SARS-CoV-2 Enfeksiyonunun Transkriptomik, Uzamsal ve Viral Olarak Karakterizasyonu | Cem Meydan

5.62K subscribers

845 views Streamed 6y ago

TÜBİTAK TBAE Biological Sciences Seminar Series SARS-CoV-2 Enfeksiyonunun Transkriptomik, Uzamsal ve Viral Olarak Moleküler Karakterizasyonu

…

more

more

Comments are turned off. Learn more

SARS-CoV-2 Enfeksiyonunun Transkriptomik, Uzamsal ve Viral Olarak Karakterizasyonu | Cem Meydan

TÜBİTAK TBAE

TÜBİTAK TBAE Biological Sciences Seminar Series SARS-CoV-2 Enfeksiyonunun Transkriptomik, Uzamsal ve Viral Olarak Moleküler Karakterizasyonu Speaker: Cem Meydan (Cornell University, USA) ABSTRACT:Given the rapid emergence of SARS-CoV-2, little is known about its genetic variation, immune system interactions, population prevalence, and environmental distribution. We developed a large-scale host, viral and microbial transcriptomic profiling platform that employs total RNA sequencing of nasopharyngeal swabs, blood specimens and tissues from autopsies along with environmental samples from urban centers and hospitals to characterize the genetic subtypes and heterogeneity of SARS-CoV-2 to create a broad molecular picture of the COVID-19 epidemic in New York City (NYC). We find significant enrichment of a NYC-distinctive clade of the virus (20C), as well as host responses in interferon, ACE, hematological, and olfaction pathways. In addition, clinical data from 50,821 patients shows evidence of a protective impact of patients taking ACE inhibitors, which is distinct from other drugs. Finally, spatial transcriptomic data from COVID-19 patient autopsy tissues reveal distinct ACE2 expression loci, with macrophage and neutrophil infiltration in the lungs. These findings can inform public health and may help develop and drive new SARS-CoV-2 diagnostic, prevention, and treatment strategies.

Transcript

Follow along using the transcript.

TÜBİTAK TBAE

5.62K subscribers

Live chat replay is not available for this video.