A Unifying Mechanism for Cancer-Driving Mutations
Release on a Nature study showing that BAF-complex mutations, found in about 20% of cancers, work by letting CTCF reshape 3D genome architecture; deleting CTCF in an animal model reverses the effect.
The other co-corresponding authors were Dr. Cem Meydan, assistant professor of research in systems and computational biomedicine at Weill Cornell Medicine; and Dr. Ari Melnick, director of the Josep Carreras Leukaemia Research Institute in Barcelon…


















