS feed\nnature >nature reviews genetics >in briefs >article\nInBriefPublished:15December2020\nYou have full access to this article via CORNELL\nGENOMICS\nUNIVERSITY LIBRARY.\nSpaceflightcauses mitochondrialstress\nDownloadPDF\nDorothy Clyde\nNature Reviews Genetics 22,69 (2021)Cite this article\nSections\nReferences\nSave article\n769 Accesses 2 Citations 2 Altmetric |Metrics\nReferences\nAuthor information\nInthis Cellarticle,thehealthrisks of spaceflight are investigatedbya wide-ranginganalysisof\nRights and permissions\ntranscriptomic,epigenomic,proteomicandmetabolomicdatafromNASA'sGeneLab.GeneLab\nAbout this article\nYour privacy, your choice\nWe use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as\nto allow video information to be shared for both marketing,analytics and editorial purposes.\nBy accepting optional cookies,you consent to the processing of your personal data-including transfers to third parties. Some third parties are outside of the European\nEconomicArea,withvaryingstandardsofdata protection.\nSee our privacy policy for more information on the use of your personal data.\nManage preferences for further information and to change your choices.\nAcceptall cookies\nReject optional cookies\nDownload references+\nAuthorinformation\nAuthors and Affiliations\nNatureReviews Genetics http://www.nature.com/nrg/\nDorothy Clyde\nCorresponding author\nCorrespondencetoDorothyClyde.\nRights and permissions\nReprintsandpermissions\nAbout this article\nCite this article\nClyde, D. Spaceflight causes mitochondrial stress. Nat Rev Genet 22, 69 (2021).\nCheckfor\nupdates\nhttps://doi.org/10.1038/s41576-020-00322-8\nDownload citation+\nPublished\nVersion of record\nIssue date\n15December2020\n15December2020\nFebruary 2021\nDOI\nhttps:/doi.org/10.1038/s41576-020-00322-8\nShare this article\nAnyone you share the following link with will be able to read this content:\nGet shareable link\nProvidedby the SpringerNatureShareditcontent-sharing initiative\nSubjects\nMetabolomics\nEpigenomics\nGenomics\nProteomics\nTranscriptomics\nBiological Responsesto Simulated Microgravity\nNature Reviews Genetics (Nat Rev Genet)ISSN1471-0064 (online)ISSN1471-0056 (print)\nDiscover content\nAbout Nature Portfolio\nPublishing policies\nAuthor&Researcherservices\nAbout us\nJournals A-Z\nNature portfolio policies\nReprints&permissions\nPress releases\nArticles by subject\nOpen access\nResearch data\nPress office\nprotocols.io\nLanguage editing\nContact us\nNature Index\nScientific editing\nNature Masterclasses\nResearch Solutions\nAdvertising &partnerships\nLibraries& institutions\nProfessional development\nRegional websites\nAdvertising\nNature Awards\nLibrarian service&tools\nNature Africa\nLibrarian portal\nPartnerships &Services\nNature Careers\nNature China\nOpen research\nMedia kits\nNature Conferences\nNature India\nRecommend to library\nBranded content\nNature Japan\nNature Middle East\nPrivacy Policy\nLegal notice\nUseof cookies\nYourprivacychoices/Managecookies\nAccessibilitystatement\nTerms&Conditions\nYour US state privacy rights\nSPRINGERNATURE\n2026SpringerNature Limited\nnaturebriefing\nEmail address\ntranslational research\ne.g.jo.smith@university.ac.uk\nSign up for the Nature Briefing:\nSign up\nTranslational Research newsletter-top\nI agreemy information will be processed in accordancewith theNatureand\nstories in biotechnology,drug discovery\nSpringer Nature Limited Privacy Policy.\nand pharma." } }, { "id": "cell2020-cen", "study": "cell2020", "outlet": "C&EN (Chemical & Engineering News)", "outlet_original": "C&EN (Chemical & Engineering News)", "outlet_score": 7, "title": "Spaceflight disrupts mitochondrial function", "title_original": "Spaceflight disrupts mitochondrial function", "language": "English", "date": "2020-12", "kind": "news", "url": "https://cen.acs.org/biological-chemistry/biochemistry/Spaceflight-disrupts-mitochondrial-function/98/web/2020/12", "archive_url": "https://web.archive.org/web/20201209144315/https://cen.acs.org/biological-chemistry/biochemistry/Spaceflight-disrupts-mitochondrial-function/98/web/2020/12", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Covers a Cell study analyzing data from mice, cell lines and 59 astronauts in NASA's GeneLab, suggesting mitochondrial dysfunction as a shared driver of spaceflight's varied bodily effects.", "topics": [ "mitochondria", "spaceflight", "genelab", "astronauts", "cell" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/cell2020-cen.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/cell2020-cen--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-cen.txt", "ocr_text": { "archived": "ACS\nC&EN\nCAS\nBecome a Member\nPublications\nLogin\nc&en\nTOPICS-\nMAGAZINE\nCOLLECTIONS-\nVIDEOS\nJOBS\n2/3FREEARTICLESLEFTTHISMONTH\nChemistry matters. Join us to get the news you\nneed.\nSEEMYOPTIONSOrLOG IN\nBIOCHEMISTRY\nSpaceflight disrupts mitochondrial function\nCell's energy-producing compartments link many physiological effects of a tripto space\nbyAllaKatsnelson,specialtoc&EN\nDECEMBER1,2020\n20201201lnp2-mitochjpg\nSHARE\nMOSTPOPULARIN\nCredit:Don W.Fawcett/Science Source\nMitochondria,the cell's O0.5-10 μm-wide energy producers, are at the center of the physiological changes caused by\nBIOLOGICALCHEMISTRY\nspaceflight.\nProtein folding: Much more intricate\nthan we thought\npaceflightisnopicnicforthebody.Musclesatrophy,bonesthin,arteriesstiffen,\nCanyouget coVID-19 in the bathroom?\ninflammationspikes,visiondeteriorates-andthat's justforstarters.But anewstudy\nshows thatthesedisparate effectsmight havea common cause:out-of-whack activity in\nGenetic studysuggests that people's\nin\nblood type may affecttheircoviD-19\nmitochondria, the energy-producing compartments in living cells (Cell 2020, DOl:\nrisk\n10.1016/j.cell.2020.11.002).Thestudyis oneofa collection ofpapers on thebiological effects\nHowweknow disinfectantsshould kill\nof spaceflight published last week in Cell.\nthe CovID-19 coronavirus\nTheresearchersanalyzedphysiologicaldatacollected inspacefrommice,mammaliancell lines,\nWhat do we know about the novel\ncoronavirus's 29 proteins?\nand 59astronauts.All of these data had been deposited in NASA's open-source GeneLab database.\nThese data include levelsofgenes,proteins,metabolites,and other physiological markers.\"The\nPeriodic Graphics: Toxins in fruits and\nvegetables\nquestion was, istherea common switch thatis systematically drivingalotof [thebody's] responses\nGeneLabandwho led the study.\"The thingthatkept popping upoverand overagain is\nmitochondrial activity.\"\nThe researchersfoundthat acrossdifferenttypes of human cells,spaceflight induces changes in\nlevelsofmitochondria-relatedmetabolitesand inexpressionofgenesregulatingkeymitochondrial\nfunctions-includingsynthesizingtheenergy-carryingmoleculeadenosinetriphosphateand\noxidizingnutrients.Changesseen inmultipletypesofmousetissues and in livingmicesentto space\nparalleled those present inastronauts.This held forboththeTwins study-which compared\nastronautsand identicaltwinsMarkand ScottKellyafterScottspentclosetoayearinspacewhile\nMark remained on Earth-andforbloodand urine samples from otherastronauts.\nScientistsstudyingspecificphysiological responsesto\nSign up for C&EN's must-read\nspace hadflagged mitochondrial effects before, says\nweekly newsletter\nBeheshti, but bytakingabird's-eye view,the\nresearcherscouldformamorecompletepictureof\nwhat happens in the body.For example,\nSubscribe\nEmail Address\nmitochondrial activity in muscle tissueis stymied,but\nin the liver it is strongly upregulated.That may be\nContact us to opt out anytime\nbecause the livertriesto regenerate some\nmitochondriatotrytopotentiallyrescuesomeofthe\ndamage being done in muscle, he says.\nAnobvious nextstep,Beheshti says,istostudywhetherpharmaceutical therapiesthatarealready\napproved to treat mitochondrial diseases or known nutritional interventions that supportthese\norganelles'function might alleviate some of the negative effects of space radiation and antigravity.\n\"Mitochondria are well-known to be exquisitely sensitiveto environmental stresses such ashigh\naltitude,cold,andheat exposure,\"says Adam Chicco,who studiesmitochondrial physiology on\nEarth and inspace at ColoradoState Universityand wasnot involved inthenew work.Thenewstudy\ninvestigatinghowmitochondrialresponsesmightaffect differentbodysystems,Chiccosays.\nChemical&EngineeringNews\nISSN0009-2347\nCopyright @2020 American Chemical Society\nYOUMIGHT ALSO LIKE..\nServingthe\nchemical, life science,\nand laboratory worlds\nASTROCHEMISTRY\nBIOLOGICAL CHEMISTRY\nBIOLOGICAL CHEMISTRY\nSmall biochemical\nHigh-salt diet throws\nPossible molecular\nmicrobiome out of\nchanges after year in\nmechanism behind\nwhack\nspace\ngastricbypass\nsurgeryidentified\nCOMMENTS\nJames Davis\n(December3,20203:21PM)\nSo...Might this have merit or be of interest? An animal study (ISs) in which there are two groups -one in which the\nthen comparison of their mitochondria give insight into whether it is a lack of gravity that is the cause of\nmitochondrialdifferences versus,say,cosmicradiationexposure?\nReply\"\nJamesDavis\n(December3,20203:21PM)\nSo...Might this have merit or be of interest? An animal study (ISS) in which there are two groups -one in which the\nanimals are maintained in\"artificial gravity\"[i.e.,a spinning wheel environment] and a control that is not.Might\nthen comparison of their mitochondria give insight into whether it is a lack of gravity that is the cause of\nmitochondrial differencesversus,say,cosmicradiationexposure?\nReply\"\nLEAVEACOMMENT\nName\nEmail*\nComments by first-time contributorswill bereviewed priortoappearing on the site.This review isdone byhumans and not\nalways immediately. Yotu may be laudatory or critical, but please stay on topic and berespectful of the author and your\nfellow readers.Wereservetherighttoremoveany commentsthatareprofane,obscene,abusive,orotherwise\ninappropriate. Email addresses are required so.that we can verify you are not a robot overiord and in case we need to\nSubmit\n*Required to comment\nABOUT\nACS\nFOLLOW US\nc&en\nChemistry for Life\nCHEMICAL&ENGINEERINGNEWS\nAbout Us\nJoin Acs\nAdvertise\nRenewMembership\nContact C&EN\nAcs Network\nEmail Address\nSubscribe\"\nSignupfor C&EN's must-read weekly newsletter\nBy clickingSubscribe'you agree to receive C&EN;'snewsletter and provide permission.for American Chemical Society (ACS\nPublications and C&EN) toemail youin accordance withthe ACS PrivacyPolicy\nCopyright2020American Chemical Society.All Rights Reserved.\nHelpIPrivacyPolicyITermsofUse", "live": "This website utilizes technologies such as cookies and others such as piano.io to enable essential sitefunctionality,as well asfor\nManage Preferences\nWTrending:\nNobelPrizes.\nLabSafetyandInnovation\nClimateSolutions\nArtificial Intelligence\nBiochemistry\nSpaceflight disrupts\nmitochondrial function\nspace\nbyAllaKatsnelson,specialtoC&EN\nDecember1,2020.3minread\nSHARE <\nSAVE\nSpaceflight is no picnic for the\nbody. Muscles atrophy, bones thin,\narteries stiffen, inflammation\nspikes, vision deteriorates-and\nthat's justfor starters.Buta new\nstudy shows that these disparate\neffects might have a common\ncause: out-of-whack activity in\nmitochondria, the energy-\nproducing compartments in living\ncells (Cell 2020, DOI:\n10.1016/j.cell.2020.11.002). The\nstudy is one of a collection of\npapers on the biological effects of\nMitochondria,the cell's 0.5-10 μm wide\nspaceflight published last week in\nenergyproducers,areatthecenterofthe\nphysiological changes caused by\nCell.\nspaceflight.\nCredittDon w. Fawcett/Science Source\nThe researchers analyzed\nphysiological data collected in\nspace from mice, mammalian cellines, and 59 astronauts. All of these\ndata had been deposited in NASA's open-source GeneLab database. These\ndata include levels of genes, proteins, metabolites, and other physiological\nmarkers.\"The question was, Is there a common switch that is\nsystematically driving a lot of [the body's] responses and connecting them\ntogether?\"says Afshin Beheshti, a NASA bioinformatician who works on\nGeneLab and who led the study. “The thing that kept popping up over and\nover again is mitochondrial activity.\"\nThe researchers found that across different types of human cells,\nspaceflight induces changes in levels of mitochondrion-related metabolites\nand in expression of genes regulating key mitochondrial functions-\nincluding synthesizing the energy-carrying molecule adenosine\ntriphosphate and oxidizing nutrients. Changes seen in multiple types of\nmouse tissues and in living mice sent to space paralleled those present in\nastronauts.This held for both the Twins Study-which compared\nastronauts and identical twins Mark and Scott Kelly after Scott spent close\ntoayearin spacewhileMarkremained onEarth-andforblood and urine\nsamples from other astronauts.\nmitochondrial effects before, says Beheshti, but by taking a bird's-eye view,\nthe researchers could form a more complete picture of what happens in the\nthe researchers could form a more complete picture of what happens in the\nbody. For example, mitochondrial activity in muscle tissue is stymied, but\nin the liver it is strongly upregulated. That may be because the liver tries to\nregenerate some mitochondria to try to potentially rescue some of the\ndamage being done in muscle, he says.\nAn obvious next step,Beheshti says, is to study whether pharmaceutical\ntherapies that are already approved to treat mitochondrial diseases or\nknown nutritional interventions that support these organelles'function\nmight alleviate some of the negative effects of spaceradiation and\nantigravity.\n\"Mitochondria are well known to be exquisitely sensitive to environmental\nstresses such as high altitude, cold, and heat exposure, says Adam Chicco,\nwho studies mitochondrial physiology on Earth and in spaceat Colorado\nState University and was not involved in the new work. The new study\nsupports their sensitivity to spaceflight as well and provides a\n\"comprehensive blueprint\"for investigating howmitochondrial responses\nmight affect different body systems, Chicco says.\nSendthereporterfeedback\nChemical & Engineering News\nISSN0009-2347\nSubmitaLettertothe Editorfor\nCopyright 2026 American Chemical\npublication\nSociety\nEnjoyed the article?\nShare \nSpaceflight disrupts\nmitochondrial\nfunction\nCell's energy-producing\ncompartments link many\nphysiological effects ofatrip\nto space\ncen.acs.org\nMore In Biochemistry\nEditor's Picks\nPopular\nCyclo-octasulfur\nMedicinesfor All\nChemistry in\nScientists spya\nCustom genetic\nuses chemistryto\nPictures:Practice\ncrown-shaped sulfur\ncodescannowbe\nimprove global\nmakesperfect\nring in mammalian\ncreated withease\nhealth\nproteins\ncells\nSeptember 15,2026 <\nOctober27.2026\nOctober 21,2026<\nSeptember 28, 2826 <\nMeetthemolecules of\nthe year 2026\nOctober 26,\n2026\nHowAndeshantavirus\ngrabs hold of human\ncells\nSuppressortRNAs\nDecades-old\nCryo-EM uncovers\nrestore cystic\ncompound drives\nnewtransitionstate\nOctober 23.\n2026\nrestorecystic\nOctober 23.\ncompound drives\nnewtransitionstate\n2026\nfibrosis protein in\nweightloss without\nfor avoltage-gated\nmodels\ncurbing appetite in\npotassium pore\nBusinessWatch:Upstate\nmice\nNew York gets big rare\nSeptember 3,2826<\nAugust 26. 2026 \nearthfacility,andmore\nAugust 26, 2826 <\nOctober 27.\n2026\nNewmembranedisarms\nPFAS\nOctober 26,\n2026\nC&EN'sElementsNewsletter\nChemistryNewsThatMatters\nStayontopofthechemistryworldwithyour\nC&ENempowers thoseinandaroundtheglobal\neditor-curatedroundupofC&EN stories\nchemical enterprise\nSubscribeto C&EN>\nEmail Address\nSubscribe\nPrivacy Policy\nC&ENMOBILEAPP\nSubscribe\nAcSChemistry Careers\nThe Edge in\nFOLLOWC&EN\nAbout C&EN\nJoin AcS\nDownloadon the\nAppStore\nin\nChemistry\nContact\nRenewMembership\nAcs Network\nAdvertise\nGETITON\nGoogle Play\nNews\nAcsBrandlab\nCAS\nAcSPublications\nStandards&Practices\nc&en\n@ACS\nHelp Accessibility Statement Privacy Policy Terms of Use Site Map Manage Cookies\nCHEMICAL&ENGINEERINGNEWS" } }, { "id": "cell2020-consortium", "study": "cell2020", "outlet": "Cell Press", "outlet_original": "Cell Press", "outlet_score": 7, "title": "The Biology of Spaceflight (Cell Press consortium landing page)", "title_original": "The Biology of Spaceflight (Cell Press consortium landing page)", "language": "English", "date": "2020-11", "kind": "interactive", "url": "https://www.cell.com/consortium/the-biology-of-spaceflight", "archive_url": "https://web.archive.org/web/20250805144409/https://www.cell.com/consortium/the-biology-of-spaceflight", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Cell Press landing page for a special collection of spaceflight biology papers, from NASA and international collaborators, covering radiation, microgravity, astronaut samples and multi-omics standards, and preparation for Mars missions.", "topics": [ "spaceflight", "astronaut health", "multi-omics", "nasa", "cell press" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/cell2020-consortium.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/cell2020-consortium--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-consortium.txt", "ocr_text": { "archived": "Science that inspires\nACell Pressresource\nPCelPress\nSubmitLog inRegister\nAbout Cell Press\nJournals\nPublish\nNews&events\nAdvanced\nSearch for...\nsearch\nIntroduction\nRadiation risks\nSpaceflight considerations\nBiological impacts\nMicrogravity\nFeatured journals\nWork inprogressandrelatedmanuscripts\nRelatedresources\nContributing lab groups\nConsortia Hub\nThe biology of spaceflight\nAs humankind reachesfor the stars to journey to thenext frontier in space,research on spaceflight biology is critical for understanding how living systems,\notherCellPress journals,includesresearcharticles,shortcommunications,andareviewarticlethatcoverstudieswithmodelsystemsandastronaut\nsamples.Thework,which wasdone in collaborationbetweenNAsAandotherspaceagencies aroundtheworld,uncoverstheimpact ofknownhazards of\nspaceflight,suchas radiation and microgravity,and discusses the standardsformulti-omics from space and the preparations needed for Mars and other\nmissionsinthenexttwodecades.\nNASAanimation\nConsiderations for the future of spaceflight experiments\nReview Open Archive\nConversations Open Archive\nFundamental Biological Features of Spaceflight: Advancing the\nAn Extraordinary Astronaut\nField to Enable Deep-Space Exploration\nCell, Vol. 183, ssue 6\nAfshinnekoo et al.\nCell,Vol.183, Issue5\nPerspective Open Access\nLetter e Open Archive\nANewEraforSpaceLifeScience:International Standardsfor\nRevamping Space-omics inEurope\nSpace Omics Processing\nMadrigal et al.\nRutter et al.\nCell Systems, Vol. 11, Issue 6\nPatterns, Vol. 1, Issue9\nPreview Open Access\nArticle Open Access\nAdvancing the Integration of Biosciences Data Sharing to\nRNAseqAnalysisof RodentSpaceflightExperimentsIs\nFurtherEnableSpaceExploration\nConfoundedby SampleCollectionTechniques\nScott et al.\nLai Polo et al.\nCell Reports, Vol.33, Issue10\niScience,Vol.23,Issue12\nArticle Open Access\nArticle Open Access\nThe Importance of Earth Reference Controls in Spaceflight\nNASA GeneLab RNA-seq consensus pipeline:Standardized\nOmicsResearch:CharacterizationofNucleolinMutantsfromthe\nprocessing of short-read RNA-seq data\nSeedling GrowthExperiments\nOverbey et al.\nManzano et al.\niScience, Vol. 24, Issue 4\niscience,Vol.23.Issue11\nGeneral biological impacts of spaceflight\nArticle Open Archive\nArticle Open Access\nComprehensive Multi-omics Analysis Reveals Mitochondrial\nBeyond Low-Earth Orbit:Characterizing Immuneand microRNA\nStress as a Central Biological Hub for Spaceflight Impact\nDifferentials following Simulated Deep Spaceflight Conditions in\nMice\nda Silveira et al.\nCell,Vol.183,Issue\nPaul et al.\niScience,Vol.23,Issue12\nArticle Open Access\nReportOpen Access\nCirculating miRNA Spaceflight Signature RevealsTargetsfor\nA Longitudinal EpigeneticAging and LeukocyteAnalysis of\nCountermeasure Development\nSimulated Space Travel:TheMars-500Mission\nMaikani et al.\nNwanaji-Enwerem et al.\nCell Reports, Vol. 33, Issue 10\nCell Reports, Vol. 33, Issue 10\nArticle Open Access\nArticle Open Access\nCell-free DNA (cfDNA) and Exosome Profiling from a Year-Long\nSpaceflight affects neuronal morphology and alters transcellular\nHuman Spaceflight RevealsCirculating Biomarkers\ndegradation of neuronal debris in adult Caenorhabditis elegans\nBezdan et al.\nLaranjeiro et al.\niScience,Vol.23,Issue12\niscience,Vol.24,ssue2\nArticle Open Access\nReference-guided metagenomics reveals genome-level\nevidenceofpotentialmicrobial transmissionfromtheIss\nenvironmenttoanastronaut'smicrobiome\nLee et al.\niScience,Vol.24,Issue2\nRadiation risks of spaceflight\nArticle Open Access\nArticle.·Open Access\nTemporal Telomereand DNADamageResponsesintheSpace\nTelomereLengthDynamics andDNADamageResponses\nRadiation Environment\nAssociated with Long-Duration Spaceflight\nLuxton et al.\nLuxton et al.\nCell Reports, Vol.33, Issue 10\nCellReports,Vol.33,Issue10\nReportOpen Access\nArticle 。 Open Access\nClonal Hematopoiesis Before, During,andAfter Human\nDNADamageBaseline Predicts Resilience to Space Radiation\nSpaceflight\nand Radiotherapy\nMencia-Trinchant et al.\nPariset et al.\nCellReports,Vol.33,Issue10\nCellReports,Vol.33,Issue10\nArticle Open Access\nArticle Open Access\nLET-Dependent Low Dose and Synergistic Inhibition of Human\nTelomerelengthdynamics inresponsetoDNAdamagein\nAngiogenesis by ChargedParticles:ValidationofmiRNAs that\nmalaria parasites\nDrive Inhibition\nReed et al.\nWuu et al.\niScience, Vol.24,Issue2\niScience,Vol.23,Issue12\nPhysiological impact of microgravity\nArticle Open Access\nArticle Open Access\nMulti-omic,Single-Cell,andBiochemicalProfilesofAstronauts\nProlonged Exposure to Microgravity Reduces Cardiac\nGuidePharmacological Strategiesfor Returningto Gravity\nContractility and Initiates Remodeling in Drosophila\nGertz et al.\nWalls et al.\nCell Reports, Vol.33, Issue10\nCell Reports, Vol.33, Issue 10\nArticle Open Access\nComparativeTranscriptomicsldentifiesNeuronalandMetabolic\nAdaptations to Hypergravity and Microgravity in Caenorhabditis\nelegans\nWillis et al.\niScience,Vol.23,Issue12\nFeatured journals\nCell Reports\nPiscience\nSneak peek - upcoming cover art for\niScience:i stands for interdisciplinary\nCell Reports\niScienceisanopenaccessjournal with\nThis cover image depicts Day 142 during the Year-\ncontinuouspublication.Exploreresearchthat\nLongMissionof ScottKelly,withtheaurora\ninspires new thinking beyond the discipline,\nborealis behind the docked Soyuz space capsule.\nincluding the spaceflight biology articles featured\nThefull issuewill bepublished on December8,\nin this collection.\n2020.\nRead the articles from this collection\npublished in Cell\nThis issue's coverart shows city lights spanning\nJapan,glimmeringbelowEarth'sthinatmosphere,\naswellastheInternationalSpaceStationwitha\ndocked Soyuz SpaceCapsule.Photograph by\nScott Kelly.\ncell Systems\nEPatterns\nCell Press Branding\nAccessthelatestresearchfromCell\nIntroducingPatterns\nScience that inspires\nSystems\nPatterns is a new gold open access journal that\nCell Presspublishesover50scientific journals\npromotesall types of data science researchand\nCell Systems provides a home for elegant work\nacross the life,physical, earth,andhealth\noutputs,and facilitates sharing and collaboration\nthat addresses fundamental questions in systems\nsciences,bothindependentlyandinpartnership\ntosolvekeyscientificproblemsregardless oftheir\nbiology.\nwith scientific societies.Learnmoreabout our\noriginating domain.\nportfolio.\nWork in progress and related manuscripts\nThebelowarticles associated with this initiativearestill undergoingpeerreviewand revision or have beenpublished elsewhere.\nHaplotype Diversity and Sequence Heterogeneity of Human Telomeresz\nGrigorev et al.\nCharacterizationof Spacesuit AssociatedMicrobialCommunitiesandTheirImplicationsforNASAMissions\nDanko et al.\nGeneticEvidenceforSelectiveTransferofMicrobesBetweenanAstronautandtheInternational SpaceStationz\nDanko et al.\nEngineeringRadioprotectiveHumanCellsUsingtheTardigradeDamageSuppressorProtein\nWestover et al.\nRelated resources\n:NASATwins StudyZ\n.NASAGeneLab7\nNASAHumanResearchRoadmap7\n.NASALifetimeSurveillanceofAstronautHealth(LSAH)z\n:NASALifeSciencesDataArchive(LSDA)z\n.NAsAAstrobiology Habitable Environments Database\n:NAsAInstitutionalScientificCollection(iSC)atAmesResearchCenter,andBiospecimenSharingProgram(BsP)7\n.IssMicrobial Tracking\nHRPSpaceRadiationElement'sNASASpaceRadiationLaboratory(NSRL)Biospecimens7\nNASAPlanetaryProtection7\nJAXA-ToMMoIntegratedBiobankforSpaceLifeScience7\n.EuropeanSpaceAgency(ESA)-ErasmusExperimentArchive(EEA)\nContributing lab groups\n:ChristopherMason,Ph.D.\n.Susan Bailey, Ph.D.\n.AfshinBeheshti,Ph.D.7\n:Sylvain Costes,Ph.D.7\n:Peter Grabham,Ph.D.7\n2CelPress\nin\nLIFE&MEDICALSCIENCESJOURNALS\nAUTHORS\nABOUT\nACCESS\nCell\nSubmit article\nAbout Cell Press\nMolecularPlant (partner)\nSubscribe\nMolecularTherapy (partner)\nOpen access\nCancer Cell\nMulti-JourmalSubmission\nClaim\nCell Chemical Biology\nMolecularTherapy Methods &Clinical\nSTAR Methods\nCOVID Hub\nRead-It-Now\nDevelopment (partner)\nCell Genomics\nSneakPeek-Preprints\nSustainability hub\nRecommendtoLibrarian\nMolecularTherapyNucleicAcids\nCell Host&Microbe\nInclusionand diversity\nPublicationAlerts\n(partner)\nCell Metabolism\nREVIEWERS\nMolecular Therapy Oncology\nInformationforreviewers\nCAREERS\n(partner)\nCell Reports\nCOLLECTIONS\nCell Press Careers\nPlant Communications (partner)\nBest ofCell Press\nCell Reports Medicine\nNEWS&EVENTS\nStem Cell Reports (partner)\nCell PressReviews\nCell Stem Cell\nNewsroom\nTrendsinBiochemicalSciences\nCell Press Selections\nCell Systems\nEvents\nTrends in Cancer\nCurrent Biology\nNucleusCollections\nCell Symposia\nTrends in Cell Biology\nSnapShotArchive\nDevelopmental Cell\nConsortia Hub\nImmunity\nTrends in Ecology&Evolution\nWebinars\nINFORMATION\nMed\nTrends inEndocrinology&\nMetabolism\nFor Librarians\nMolecular Cell\nTrends in Genetics\nMULTIMEDIA\nNeuron\nTrends in Immunology\nCell Press Podcast\nStructure\nTrends in Microbiology\nCell Press Videos\nAmericanJoumalofHumanGenetics\nTrendsinMolecularMedicine\nColoring and Comics\n(partner)\nTrends in Neurosciences\nCell PictureShow\nBiophysical Joumal (partner)\nTrends inNeurosciences\nBiophysical Joumal (partner)\nResearch Arc\nBiophysical Reports (partner)\nTrends in Parasitology\nHumanGeneticsandGenomics\nTrendsinPharmacologicalSciences\nAdvances (partner)\nTrends in Plant Science\nPHYSICALSCIENCES&ENGINEERINGJOURNALS\nCell Biomaterials\nJoule\nCell ReportsPhysical Science\nMatter\nChem\nNewton\nChem Catalysis\nTrends in Chemistry\nDevice\nMULTIDISCIPLINARYJOURNALS\nCellReportsMethods\nSTARProtocols\nCell Reports Sustainability\nNexus (partner)\nHeliyon\nThe Innovation (partner)\niscience\nTrends in Biotechnology\nOne Earth\nTrends in Cognitive Sciences\nPattems\nThecontent on this site is intendedforhealthcareprofessionals and researchersacross all fields ofscience.\nAll content on this site:Copyright2025ElsevierInc.,its licensors, and contributors.\nAll rights arereserved, including thosefortext anddata mining.Altraining,andsimilartechnologies.\nForallopenaccesscontent,therelevant licensingtermsapply.\nPrivacyPolicy Terms&Conditions Accessibility Help&Support Contact\n&RELX", "live": "CelPress\nSubmit Log in Register\nJournals\nNews &events\nAbout Cell Press\nPublish\nAdvanced\nSearch fo...\nsearch\nThe biology of spaceflight\nThe biology of spaceflight\nCellPress/Consortiahub/Thebiologyofspaceflight\nConsiderations for the\nAs humankindreaches forthe stars to journey to the next frontier in space,research on spaceflight biology is\nfuture of spaceflight\ncriticalforunderstandinghow livingsystems,includinghumanhealth,maybeaffectedbyspaceflightand space\nexperiments\nexploration.This special collectionon thebiologyof spaceflight,published in Cell and other Cell Press journals,\nGeneral biological\nincludesresearcharticles,short communications,anda reviewarticlethat coverstudieswithmodel systems\nimpactsofspaceflight\nRadiationrisks of\nspaceflight\ndiscussesthestandardsformulti-omics fromspaceand the preparationsneeded forMarsand othermissions\nin the next two decades.\nPhysiological impact of\nmicrogravity\nFeatured journals\nWork in progress and\nrelatedmanuscripts\nRelated resources\nContributing labgroups\nConsiderations for the future of spaceflight experiments\nReviewOpen Archive\nConversationsOpen Archive\nFundamental Biological Features of Spaceflight:\nAnExtraordinaryAstronaut\nAdvancingtheFieldtoEnableDeep-Space\nExploration\nCell,Vol.183, Issue6\nEbrahimAfshinnekoo,RyanT.Scott,MatthewJ.\nMacKay,EloisePariset,EgleCekanaviciute,Richard\nBarker,and others\nCell, Vol. 183, Issue5\nPerspective OpenAccess\nLetter OpenArchive\nANewEra for Space Life Science:International\nRevamping Space-omics in Europe\nStandards for Space Omics Processing\nPedroMadrigal,AlexanderGabel,AliciaVillacampa,Aranzazu\nLindsayRutter,RichardBarker,DanielaBezdan,Henry\nManzano,Colleen S.Deane,Daniela Bezdan,andothers\nCope,Sylvain V.Costes,LovorkaDegoricja,and others\nCell Systems, Vol. 11, Issue 6\nPatterns, Vol. 1, Issue 9\nPreview Open Access\nArticle Open Access\nAdvancing the Integration of BiosciencesData\nRNAseqAnalysisofRodentSpaceflight\nSharingtoFurther Enable Space Exploration\nExperimentsIsConfoundedbySample\nCollection Techniques\nRyanT.Scott,KirillGrigorev,GrahamMackintosh,SamrawitG\nGebre,ChristopherE.Mason,MarthaE.DelAlto,andothers\nSan-Huei Lai Polo,Amanda M.Saravia-Butler, Valery\nCellReports,Vol.33Issue10\nBoyko,MarieT.Dinh,Yi-ChunChen,HomerFogle,andothers\niScience,Vol.23,Issue12\nArticle Open Access\nArticle Open Access\nThe Importanceof EarthReferenceControls in\nNAsA GeneLabRNA-seq consensus pipeline:\nSpaceflight-OmicsResearch:Characterization\nStandardized processing of short-read RNA-seq\nheImportanceotEartnReterenceControlsIn\nNASAGeneLabRNA-segconsensuspipeline:\nSpaceflight-OmicsResearch:Characterization\nStandardized processing of short-read RNA-seq\nof NucleolinMutantsfromtheSeedlingGrowth\ndata\nExperiments\nEliahG.Overbey.Amanda M.Saravia-Butler,Zhe\nAranzazu Manzano,Alicia Villacampa,JulioSaez\nZhang,Komal S.Rathi, Homer Fogle, Willian A.da\nVasquez,JohnZ.Kiss,F.JavierMedina,RaulHeanz\nSilveira, and others\niScience,Vol.23,Issue11\niScience,Vol.24,Issue4\nGeneral biological impacts of spaceflight\nArticle Open Archive\nArticle Open Access\nComprehensive Multi-omicsAnalysis Reveals\nBeyond Low-Earth Orbit:Characterizing Immune\nMitochondrial StressasaCentral Biological Hub\nandmicroRNADifferentialsfollowing Simulated\nfor Spaceflight Impact\nDeep Spaceflight Conditions in Mice\nWillian A.da silveira, Hossein Fazelinia, Sara Brin\nAmberM.Paul,MargarethCheng-Campbell,ElizabethA.\nRosenthal, Evagelia C.Laiakis,Man S.Kim\nCemMeydan\nBlaber, Sulekha Anand, Sharmila Bhattacharya,Sara R.\nothers\nZwart, and others\nCell, Vol.183, Issue 5\niScience, Vol. 23, Issue 12\nArticleOpen Access\nReport Open Access\nCirculating miRNA Spaceflight Signature\nA Longitudinal Epigenetic Aging and Leukocyte\nRevealsTargetsfor Countermeasure\nAnalysis ofSimulated Space Travel:TheMars-\nDevelopment\n500Mission\nSherina Malkani,ChristopherR.Chin,Egle\nJamajiC.Nwanaji-Enwerem,UzojiNwanaji-Enwerem,Lars\nCekanaviciute,Marie Mortreux, Hazeem Okinula, Marcel\nVan Der Laan, Jonathan M. Galazka, Nancy S.\nTarbier,and others\nRedeker,AndresCardenas\nCell Reports,Vol.33, Issue10\nCell Reports,Vol:33,Issue10\nArticle Open Access\nArticle Open Access\nCell-freeDNA(cfDNA)and ExosomeProfiling\nSpaceflight affects neuronal morphologyand\nfroma Year-Long Human SpaceflightReveals\nalters transcellulardegradation of neuronal\nCirculating Biomarkers\ndebris in adult Caenorhabditis elegans\nDaniela Bezdan,Kirill Grigorev\nCemMeydan FannyA.\nRicardo Laranjeiro,GirishHarinath,AmeliaK\nPelissierVattr,MicheeCof,VarhaRaoandoth\nPollard,ChristopherJ.Gaffney,ColleenS.Deane,Siva\niScience, Vol.23,Issue12\nVanapalli,and others\niScience,Vol.24,Issue 2\nArticle Open Access\nReference-guidedmetagenomicsreveals\ngenome-levelevidenceof potentialmicrobial\ntransmissionfromtheIsSenvironmenttoan\nastronaut'smicrobiome\nMichaelD.Lee,AubrieO'Rourke,HemanLorenzi,Brad M.\nBebout, Chris L.Dupont, R.Craig Everroad\niScience,Vol.24,Issue2\nRadiation risks of spaceflight\nArticle Open Access\nArticle Open Access\nTemporal Telomere and DNADamage\nTelomere Length Dynamics and DNA Damage\nResponses in theSpace RadiationEnvironment\nResponsesAssociatedwithLong-Duration\nJared J.Luxton,Miles J.McKenna,Lynn.TaylorKerry\nSpaceflight\nGeorge, Sara R.Zwart, Brian E.Crucian, and others\nJared J.Luxton, Miles J. McKenna, Aidan Lewis, Lynn E.\nCellReports,Vol.33,Issue10\nTaylor,KerryAGeorge,SameerM.Dixit,and others\nCell Reports, Vol. 33, Issue 10\nReport Open Access\nArticle Open Access\nClonal HematopoiesisBefore,During,andAfter\nDNADamageBaselinePredicts Resilienceto\nHumanSpaceflight\nSpace Radiation and Radiotherapy\nNuriaMencia-Trinchant,MatthewJ.MacKay,Christopher\nEloisePariset,AntonellaBertucci,MargauxPetay,Sherina\nChin,EbrahimAfshinnekoo,JonathanFoox\nCemMeydan\nMalkani,AlejandraLopez Macha,IvanG.PaulinoLima,and\nothers\nothers\nCell Reports, Vol.33, Issue10\nCell Reports, Vol.33, Issue 10\nCellReports,Vol.33,Issue10\nCellReports,Vol.33,Issue10\nArticle Open Access\nArticle Open Access\nLET-Dependent LowDoseand Synergistic\nTelomere length dynamics in response to DNA\nInhibitionof HumanAngiogenesis byCharged\ndamage in malaria parasites\nParticles:Validationof miRNAs thatDrive\nJakeReed,LauraA.Kirkman,BjornF.Kafsack,Christopher\nInhibition\nMason,KirkW.Deitsch\nYen-Ruh Wuu, Burong Hu, Hazeem Okunola,Amber M.\niScience, Vol. 24, Issue 2\nPaul,ElizabethA.Blaber,MargarethCheng-Campbelland\nothers\niscience,Vol.23,Issue12\nPhysiological impact of microgravity\nArticle Open Access\nArticle ·Open Access\nMulti-omic,Single-Cell,andBiochemical Profiles\nProlonged Exposureto MicrogravityReduces\nofAstronautsGuidePharmacological Strategies\nCardiac Contractility and Initiates Remodeling in\nfor Returning to Gravity\nDrosophila\nMonica LGertz,ChristopherR.Chin,Delia\nStanleyWalls,SodaDiop,RyanBirse,Lisa Emen,Zhuohui\nTomoiagaMatthewMacKay.Christina Chang.Daniel\nGan,SreehariKalvakuri,andothers\nButler,and others\nCellReports,Vol.33,ssue10\nCellReports,Vol.33,Issue10\nArticle Open Access\nComparativeTranscriptomics Identifies Neuronal\nandMetabolicAdaptationstoHypergravityand\nMicrogravity in Caenorhabditis elegans\nCraig R.G.Wilis,Nathaniel J.Szewczyk,SylvainV\nCostes,IngridA.Udranszky,SigridS.Reinsch,Timothy\nEtheridge,andothers\niscience,Vol.23.Issue12\nFeatured journals\nReadthe articlesfromthis\nSneak peek-upcoming\niScience:istandsfor\nI coverartfor Cell Reports\ncollectionpublished in Cell\ninterdisciplinary\nThis issue's cover art shows city\nThiscoverimagedepictsDay142\niScience is anopen access journal\nduring the Year-Long Mission of\nlightsspanningJapan,glimmering\nwith continuous publication.\nbelow Earth's thin atmosphere,as\nScott Kelly,withtheauroraborealis\nExploreresearchthatinspiresnew\nbehindthedocked Soyuzspace\nwellastheInternationalSpace\nthinking beyond the discipline,\nStationwithadocked SoyuzSpace\ncapsule.The full issue will be\nincluding the spaceflight biology\nCapsule.Photograph by Scott\npublishedon December 8,2020.\narticlesfeatured inthiscollection.\nKelly.\nAccess the latest research Introducing Patterns\nScience that inspires\nfrom Cell Systems\nPatterns is anewgold openaccess\nCell Press publishes over50\njournal that promotes all types of\nCell Systems providesa homefor\nscientific journals acrossthe life,\ndata science research and outputs,\nelegant workthataddresses\nphysical, earth,and health\nand facilitates sharing and\nfundamentalquestions in systems\nsciences,both independentlyand\ncollaborationto solvekey scientific\nbiology.\nin partnershipwith scientific\nproblems regardless of their\nsocieties.Learn moreabout our\noriginating domain.\nportfolio.\noriginating domain.\nportfolio.\nWork in progress and related manuscripts\nThe below articles associated with this initiative are stll undergoing peer reviewand revision or have been\npublishedelsewhere.\nHaplotypeDiversityandSequenceHeterogeneityof HumanTelomeres\nGrigorev et al.\nCharacterizationofSpacesuitAssociated Microbial CommunitiesandTheirImplicationsforNASAMissions\nDanko et al.\nGenetic Evidencefor SelectiveTransferof Microbes Between an Astronaut and the International Space Station\nDanko et al.\nEngineeringRadioprotectiveHumanCellsUsingtheTardigradeDamageSuppressorProteinz\nWestover et al.\nRelated resources\n.NASATwins Studyz\n·NASAGeneLab\n.NASAHumanResearchRoadmap\n·NASALifetimeSurveillanceofAstronautHealth(LSAH)\n:NASALifeSciencesDataArchive(LSDA)z\n:NASAAstrobiologyHabitableEnvironmentsDatabase7\n.NASA Institutional Scientific Collection (ISC)at Ames Research Center,and Biospecimen Sharing\nProgram(BSP)\n.ISSMicrobial Trackingz\n.HRPSpaceRadiationElement'sNASASpaceRadiationLaboratory(NSRL)Biospecimens\nNASAPlanetaryProtection\n:JAXA-ToMMoIntegratedBiobankforSpaceLifeSciencez\n:European SpaceAgency(ESA)-Erasmus ExperimentArchive(EEA)\nContributing lab groups\nThebelow lab groups are core contributors to this article collection.Each group isrepresented by their principal\ninvestigator.\nChristopher Mason, Ph.D.\n·Susan Bailey,Ph.D.\nAfshinBeheshti,Ph.D.\n.SylvainCostes,Ph.D.7\nPeter Grabham, Ph.D.7\nCelPress\nAUTHORS\nABOUT\nLIFE&MEDICALSCIENCESJOURNALS\nACCESS\nCell\nAbout Cell Press\nMolecularPlant (partner)\nSubmit article\nSubscribe\nCancer Cell\nMolecularTherapy (partner)\nMulti-Joumal Submission\nOpenaccess\nClaim\nCell Chemical Biology\nMolecular Therapy Advances\nCOVID Hub\nSTARMethods\nRead-It-Now\n(partner)\nCell Genomics\nSneakPeek-Preprints\nSustainability hub\nRecommendtoLibrarian\nMolecularTherapyNucleicAcids\nCellGeloncs\nSheakPeek-Plephmts\nSustanabtyub\nReconmendtoLianan\nMolecularTherapyNucleicAcids\nCell Host&Microbe\nInclusion\n(partner)\nPublicationAlerts\nCellMetabolism\nREVIEWERS\nMolecular Therapy Oncology\nInformationforreviewers\nCAREERS\n(partner)\nCell Reports\nCOLLECTIONS\nCell PressCareers\nPlant Communications (partner)\nBestofCell Press\nCellReports Medicine\nNEWS&EVENTS\nStemCellReports (partner)\nCell PressReviews\nCell StemCell\nNewsroom\nCell Systems\nTrendsin Biochemical Sciences\nEvents\nINFORMATION\nCurrent Biology\nTrends in Cancer\nCell Press Symposia\nFor Librarians\nDevelopmental Cell\nTrends in Cell Biology\nConsortia Hub\nImmunity\nTrends in Ecology&Evolution\nWebinars\nMed\nTrends in Endocrinology&\nMetabolism\nMolecular Cell\nTrends in Genetics\nNeuron\nTrends in Immunology\nStructure\nTrends in Microbiology\nAmericanJourmalofHumanGenetics\n(partner)\nTrends in Molecular Medicine\nBiophysical Joumal (partner)\nTrends in Neurosciences\nBiophysical Reports(partner)\nTrends in Parasitology\nHuman Genetics and Genomics\nTrendsinPhamacologicalSciences\nAdvances (partner)\nTrends in Plant Science\nPHYSICALSCIENCES&ENGINEERINGJOURNALS\nCell Biomaterials\nJoule\nCell Reports Physical Science\nMatter\nChem\nMatter & Light\nChem Catalysis\nNewton\nChem Circularity\nTrends in Chemistry\nDevice\nMULTIDISCIPLINARYJOURNALS\nCell PressBlue\nSTARProtocols\nCell Reports Methods\nNexus (partnen)\nCell Reports Sustainability\nThe Innovation (partner)\nHeliyon\nTrends in Biotechnology\niscience\nTrends in Cognitive Sciences\nOne Earth\nTrendsOpen\nPattems\nThe content on this site is intended for healthcare professionals and researchers across all fields of science.\nAllcontentonthis site:Copyright2026ElsevierInc.,its licensors,andcontributors.\nForallopenaccesscontent,therelevant licensingtermsapply.\nPrivacy Policy\nCookiesettingsTerms&Conditions AccessibilityHelp&Support\n Contact\nResponsible Al\nCRELX" } }, { "id": "cell2020-scinews", "study": "cell2020", "outlet": "Sci.News", "outlet_original": "Sci.News", "outlet_score": 5, "title": "Spaceflight Impairs Mitochondrial Function, New Research Shows", "title_original": "Spaceflight Impairs Mitochondrial Function, New Research Shows", "language": "English", "date": "2020-11", "kind": "news", "url": "https://www.sci.news/medicine/spaceflight-mitochondrial-function-09092.html", "archive_url": "https://web.archive.org/web/20260123042247/https://www.sci.news/medicine/spaceflight-mitochondrial-function-09092.html", "names_meydan": false, "meydan_context": "", "passage_naming_meydan": "", "summary": "Reports a Cell study using multi-omics data from 59 astronauts and GeneLab samples, finding that gravity changes and radiation can impair mitochondria, linking to geriatric-like health issues.", "topics": [ "mitochondria", "multi-omics", "spaceflight", "radiation", "astronaut health" ], "audience": "science-press", "thumbnail": "media-archive/thumbs/cell2020-scinews.jpg", "passage_image": "", "full_screenshot": "media-archive/shots/cell2020-scinews--archived.jpg", "saved_html": "", "saved_article_text": "media-archive/text/cell2020-scinews.txt", "ocr_text": { "archived": "Home\nAbout Us\nNews Archive\nCopyright\nContact Us\nRSS\nPrivacy Policy\nSCI NEWS\nTop Headlines:\nHOME\nSPACEEXPLORATION\nPALEONTOLOGY\nPHYSICS\nMEDICINE\nGENETICS\nGEOLOGY\nASTRONOMY\nARCHAEOLOGY\nBIOLOGY\nMORE\nSpaceflight Impairs Mitochondrial\nLATEST NEWS\nFunction, New Research Shows\nBiologists 'Resurrect 3.2-Billion-\nYear-Old Enzyme\nJan 22, 2026|Astrobiology\nNov26,2020byNewsStaff\n